Daniel Calabrese, MD

Asst Professor in Residence

Dr. Calabrese is an Assistant Professor of Medicine at UCSF and a Staff Physician at the San Francisco VA Medical Center. He received his undergraduate degree from Washington University in St. Louis and completed his MD at Case Western Reserve University School of Medicine.

He serves as an attending physician in the intensive care unit, pulmonary consult service and outpatient pulmonary clinic at the SF VAMC. He is also an attending physician for the Advanced Lung Disease Service at UCSF Parnassus where he evaluates patients in the lung transplant clinics. He is active in the International Society for Heart and Lung Transplantation.

His research focuses on the mechanisms for innate immune inflammation in lung transplant outcomes. This research uses mouse models of human lung disease and human tissue samples to understand primary graft dysfunction, antibody-mediated rejection and chronic lung allograft dysfunction. The goal of this work is to improve outcomes following lung transplantation.

Education
2020 - Diversity, Equity, and Inclusion Champion Training, University of California San Francisco
Fellowship, 07/2018 - Pulmonary and Critical Care, University of California San Francisco
Residency, 07/2014 - Internal Medicine, University of Washington
MD, 05/2011 - , Case Western Reserve University
BS, 05/2006 - Anthropology, Biology, Washington University in St. Louis
Honors and Awards
  • Young Physician-Scientist Award, ASCI, 2023
  • Research and Immunology Professional Community Award for Excellence, ISHLT, 2022-2023
Websites
Publications

  1. Tsao T, Qiu L, Bharti R, Shemesh A, Hernandez AM, Cleary SJ, Greenland NY, Santos J, Shi R, Bai L, Richardson J, Dilley K, Will M, Tomasevic N, Sputova T, Salles A, Kang J, Zhang D, Hays SR, Kukreja J, Singer JP, Lanier LL, Looney MR, Greenland JR, Calabrese DR. CD94+ Natural Killer cells potentiate pulmonary ischemia-reperfusion injury. The European respiratory journal 2024. PMID: 39190789


  2. Mohanty RP, Moghbeli K, Singer JP, Calabrese DR, Hays SR, Iasella C, Lieber S, Leard LE, Shah RJ, Venado A, Kleinhenz ME, Golden JA, Martinu T, Love C, Ward R, Langelier CR, McDyer J, Greenland JR. Small airway brush gene expression predicts chronic lung allograft dysfunction and mortality. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2024. PMID: 39115489


  3. Calabrese DR. Of rivers, recipients and rejection: revelations from deep immune phenotyping of lung allograft transbronchial biopsy tissue. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2024. PMID: 38986971


  4. Bharti R, Calabrese DR. Innate and adaptive effector immune drivers of cytomegalovirus disease in lung transplantation: a double-edged sword. Frontiers in Transplantation 2024. PMID: 38993763


  5. Calabrese DR, Shaver CM. The Emperor Has Some Clothes: Emerging Molecular Diagnostics in Post-Lung Transplant Decision Making. American journal of respiratory and critical care medicine 2024. PMID: 38387008


  6. Calabrese DR, Yellamilli S, Ekstrand C, Singer JP, Hays SR, Leard LE, Shah RJ, Venado A, Kolaitis NA, Perez A, Combes A, Greenland JR. Macrophage and CD8 T Cell Discordance are Associated with Acute Lung Allograft Dysfunction Progression. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2024. PMID: 38367738


  7. Prather AA, Gao Y, Betancourt L, Kordahl RC, Sriram A, Huang CY, Hays SR, Kukreja J, Calabrese DR, Venado A, Greenland JR, Singer JP. Disturbed sleep is associated with worse patient-reported outcomes and chronic lung allograft dysfunction after lung transplantation. medRxiv : the preprint server for health sciences 2023. PMID: 37873197


  8. Aguilar OA, Qualls AE, Gonzalez-Hinojosa MDR, Obeidalla S, Kerchberger VE, Tsao T, Singer JP, Looney MR, Raymond W, Hays SR, Golden JA, Kukreja J, Shaver CM, Ware LB, Christie J, Diamond JM, Lanier LL, Greenland JR, Calabrese DR, LTOG Investigators. MICB Genomic Variant is Associated with NKG2D-mediated Acute Lung Injury and Death. American journal of respiratory and critical care medicine 2023. PMID: 37878820


  9. Santos J, Wang P, Shemesh A, Liu F, Tsao T, Aguilar OA, Cleary SJ, Singer JP, Gao Y, Hays SR, Golden J, Leard LE, Kleinhenz ME, Kolaitis NA, Shah RJ, Venado A, Kukreja J, Weigt SS, Belperio JA, Lanier LL, Looney MR, Greenland JR, Calabrese DR. CCR5 drives NK cell-associated airway damage in pulmonary ischemia-reperfusion injury. JCI insight 2023. PMID: 37788115


  10. Greenland JR, Guo R, Lee S, Tran L, Kapse B, Kukreja J, Hays SR, Golden JA, Calabrese DR, Singer JP, Wolters PJ. Short Airway Telomeres are Associated with Primary Graft Dysfunction and Chronic Lung Allograft Dysfunction. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2023. PMID: 37648073


  11. Santos J, Hays SR, Golden JA, Calabrese DR, Kolaitis N, Kleinhenz ME, Shah R, Estrada AV, Leard LE, Kukreja J, Singer JP, Greenland JR. Decreased Lymphocytic Bronchitis Severity in the Era of Azithromycin Prophylaxis. Transplantation direct 2023. PMID: 37575951


  12. Calabrese DR, Greenland JR. Theseus and the search for an antibody-mediated rejection molecular state in lung transplant biopsies. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2023. PMID: 37562578


  13. Singer JP, Gao Y, Huang CY, Kordahl RC, Sriram A, Hays SR, Kukreja J, Venado A, Calabrese DR, Greenland JR. The Association Between Frailty and Chronic Lung Allograft Dysfunction After Lung Transplantation. Transplantation 2023. PMID: 37287095


  14. Bromberger B, Calabrese DR, Brzezinski M, Kukreja J. Regadenoson is all the RAGE: Targeting the inflammatory cascade in Primary Graft Dysfunction. The Annals of thoracic surgery 2023. PMID: 37062341


  15. Calabrese DR, London MJ. Paradox of Power: Dynamic Tools to Predict Respiratory Failure in Spontaneously Breathing Patients. Anesthesiology 2023. PMID: 36749420


  16. Singer JP, Christie JD, Diamond JM, Anderson MA, Benvenuto LA, Gao Y, Arcasoy SM, Lederer DJ, Calabrese D, Wang P, Hays SR, Kukreja J, Venado A, Kolaitis NA, Leard LE, Shah RJ, Kleinhenz ME, Golden J, Betancourt L, Oyster M, Zaleski D, Adler J, Kalman L, Balar P, Patel S, Medikonda N, Koons B, Tevald M, Covinsky KE, Greenland JR, Katz PK. Development of the Lung Transplant Frailty Scale (LT-FS). The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2023. PMID: 36925382


  17. Singer JP, Calfee CS, Delucchi K, Diamond JM, Anderson MA, Benvenuto LA, Gao Y, Wang P, Arcasoy SM, Lederer DJ, Hays SR, Kukreja J, Venado A, Kolaitis NA, Leard L LE, Shah RJ, Kleinhenz ME, Golden J, Betancourt L, Oyster M, Brown M, Zaleski D, Medikonda N, Kalman L, Balar P, Patel S, Calabrese DR, Greenland JR, Christie JD. Subphenotypes of frailty in lung transplant candidates. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2023. PMID: 36740192


  18. Odisho AY, Liu AW, Maiorano AR, Bigazzi MOA, Medina E, Leard LE, Shah R, Venado A, Perez A, Golden J, Kleinhenz ME, Kolaitis NA, Maheshwari J, Trinh BN, Kukreja J, Greenland J, Calabrese D, Neinstein AB, Singer JP, Hays SR. Design and implementation of a digital health home spirometry intervention for remote monitoring of lung transplant function. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2023. PMID: 37031033


  19. Kolaitis NA, Chen H, Calabrese DR, Kumar K, Obata J, Bach C, Golden JA, Simon MA, Kukreja J, Hays SR, Leard LE, Singer JP, De Marco T. The Lung Allocation Score Remains Inequitable for Patients with PAH, Even After the 2015 Revision. American journal of respiratory and critical care medicine 2022. PMID: 36094471


  20. Calabrese DR, Chong T, Singer JP, Rajalingam R, Hays SR, Kukreja J, Leard L, Golden JA, Lanier LL, Greenland JR. CD16+ natural killer cells in bronchoalveolar lavage are associated with antibody-mediated rejection and chronic lung allograft dysfunction. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2023. PMID: 36695619


  21. Macrae TA, Lazo J, Viduya J, Florez R, Dewey K, Gao Y, Singer JP, Hays SR, Golden JA, Kukreja J, Greenland JR, Calabrese DR. Frailty and genetic risk predict fracture after lung transplantation. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2023. PMID: 36695698


  22. Calabrese DR, Tsao T, Magnen M, Valet C, Gao Y, Mallavia B, Tian JJ, Aminian EA, Wang KM, Shemesh A, Punzalan EB, Sarma A, Calfee CS, Christenson SA, Langelier CR, Hays SR, Golden JA, Leard LE, Kleinhenz ME, Kolaitis NA, Shah RJ, Venado A, Lanier LL, Greenland JR, Sayah DM, Ardehali A, Kukreja J, Weigt SS, Belperio JA, Singer JP, Looney MR. NKG2D receptor activation drives primary graft dysfunction severity and poor lung transplantation outcomes. JCI insight 2022. PMID: 36346670


  23. Shemesh A, Su Y, Calabrese DR, Chen D, Arakawa-Hoyt J, Roybal KT, Heath JR, Greenland JR, Lanier LL. Diminished cell proliferation promotes natural killer cell adaptive-like phenotype by limiting FceRI? expression. The Journal of experimental medicine 2022. PMID: 36066491


  24. Santos J, Calabrese DR, Greenland JR. Lymphocytic Airway Inflammation in Lung Allografts. Frontiers in immunology 2022. PMID: 35911676


  25. Valet C, Magnen M, Qiu L, Cleary SJ, Wang KM, Ranucci S, Grockowiak E, Boudra R, Conrad C, Seo Y, Calabrese DR, Greenland JR, Leavitt AD, Passegué E, Mendez-Ferrer S, Swirski FK, Looney MR. Sepsis promotes splenic production of a protective platelet pool with high CD40 ligand expression. 2022. PMID: 35192546


  26. Greenland NY, Deiter F, Calabrese DR, Hays SR, Kukreja J, Leard LE, Kolaitis NA, Golden JA, Singer JP, Greenland JR. Inflammation on bronchoalveolar lavage cytology is associated with decreased chronic lung allograft dysfunction-free survival. 2022. PMID: 35246990


  27. Wang P, Leung J, Lam A, Lee S, Calabrese DR, Hays SR, Golden JA, Kukreja J, Singer JP, Wolters PJ, Tang Q, Greenland JR. Lung transplant recipients with idiopathic pulmonary fibrosis have impaired alloreactive immune responses. 2021. PMID: 34924263


  28. Dugger DT, Calabrese DR, Gao Y, Deiter F, Tsao T, Maheshwari J, Hays SR, Leard L, Kleinhenz ME, Shah R, Golden J, Kukreja J, Gordon ED, Singer JP, Greenland JR. Lung Allograft Epithelium DNA Methylation Age Is Associated With Graft Chronologic Age and Primary Graft Dysfunction. 2021. PMID: 34691018


  29. Calabrese DR. Ribavirin to the Rescue: Natural Killer Cell Function After Hepatitis C Virus Treatment in Liver Transplant Recipients. Transplantation 2021. PMID: 33587428


  30. Maheshwari JA, Kolaitis NA, Anderson MR, Benvenuto L, Gao Y, Katz PP, Greenland J, Wolters PJ, Covinsky K, Hays SR, Kukreja J, Calabrese DR, Venado A, Shah RJ, Leard LE, Trinh B, Huang CY, Glidden D, Kleinhenz ME, Golden JA, Sutter N, Tietje-Ulrich G, Criner RN, Arcasoy SM, Christie JD, Diamond J, Singer JP. Construct and Predictive Validity of Sarcopenia in Lung Transplant Candidates. Annals of the American Thoracic Society 2021. PMID: 33565917


  31. A. Venado, J.P. Singer, L.E. Leard, R. Shah, M.E. Kleinhenz, J. Golden, A. Perez, N. Kolaitis, D. Calabrese, J. Maheshwari, B. Trinh, J. Kukreja, S. Hays. Measuring Quality in Lung Transplant Care: The QUILT Initiative. The Journal of Heart and Lung Transplantation 2021. PMID:


  32. DeBolt CL, Gao Y, Sutter N, Soong A, Leard L, Jeffrey G, Kleinhenz ME, Calabrese D, Greenland J, Venado A, Hays SR, Shah R, Kukreja J, Trinh B, Kolaitis NA, Douglas V, Diamond JM, Smith P, Singer J. The association of post-operative delirium with patient-reported outcomes and mortality after lung transplantation. Clinical transplantation 2021. PMID: 33682171


  33. Hoover J, Mintz MA, Deiter F, Aminian E, Chen J, Hays SR, Singer JP, Calabrese DR, Kukreja J, Greenland JR. Rapid molecular detection of airway pathogens in lung transplant recipients. Transplant infectious disease : an official journal of the Transplantation Society 2021. PMID: 33523538


  34. Calabrese DR, Aminian E, Mallavia B, Liu F, Cleary SJ, Aguilar OA, Wang P, Singer JP, Hays SR, Golden JA, Kukreja J, Dugger D, Nakamura M, Lanier LL, Looney MR, Greenland JR. Natural killer cells activated through NKG2D mediate lung ischemia-reperfusion injury. The Journal of clinical investigation 2021. PMID: 33290276


  35. Daniel R. Calabrese. Ribavirin to the Rescue: Natural Killer Cell Function After Hepatitis C Virus Treatment in Liver Transplant Recipients Transplantation 2020. PMID:


  36. Cleary SJ, Kwaan N, Tian JJ, Calabrese DR, Mallavia B, Magnen M, Greenland JR, Urisman A, Singer JP, Hays SR, Kukreja J, Hay AM, Howie HL, Toy P, Lowell CA, Morrell CN, Zimring JC, Looney MR. Complement activation on endothelium initiates antibody-mediated acute lung injury. The Journal of clinical investigation 2020. PMID: 32730229


  37. Venado A, Kolaitis NA, Huang CY, Gao Y, Glidden DV, Soong A, Sutter N, Katz PP, Greenland JR, Calabrese DR, Hays SR, Golden JA, Shah RJ, Leard LE, Kukreja J, Deuse T, Wolters PJ, Covinsky K, Blanc PD, Singer JP. Frailty after lung transplantation is associated with impaired health-related quality of life and mortality. Thorax 2020. PMID: 32376733


  38. Kolaitis NA, Calabrese DR, Ahearn P, Venado A, Florez R, Lei HL, Isaak K, Henricksen E, Martinez E, Chong T, Shah RJ, Leard LE, Kleinhenz ME, Golden J, De Marco T, Greenland JR, Kukreja J, Hays SR, Blanc PD, Singer JP. Tacrolimus trough monitoring guided by mass spectrometry without accounting for assay differences is associated with acute kidney injury in lung transplant recipients. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 2019. PMID: 31696925


  39. Calabrese DR, Wang P, Chong T, Hoover J, Singer JP, Torgerson D, Hays SR, Golden JA, Kukreja J, Dugger D, Christie JD, Investigators L, Greenland JR. Dectin-1 genetic deficiency predicts chronic lung allograft dysfunction and death. JCI insight 2019. PMID: 31613800


  40. Calabrese DR. At the bottom of Thomas Bayes' tea cup: Practical applications of lung transplant immunophenotyping. Transplantation 2018. PMID: 30461722


  41. Calabrese DR, Chong T, Wang A, Singer JP, Gottschall M, Hays SR, Golden JA, Kukreja J, Lanier LL, Tang Q, Greenland JR. NKG2C natural killer cells in bronchoalveolar lavage are associated with cytomegalovirus viremia and poor outcomes in lung allograft recipients. Volume 103 of Issue 3. Transplantation 2018. PMID: 30211828


  42. Calabrese DR, Lanier LL, Greenland JR. Natural killer cells in lung transplantation. Volume 74 of Issue 4. Thorax 2018. PMID: 30381399


  43. Calabrese DR, Florez R, Dewey K, Hui C, Torgerson D, Chong T, Faust H, Rajalingam R, Hays SR, Golden JA, Kukreja J, Singer JP, Greenland JR. Genotypes associated with tacrolimus pharmacokinetics impact clinical outcomes in lung transplant recipients. Volume 32 of Issue 8. Clinical transplantation 2018. PMID: 29920787


  44. Greenland JR, Sun H, Calabrese D, Chong T, Singer JP, Kukreja J, Hays SR, Golden JA, Caughey GH, Venstrom JM, Rajalingam R. HLA Mismatching Favoring Host-Versus-Graft NK Cell Activity Via KIR3DL1 Is Associated With Improved Outcomes Following Lung Transplantation. Volume 17 of Issue 8. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2017. PMID: 28375571


  45. Calabrese DR, Wang L, Harms MP, Ratnanather JT, Barch DM, Cloninger CR, Thompson PA, Miller MI, Csernansky JG. Cingulate gyrus neuroanatomy in schizophrenia subjects and their non-psychotic siblings. Volume 104 of Issue 1-3. Schizophrenia research 2008. PMID: 18692994


  46. Calabrese DR, Hullar TE. Planar relationships of the semicircular canals in two strains of mice. Volume 7 of Issue 2. Journal of the Association for Research in Otolaryngology : JARO 2006. PMID: 16718609