Dolores Shoback, MD

Prof in Rsd

Dr. Dolores Shoback cares for patients with a variety of disorders related to the endocrine system, focusing particularly on metabolic bone disease, parathyroid disorders and osteoporosis. She also directs UCSF's physician training program in diabetes, endocrinology and metabolism.

Shoback's research interests include metabolic bone disease, the calcium-sensing receptor and parathyroid hormone.

Shoback completed her undergraduate studies at the University of Pennsylvania. She earned her medical degree from the Johns Hopkins School of Medicine and completed a residency in internal medicine at the Johns Hopkins Hospital. She completed a fellowship in endocrinology at Brigham and Women's Hospital.

Publications

  1. Clarke BL, Khan AA, Rubin MR, Schwarz P, Vokes T, Shoback DM, Gagnon C, Palermo A, Abbott LG, Hofbauer LC, Kohlmeier L, Cetani F, Pihl S, An X, Smith AR, Lai B, Ukena J, Sibley CT, Shu AD, Rejnmark L. Efficacy and Safety of TransCon PTH in Adults with Hypoparathyroidism: 52-Week Results From the Phase 3 PaTHway Trial. The Journal of clinical endocrinology and metabolism 2024. PMID: 39376010


  2. Rejnmark L, Gosmanova EO, Khan AA, Makita N, Imanishi Y, Takeuchi Y, Sprague S, Shoback DM, Kohlmeier L, Rubin MR, Palermo A, Schwarz P, Gagnon C, Tsourdi E, Zhao C, Makara MA, Ominsky MS, Lai B, Ukena J, Sibley CT, Shu AD. Palopegteriparatide Treatment Improves Renal Function in Adults with Chronic Hypoparathyroidism: 1-Year Results from the Phase 3 PaTHway Trial. Advances in therapy 2024. PMID: 38691316


  3. Faiq S, Lavelle K, Hu T, Shoback D, Ku G. Cinacalcet increases renal calcium excretion in PTHrP-mediated hypercalcemia: a case report. BMC endocrine disorders 2023. PMID: 37328745


  4. Watts NB, Bilezikian JP, Bone HG, Clarke BL, Denham D, Levine MA, Mannstadt M, Peacock M, Rothman JG, Vokes TJ, Warren ML, Yin S, Sherry N, Shoback DM. Long-Term Safety and Efficacy of Recombinant Human Parathyroid Hormone (1-84) in Adults With Chronic Hypoparathyroidism. Journal of the Endocrine Society 2023. PMID: 37091306


  5. Shen WT, Kebebew E, Shoback D, Liu C, Gosnell JE, Caron NR. In Memoriam: Orlo H. Clark, MD (1941-2022). Thyroid : official journal of the American Thyroid Association 2023. PMID: 36719769


  6. Pasieka JL, Wentworth K, Yeo CT, Cremers S, Dempster D, Fukumoto S, Goswami R, Houillier P, Levine MA, Pasternak JD, Perrier ND, Sitges-Serra A, Shoback DM. Etiology and Pathophysiology of Hypoparathyroidism: A Narrative Review. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2022. PMID: 36153665


  7. Khan AA, Bilezikian JP, Brandi ML, Clarke BL, Gittoes NJ, Pasieka JL, Rejnmark L, Shoback DM, Potts JT, Guyatt GH, Mannstadt M. Evaluation and Management of Hypoparathyroidism Summary Statement and Guidelines from the Second International Workshop. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2022. PMID: 36054621


  8. Khan AA, Rubin MR, Schwarz P, Vokes T, Shoback DM, Gagnon C, Palermo A, Marcocci C, Clarke BL, Abbott LG, Hofbauer LC, Kohlmeier L, Pihl S, An X, Eng WF, Smith AR, Ukena J, Sibley CT, Shu AD, Rejnmark L. Efficacy and Safety of Parathyroid Hormone Replacement With TransCon PTH in Hypoparathyroidism: 26-Week Results From the Phase 3 PaTHway Trial. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2022. PMID: 36271471


  9. Kim TY, Schwartz AV, Li X, Xu K, Kazakia GJ, Grunfeld C, Nissenson RA, Shoback DM, Schafer AL. Bone marrow adipose tissue composition and glycemic improvements after gastric bypass surgery. Bone reports 2022. PMID: 35734226


  10. Wysham KD, Shofer J, Lui G, Trupin L, Andrews JS, Black DM, Graf J, Shoback DM, Katz PP. Low cumulative disease activity is associated with higher bone mineral density in a majority Latinx and Asian US rheumatoid arthritis cohort. 2022. PMID: 35152085


  11. Seib CD, Meng T, Suh I, Harris AHS, Covinsky KE, Shoback DM, Trickey AW, Kebebew E, Tamura MK. Risk of Fracture Among Older Adults With Primary Hyperparathyroidism Receiving Parathyroidectomy vs Nonoperative Management. 2021. PMID: 34842909


  12. Kim SJ, Shoback DM. Sporadic Primary Hyperparathyroidism. 2021. PMID: 34774237


  13. Gittoes N, Rejnmark L, Ing SW, Brandi ML, Björnsdottir S, Hahner S, Hofbauer LC, Houillier P, Khan AA, Levine MA, Mannstadt M, Shoback DM, Vokes TJ, Zhang P, Marelli C, Germak J, Clarke BL. The PARADIGHM (physicians advancing disease knowledge in hypoparathyroidism) registry for patients with chronic hypoparathyroidism: study protocol and interim baseline patient characteristics. 2021. PMID: 34801015


  14. Schafer AL, Shoback DM. A Distinction Without a Difference-Does It Matter Whether Fractures Are Nontraumatic or Traumatic? JAMA internal medicine 2021. PMID: 34096970


  15. Wysham KD, Baker JF, Shoback DM. Osteoporosis and fractures in rheumatoid arthritis. Current opinion in rheumatology 2021. PMID: 33651725


  16. Cauley JA, Shoback DM. Bone age is not just for kids. eLife 2021. PMID: 33650970


  17. Wysham KD, Shoback DM, Andrews JS, Katz PP. Sex differences in frailty and its association with low bone mineral density in rheumatoid arthritis. Bone reports 2020. PMID: 32509932


  18. Clarke BL, Shoback DM. A bridge too far? Attempting to bridge the treatment gap in osteoporosis. Endocrine 2020. PMID: 32441027


  19. Chang W, Tu CL, Jean-Alphonse FG, Herberger A, Cheng Z, Hwong J, Ho H, Li A, Wang D, Liu H, White AD, Suh I, Shen W, Duh QY, Khanafshar E, Shoback DM, Xiao K, Vilardaga JP. PTH hypersecretion triggered by a GABAB1 and Ca2+-sensing receptor heterocomplex in hyperparathyroidism. Nature metabolism 2020. PMID: 32694772


  20. Shoback D, Rosen CJ, Black DM, Cheung AM, Murad MH, Eastell R. Pharmacological Management of Osteoporosis in Postmenopausal Women: An Endocrine Society Guideline Update. The Journal of clinical endocrinology and metabolism 2020. PMID: 32068863


  21. Kim TY, Shoback DM, Black DM, Rogers SJ, Stewart L, Carter JT, Posselt AM, King NJ, Schafer AL. Increases in PYY and Uncoupling of Bone Turnover Are Associated with Loss of Bone Mass After Gastric Bypass Surgery. Bone 2019. PMID: 31689523


  22. Mannstadt M, Clarke BL, Bilezikian JP, Bone H, Denham D, Levine MA, Peacock M, Rothman J, Shoback DM, Warren ML, Watts NB, Lee HM, Sherry N, Vokes TJ. Safety and Efficacy of 5 Years of Treatment With Recombinant Human Parathyroid Hormone in Adults With Hypoparathyroidism. The Journal of clinical endocrinology and metabolism 2019. PMID: 31369089


  23. Cheng Z, Li A, Tu CL, Santa Maria C, Szeto N, Herberger A, Chen TH, Song F, Wang J, Liu X, Shoback DM, Chang W. Calcium-sensing Receptors in Chondrocytes and Osteoblasts Are Required for Callus Maturation and Fracture Healing in Mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2019. PMID: 31498905


  24. Cheng C, Wentworth K, Shoback DM. New Frontiers in Osteoporosis Therapy. Annual review of medicine 2019. PMID: 31509477


  25. Wentworth K, Shoback D. Applying the Guidelines for Primary Hyperparathyroidism: The Path Not Taken. JAMA internal medicine 2019. PMID: 31305872


  26. Eastell R, Rosen CJ, Black DM, Cheung AM, Murad MH, Shoback D. Pharmacological Management of Osteoporosis in Postmenopausal Women: An Endocrine Society* Clinical Practice Guideline. The Journal of clinical endocrinology and metabolism 2019. PMID: 30907953


  27. Alba D, Wu L, Cawthon PM, Mulligan K, Lang T, Patel S, King NJ, Carter JT, Rogers SJ, Posselt AM, Stewart L, Shoback DM, Schafer AL. Changes in lean mass, absolute and relative muscle strength, and physical performance after gastric bypass surgery. The Journal of clinical endocrinology and metabolism 2019. PMID: 30657952


  28. Cheng C, Shoback D. Mechanisms Underlying Normal Fracture Healing and Risk Factors for Delayed Healing. Current osteoporosis reports 2019. PMID: 30671884


  29. Kim SJ, Peluso MJ, Wang Y, Bikle D, Shoback D, Kim S. Rapid onset of hypercalcemia from high-grade lymphoma in the setting of HIV-related immune reconstitution inflammatory syndrome. Bone reports 2018. PMID: 30627599


  30. Babey M, Brandi ML, Shoback D. Conventional Treatment of Hypoparathyroidism. Endocrinology and metabolism clinics of North America 2018. PMID: 30390820


  31. Lee JY, Shoback DM. Familial hypocalciuric hypercalcemia and related disorders. Best practice & research. Clinical endocrinology & metabolism 2018. PMID: 30449544


  32. Wysham KD, Shoback DM, Imboden JB, Katz PP. Association of High Anti-Cyclic Citrullinated Peptide Seropositivity and Lean Mass Index with Low Bone Mineral Density in Rheumatoid Arthritis. Arthritis care & research 2017. PMID: 29106028


  33. Schafer AL, Kazakia GJ, Vittinghoff E, Stewart L, Rogers SJ, Kim TY, Carter JT, Posselt AM, Pasco C, Shoback DM, Black DM. Effects of Gastric Bypass Surgery on Bone Mass and Microarchitecture Occur Early and Particularly Impact Postmenopausal Women. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2017. PMID: 29281126


  34. Vokes TJ, Mannstadt M, Levine MA, Clarke BL, Lakatos P, Chen K, Piccolo R, Krasner A, Shoback DM, Bilezikian JP. Recombinant Human Parathyroid Hormone Effect on Health-Related Quality of Life in Adults With Chronic Hypoparathyroidism. Volume 103 of Issue 2. The Journal of clinical endocrinology and metabolism 2018. PMID: 29099947


  35. Mannstadt M, Bilezikian JP, Thakker RV, Hannan FM, Clarke BL, Rejnmark L, Mitchell DM, Vokes TJ, Winer KK, Shoback DM. Hypoparathyroidism. Volume 3. Nature reviews. Disease primers 2017. PMID: 28980621


  36. Wu CC, Econs MJ, DiMeglio LA, Insogna KL, Levine MA, Orchard PJ, Miller WP, Petryk A, Rush ET, Shoback DM, Ward LM, Polgreen LE. Diagnosis and Management of Osteopetrosis: Consensus Guidelines From the Osteopetrosis Working Group. Volume 102 of Issue 9. The Journal of clinical endocrinology and metabolism 2017. PMID: 28655174


  37. Mannstadt M, Bilezikian JP, Thakker RV, Hannan FM, Clarke BL, Rejnmark L, Mitchell DM, Vokes TJ, Winer KK, Shoback DM. Hypoparathyroidism. Volume 3. Nature reviews. Disease primers 2017. PMID: 28857066


  38. Kim TY, Schwartz AV, Li X, Xu K, Black DM, Petrenko DM, Stewart L, Rogers SJ, Posselt AM, Carter JT, Shoback DM, Schafer AL. Bone Marrow Fat Changes After Gastric Bypass Surgery Are Associated With Loss of Bone Mass. Volume 32 of Issue 11. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2017. PMID: 28791737


  39. Malmstroem S, Rejnmark L, Imboden JB, Shoback DM, Bikle DD. Current Assays to Determine Free 25-Hydroxyvitamin D in Serum. Volume 100 of Issue 5. Journal of AOAC International 2017. PMID: 28492133


  40. Shoback D. Does parathyroid hormone control bone quality? Volume 56 of Issue 1. Endocrine 2017. PMID: 28042646


  41. Clarke BL, Vokes TJ, Bilezikian JP, Shoback DM, Lagast H, Mannstadt M. Effects of parathyroid hormone rhPTH(1-84) on phosphate homeostasis and vitamin D metabolism in hypoparathyroidism: REPLACE phase 3 study. Volume 55 of Issue 1. Endocrine 2016. PMID: 27734257


  42. Cappola AR, Shoback DM. Osteoporosis Therapy in Postmenopausal Women With High Risk of Fracture. Volume 316 of Issue 7. JAMA 2016. PMID: 27533154


  43. Brandi ML, Bilezikian JP, Shoback D, Bouillon R, Clarke BL, Thakker RV, Khan AA, Potts JT. Management of Hypoparathyroidism: Summary Statement and Guidelines. Volume 101 of Issue 6. The Journal of clinical endocrinology and metabolism 2016. PMID: 26943719


  44. Shoback DM, Bilezikian JP, Costa AG, Dempster D, Dralle H, Khan AA, Peacock M, Raffaelli M, Silva BC, Thakker RV, Vokes T, Bouillon R. Presentation of Hypoparathyroidism: Etiologies and Clinical Features. Volume 101 of Issue 6. The Journal of clinical endocrinology and metabolism 2016. PMID: 26943721


  45. Santa Maria C, Cheng Z, Li A, Wang J, Shoback D, Tu CL, Chang W. Interplay between CaSR and PTH1R signaling in skeletal development and osteoanabolism. Volume 49. Seminars in cell & developmental biology 2015. PMID: 26688334


  46. Hindi SM, Wang Y, Jones KD, Nussbaum JC, Chang Y, Masharani U, Bikle D, Shoback DM, Hsiao EC. A Case of Hypercalcemia and Overexpression of CYP27B1 in Skeletal Muscle Lesions in a Patient with HIV Infection After Cosmetic Injections with Polymethylmethacrylate (PMMA) for Wasting. Volume 97 of Issue 6. Calcified tissue international 2015. PMID: 26253396


  47. Bollerslev J, Rejnmark L, Marcocci C, Shoback DM, Sitges-Serra A, van Biesen W, Dekkers OM. European Society of Endocrinology Clinical Guideline: Treatment of chronic hypoparathyroidism in adults. Volume 173 of Issue 2. European journal of endocrinology 2015. PMID: 26160136


  48. Shah AD, Hsiao EC, O'Donnell B, Salmeen K, Nussbaum R, Krebs M, Baumgartner-Parzer S, Kaufmann M, Jones G, Bikle DD, Wang Y, Mathew AS, Shoback D, Block-Kurbisch I. Maternal Hypercalcemia Due to Failure of 1,25-Dihydroxyvitamin-D3 Catabolism in a Patient With CYP24A1 Mutations. Volume 100 of Issue 8. The Journal of clinical endocrinology and metabolism 2015. PMID: 26097993


  49. Shah AD, Shoback D, Lewiecki EM. Sclerostin inhibition: a novel therapeutic approach in the treatment of osteoporosis. Volume 7. International journal of women's health 2015. PMID: 26082665


  50. Schafer AL, Weaver CM, Black DM, Wheeler AL, Chang H, Szefc GV, Stewart L, Rogers SJ, Carter JT, Posselt AM, Shoback DM, Sellmeyer DE. Intestinal Calcium Absorption Decreases Dramatically After Gastric Bypass Surgery Despite Optimization of Vitamin D Status. Volume 30 of Issue 8. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2015. PMID: 25640580


  51. Schafer AL, Li X, Schwartz AV, Tufts LS, Wheeler AL, Grunfeld C, Stewart L, Rogers SJ, Carter JT, Posselt AM, Black DM, Shoback DM. Changes in vertebral bone marrow fat and bone mass after gastric bypass surgery: A pilot study. Volume 74. Bone 2015. PMID: 25603463


  52. Lai JC, Shoback DM, Zipperstein J, Lizaola B, Tseng S, Terrault NA. Bone Mineral Density, Bone Turnover, and Systemic Inflammation in Non-cirrhotics with Chronic Hepatitis C. Volume 60 of Issue 6. Digestive diseases and sciences 2015. PMID: 25563723


  53. Eastell R, Brandi ML, Costa AG, D'Amour P, Shoback DM, Thakker RV. Diagnosis of asymptomatic primary hyperparathyroidism: proceedings of the Fourth International Workshop. Volume 99 of Issue 10. The Journal of clinical endocrinology and metabolism 2014. PMID: 25162666


  54. Marcocci C, Bollerslev J, Khan AA, Shoback DM. Medical management of primary hyperparathyroidism: proceedings of the fourth International Workshop on the Management of Asymptomatic Primary Hyperparathyroidism. Volume 99 of Issue 10. The Journal of clinical endocrinology and metabolism 2014. PMID: 25162668


  55. Schafer AL, Mumm S, El-Sayed I, McAlister WH, Horvai AE, Tom AM, Hsiao EC, Schaefer FV, Collins MT, Anderson MS, Whyte MP, Shoback DM. Panostotic expansile bone disease with massive jaw tumor formation and a novel mutation in the signal peptide of RANK. Volume 29 of Issue 4. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2014. PMID: 24014458


  56. Canales BK, Schafer AL, Shoback DM, Carpenter TO. Gastric bypass in obese rats causes bone loss, vitamin D deficiency, metabolic acidosis, and elevated peptide YY. Volume 10 of Issue 5. Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery 2014. PMID: 24969093


  57. Hong SH, Dvorak-Ewell M, Stevens HY, Barish GD, Castro GL, Nofsinger R, Frangos JA, Shoback D, Evans RM. Rescue of a primary myelofibrosis model by retinoid-antagonist therapy. Volume 110 of Issue 47. Proceedings of the National Academy of Sciences of the United States of America 2013. PMID: 24191050


  58. Mannstadt M, Clarke BL, Vokes T, Brandi ML, Ranganath L, Fraser WD, Lakatos P, Bajnok L, Garceau R, Mosekilde L, Lagast H, Shoback D, Bilezikian JP. Efficacy and safety of recombinant human parathyroid hormone (1-84) in hypoparathyroidism (REPLACE): a double-blind, placebo-controlled, randomised, phase 3 study. Volume 1 of Issue 4. The lancet. Diabetes & endocrinology 2013. PMID: 24622413


  59. Cheng Z, Liang N, Chen TH, Li A, Santa Maria C, You M, Ho H, Song F, Bikle D, Tu C, Shoback D, Chang W. Sex and age modify biochemical and skeletal manifestations of chronic hyperparathyroidism by altering target organ responses to Ca2+ and parathyroid hormone in mice. Volume 28 of Issue 5. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2013. PMID: 23239173


  60. Schafer AL, Burghardt AJ, Sellmeyer DE, Palermo L, Shoback DM, Majumdar S, Black DM. Postmenopausal women treated with combination parathyroid hormone (1-84) and ibandronate demonstrate different microstructural changes at the radius vs. tibia: the PTH and Ibandronate Combination Study (PICS). Volume 24 of Issue 10. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2013. PMID: 23589163


  61. Nemeth EF, Shoback D. Calcimimetic and calcilytic drugs for treating bone and mineral-related disorders. Volume 27 of Issue 3. Best practice & research. Clinical endocrinology & metabolism 2013. PMID: 23856266


  62. Park-Sigal J, Don BR, Porzig A, Recker R, Griswold V, Sebastian A, Duh QY, Portale AA, Shoback D, Schambelan M. Severe hypercalcemic hyperparathyroidism developing in a patient with hyperaldosteronism and renal resistance to parathyroid hormone. Volume 28 of Issue 3. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2013. PMID: 23074096


  63. Schafer AL, Sellmeyer DE, Palermo L, Hietpas J, Eastell R, Shoback DM, Black DM. Six months of parathyroid Hormone (1-84) administered concurrently versus sequentially with monthly ibandronate over two years: the PTH and ibandronate combination study (PICS) randomized trial. Volume 97 of Issue 10. The Journal of clinical endocrinology and metabolism 2012. PMID: 22791766


  64. Khosla S, Bilezikian JP, Dempster DW, Lewiecki EM, Miller PD, Neer RM, Recker RR, Shane E, Shoback D, Potts JT. Benefits and risks of bisphosphonate therapy for osteoporosis. Volume 97 of Issue 7. The Journal of clinical endocrinology and metabolism 2012. PMID: 22523337


  65. Dvorak-Ewell MM, Chen TH, Liang N, Garvey C, Liu B, Tu C, Chang W, Bikle DD, Shoback DM. Osteoblast extracellular Ca2+ -sensing receptor regulates bone development, mineralization, and turnover. Volume 26 of Issue 12. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011. PMID: 21956637


  66. Prasad AP, George V, Porzig A, Horvai AE, Gross A, Shoback D, Link TM. Progressive craniofacial bone loss after cosmetic surgery at the forehead. Volume 41 of Issue 4. Skeletal radiology 2011. PMID: 22127344


  67. Schafer AL, Sellmeyer DE, Schwartz AV, Rosen CJ, Vittinghoff E, Palermo L, Bilezikian JP, Shoback DM, Black DM. Change in undercarboxylated osteocalcin is associated with changes in body weight, fat mass, and adiponectin: parathyroid hormone (1-84) or alendronate therapy in postmenopausal women with osteoporosis (the PaTH study). Volume 96 of Issue 12. The Journal of clinical endocrinology and metabolism 2011. PMID: 21994958


  68. Bilezikian JP, Khan A, Potts JT, Brandi ML, Clarke BL, Shoback D, Jüppner H, D'Amour P, Fox J, Rejnmark L, Mosekilde L, Rubin MR, Dempster D, Gafni R, Collins MT, Sliney J, Sanders J. Hypoparathyroidism in the adult: epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research. Volume 26 of Issue 10. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011. PMID: 21812031


  69. Peacock M, Bilezikian JP, Bolognese MA, Borofsky M, Scumpia S, Sterling LR, Cheng S, Shoback D. Cinacalcet HCl reduces hypercalcemia in primary hyperparathyroidism across a wide spectrum of disease severity. Volume 96 of Issue 1. The Journal of clinical endocrinology and metabolism 2010. PMID: 20943783


  70. Dong Q, Cheng Z, Chang W, Blackman BE, Conte FA, Hu J, Shoback D, Miller WL. Naturally-occurring mutation in the calcium-sensing receptor reveals the significance of extracellular domain loop III region for class C G-protein-coupled receptor function. Volume 95 of Issue 10. The Journal of clinical endocrinology and metabolism 2010. PMID: 20631026


  71. Chang W, Dvorak M, Shoback D. Assessing constitutive activity of extracellular calcium-sensing receptors in vitro and in bone. Volume 484. Methods in enzymology 2010. PMID: 21036236


  72. Peacock M, Bolognese MA, Borofsky M, Scumpia S, Sterling LR, Cheng S, Shoback D. Cinacalcet treatment of primary hyperparathyroidism: biochemical and bone densitometric outcomes in a five-year study. Volume 94 of Issue 12. The Journal of clinical endocrinology and metabolism 2009. PMID: 19837909


  73. Pao VY, Chang S, Shoback DM, Bikle DD. Hypercalcemia and overexpression of CYP27B1 in a patient with nephrogenic systemic fibrosis: clinical vignette and literature review. Volume 24 of Issue 6. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009. PMID: 19113910


  74. Marcocci C, Chanson P, Shoback D, Bilezikian J, Fernandez-Cruz L, Orgiazzi J, Henzen C, Cheng S, Sterling LR, Lu J, Peacock M. Cinacalcet reduces serum calcium concentrations in patients with intractable primary hyperparathyroidism. Volume 94 of Issue 8. The Journal of clinical endocrinology and metabolism 2009. PMID: 19470620


  75. Khan A, Grey A, Shoback D. Medical management of asymptomatic primary hyperparathyroidism: proceedings of the third international workshop. Volume 94 of Issue 2. The Journal of clinical endocrinology and metabolism 2009. PMID: 19193912


  76. Chang W, Tu C, Chen TH, Bikle D, Shoback D. The extracellular calcium-sensing receptor (CaSR) is a critical modulator of skeletal development. Volume 1 of Issue 35. Science signaling 2008. PMID: 18765830


  77. Shoback D. Clinical practice. Hypoparathyroidism. Volume 359 of Issue 4. The New England journal of medicine 2008. PMID: 18650515


  78. Silverberg SJ, Rubin MR, Faiman C, Peacock M, Shoback DM, Smallridge RC, Schwanauer LE, Olson KA, Klassen P, Bilezikian JP. Cinacalcet hydrochloride reduces the serum calcium concentration in inoperable parathyroid carcinoma. The Journal of clinical endocrinology and metabolism 2007. PMID: 17666472


  79. Cheng Z, Tu C, Rodriguez L, Chen TH, Dvorak MM, Margeta M, Gassmann M, Bettler B, Shoback D, Chang W. Type B gamma-aminobutyric acid receptors modulate the function of the extracellular Ca2+-sensing receptor and cell differentiation in murine growth plate chondrocytes. Volume 148 of Issue 10. Endocrinology 2007. PMID: 17615148


  80. Chang W, Tu C, Cheng Z, Rodriguez L, Chen TH, Gassmann M, Bettler B, Margeta M, Jan LY, Shoback D. Complex formation with the Type B gamma-aminobutyric acid receptor affects the expression and signal transduction of the extracellular calcium-sensing receptor. Studies with HEK-293 cells and neurons. Volume 282 of Issue 34. The Journal of biological chemistry 2007. PMID: 17591780


  81. Dvorak MM, Chen TH, Orwoll B, Garvey C, Chang W, Bikle DD, Shoback DM. Constitutive activity of the osteoblast Ca2+-sensing receptor promotes loss of cancellous bone. Volume 148 of Issue 7. Endocrinology 2007. PMID: 17412806


  82. Shoback D. Update in osteoporosis and metabolic bone disorders. Volume 92 of Issue 3. The Journal of clinical endocrinology and metabolism 2007. PMID: 17341572


  83. Cheng Z, Tu C, Rodriguez L, Dvorak MM, Margeta M, Gassmann M, Bettler B, Shoback D, Chang W. WITHDRAWN: Type B gamma-aminobutyric Acid Receptors Modulate the Expression and Function of the Extracellular Ca2+-sensing Receptor in Murine Growth Plate Chondrocytes. Endocrinology 2006. PMID: 16728489


  84. Rodriguez L, Tu C, Cheng Z, Chen TH, Bikle D, Shoback D, Chang W. Expression and functional assessment of an alternatively spliced extracellular Ca2+-sensing receptor in growth plate chondrocytes. Volume 146 of Issue 12. Endocrinology 2005. PMID: 16166224


  85. Chang W, Rodriguez L, Chen TH, Tu C, Shoback D. Extracellular Ca2+-sensing in cartilage. Journal of musculoskeletal & neuronal interactions 2004. PMID: 15758285


  86. Peacock M, Bilezikian JP, Klassen PS, Guo MD, Turner SA, Shoback D. Cinacalcet hydrochloride maintains long-term normocalcemia in patients with primary hyperparathyroidism. Volume 90 of Issue 1. The Journal of clinical endocrinology and metabolism 2004. PMID: 15522938


  87. Loretz CA, Pollina C, Hyodo S, Takei Y, Chang W, Shoback D. cDNA cloning and functional expression of a Ca2+-sensing receptor with truncated C-terminal tail from the Mozambique tilapia (Oreochromis mossambicus). Volume 279 of Issue 51. The Journal of biological chemistry 2004. PMID: 15456780


  88. Earle KE, Seneviratne T, Shaker J, Shoback D. Fanconi's syndrome in HIV+ adults: report of three cases and literature review. Volume 19 of Issue 5. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004. PMID: 15068493


  89. Chang W, Shoback D. Extracellular Ca2+-sensing receptors--an overview. Volume 35 of Issue 3. Cell calcium 2004. PMID: 15200142


  90. Shoback DM, Bilezikian JP, Turner SA, McCary LC, Guo MD, Peacock M. The calcimimetic cinacalcet normalizes serum calcium in subjects with primary hyperparathyroidism. Volume 88 of Issue 12. The Journal of clinical endocrinology and metabolism 2003. PMID: 14671147


  91. Shattuck TM, Välimäki S, Obara T, Gaz RD, Clark OH, Shoback D, Wierman ME, Tojo K, Robbins CM, Carpten JD, Farnebo LO, Larsson C, Arnold A. Somatic and germ-line mutations of the HRPT2 gene in sporadic parathyroid carcinoma. Volume 349 of Issue 18. The New England journal of medicine 2003. PMID: 14585940


  92. Shattuck TM, Kim TS, Costa J, Yandell DW, Imanishi Y, Palanisamy N, Gaz RD, Shoback D, Clark OH, Monchik JM, Wierman ME, Hollenberg A, Tojo K, Chaganti RS, Arnold A. Mutational analyses of RB and BRCA2 as candidate tumour suppressor genes in parathyroid carcinoma. Volume 59 of Issue 2. Clinical endocrinology 2003. PMID: 12864795


  93. Antoniucci DM, Shoback D. Calcimimetics in the treatment of primary hyperparathyroidism. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002. PMID: 12412791


  94. Chang W, Tu C, Pratt S, Chen TH, Shoback D. Extracellular Ca(2+)-sensing receptors modulate matrix production and mineralization in chondrogenic RCJ3.1C5.18 cells. Volume 143 of Issue 4. Endocrinology 2002. PMID: 11897705


  95. Chang W, Pratt S, Chen TH, Bourguignon L, Shoback D. Amino acids in the cytoplasmic C terminus of the parathyroid Ca2+-sensing receptor mediate efficient cell-surface expression and phospholipase C activation. The Journal of biological chemistry 2001. PMID: 11535593


  96. Shoback D, Chang W. Starvation amidst plenty--rickets and hypercalcemia in calcium receptor knockout mice. Endocrinology 2001. PMID: 11517147


  97. Chang W, Pratt SA, Chen TH, Tu CL, Mikala G, Schwartz A, Shoback D. Parathyroid cells express dihydropyridine-sensitive cation currents and L-type calcium channel subunits. American journal of physiology. Endocrinology and metabolism 2001. PMID: 11404236


  98. Imboden JB, Shoback DM, Inokuchi S. Analysis of inositol phospholipid turnover during lymphocyte activation. Current protocols in immunology 2001. PMID: 18432702


  99. Chang W, Chen TH, Pratt S, Shoback D. Amino acids in the second and third intracellular loops of the parathyroid Ca2+-sensing receptor mediate efficient coupling to phospholipase C. The Journal of biological chemistry 2000. PMID: 10764812


  100. Noor M, Shoback D. Paget's disease of bone: diagnosis and treatment update. Current rheumatology reports 2000. PMID: 11123042


  101. Chang W, Pratt S, Chen TH, Shoback D. Protein kinase C activation blocks calcium receptor signaling in Xenopus laevis oocytes. Molecular and cellular endocrinology 1999. PMID: 10630401


  102. Chang W, Tu C, Chen TH, Komuves L, Oda Y, Pratt SA, Miller S, Shoback D. Expression and signal transduction of calcium-sensing receptors in cartilage and bone. Endocrinology 1999. PMID: 10579354


  103. Chang W, Tu C, Bajra R, Komuves L, Miller S, Strewler G, Shoback D. Calcium sensing in cultured chondrogenic RCJ3.1C5.18 cells. Endocrinology 1999. PMID: 10098531


  104. Khovidhunkit W, Shoback DM. Clinical effects of raloxifene hydrochloride in women. Annals of internal medicine 1999. PMID: 10068418


  105. Chang W, Chen TH, Pratt S, Shoback D. Regulation of extracellular calcium-activated cation currents by cAMP in parathyroid cells. The American journal of physiology 1998. PMID: 9688621


  106. Loh KC, Duh QY, Shoback D, Gee L, Siperstein A, Clark OH. Clinical profile of primary hyperparathyroidism in adolescents and young adults. Clinical endocrinology 1998. PMID: 9640410


  107. Chang W, Pratt S, Chen TH, Nemeth E, Huang Z, Shoback D. Coupling of calcium receptors to inositol phosphate and cyclic AMP generation in mammalian cells and Xenopus laevis oocytes and immunodetection of receptor protein by region-specific antipeptide antisera. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1998. PMID: 9556057


  108. Loh K, Matthay KK, Hoover M, Bracho FA, Cortez AB, Conte FA, Albanese CT, Miller TR, Price DC, Flores AJ, Kaviani A, Shoback D. Hypercalcemia in malignant paraganglioma due to parathyroid hormone-related protein. Hormone research 1998. PMID: 9838243


  109. Chang W, Chen TH, Pratt SA, Yen B, Fu M, Shoback D. Parathyroid Ca(2+)-conducting currents are modulated by muscarinic receptor agonists and antagonists. The American journal of physiology 1997. PMID: 9374672


  110. Huang Z, Chen Y, Pratt S, Chen TH, Bambino T, Nissenson RA, Shoback DM. The N-terminal region of the third intracellular loop of the parathyroid hormone (PTH)/PTH-related peptide receptor is critical for coupling to cAMP and inositol phosphate/Ca2+ signal transduction pathways. The Journal of biological chemistry 1996. PMID: 8969199


  111. Chang W, Chen TH, Gardner P, Shoback D. Regulation of Ca(2+)-conducting currents in parathyroid cells by extracellular Ca(2+) and channel blockers. The American journal of physiology 1995. PMID: 7491938


  112. Huang Z, Chen Y, Pratt S, Chen TH, Bambino T, Shoback DM, Nissenson RA. Mutational analysis of the cytoplasmic tail of the G protein-coupled receptor for parathyroid hormone (PTH) and PTH-related protein: effects on receptor expression and signaling. Molecular endocrinology (Baltimore, Md.) 1995. PMID: 7491116


  113. Funk JL, Shoback DM, Genant HK. Transient osteoporosis of the hip in pregnancy: natural history of changes in bone mineral density. Clinical endocrinology 1995. PMID: 7586609


  114. Shoback D, Chen TH, Pratt S, Lattyak B. Thapsigargin stimulates intracellular calcium mobilization and inhibits parathyroid hormone release. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1995. PMID: 7639110


  115. Chen TH, Pratt SA, Shoback DM. Injection of bovine parathyroid poly(A)+ RNA into Xenopus oocytes confers sensitivity to high extracellular calcium. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1994. PMID: 7511319


  116. Shoback DM, Chen TH, Lattyak B, King K, Johnson RM. Effects of high extracellular calcium and strontium on inositol polyphosphates in bovine parathyroid cells. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1993. PMID: 8352071


  117. Nissenson RA, Huang Z, Blind E, Shoback D. Structure and function of the receptor for parathyroid hormone and parathyroid hormone-related protein. Receptor 1993. PMID: 8167570


  118. Shoback DM, Chen TH. Effects of protein kinase C activation on inositol phosphate generation and intracellular Ca2+ mobilization in bovine parathyroid cells. Endocrinology 1990. PMID: 2361470


  119. McGhee JG, Shoback DM. Effects of phosphatidic acid on parathyroid hormone release, intracellular free Ca2+, and inositol phosphates in dispersed bovine parathyroid cells. Endocrinology 1990. PMID: 2153532


  120. Membreño L, Chen TH, Woodley S, Gagucas R, Shoback D. The effects of protein kinase-C agonists on parathyroid hormone release and intracellular free Ca2+ in bovine parathyroid cells. Endocrinology 1989. PMID: 2536321


  121. Shoback DM, Membreno LA, McGhee JG. High calcium and other divalent cations increase inositol trisphosphate in bovine parathyroid cells. Endocrinology 1988. PMID: 3260174


  122. Shoback DM, McGhee JM. Fluoride stimulates the accumulation of inositol phosphates, increases intracellular free calcium, and inhibits parathyroid hormone release in dispersed bovine parathyroid cells. Endocrinology 1988. PMID: 2836175


  123. Gavin LA, Moeller M, Shoback D, Cavalieri RR. Reverse T3 and modulators of the calcium messenger system rapidly decrease T4-5'-deiodinase II activity in cultured mouse neuroblastoma cells. Thyroidology 1988. PMID: 2484895


  124. Rabinowe SL, Redgrave JE, Shoback DM, Podolsky S, Hollenberg NK, Williams GH. Renin suppression by saline is blunted in nonmodulating essential hypertension. Hypertension (Dallas, Tex. : 1979) 1987. PMID: 3308701


  125. Brown EM, Watson EJ, Thatcher JG, Koletsky R, Dawson-Hughes BF, Posillico JT, Shoback DM. Ouabain and low extracellular potassium inhibit PTH secretion from bovine parathyroid cells by a mechanism that does not involve increases in the cytosolic calcium concentration. Metabolism: clinical and experimental 1987. PMID: 3025550


  126. Hollenberg NK, Moore T, Shoback D, Redgrave J, Rabinowe S, Williams GH. Abnormal renal sodium handling in essential hypertension. Relation to failure of renal and adrenal modulation of responses to angiotensin II. The American journal of medicine 1986. PMID: 3752141


  127. Imboden JB, Shoback DM, Pattison G, Stobo JD. Cholera toxin inhibits the T-cell antigen receptor-mediated increases in inositol trisphosphate and cytoplasmic free calcium. Proceedings of the National Academy of Sciences of the United States of America 1986. PMID: 3016713


  128. LeBoff MS, Shoback D, Brown EM, Thatcher J, Leombruno R, Beaudoin D, Henry M, Wilson R, Pallotta J, Marynick S. Regulation of parathyroid hormone release and cytosolic calcium by extracellular calcium in dispersed and cultured bovine and pathological human parathyroid cells. The Journal of clinical investigation 1985. PMID: 3965511


  129. Shoback DM, Thatcher JG, Brown EM. Interaction of extracellular calcium and magnesium in the regulation of cytosolic calcium and PTH release in dispersed bovine parathyroid cells. Molecular and cellular endocrinology 1984. PMID: 6510551


  130. Shoback DM, Brown EM. PTH release stimulated by high extracellular potassium is associated with a decrease in cytosolic calcium in bovine parathyroid cells. Biochemical and biophysical research communications 1984. PMID: 6487306


  131. Weiss A, Imboden J, Shoback D, Stobo J. Role of T3 surface molecules in human T-cell activation: T3-dependent activation results in an increase in cytoplasmic free calcium. Proceedings of the National Academy of Sciences of the United States of America 1984. PMID: 6234599


  132. Shoback DM, Brown EM. Forskolin increases cellular cyclic adenosine monophosphate content and parathyroid hormone release in dispersed bovine parathyroid cells. Metabolism: clinical and experimental 1984. PMID: 6328173


  133. Shoback DM, Thatcher J, Leombruno R, Brown EM. Relationship between parathyroid hormone secretion and cytosolic calcium concentration in dispersed bovine parathyroid cells. Proceedings of the National Academy of Sciences of the United States of America 1984. PMID: 6328497


  134. Brown EM, Shoback DM. The relationship between PTH secretion and cytosolic calcium concentration in bovine parathyroid cells. Progress in clinical and biological research 1984. PMID: 6096881


  135. Shoback DM, Williams GH, Moore TJ, Dluhy RG, Podolsky S, Hollenberg NK. Defect in the sodium-modulated tissue responsiveness to angiotensin II in essential hypertension. The Journal of clinical investigation 1983. PMID: 6358261


  136. Shoback DM, Williams GH, Swartz SL, Davies RO, Hollenberg NK. Time course and effect of sodium intake on vascular and hormonal responses to enalapril (MK 421) in normal subjects. Journal of cardiovascular pharmacology 1983. PMID: 6196548


  137. Shoback DM, Williams GH, Hollenberg NK, Davies RO, Moore TJ, Dluhy RG. Endogenous angiotensin II as a determinant of sodium-modulated changes in tissue responsiveness to angiotensin II in normal man. The Journal of clinical endocrinology and metabolism 1983. PMID: 6309884


  138. Serfas D, Shoback DM, Lorell BH. Phaeochromocytoma and hypertrophic cardiomyopathy: apparent suppression of symptoms and noradrenaline secretion by calcium-channel blockade. Lancet (London, England) 1983. PMID: 6136843


  139. Shoback D, Thatcher J, Leombruno R, Brown E. Effects of extracellular Ca++ and Mg++ on cytosolic Ca++ and PTH release in dispersed bovine parathyroid cells. Endocrinology 1983. PMID: 6861713


  140. Vlay SC, Blumenthal DS, Shoback D, Fehir K, Bulkley BH. Delayed acute myocardial infarction after blunt chest trauma in a young woman. American heart journal 1980. PMID: 7446393


  141. Shoback D. Familial cryoglobulinemia. The Johns Hopkins medical journal 1977. PMID: 859235


  142. Shoback D, Kan JA. Clinical-pathological conference. The Johns Hopkins medical journal 1977. PMID: 850338


  143. Shoback D. Pheochromocytoma. The Johns Hopkins medical journal 1976. PMID: 972438