David Daikh, MD

Professor Emeritus

Dr. Daikh is the Rheumatology Division Chief at the SFVA Medical Center, and director of the rheumatology fellowship program at UCSF. Dr. Daikh is a UCSF Department of Medicine Master Clinician and a member of the UCSF Academy of Medical Educators. Dr. Daikh’s research has focused on immune mechanisms of rheumatic disease and novel approaches to immunotherapy. Dr. Daikh is a past president of the Rheumatology Research Foundation and is the Immediate Past President of the American College of Rheumatology.

Education
2018 - Diversity, Equity, and Inclusion Champion Training, University of California
Fellowship, 6/1997 - Rheumatology, University of California, San Francisco
Residency, 6/1994 - Internal Medicine, University of California, San Francisco
PhD, 6/1991 - Biochemistry and Molecular Biology, Oregon Health Sciences University
MD, 6/1991 - Medicine, Oregon Health Sciences University
Websites
Publications

  1. Maharaj AB, Daikh DI. Diagnosing rheumatoid arthritis: challenges and opportunities. 2022. PMID: 35260335


  2. Daikh DI. Rheumatoid arthritis: Evolving recognition of a common disease. 2022. PMID: 35249826


  3. Aringer M, Brinks R, Dörner T, Daikh D, Mosca M, Ramsey-Goldman R, Smolen JS, Wofsy D, Boumpas DT, Kamen DL, Jayne D, Cervera R, Costedoat-Chalumeau N, Diamond B, Gladman DD, Hahn B, Hiepe F, Jacobsen S, Khanna D, Lerstrøm K, Massarotti E, McCune J, Ruiz-Irastorza G, Sanchez-Guerrero J, Schneider M, Urowitz M, Bertsias G, Hoyer BF, Leuchten N, Schmajuk G, Tani C, Tedeschi SK, Touma Z, Anic B, Assan F, Chan TM, Clarke AE, Crow MK, Czirják L, Doria A, Graninger W, Halda-Kiss B, Hasni S, Izmirly PM, Jung M, Kumánovics G, Mariette X, Padjen I, Pego-Reigosa JM, Romero-Diaz J, Rúa-Figueroa Í, Seror R, Stummvoll GH, Tanaka Y, Tektonidou MG, Vasconcelos C, Vital EM, Wallace DJ, Yavuz S, Meroni PL, Fritzler MJ, Naden R, Costenbader K, Johnson SR. European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) SLE classification criteria item performance. Annals of the rheumatic diseases 2021. PMID: 33568386


  4. Johnson SR, Brinks R, Costenbader KH, Daikh D, Mosca M, Ramsey-Goldman R, Smolen JS, Wofsy D, Boumpas DT, Kamen DL, Jayne D, Cervera R, Costedoat-Chalumeau N, Diamond B, Gladman DD, Hahn B, Hiepe F, Jacobsen S, Khanna D, Lerstrøm K, Massarotti E, McCune J, Ruiz-Irastorza G, Sanchez-Guerrero J, Schneider M, Urowitz M, Bertsias G, Hoyer BF, Leuchten N, Tani C, Tedeschi SK, Touma Z, Schmajuk G, Anic B, Assan F, Chan TM, Clarke AE, Crow MK, Czirják L, Doria A, Graninger WB, Halda-Kiss B, Hasni S, Izmirly PM, Jung M, Kumánovics G, Mariette X, Padjen I, Pego-Reigosa JM, Romero-Diaz J, Rúa-Figueroa Í, Seror R, Stummvoll GH, Tanaka Y, Tektonidou MG, Vasconcelos C, Vital EM, Wallace DJ, Yavuz S, Meroni PL, Fritzler MJ, Naden R, Dörner T, Aringer M. Performance of the 2019 EULAR/ACR classification criteria for systemic lupus erythematosus in early disease, across sexes and ethnicities. Annals of the rheumatic diseases 2020. PMID: 32816709


  5. Daikh DI. ANA and lupus. Label vs Meaning. Arthritis care & research 2019. PMID: 31058455


  6. Aringer M, Costenbader K, Daikh D, Brinks R, Mosca M, Ramsey-Goldman R, Smolen JS, Wofsy D, Boumpas DT, Kamen DL, Jayne D, Cervera R, Costedoat-Chalumeau N, Diamond B, Gladman DD, Hahn B, Hiepe F, Jacobsen S, Khanna D, Lerstrøm K, Massarotti E, McCune J, Ruiz-Irastorza G, Sanchez-Guerrero J, Schneider M, Urowitz M, Bertsias G, Hoyer BF, Leuchten N, Tani C, Tedeschi SK, Touma Z, Schmajuk G, Anic B, Assan F, Chan TM, Clarke AE, Crow MK, Czirják L, Doria A, Graninger W, Halda-Kiss B, Hasni S, Izmirly PM, Jung M, Kumánovics G, Mariette X, Padjen I, Pego-Reigosa JM, Romero-Diaz J, Rúa-Figueroa Fernández Í, Seror R, Stummvoll GH, Tanaka Y, Tektonidou MG, Vasconcelos C, Vital EM, Wallace DJ, Yavuz S, Meroni PL, Fritzler MJ, Naden R, Dörner T, Johnson SR. 2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus. Arthritis & rheumatology (Hoboken, N.J.) 2019. PMID: 31385462


  7. Aringer M, Costenbader K, Daikh D, Brinks R, Mosca M, Ramsey-Goldman R, Smolen JS, Wofsy D, Boumpas DT, Kamen DL, Jayne D, Cervera R, Costedoat-Chalumeau N, Diamond B, Gladman DD, Hahn B, Hiepe F, Jacobsen S, Khanna D, Lerstrøm K, Massarotti E, McCune J, Ruiz-Irastorza G, Sanchez-Guerrero J, Schneider M, Urowitz M, Bertsias G, Hoyer BF, Leuchten N, Tani C, Tedeschi SK, Touma Z, Schmajuk G, Anic B, Assan F, Chan TM, Clarke AE, Crow MK, Czirják L, Doria A, Graninger W, Halda-Kiss B, Hasni S, Izmirly PM, Jung M, Kumánovics G, Mariette X, Padjen I, Pego-Reigosa JM, Romero-Diaz J, Rúa-Figueroa Fernández Í, Seror R, Stummvoll GH, Tanaka Y, Tektonidou MG, Vasconcelos C, Vital EM, Wallace DJ, Yavuz S, Meroni PL, Fritzler MJ, Naden R, Dörner T, Johnson SR. 2019 European League Against Rheumatism/American College of Rheumatology classification criteria for systemic lupus erythematosus. Annals of the rheumatic diseases 2019. PMID: 31383717


  8. Aringer M, Daikh DI. How should we consider Lupus without ANA? Arthritis care & research 2018. PMID: 30035362


  9. Daikh DI. Presidential Address. Arthritis & rheumatology (Hoboken, N.J.) 2019. PMID: 30698363


  10. Tedeschi SK, Johnson SR, Boumpas DT, Daikh D, Dörner T, Diamond B, Jacobsen S, Jayne D, Kamen DL, McCune WJ, Mosca M, Ramsey-Goldman R, Ruiz-Irastorza G, Schneider M, Urowitz M, Wofsy D, Smolen JS, Naden RP, Aringer M, Costenbader KH. Multicriteria decision analysis process to develop new classification criteria for systemic lupus erythematosus. Annals of the rheumatic diseases 2019. PMID: 30692164


  11. Johnson SR, Khanna D, Daikh D, Cervera R, Costedoat-Chalumeau N, Gladman DD, Hahn BH, Hiepe F, Sánchez-Guerrero J, Massarotti E, Boumpas DT, Costenbader KH, Jayne D, Dörner T, Kamen DL, Mosca M, Ramsey-Goldman R, Smolen JS, Wofsy D, Aringer M. Use of Consensus Methodology to Determine Candidate Items for Systemic Lupus Erythematosus Classification Criteria. The Journal of rheumatology 2018. PMID: 30554156


  12. Schmajuk G, Hoyer BF, Aringer M, Johnson SR, Daikh DI, Dörner T. Multicenter Delphi Exercise to Identify Important Key Items for Classifying Systemic Lupus Erythematosus. Arthritis care & research 2018. PMID: 29287313


  13. Leuchten N, Milke B, Winkler-Rohlfing B, Daikh D, Dörner T, Johnson SR, Aringer M. Early symptoms of systemic lupus erythematosus (SLE) recalled by 339 SLE patients. Lupus 2018. PMID: 29771193


  14. van der Heijde D, Daikh DI, Betteridge N, Burmester GR, Hassett AL, Matteson EL, van Vollenhoven R, Lakhanpal S. Common Language Description of the Term Rheumatic and Musculoskeletal Diseases (RMDs) for Use in Communication With the Lay Public, Healthcare Providers, and Other Stakeholders Endorsed by the European League Against Rheumatism (EULAR) and the American Co Arthritis & rheumatology (Hoboken, N.J.) 2018. PMID: 29532625


  15. van der Heijde D, Daikh DI, Betteridge N, Burmester GR, Hassett AL, Matteson EL, van Vollenhoven R, Lakhanpal S. Common language description of the term rheumatic and musculoskeletal diseases (RMDs) for use in communication with the lay public, healthcare providers and other stakeholders endorsed by the European League Against Rheumatism (EULAR) and the American Col Annals of the rheumatic diseases 2018. PMID: 29525777


  16. Tedeschi SK, Johnson SR, Boumpas D, Daikh D, Dörner T, Jayne D, Kamen D, Lerstrøm K, Mosca M, Ramsey-Goldman R, Sinnette C, Wofsy D, Smolen JS, Naden RP, Aringer M, Costenbader KH. Developing and Refining New Candidate Criteria for Systemic Lupus Erythematosus Classification: An International Collaboration. Volume 70 of Issue 4. Arthritis care & research 2018. PMID: 28692774


  17. Leuchten N, Hoyer A, Brinks R, Schoels M, Schneider M, Smolen J, Johnson SR, Daikh D, Dörner T, Aringer M, Bertsias G. Performance of Antinuclear Antibodies for Classifying Systemic Lupus Erythematosus: A Systematic Literature Review and Meta-Regression of Diagnostic Data. Arthritis care & research 2018. PMID: 28544593


  18. Daikh DI, Costenbader KH. How Do We Classify "Incomplete Lupus?" Arthritis care & research 2017. PMID: 28118516


  19. Schmajuk G, Tonner C, Miao Y, Yazdany J, Gannon J, Boscardin WJ, Daikh DI, Steinman MA. Folic Acid Supplementation Is Suboptimal in a National Cohort of Older Veterans Receiving Low Dose Oral Methotrexate. PloS one 2016. PMID: 27977768


  20. Andrews JS, Trupin L, Hough CL, Daikh DI, Yelin EH, Katz PP. Serum biomarkers of inflammation and muscle strength among women with systemic lupus erythematosus. Cytokine 2016. PMID: 27863333


  21. Bays A, Wahl E, Daikh DI, Yazdany J, Schmajuk G. Implementation of disease activity measurement for rheumatoid arthritis patients in an academic rheumatology clinic. Volume 16 of Issue a. BMC health services research 2016. PMID: 27527720


  22. Daikh DI, Chen PP. Advances in managing ankylosing spondylitis. F1000prime reports 2014. PMID: 25343035


  23. Schmajuk G, Miao Y, Yazdany J, Boscardin WJ, Daikh DI, Steinman MA. Identification of risk factors for elevated transaminases in methotrexate users through an electronic health record. Volume 66 of Issue 8. Arthritis care & research 2014. PMID: 24470205


  24. Yazdany J, Schmajuk G, Robbins M, Daikh D, Beall A, Yelin E, Barton J, Carlson A, Margaretten M, Zell J, Gensler LS, Kelly V, Saag K, King C. Choosing wisely: the American College of Rheumatology's Top 5 list of things physicians and patients should question. Volume 65 of Issue 3. Arthritis care & research 2013. PMID: 23436818


  25. Mohr DC, Lovera J, Brown T, Cohen B, Neylan T, Henry R, Siddique J, Jin L, Daikh D, Pelletier D. A randomized trial of stress management for the prevention of new brain lesions in MS. Neurology 2012. PMID: 22786596


  26. Hahn BH, McMahon MA, Wilkinson A, Wallace WD, Daikh DI, Fitzgerald JD, Karpouzas GA, Merrill JT, Wallace DJ, Yazdany J, Ramsey-Goldman R, Singh K, Khalighi M, Choi SI, Gogia M, Kafaja S, Kamgar M, Lau C, Martin WJ, Parikh S, Peng J, Rastogi A, Chen W, Grossman JM. American College of Rheumatology guidelines for screening, treatment, and management of lupus nephritis. Volume 64 of Issue 6. Arthritis care & research 2012. PMID: 22556106


  27. Daikh DI, St Clair EW. Updated recommendations for the treatment of rheumatoid arthritis: another step on a long road. Arthritis care & research 2012. PMID: 22473919


  28. Ashouri JF, Daikh DI. Rheumatic manifestations of cancer. Rheumatic diseases clinics of North America 2011. PMID: 22075194


  29. Charles JF, Eberle C, Daikh DI, Rooney T. Resolution of recurrent fusarium arthritis after prolonged antifungal therapy. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 2011. PMID: 21169847


  30. Scalapino KJ, Daikh DI. Suppression of glomerulonephritis in NZB/NZW lupus prone mice by adoptive transfer of ex vivo expanded regulatory T cells. PloS one 2009. PMID: 19551149


  31. Gupta VA, Hermiston ML, Cassafer G, Daikh DI, Weiss A. B cells drive lymphocyte activation and expansion in mice with the CD45 wedge mutation and Fas deficiency. The Journal of experimental medicine 2008. PMID: 19001138


  32. Scalapino KJ, Daikh DI. CTLA-4: a key regulatory point in the control of autoimmune disease. Immunological reviews 2008. PMID: 18613834


  33. Bahjat FR, Pine PR, Reitsma A, Cassafer G, Baluom M, Grillo S, Chang B, Zhao FF, Payan DG, Grossbard EB, Daikh DI. An orally bioavailable spleen tyrosine kinase inhibitor delays disease progression and prolongs survival in murine lupus. Arthritis and rheumatism 2008. PMID: 18438845


  34. Kinder BW, Collard HR, Koth L, Daikh DI, Wolters PJ, Elicker B, Jones KD, King TE. Idiopathic nonspecific interstitial pneumonia: lung manifestation of undifferentiated connective tissue disease? Volume 176 of Issue 7. American journal of respiratory and critical care medicine 2007. PMID: 17556720


  35. Buxbaum J, Qian P, Khuu C, Shneider BL, Daikh DI, Gershwin ME, Allen PM, Peters MG. Novel model of antigen-specific induction of bile duct injury. Volume 131 of Issue 6. Gastroenterology 2006. PMID: 17087941


  36. Scalapino KJ, Tang Q, Bluestone JA, Bonyhadi ML, Daikh DI. Suppression of disease in New Zealand Black/New Zealand White lupus-prone mice by adoptive transfer of ex vivo expanded regulatory T cells. Journal of immunology (Baltimore, Md. : 1950) 2006. PMID: 16849451


  37. Daikh DI, Gillis J, Wofsy D. Inhibition of T cell costimulation: an emerging therapeutic strategy for autoimmune rheumatic diseases. Volume 55 of Issue 2. Arthritis and rheumatism 2006. PMID: 16583382


  38. Daikh DI. The Vioxx debacle revisited. The American journal of medicine 2005. PMID: 16164908


  39. Davidson A, Diamond B, Wofsy D, Daikh D. Block and tackle: CTLA4Ig takes on lupus. Volume 14 of Issue 3. Lupus 2005. PMID: 15807196


  40. Cunnane G, Chan OT, Cassafer G, Brindis S, Kaufman E, Yen TS, Daikh DI. Prevention of renal damage in murine lupus nephritis by CTLA-4Ig and cyclophosphamide. Arthritis and rheumatism 2004. PMID: 15146424


  41. Cunnane G, Warnock M, Fye KH, Daikh DI. Accelerated nodulosis and vasculitis following etanercept therapy for rheumatoid arthritis. Arthritis and rheumatism 2002. PMID: 12209493


  42. Schumacher HR, Boice JA, Daikh DI, Mukhopadhyay S, Malmstrom K, Ng J, Tate GA, Molina J. Randomised double blind trial of etoricoxib and indometacin in treatment of acute gouty arthritis. BMJ (Clinical research ed.) 2002. PMID: 12077033


  43. Wofsy D, Daikh DI. Treatment of autoimmune diseases by inhibition of T-cell costimulation. Volume 12 of Issue 1. Modern rheumatology 2002. PMID: 24383824


  44. Daikh DI, Wofsy D. Cutting edge: reversal of murine lupus nephritis with CTLA4Ig and cyclophosphamide. Journal of immunology (Baltimore, Md. : 1950) 2001. PMID: 11207238


  45. Daikh DI, Wofsy D. Treatment of autoimmunity by inhibition of T cell costimulation. Advances in experimental medicine and biology 2001. PMID: 11505969


  46. Majeti R, Xu Z, Parslow TG, Olson JL, Daikh DI, Killeen N, Weiss A. An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity. Cell 2000. PMID: 11163182


  47. Daikh DI, Wofsy D. Effects of anti-B7 monoclonal antibodies on humoral immune responses. Volume 12 of Issue 2. Journal of autoimmunity 1999. PMID: 10047430


  48. Daikh DI, Wofsy D. On the horizon: clinical trials of new immunosuppressive strategies for autoimmune diseases. Volume 30 of Issue 8. Transplantation proceedings 1998. PMID: 9865285


  49. Wofsy D, Daikh DI. Opportunities for future biological therapy in SLE. Volume 12 of Issue 3. Bailliere's clinical rheumatology 1998. PMID: 9890111


  50. Daikh DI, Finck BK, Linsley PS, Hollenbaugh D, Wofsy D. Long-term inhibition of murine lupus by brief simultaneous blockade of the B7/CD28 and CD40/gp39 costimulation pathways. Volume 159 of Issue 7. Journal of immunology (Baltimore, Md. : 1950) 1997. PMID: 9317105


  51. Daikh D, Wofsy D, Imboden JB. The CD28-B7 costimulatory pathway and its role in autoimmune disease. Volume 62 of Issue 2. Journal of leukocyte biology 1997. PMID: 9261329