Iris Otani, MD

Associate Professor

Dr. Iris Otani is an allergist/immunologist with expertise in drug allergy and secondary hypogammaglobulinemia. She is the Medical and Quality Improvement Director for Adult Allergy/Immunology and sees patients in the UCSF Parnassus Allergy/Immunology and Drug Allergy Testing Clinics. Her academic interests also include medical education and quality improvement. She is the associate program director for the UCSF Allergy/Immunology Fellowship Training Program. She has pursued further training in quality improvement and was selected to join the Learning Health System Coach program at UCSF Health, a faculty development program for faculty who lead continuous improvement in their clinical settings. She serves on the editorial board of the Annals of Allergy Asthma & Immunology.

Education
2020 - Diversity, Equity, and Inclusion Champion Training, University of California, San Francisco
2016 - Allergy/Immunology, Massachusetts General Hospital Allergy/Immunology Fellowship
- Internal Medicine, Santa Clara Valley Medical Center Internal Medicine Residency
BS, - Biology, Stanford University
MD, - , UCSD School of Medicine
Honors and Awards
  • Exceptional Physician Award, UCSF Health, 2023
  • Excellence in Teaching Award, UCSF Haile T. Debas Academy of Medical Educators, 2021
Publications

  1. Tsao LR, Li L, Robertson PA, Irani RA, Otani IM. Aspirin/NSAID hypersensitivity evaluations in pregnancy: a case series of initiating low-dose aspirin. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2024. PMID: 39383942


  2. Monahan R, Otani IM. Delayed drug reactions: The next frontier in drug allergy? Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2024. PMID: 39097346


  3. Monahan R, Otani IM. The shifting paradigm of gastrointestinal disease associated with antibody deficiencies. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2024. PMID: 38839140


  4. Tsao LR, Wen S, Lamar RC, Irani RA, Otani IM. Promoting Prenatal Penicillin Allergy Evaluations: A Multi-Year Process Improvement Study. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2024. PMID: 38521341


  5. Young FD, Aung S, Tang M, Anstey KM, Lee MC, Alfaro E, Cinar P, Ho H, Otani IM. Rechallenges without desensitization following platinum-based chemotherapy reactions. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 2024. PMID: 38347725


  6. Lulu Tsao, Lily Li, Patricia Robertson, Roxanna Irani, Iris Otani. Evaluation of Aspirin/NSAID Hypersensitivity During Pregnancy. Journal of Allergy and Clinical Immunology 2024. PMID:


  7. John Accarino, Elizabeth Phillips, Aleena Banerji, Allison Ramsey, Alexei Gonzalez-Estrada, Cosby Stone, Iris Otani, David Khan, Timothy Chow, Anne Liu, Anna Arroyo, Andrew King, Yuqing Zhang, Kimberly Blumenthal. PEN-FAST Assessment Using Patient-Reported Reaction Histories in a Multi-Site Prospective United States Cohort. Journal of Allergy and Clinical Immunology 2024. PMID:


  8. Kimberly Blumenthal, Allison Ramsey, Elizabeth Phillips, Alexei Gonzalez-Estrada, John Accarino, Aleena Banerji, Cosby Stone, Iris Otani, David Khan, Timothy Chow, Anne Liu, Anna Arroyo, Andrew King, Yuqing Zhang. Predicting Penicillin Allergy from Patient-Reported Data: A Multi-Site Prospective Study from The United States Drug Allergy Registry. Journal of Allergy and Clinical Immunology 2024. PMID:


  9. Monahan R, Alfaro E, Ho H, Otani IM, Tsao LR. Hereditary Alpha Tryptasemia Presenting as Recurrent Chemotherapy Hypersensitivity Reactions. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2023. PMID: 38151098


  10. Khan DA, Phillips EJ, Accarino JJ, Gonzalez-Estrada A, Otani IM, Ramsey A, Arroyo AC, Banerji A, Chow T, Liu AY, Stone CA, Blumenthal KG. United States Drug Allergy Registry (USDAR) grading scale for immediate drug reactions. The Journal of allergy and clinical immunology 2023. PMID: 37652140


  11. Accarino JJO, Ramsey A, Samarakoon U, Phillips E, Gonzalez-Estrada A, Otani IM, Fu X, Banerji A, Stone CA, Khan DA, Blumenthal KG, United States Drug Allergy Registry Study Team. Drug allergy in older adults: A study from the United States Drug Allergy Registry. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2023. PMID: 37557950


  12. Greenhawt M, Dribin TE, Abrams EM, Shaker M, Chu DK, Golden DB, Akin C, Anagnostou A, ALMuhizi F, Alqurashi W, Arkwright P, Baldwin JL, Banerji A, Bégin P, Ben-Shoshan M, Bernstein J, Bingeman TA, Bindslev-Jensen C, Blumenthal K, Byrne A, Cahil J, Cameron S, Campbell D, Campbell R, Cavender M, Chan ES, Chinthrajah S, Comberiatti P, Eastman JJ, Ellis AK, Fleischer DM, Fox A, Frischmeyer-Guerrerio PA, Gagnon R, Garvey LH, Grayson MH, Clarisse Isabwe GA, Hartog N, Hendron D, Horner CC, O'B Hourihane J, Iglesia E, Kan M, Kaplan B, Katelaris CH, Kim H, Kelso JM, Kahn DA, Lang D, Ledford D, Levin M, Lieberman JA, Loh R, Mack DP, Mazer B, Mody K, Mosnaim G, Munblit D, Mustafa SS, Nanda A, Nathan R, Oppenheimer J, Otani IM, Park M, Pawankar R, Perrett KP, Peter J, Phillips EJ, Picard M, Pitlick M, Ramsey A, Rasmussen TH, Rathkopf MM, Reddy H, Robertson K, Rodriguez Del Rio P, Sample S, Sheshradi A, Shiek J, Sindher SB, Spergel JM, Stone CA, Stukus D, Tang ML, Tracy JM, Turner PJ, Vander Leek TK, Wallace DV, Wang J, Wasserman S, Weldon D, Wolfson AR, Worm M, Yacoub MR. Updated Guidance Regarding The Risk ofAllergic Reactions to COVID-19 Vaccines and Recommended Evaluation and Management: A GRADE Assessment, and International Consensus Approach. The Journal of allergy and clinical immunology 2023. PMID: 37295474


  13. Otani IM, Tang M, Wang L, Anstey KM, Hilts-Horeczko A, Li F, Le VP, Lee M, Bystritsky R, Mulliken JS, Wattier RL, Blumenthal KG, Doernberg SB. Impact of an Inpatient Allergy Guideline on β-Lactam and Alternative Antibiotic Use. The journal of allergy and clinical immunology. In practice 2023. PMID: 37182569


  14. Rose Monahan, Alyssa Perez, Joey Lew, Megan Casey, Lorriana Leard, Steven Hays, Iris Otani. IgG Replacement Therapy Use in Patients with Hypogammaglobulinemia after Lung Transplant. Clinical Immunology 2023. PMID:


  15. Rose Monahan, Fernanda Young, Emely Alfaro, Carlo Legasto, Dorothy Wang, Jessica Zheng, Lulu Tsao, Hansen Ho, Iris Otani. Access To Outpatient Chemotherapy Desensitization Improved With Implementation Of A Multidisciplinary Pharmacy, Nursing, And Allergist Team. Journal of Allergy and Clinical Immunology 2023. PMID:


  16. John Accarino, Allison Ramsey, Upeka Samarakoon, Iris Otani, Alexei Gonzalez-Estrada, Xiaoqing Fu, Elizabeth Phillips, Cosby Stone, Aleena Banerji, Kimberly Blumenthal. Drug Allergy Assessments in Older Adults: A Multi-Site Prospective Study from the United States Drug Allergy Registry. Journal of Allergy and Clinical Immunology 2023. PMID:


  17. Jiang SY, Tang M, Desai K, Song P, Eng J, Otani IM. Medicine resident perceptions regarding �-lactam antibiotic prescribing in patients with penicillin allergy. The journal of allergy and clinical immunology. In practice 2022. PMID: 36280135


  18. Otani IM, Tsao LR, Tang M. COVID-19 Vaccine Administration in Patients with Reported Reactions to Polyethylene Glycol- and Polysorbate-Containing Therapeutics. 2022. PMID: 35288274


  19. Otani IM, Lehman HK, Jongco AM, Tsao LR, Azar A, Tarrant T, Engel E, Walter JE, Truong TQ, Khan DA, Ballow M, Cunningham-Rundles C, Lu H, Kwan M, Barmettler S. Practical Guidance for the Diagnosis and Management of Secondary Hypogammaglobulinemia: A Work Group Report of the AAAAI Primary Immunodeficiency and Altered Immune Response Committees. 2022. PMID: 35176351


  20. Fernanda Young, Karen Anstey, Hansen Ho, Emely Alfaro, Pelin Cinar, Iris Otani. Direct Rechallenges, Slowed Infusions, and Titrated Infusions following Platinum Hypersensitivity Reactions: Review of 5-Year Experience. Journal of Allergy and Clinical Immunology 2022. PMID:


  21. Iris Otani, Monica Tang, Karen Anstey, Lusha Wang, Alexandra Hilts-Horeczko, Fanny Li, Vincent Le, Melissa Lee, Jennifer Mulliken, Rachel Bystritsky, Sarah Doernberg. Implementing a Hospital-Wide Inpatient Beta-Lactam Allergy Guideline Leads to Consistent Increases in Beta-Lactam Use. Journal of Allergy and Clinical Immunology 2022. PMID:


  22. Kimberly Blumenthal, Allison Ramsey, Upeka Samarakoon, Iris Otani, Alexei Gonzalez-Estrada, Aleena Banerji, Anne Liu, Paige Wickner, Cosby Stone, Miguel Park, Christian Mancini, Allen Judd, Catherine Ahola, Xiaoqing Fu, Yuqing Zhang, Karen Donelan, S Shahzad Mustafa, Holly Blue, Dawn Sheflin, Tyler Harkness, David Khan, Wendy Garzon-Siatoya, Dan Morgenstern-Kaplan, Madeline Marks, Amy Kerrigan, Christine Rukasin, Elizabeth Phillips. The United States Drug Allergy Registry: A Prospective Longitudinal Cohort Study of Patients Tested for Drug Allergies. Journal of Allergy and Clinical Immunology 2022. PMID:


  23. Ruchi Shah, Lulu Tsao, Jessica Zheng, Monica Tang, Iris Otani. Urticarial and Eczematous Eruptions Following mRNA COVID-19 Vaccination in Patients With and Without Chronic Urticaria and Atopic Dermatitis. Journal of Allergy and Clinical Immunology 2022. PMID:


  24. Anstey KM, Tsao L, Otani IM. Drug Allergy Delabeling Programs: Recent Strategies and Targeted Populations. 2022. PMID: 35031956


  25. F. Young, L. Pincus, W. Ai, I. Otani. M060 SUCCESSFUL REINTRODUCTION OF MOGAMULIZUMAB VIA OUTPATIENT ONE DILUTION DESENSITIZATION PROTOCOLS FOLLOWING RECURRENT DELAYED CUTANEOUS REACTIONS. 2021. PMID:


  26. Tsao LR, Otani IM. One-Bag Desensitization Protocols in the Management of Chemotherapy Hypersensitivity. 2021. PMID: 34749948


  27. Lew J, Casey M, Leard LE, Hays S, Otani IM. Perceptions Around Lung Transplant-Associated Hypogammaglobulinemia. Journal of clinical immunology 2021. PMID: 34351551


  28. Tsao LR, Young FD, Otani IM, Castells MC. Hypersensitivity Reactions to Platinum Agents and Taxanes. Clinical reviews in allergy & immunology 2021. PMID: 34338975


  29. Anstey KM, Choi L, Dawson D, Kleinhenz ME, Otani IM. Enabling antibiotic allergy evaluations and reintroduction of first-line antibiotics for patients with cystic fibrosis. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2021. PMID: 34048884


  30. Tsao LR, Villanueva SA, Pines DA, Pham MN, Choo EM, Tang MC, Otani IM. Impact of Rapid Transition to Telemedicine-Based Delivery on Allergy/Immunology Care During COVID-19. The journal of allergy and clinical immunology. In practice 2021. PMID: 33894393


  31. M. Casey, J. Lew, S. Hays, L. Leard, I. Otani. Hypogammaglobulinemia Identification and Management in Lung Transplant Patients: Survey of Provider Practices. 2021. PMID:


  32. I.M. Otani, J. Lew, M. Casey, A. Perez, L. Zhang, L. Leard, S. Hays. Screening for Severe Hypogammaglobulinemia in Lung Transplant Recipients. 2021. PMID:


  33. Anstey KM, Anstey JE, Doernberg SB, Chen LL, Otani IM. Perioperative use and safety of cephalosporin antibiotics in patients with documented penicillin allergy. The journal of allergy and clinical immunology. In practice 2021. PMID: 33766583


  34. Lulu Tsao, Stephanie Anne Villanueva Ferraris, David Pines, Eugene Choo, Michele Pham, Monica Tang, Lorianna Leard, Andrew Gross, Cameron Ashbaugh, Lei Choi, Iris Otani. Rapid Adoption of Video Visits and Return-to-Clinic Procedures to Maintain Access to Allergy/Immunology Care Delivery During COVID-19. 2021. PMID:


  35. Fung M, Otani I, Pham M, Babik J. Zoonotic coronavirus epidemics: Severe acute respiratory syndrome, Middle East respiratory syndrome, and coronavirus disease 2019. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2020. PMID: 33310180


  36. L. Tsao, R. Irani, G. Rosenbluth, L. Choi, I. Otani. A055 EXPANDING PENICILLIN ALLERGY EVALUATION FOR PRENATAL PATIENTS. Annals of Allergy Asthma & Immunology 2020. PMID:


  37. Broyles AD, Banerji A, Barmettler S, Biggs CM, Blumenthal K, Brennan PJ, Breslow RG, Brockow K, Buchheit KM, Cahill KN, Cernadas J, Chiriac AM, Crestani E, Demoly P, Dewachter P, Dilley M, Farmer JR, Foer D, Fried AJ, Garon SL, Giannetti MP, Hepner DL, Hong DI, Hsu JT, Kothari PH, Kyin T, Lax T, Lee MJ, Lee-Sarwar K, Liu A, Logsdon S, Louisias M, MacGinnitie A, Maciag M, Minnicozzi S, Norton AE, Otani IM, Park M, Patil S, Phillips EJ, Picard M, Platt CD, Rachid R, Rodriguez T, Romano A, Stone CA, Torres MJ, Verdú M, Wang AL, Wickner P, Wolfson AR, Wong JT, Yee C, Zhou J, Castells M. Practical Guidance for the Evaluation and Management of Drug Hypersensitivity: Specific Drugs. The journal of allergy and clinical immunology. In practice 2020. PMID: 33039007


  38. Lee M, Nguyen J, Fuleihan R, Gundling K, Cunningham-Rundles C, Otani IM. Neurologic Conditions and Symptoms Reported Among Common Variable Immunodeficiency Patients in the USIDNET. Journal of clinical immunology 2020. PMID: 32901355


  39. Blumenthal KG, Harkness T, Phillips EJ, Ramsey A, Banerji A, Samarakoon U, Stone C, Fu X, Khan DA, Otani I, Camargo CA, Zhang Y, Donelan K. Patient Characteristics and Concerns About Drug Allergy: A Report from the United States Drug Allergy Registry. The journal of allergy and clinical immunology. In practice 2020. PMID: 32853819


  40. Anstey KM, Lee M, Dawson D, Jue V, Budzik JM, Yu M, Kleinhenz ME, Otani IM. Antibiotic Adverse Reactions in Adult Cystic Fibrosis Patients. The journal of allergy and clinical immunology. In practice 2020. PMID: 32673878


  41. Otani IM, Castells M. Novel Roles for Platinum and Taxane Agent Skin Testing in Risk Stratification of Chemotherapy Hypersensitivity. The journal of allergy and clinical immunology. In practice 2020. PMID: 32389278


  42. Karen Anstey, Mary Ellen Kleinhenz, Iris Otani. Development of an Antibiotic Allergy Program to Address a Clinical Gap in the Antibiotic Stewardship of Cystic Fibrosis Patients. Journal of Allergy and Clinical Immunology 2020. PMID:


  43. Lulu Tsao, Riley Bove, Tanya Krishnakumar, Iris Otani. Hypogammaglobulinemia in Patients with Neuromyelitis Optica (NMO). Journal of Allergy and Clinical Immunology 2020. PMID:


  44. Michael Lee, John Routes, Rebecca Marsh, Ramsay Fuleihan, Patricia Lugar, Charlotte Cunningham-Rundles, Elizabeth Garabedian, Iris Otani. Primary Immunodeficiency Diagnoses seen in Patients with Chronic Lung Disease: Findings from the USIDNET Registry. Journal of Allergy and Clinical Immunology 2020. PMID:


  45. K. Anstey, M. Kleinhenz, I. Otani. A006 ADVERSE DRUG REACTIONS IN CYSTIC FIBROSIS PATIENTS: USING DATA TO DEVELOP AN ANTIBIOTIC EVALUATION PROGRAM. Annals of Allergy Asthma & Immunology 2019. PMID:


  46. Jennifer S Mulliken, Rachel Bystritsky, Karen Anstey, Iris M Otani, Sarah B Doernberg. 2543. Implementation of a Fellow-Driven ?-Lactam Allergy De-Labeling Initiative on an Inpatient ID Consult Service. Open forum infectious diseases 2019. PMID:


  47. Paula Song, Michael Hwa, Jen Eng, Iris M. Otani. Beta-lactam Administration Patterns at a Safety-net Hospital with Limited Access to Inpatient Penicillin Skin Testing. Journal of Allergy and Clinical Immunology 2019. PMID:


  48. Lulu Tsao, Iris M. Otani, Riley Bove. Hypogammaglobulinemia in Multiple Sclerosis Patients Receiving Disease-Modifying Immunomodulatory Agents. Journal of Allergy and Clinical Immunology 2019. PMID:


  49. Karen Anstey, James Anstey, Alexandra Hilts-Horeczko, Sarah B. Doernberg, Lee-Lynn Chen, Iris M. Otani. Perioperative Use and Safety of Cephalosporin Antibiotics in Patients with Documented Penicillin Allergy. Journal of Allergy and Clinical Immunology 2019. PMID:


  50. Sara Seghezzo, Lulu Tsao, Iris M. Otani. Strategies for Discontinuing Omalizumab in Patients with Chronic Urticaria: Real-World Findings. Journal of Allergy and Clinical Immunology 2019. PMID:


  51. Busse PJ, Christiansen SC, Birmingham JM, Overbey JR, Banerji A, Otani IM, Lumry W, Goryachkovsky A, Zuraw BL. Development of a health-related quality of life instrument for patients with hereditary angioedema living in the United States. The journal of allergy and clinical immunology. In practice 2018. PMID: 30550806


  52. Otani IM, Carroll RW, Yager P, Kroshinsky D, Murphy S, Hornick JL, Akin C, Castells M, Walter JE. Diffuse cutaneous mastocytosis with novel somatic KIT mutation K509I and association with tuberous sclerosis. Clinical case reports 2018. PMID: 30214774


  53. Otani IM, Levin AS, Banerji A. Cutaneous Manifestations of Reactions to Biologics. Current allergy and asthma reports 2018. PMID: 29464437


  54. Jenna T. Nguyen, Iris M. Otani. Documentation of Adverse Drug Reactions in Electronic Medical Records: Areas for Improvement and Impact on Clinical Outcomes. Journal of Allergy and Clinical Immunology 2018. PMID:


  55. Iris M. Otani, Alexi Otrakji, Niki Holtzman, Matthew Iandoli, Kimberly G. Blumenthal, Aleena Banerji, Gloria Salazar. Impact of a Novel Radiocontrast Media Reaction Treatment Algorithm in Simulation Settings of Anaphylaxis. Journal of Allergy and Clinical Immunology 2018. PMID:


  56. Iris M. Otani. Chapter 23 Corticosteroids. Drug Allergy Testing 2018. PMID:


  57. Otani IM, Lax T, Long AA, Slawski BR, Camargo CA, Banerji A. Utility of Risk Stratification for Paclitaxel Hypersensitivity Reactions. The journal of allergy and clinical immunology. In practice 2017. PMID: 28986119


  58. Otani IM, Wong J, Banerji A. Platinum Chemotherapy Hypersensitivity: Prevalence and Management. Immunology and allergy clinics of North America 2017. PMID: 28965633


  59. Otani IM, Banerji A. Acquired C1 Inhibitor Deficiency. Immunology and allergy clinics of North America 2017. PMID: 28687105


  60. Otani IM, Nadeau KC. Biologic Therapies for Immunoglobulin E-mediated Food Allergy and Eosinophilic Esophagitis. Immunology and allergy clinics of North America 2017. PMID: 28366483


  61. Barmettler S, Otani IM, Minhas J, Abraham RS, Chang Y, Dorsey MJ, Ballas ZK, Bonilla FA, Ochs HD, Walter JE. Gastrointestinal Manifestations in X-linked Agammaglobulinemia. Journal of clinical immunology 2017. PMID: 28236219


  62. Otani IM, Lumry WR, Hurwitz S, Li HH, Craig TJ, Holtzman NS, Iandoli MI, Tucker J, Riedl MA, Zuraw BL, Banerji A. Subcutaneous Icatibant for the Treatment of Hereditary Angioedema Attacks: Comparison of Home Self-Administration with Administration at a Medical Facility. The journal of allergy and clinical immunology. In practice 2016. PMID: 27818136


  63. Otani IM, Christiansen SC, Busse P, Camargo CA, Zuraw BL, Riedl MA, Banerji A. Emergency Department Management of Hereditary Angioedema Attacks: Patient Perspectives. The journal of allergy and clinical immunology. In practice 2016. PMID: 27665386


  64. Levin AS, Otani IM, Lax T, Hochberg E, Banerji A. Reactions to Rituximab in an Outpatient Infusion Center: A 5-Year Review. The journal of allergy and clinical immunology. In practice 2016. PMID: 27497683


  65. Otani IM, Banerji A. Immediate and Delayed Hypersensitivity Reactions to Corticosteroids: Evaluation and Management. Current allergy and asthma reports 2016. PMID: 26857016


  66. Otani IM, Banerji A. Immediate and Delayed Hypersensitivity Reactions to Proton Pump Inhibitors: Evaluation and Management. Current allergy and asthma reports 2016. PMID: 26810177


  67. Iris Otani, William R. Lumry, Huamin Henry Li, Chevy Chase, Timothy J. Craig, Marc A. Riedl, Bruce L. Zuraw, Aleena Banerji. Subcutaneous Icatibant for the Treatment of Acute Attacks of Hereditary Angioedema: Comparison of Self-Administration to Administration at a Medical Facility. Journal of Allergy and Clinical Immunology 2016. PMID:


  68. Otani IM, Kuhlen JL, Blumenthal KG, Guyer A, Banerji A. A role for vancomycin epicutaneous skin testing in the evaluation of perioperative anaphylaxis. The journal of allergy and clinical immunology. In practice 2015. PMID: 26246124


  69. Arasi S, Otani IM, Klingbeil E, Bégin P, Kearney C, Dominguez TL, Block WM, O'Riordan G, Nadeau KC. Two year effects of food allergen immunotherapy on quality of life in caregivers of children with food allergies. Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 2014. PMID: 25788951


  70. Otani IM, Bégin P, Kearney C, Dominguez TL, Mehrotra A, Bacal LR, Wilson S, Nadeau K. Multiple-allergen oral immunotherapy improves quality of life in caregivers of food-allergic pediatric subjects. Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 2014. PMID: 24860608


  71. Otani IM, Anilkumar AA, Newbury RO, Bhagat M, Beppu LY, Dohil R, Broide DH, Aceves SS. Anti-IL-5 therapy reduces mast cell and IL-9 cell numbers in pediatric patients with eosinophilic esophagitis. The Journal of allergy and clinical immunology 2013. PMID: 23623266


  72. Iris Otani, Tina L.R. Dominguez, Alicia Sciancalepore, Anjuli Mehrotra, Daniela Pineda, Kari Nadeau. Multi-Allergen Oral Immunotherapy Improves Quality of Life in Subjects with Food Allergies. Journal of Allergy and Clinical Immunology 2013. PMID:


  73. I.M. Otani, M. Bhagat, R.O. Newbury, R. Dohil, D.H. Broide, S.S. Aceves. The Effect of Anti-IL-5 Therapy on Esophageal Mastocytosis in Pediatric Eosinophilic Esophagitis. Journal of Allergy and Clinical Immunology 2012. PMID:


  74. Kashiwakura J, Otani IM, Kawakami T. Monomeric IgE and mast cell development, survival and function. Advances in experimental medicine and biology 2011. PMID: 21713650


  75. Putcha GV, Bejjani BA, Bleoo S, Booker JK, Carey JC, Carson N, Das S, Dempsey MA, Gastier-Foster JM, Greinwald JH, Hoffmann ML, Jeng LJ, Kenna MA, Khababa I, Lilley M, Mao R, Muralidharan K, Otani IM, Rehm HL, Schaefer F, Seltzer WK, Spector EB, Springer MA, Weck KE, Wenstrup RJ, Withrow S, Wu BL, Zariwala MA, Schrijver I. A multicenter study of the frequency and distribution of GJB2 and GJB6 mutations in a large North American cohort. Genetics in medicine : official journal of the American College of Medical Genetics 2007. PMID: 17666888


  76. Otani I, Conrad DH, Ruddy S. Enhancement of IGE-induced mediator release from rat peritoneal mast cells by serum-treated zymosan. Cellular immunology 1984. PMID: 6205769


  77. Kuroda M, Akiyama T, Otani I, Kusunoki N, Tohfuku Y, Imura M, Tamai T, Takeda R. [Renal disease in the nail-patella syndrome: report of an affected family and studies of renal disease susceptibility and HLA (author's transl)]. Nihon Jinzo Gakkai shi 1978. PMID: 713167