Di Lang, PhD, MS, BS

Assistant Adjunct Professor

My research interests focus on understanding the membrane nanodomain mediated compartmentalized cellular and molecular functioning and regulation of proteins in the cardiac physiology and pathology and developing therapeutic strategies targeting the cell cytoarchitectures using animal models, primary cardiomyocytes and human induced pluripotent stem cells (hiPSCs).

Education
- Postdoc in Pharmacology, University of California Davis
- Scientist in Medicine, University of Wisconsin Madison
Ph.D., - Biomedical Engineering, Washington University in St. Louis
Publications

  1. Ruan H, Mandla R, Ravi N, Galang G, Soe AW, Olgin JE, Lang D, Vedantham V. Cholecystokinin-A Signaling Regulates Automaticity of Pacemaker Cardiomyocytes and Shortens Sinus Node Recovery Time. bioRxiv : the preprint server for biology 2023. PMID: 36747643


  2. Gessner S, Martin ZA, Reiche MA, Santos JA, Dinkele R, Ramudzuli A, Dhar N, de Wet TJ, Anoosheh S, Lang DM, Aaron J, Chew TL, Herrmann J, Müller R, McKinney JD, Woodgate R, Mizrahi V, Venclovas C, Lamers MH, Warner DF. Investigating the composition and recruitment of the mycobacterial ImuA'-ImuB-DnaE2 mutasome. eLife 2023. PMID: 37530405


  3. Ding Y, Lang D, Yan J, Bu H, Li H, Jiao K, Yang J, Ni H, Morotti S, Le T, Clark KJ, Port J, Ekker SC, Cao H, Zhang Y, Wang J, Grandi E, Li Z, Shi Y, Li Y, Glukhov AV, Xu X. A phenotype-based forward genetic screen identifies Dnajb6 as a sick sinus syndrome gene. eLife 2022. PMID: 36255053


  4. Lang D. Beyond Diagnosis: a Novel Microbiota Dependent Biomarker and Target for Atherosclerosis. Circulation research 2022. PMID: 35981000


  5. Lang D,* Medvedev RY, Ratajczyk L, Zheng J, Yuan X, Lim E, Han OY, Valdivia HH, Glukhov AV.* *: corresponding author. Region-specific distribution of transversal-axial tubule system organization underlies heterogeneity of calcium dynamics in the right atrium American Journal of Physiology-Heart and Circulatory Physiology 2022. PMID:


  6. Turner D, Tyan L, DeGuire F, Medvedev R, Stroebel S, Lang D, Glukhov AV.. Caveolin-3 prevents swelling-induced membrane damage via regulation of ICI, swell activity Biophysical journal 2022. PMID:


  7. Napiwocki BN, Stempien A, Lang D, Kruepke RA, Kim G, Zhang J, Eckhardt LL, Glukhov AV, Kamp TJ, Crone WC. Micropattern platform promotes extracellular matrix remodeling by human PSC‐derived cardiac fibroblasts and enhances contractility of co‐cultured cardiomyocytes Physiological reports 2021. PMID:


  8. Lang D, Glukhov AV. Cellular and molecular mechanisms of functional hierarchy of pacemaker clusters in the sinoatrial node: New insights into sick sinus syndrome Journal of Cardiovascular Development and Disease 2021. PMID:


  9. Napiwocki BN, Lang D, Stempien A, Zhang J, Vaidyanathan R, Makielski JC, Eckhardt LL, Glukhov AV, Kamp TJ, Crone WC. Aligned human cardiac syncytium for in vitro analysis of electrical, structural, and mechanical readouts Biotechnology and bioengineering 2021. PMID:


  10. de Lange WJ, Farrell ET, Kreitzer CR, Jacobs DR, Lang D, Glukhov AV, Ralphe JC.. Human iPSC-engineered cardiac tissue platform faithfully models important cardiac physiology American Journal of Physiology-Heart and Circulatory Physiology 2021. PMID:


  11. Reilly L, Alvarado FJ, Lang D, Abozeid S, Van Ert H, Spellman C, Warden J, Makielski JC, Glukhov AV, Eckhardt LL. Genetic Loss of I K1 Causes Adrenergic-Induced Phase 3 Early Afterdepolariz ations and Polymorphic and Bidirectional Ventricular Tachycardia Circulation: Arrhythmia and Electrophysiology 2020. PMID:


  12. Lang D, Calaghan SC, Gorelik J, Glukhov AV.. Cardiomyocyte Microdomains: An Emerging Concept of Local Regulation and Remodeling Frontiers in physiology 2020. PMID:


  13. lexanian RA, Mahapatra K, Lang D, Vaidyanathan R, Markandeya YS, Gill RK, Zhai AJ, Dhillon A, Lea MR, Abozeid S, Schmuck EG. Induced cardiac progenitor cells repopulate decellularized mouse heart scaffolds and differentiate to generate cardiac tissue Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 2020. PMID:


  14. Egorov YV,* Lang D,* Tyan L, Turner D, Lim E, Piro ZD, Hernandez JJ, Lodin R, Wang R, Schmuck EG, Raval AN, Glukhov AV. *: co-first author. Caveolae‐Mediated Activation of Mechanosensitive Chloride Channels in Pulmonary Veins Triggers Atrial Arrhythmogenesis Journal of the American Heart Association 2019. PMID:


  15. Biermann M, Cai W,* Lang D,* Hermsen J, Profio L, Zhou Y, Czirok A, Isai DG, Napiwocki BN, Rodriguez AM, Brown ME, Glukhov AV, Kamp TJ. *: Authors contribute equally. Epigenetic priming of human pluripotent stem cell-derived cardiac progenitor cells accelerates cardiomyocyte maturation Stem Cells 2019. PMID:


  16. Tyan L, Foell JD, Vincent KP, Woon MT, Mesquitta WT, Lang D, Best JM, Ackerman MJ, McCulloch AD, Glukhov AV, Balijepalli RC, Kamp TJ.. Long QT syndrome caveolin‐3 mutations differentially modulate Kv4 and Cav1. 2 channels to contribute to action potential prolongation The Journal of physiology 2019. PMID:


  17. Lang D, Glukhov AV. Functional microdomains in heart’s pacemaker: A step beyond classical electrophysiology and remodeling Frontiers in physiology 2018. PMID:


  18. Lang D, Sato D, Jiang Y, Ginsburg KS, Ripplinger CM, Bers DM. Calcium-dependent arrhythmogenic foci created by weakly coupled myocytes in the failing heart Circulation research 2017. PMID:


  19. Murphy SR, Wang L, Wang Z, Domondon P, Lang D, Habecker BA, Myles RC, Ripplinger CM.. β-Adrenergic inhibition prevents action potential and calcium handling changes during regional myocardial ischemia Frontiers in physiology 2017. PMID:


  20. Cheng J, Kyle JW, Lang D, Wiedmeyer B, Guo J, Yin K, Huang L, Vaidyanathan R, Su T, Makielski JC.. An East Asian common variant vinculin P. Asp841His was associated with sudden unexplained nocturnal death syndrome in the Chinese Han population Journal of the American Heart Association 2017. PMID:


  21. 16. Cheng J, Kyle JW, Wiedmeyer B, Lang D, Vaidyanathan R, Makielski JC. Vinculin variant M94I identified in sudden unexplained nocturnal death syndrome decreases cardiac sodium current Scientific Reports 2017. PMID:


  22. Lang D, Glukhov AV. High-resolution optical mapping of the mouse sino-atrial node JoVE 2016. PMID:


  23. 18. Zhang L,* Tester DJ,* Lang D,* Chen Y, Zheng J, Gao R, Corliss RF, Tang S, Kyle JW, Liu C, Ackerman MJ, Makielski JC, Cheng JD. *: co-first author. Does sudden unexplained nocturnal death syndrome remain the autopsy-negative disorder: a gross, microscopic, and molecular autopsy investigation in Southern China Mayo Clinic proceedings 2016. PMID:


  24. Lang D, Holzem K, Kang C, Xiao M, Hwang HJ, Ewald GA, Yamada KA, Efimov IR.. Arrhythmogenic remodeling of β2 versus β1 adrenergic signaling in the human failing heart Circulation: Arrhythmia and Electrophysiology. 2015. PMID:


  25. Despa S, Shui B, Bossuyt J, Lang D, Kotlikoff MI, Bers DM. Junctional cleft [Ca2+] i measurements using novel cleft-targeted Ca2+ sensors Circulation research 2014. PMID:


  26. Janardhan AH, Gutbrod SR, Li W, Lang D, Schuessler RB, Efimov IR. Multistage electrotherapy delivered through chronically-implanted leads terminates atrial fibrillation with lower energy than a single biphasic shock Journal of the American College of Cardiology 2014. PMID:


  27. Lang, D., Gutbrod, S., Laughner, J., Efimov, IR. Manu of Research Techniques in Cardiovascular Medicine Chapter 7: Optical Mapping of the Heart 2013. PMID:


  28. Luo M, Guan X, Luczak ED, Lang D, Kutschke W, Gao Z, Yang J, Glynn P, Sossalla S, Swaminathan PD, Weiss RM, Anderson M,. Diabetes increases mortality after myocardial infarction by oxidizing CaMKII The Journal of clinical investigation 2013. PMID:


  29. Lou Q, Janks DL, Holzem KM, Lang D, Onal B, Ambrosi CM, Fedorov VV, Wang IW, Efimov IR. Right ventricular arrhythmogenesis in failing human heart: the role of conduction and repolarization remodeling American Journal of Physiology-Heart and Circulatory Physiology 2012. PMID:


  30. Cheng YJ,* Lang D,* Caruthers SD, Efimov IR, Chen J, Wickline SA. *: co-first author. Focal but reversible diastolic sheet dysfunction reflects regional calcium mishandling in dystrophic mdx mouse hearts American Journal of Physiology-Heart and Circulatory Physiology 2012. PMID:


  31. Janardhan, AJ., Lang, D., Efimov, IR. Cardiac Mapping, Ed: M. Shenasa Chapter 9: Optical Mapping of the SA node and AV node 2012. PMID:


  32. Lang D, Petrov V, Lou Q, Osipov G, Efimov IR. Spatiotemporal control of heart rate in a rabbit heart Journal of electrocardiology 2011. PMID:


  33. Lang D, Glukhov AV, Efimova T, Efimov IR. Role of Pyk2 in cardiac arrhythmogenesis American Journal of Physiology-Heart and Circulatory Physiology 2011. PMID:


  34. Lang D, Sulkin M, Lou Q, Efimov IR. Optical mapping of action potentials and calcium transients in the mouse heart JoVE 2011. PMID:


  35. Xu YK, Xu KD, Li JY, Feng LQ, Lang D, Zheng XX. Bi-directional transport of GLUT4 vesicles near the plasma membrane of primary rat adipocytes Biochemical and biophysical research communications 2007. PMID: