Feroz Papa, MD, PhD

Professor

Education
Postdoctoral fellowship, - Biochemistry, University of California, San Francisco
Clinical fellowship, - Endocrinology, University of California, San Francisco
Residency, - Internal medicine, University of California, San Francisco
PhD, - Biochemistry and Molecular Biology, University of Chicago
MD, - Medicine, University of Chicago
Websites
Publications

  1. Jourdan Le Saux C, Ho TC, Brumwell AM, Kathiriya JJ, Wei Y, Hughes JB, Garakani K, Atabai K, Auyeung VC, Papa FR, Chapman HA. BCL-2 Modulates IRE1α Activation to Attenuate ER Stress and Pulmonary Fibrosis. American journal of respiratory cell and molecular biology 2023. PMID: 38117250


  2. Massoudi D, Gorman S, Kuo YM, Iwawaki T, Oakes SA, Papa FR, Gould DB. Deletion of the Unfolded Protein Response Transducer IRE1a Is Detrimental to Aging Photoreceptors and to ER Stress-Mediated Retinal Degeneration. Investigative ophthalmology & visual science 2023. PMID: 37097227


  3. Auyeung VC, Downey MS, Thamsen M, Wenger TA, Backes BJ, Sheppard D, Papa FR. IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosis. 2022. PMID: 35170357


  4. Feldman HC, Ghosh R, Auyeung VC, Mueller JL, Kim JH, Potter ZE, Vidadala VN, Perera BGK, Olivier A, Backes BJ, Zikherman J, Papa FR, Maly DJ. ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR. Nature chemical biology 2021. PMID: 34556859


  5. Yamashita Y, Morita S, Hosoi H, Kobata H, Kishimoto S, Ishibashi T, Mishima H, Kinoshita A, Backes BJ, Yoshiura KI, Papa FR, Sonoki T, Tamura S. Targeting Adaptive IRE1a Signaling and PLK2 in Multiple Myeloma: Possible Anti-Tumor Mechanisms of KIRA8 and Nilotinib. International journal of molecular sciences 2020. PMID: 32878237


  6. Ishibashi T, Morita S, Kishimoto S, Uraki S, Takeshima K, Furukawa Y, Inaba H, Ariyasu H, Iwakura H, Furuta H, Nishi M, Papa FR, Akamizu T. nAChR signaling regulates IRE1a activation to protect ß cells against terminal unfolded protein response under irremediable ER stress. Journal of diabetes investigation 2020. PMID: 31925927


  7. Moore PC, Qi JY, Thamsen M, Ghosh R, Peng J, Gliedt MJ, Meza-Acevedo R, Warren RE, Hiniker A, Kim GE, Maly DJ, Backes BJ, Papa FR, Oakes SA. Parallel signaling through IRE1a and PERK regulates pancreatic neuroendocrine tumor growth and survival. Cancer research 2019. PMID: 31672843


  8. Feldman HC, Vidadala VN, Potter ZE, Papa FR, Backes BJ, Maly DJ. Development of a Chemical Toolset for Studying the Paralog-Specific Function of IRE1. ACS chemical biology 2019. PMID: 31609569


  9. Ghosh R, Colon-Negron K, Papa FR. Endoplasmic reticulum stress, degeneration of pancreatic islet ß-cells, and therapeutic modulation of the unfolded protein response in diabetes. Molecular metabolism 2019. PMID: 31500832


  10. Gonzalez-Teuber V, Albert-Gasco H, Auyeung VC, Papa FR, Mallucci GR, Hetz C. Small Molecules to Improve ER Proteostasis in Disease. Trends in pharmacological sciences 2019. PMID: 31377018


  11. Igbaria A, Merksamer PI, Trusina A, Tilahun F, Johnson JR, Brandman O, Krogan NJ, Weissman JS, Papa FR. Chaperone-mediated reflux of secretory proteins to the cytosol during endoplasmic reticulum stress. Proceedings of the National Academy of Sciences of the United States of America 2019. PMID: 31101715


  12. Thamsen M, Ghosh R, Auyeung VC, Brumwell A, Chapman HA, Backes BJ, Perara G, Maly DJ, Sheppard D, Papa FR. Small molecule inhibition of IRE1a kinase/RNase has anti-fibrotic effects in the lung. PloS one 2019. PMID: 30625178


  13. Scott A. Oakes, Paul C. Moore, Jenny Y. Qi, Rachel Warren, Maike Thamsen, Rajarshi Ghosh, Micah J. Gliedt, Anne Hiniker, Grace E. Kim, Dustin J. Maly, Bradley J. Backes, Feroz R. Papa. Pancreatic Neuroendocrine Tumors Require Homeostatic Signaling from the Unfolded Protein Response. The FASEB Journal 2018. PMID:


  14. Hetz C, Papa FR. The Unfolded Protein Response and Cell Fate Control. Molecular cell 2017. PMID: 29107536


  15. Morita S, Villalta SA, Feldman HC, Register AC, Rosenthal W, Hoffmann-Petersen IT, Mehdizadeh M, Ghosh R, Wang L, Colon-Negron K, Meza-Acevedo R, Backes BJ, Maly DJ, Bluestone JA, Papa FR. Targeting ABL-IRE1a Signaling Spares ER-Stressed Pancreatic ß Cells to Reverse Autoimmune Diabetes. Cell metabolism 2017. PMID: 28467938


  16. Morita S, Villalta SA, Feldman HC, Register AC, Rosenthal W, Hoffmann-Petersen IT, Mehdizadeh M, Ghosh R, Wang L, Colon-Negron K, Meza-Acevedo R, Backes BJ, Maly DJ, Bluestone JA, Papa FR. Targeting ABL-IRE1a Signaling Spares ER-Stressed Pancreatic ß Cells to Reverse Autoimmune Diabetes. Cell metabolism 2017. PMID: 28380378


  17. Scott A. Oakes, Jenny Y. Qi, Paul C Moore, Rachel A. Warren, Maike Thamsen, Rajarshi Ghosh, Micah J. Gliedt, Dustin J. Maly, Bradley J Backes, Feroz R. Papa. The Unfolded Protein Response Regulates Pancratic Neuroendocrine Tumor Growth. The FASEB Journal 2017. PMID:


  18. Papa F, Lippolis R, Sardaro N, Gnoni A, Scacco S. All trans retinoic acid depresses the content and activity of the mitochondrial ATP synthase in human keratinocytes. Biochemical and biophysical research communications 2016. PMID: 27856255


  19. Jenny Y. Qi, Paul C. Moore, Maike Thamsen, Rajarshi Ghosh, Micah J. Gliedt, Dustin J. Maly, Bradley J. Backes, Feroz R. Papa, Scott A. Oakes. Abstract 2862: The balance of divergent IRE1a signaling regulates pancreatic neuroendocrine tumor growth. Molecular and Cellular Biology, Genetics 2016. PMID:


  20. Feldman HC, Tong M, Wang L, Meza-Acevedo R, Gobillot TA, Lebedev I, Gliedt MJ, Hari SB, Mitra AK, Backes BJ, Papa FR, Seeliger MA, Maly DJ. Structural and Functional Analysis of the Allosteric Inhibition of IRE1a with ATP-Competitive Ligands. ACS chemical biology 2016. PMID: 27227314


  21. Valentine CD, Anderson MO, Papa FR, Haggie PM. Correction: X-Box Binding Protein 1 (XBP1s) Is a Critical Determinant of Pseudomonas aeruginosa Homoserine Lactone-Mediated Apoptosis. PLoS pathogens 2016. PMID: 27191388


  22. Watkin LB, Jessen B, Wiszniewski W, Vece TJ, Jan M, Sha Y, Thamsen M, Santos-Cortez RL, Lee K, Gambin T, Forbes LR, Law CS, Stray-Pedersen A, Cheng MH, Mace EM, Anderson MS, Liu D, Tang LF, Nicholas SK, Nahmod K, Makedonas G, Canter DL, Kwok PY, Hicks J, Jones KD, Penney S, Jhangiani SN, Rosenblum MD, Dell SD, Waterfield MR, Papa FR, Muzny DM, Zaitlen N, Leal SM, Gonzaga-Jauregui C. COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis. Volume 47 of Issue 6. Nature genetics 2015. PMID: 25894502


  23. Maly DJ, Papa FR. Druggable sensors of the unfolded protein response. Nature chemical biology 2014. PMID: 25325700


  24. Oakes SA, Papa FR. The role of endoplasmic reticulum stress in human pathology. Annual review of pathology 2014. PMID: 25387057


  25. Ghosh R, Wang L, Wang ES, Perera BG, Igbaria A, Morita S, Prado K, Thamsen M, Caswell D, Macias H, Weiberth KF, Gliedt MJ, Alavi MV, Hari SB, Mitra AK, Bhhatarai B, Schürer SC, Snapp EL, Gould DB, German MS, Backes BJ, Maly DJ, Oakes SA, Papa FR. Allosteric inhibition of the IRE1a RNase preserves cell viability and function during endoplasmic reticulum stress. Cell 2014. PMID: 25018104


  26. Sedwick C, Papa F. Feroz Papa: Saving cells from themselves. The Journal of cell biology 2014. PMID: 24590168


  27. Kanekura K, Ishigaki S, Merksamer PI, Papa FR, Urano F. Establishment of a system for monitoring endoplasmic reticulum redox state in mammalian cells. Laboratory investigation; a journal of technical methods and pathology 2013. PMID: 24042438


  28. Valentine CD, Anderson MO, Papa FR, Haggie PM. X-box binding protein 1 (XBP1s) is a critical determinant of Pseudomonas aeruginosa homoserine lactone-mediated apoptosis. PLoS pathogens 2013. PMID: 23990788


  29. Cha SI, Ryerson CJ, Lee JS, Kukreja J, Barry SS, Jones KD, Elicker BM, Kim DS, Papa FR, Collard HR, Wolters PJ. Cleaved cytokeratin-18 is a mechanistically informative biomarker in idiopathic pulmonary fibrosis. Respiratory research 2012. PMID: 23167970


  30. Wang L, Perera BG, Hari SB, Bhhatarai B, Backes BJ, Seeliger MA, Schürer SC, Oakes SA, Papa FR, Maly DJ. Divergent allosteric control of the IRE1a endoribonuclease using kinase inhibitors. Nature chemical biology 2012. PMID: 23086298


  31. Upton JP, Wang L, Han D, Wang ES, Huskey NE, Lim L, Truitt M, McManus MT, Ruggero D, Goga A, Papa FR, Oakes SA. IRE1a cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2. Science (New York, N.Y.) 2012. PMID: 23042294


  32. Papa FR. Endoplasmic reticulum stress, pancreatic ß-cell degeneration, and diabetes. Cold Spring Harbor perspectives in medicine 2012. PMID: 22951443


  33. Lerner AG, Upton JP, Praveen PV, Ghosh R, Nakagawa Y, Igbaria A, Shen S, Nguyen V, Backes BJ, Heiman M, Heintz N, Greengard P, Hui S, Tang Q, Trusina A, Oakes SA, Papa FR. IRE1a induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. Cell metabolism 2012. PMID: 22883233


  34. Meares GP, Hughes KJ, Naatz A, Papa FR, Urano F, Hansen PA, Benveniste EN, Corbett JA. IRE1-dependent activation of AMPK in response to nitric oxide. Molecular and cellular biology 2011. PMID: 21896783


  35. Shore GC, Papa FR, Oakes SA. Signaling cell death from the endoplasmic reticulum stress response. Current opinion in cell biology 2010. PMID: 21146390


  36. Merksamer PI, Papa FR. The UPR and cell fate at a glance. Journal of cell science 2010. PMID: 20332117


  37. Lei X, Zhang S, Barbour SE, Bohrer A, Ford EL, Koizumi A, Papa FR, Ramanadham S. Spontaneous development of endoplasmic reticulum stress that can lead to diabetes mellitus is associated with higher calcium-independent phospholipase A2 expression: a role for regulation by SREBP-1. The Journal of biological chemistry 2009. PMID: 20032468


  38. Dan Han, Alana G. Lerner, Lieselotte Vande Walle, John-Paul Upton, Weihong Xu, Andrew Hagen, Bradley J. Backes, Scott A. Oakes, Feroz R. Papa. IRE1a Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates. Journal of End-to-End-testing 2009. PMID:


  39. Dan Han, Alana G. Lerner, Lieselotte Vande Walle, John-Paul Upton, Weihong Xu, Andrew Hagen, Bradley J. Backes, Scott A. Oakes, Feroz R. Papa. IRE1a Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates. Journal of End-to-End-testing 2009. PMID:


  40. Han D, Lerner AG, Vande Walle L, Upton JP, Xu W, Hagen A, Backes BJ, Oakes SA, Papa FR. IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. Cell 2009. PMID: 19665977


  41. Trusina A, Papa FR, Tang C. Rationalizing translation attenuation in the network architecture of the unfolded protein response. Proceedings of the National Academy of Sciences of the United States of America 2008. PMID: 19075238


  42. Merksamer PI, Trusina A, Papa FR. Real-time redox measurements during endoplasmic reticulum stress reveal interlinked protein folding functions. Cell 2008. PMID: 19026441


  43. Upton JP, Austgen K, Nishino M, Coakley KM, Hagen A, Han D, Papa FR, Oakes SA. Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress. Molecular and cellular biology 2008. PMID: 18426910


  44. Ala Trusina, Feroz Papa, Chao Tang. Translation Attenuation Mechanism in Unfolded Protein Response. 2008. PMID:


  45. Han D, Upton JP, Hagen A, Callahan J, Oakes SA, Papa FR. A kinase inhibitor activates the IRE1alpha RNase to confer cytoprotection against ER stress. Biochemical and biophysical research communications 2007. PMID: 18035051


  46. Bernales S, Papa FR, Walter P. Intracellular signaling by the unfolded protein response. Annual review of cell and developmental biology 2006. PMID: 16822172


  47. Credle JJ, Finer-Moore JS, Papa FR, Stroud RM, Walter P. On the mechanism of sensing unfolded protein in the endoplasmic reticulum. Proceedings of the National Academy of Sciences of the United States of America 2005. PMID: 16365312


  48. Papa FR, Zhang C, Shokat K, Walter P. Bypassing a kinase activity with an ATP-competitive drug. Science (New York, N.Y.) 2003. PMID: 14564015


  49. Papa FR, Amerik AY, Hochstrasser M. Interaction of the Doa4 deubiquitinating enzyme with the yeast 26S proteasome. Molecular biology of the cell 1999. PMID: 10069815


  50. Hansen-Hagge TE, Janssen JW, Hameister H, Papa FR, Zechner U, Seriu T, Jauch A, Becke D, Hochstrasser M, Bartram CR. An evolutionarily conserved gene on human chromosome 5q33-q34, UBH1, encodes a novel deubiquitinating enzyme. Genomics 1998. PMID: 9615226


  51. Zhu Y, Carroll M, Papa FR, Hochstrasser M, D'Andrea AD. DUB-1, a deubiquitinating enzyme with growth-suppressing activity. Proceedings of the National Academy of Sciences of the United States of America 1996. PMID: 8622927


  52. DeMarini DJ, Papa FR, Swaminathan S, Ursic D, Rasmussen TP, Culbertson MR, Hochstrasser M. The yeast SEN3 gene encodes a regulatory subunit of the 26S proteasome complex required for ubiquitin-dependent protein degradation in vivo. Molecular and cellular biology 1995. PMID: 7565784


  53. Hochstrasser M, Papa FR, Chen P, Swaminathan S, Johnson P, Stillman L, Amerik AY, Li SJ. The DOA pathway: studies on the functions and mechanisms of ubiquitin-dependent protein degradation in the yeast Saccharomyces cerevisiae. Cold Spring Harbor symposia on quantitative biology 1995. PMID: 8824423


  54. Papa FR, Hochstrasser M. The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene. Nature 1993. PMID: 8247125