Catherine Koss, MD

Assoc Professor in Residence

Catherine Koss, MD is an Assistant Professor of Medicine in the Division of HIV, Infectious Diseases, and Global Medicine at San Francisco General Hospital. Dr. Koss conducts clinical research on HIV prevention and treatment, with a major focus on adherence measurement and strategies to optimize uptake of and adherence to pre-exposure prophylaxis (PrEP) among women in the United States and eastern Africa. She also has an interest in adherence to treatment and virologic outcomes among pregnant and postpartum women living with HIV. She is an attending physician on the HIV and Infectious Diseases consult service at San Francisco General Hospital and a clinical provider at the Ward 86 clinic.

Education
2019 - Diversity, Equity, and Inclusion Champion Training, University of California
AB, - Biochemical Sciences, Harvard College
MD, - , Northwestern University
- Fellowship, Infectious Diseases, University of California, San Francisco
- Residency, Internal Medicine, University of California, San Francisco
Honors and Awards
  • Teri Liegler, PhD, Young Scientist Career Award, University of California, San Francisco, 2021
  • Population Health and Health Equity Scholar, University of California, San Francisco, 2020
  • IAS TB/HIV Research Prize, co-author, International AIDS Society, 2016
  • Early Career Award for Excellence in Clinical Research, UCSF Center for AIDS Research, 2016
  • Chief Fellow, Division of Infectious Diseases, University of California, San Francisco, 2013
  • John P. Phair Medical Student Award in infectious diseases, Northwestern University, 2009
  • Neil Stone Award for professionalism and compassion in medicine, Northwestern University, 2009
Websites
Publications

  1. Kamya MR, Balzer LB, Ayieko J, Kabami J, Kakande E, Chamie G, Sutter N, Sunday H, Litunya J, Schwab J, Schrom J, Bacon M, Koss CA, Rinehart AR, Petersen M, Havlir DV, SEARCH Consortium. Dynamic choice HIV prevention with cabotegravir long-acting injectable in rural Uganda and Kenya: a randomised trial extension. The lancet. HIV 2024. PMID: 39395424


  2. Koss CA, Gandhi M, Halvas EK, Okochi H, Chu C, Glidden DV, Georgetti Gomez L, Heaps AL, Conroy AA, Tran M, Shetler C, Hoeth D, Kuncze K, Louie A, Rivera Garza H, Wafula Mugoma E, Penrose KJ, Chohan BH, Ayieko JO, Mills A, Patel RR, Mellors JW, Parikh UM. First Case of HIV Seroconversion With Integrase Resistance Mutations on Long-Acting Cabotegravir for Prevention in Routine Care. Open forum infectious diseases 2024. PMID: 39229286


  3. Gandhi M, Hill L, Grochowski J, Nelson A, Koss CA, Mayorga-Munoz F, Oskarsson J, Shiels M, Avery A, Bamford L, Baron J, Short WR, Hileman CO. Case Series of People With HIV on the Long-Acting Combination of Lenacapavir and Cabotegravir: Call for a Trial. Open forum infectious diseases 2024. PMID: 38628952


  4. Kabami J, Koss CA, Sunday H, Biira E, Nyabuti M, Balzer LB, Gupta S, Chamie G, Ayieko J, Kakande E, Bacon MC, Havlir D, Kamya MR, Petersen M, SEARCH Study Team. Randomized Trial of Dynamic Choice HIV Prevention at Antenatal and Postnatal Care Clinics in Rural Uganda and Kenya. Journal of acquired immune deficiency syndromes (1999) 2024. PMID: 38489493


  5. Koss CA, Ayieko J, Kabami J, Balzer LB, Kakande E, Sunday H, Nyabuti M, Wafula E, Shade S, Biira E, Opel F, Atuhaire HN, Okochi H, Ogachi S, Gandhi M, Bacon MC, Bukusi EA, Chamie G, Petersen ML, Kamya MR, Havlir DV, SEARCH study team. Dynamic choice HIV prevention intervention at outpatient departments in rural Kenya and Uganda: a randomized trial. AIDS (London, England) 2023. PMID: 37861683


  6. Kabami J, Kakande E, Chamie G, Balzer LB, Petersen ML, Camlin CS, Nyabuti M, Koss CA, Bukusi EA, Kamya MR, Havlir DV, Ayieko J. Uptake of a patient-centred dynamic choice model for HIV prevention in rural Kenya and Uganda: SEARCH SAPPHIRE study. Journal of the International AIDS Society 2023. PMID: 37408473


  7. Marquez C, Chen Y, Atukunda M, Chamie G, Balzer LB, Kironde J, Ssemmondo E, Mwangwa F, Kabami J, Owaraganise A, Kakande E, Abbott R, Ssekyanzi B, Koss C, Kamya MR, Charlebois ED, Havlir DV, Petersen ML. The Association Between Social Network Characteristics and Tuberculosis Infection Among Adults in Nine Rural Ugandan Communities. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2022. PMID: 35982635


  8. Camlin CS, Getahun M, Koss CA, Owino L, Akatukwasa C, Itiakorit H, Onyango A, Bakanoma R, Atwine F, Maeri I, Ayieko J, Atukunda M, Owaraganise A, Mwangwa F, Sang N, Kabami J, Kaplan RL, Chamie G, Petersen ML, Cohen CR, Bukusi EA, Kamya MR, Havlir DV, Charlebois ED. Providers' Attitudes and Experiences with Pre-Exposure Prophylaxis Implementation in a Population-Based Study in Kenya and Uganda. AIDS patient care and STDs 2022. PMID: 36201226


  9. Parikh UM, Koss CA, Mellors JW. Long-Acting Injectable Cabotegravir for HIV Prevention: What Do We Know and Need to Know about the Risks and Consequences of Cabotegravir Resistance? Current HIV/AIDS reports 2022. PMID: 36112336


  10. Phillips AN, Bershteyn A, Revill P, Bansi-Matharu L, Kripke K, Boily MC, Martin-Hughes R, Johnson LF, Mukandavire Z, Jamieson L, Meyer-Rath G, Hallett TB, Ten Brink D, Kelly SL, Nichols BE, Bendavid E, Mudimu E, Taramusi I, Smith J, Dalal S, Baggaley R, Crowley S, Terris-Prestholt F, Godfrey-Faussett P, Mukui I, Jahn A, Case KK, Havlir D, Petersen M, Kamya M, Koss CA, Balzer LB, Apollo T, Chidarikire T, Mellors JW, Parikh UM, Godfrey C, Cambiano V, HIV Modelling Consortium. Cost-effectiveness of easy-access, risk-informed oral pre-exposure prophylaxis in HIV epidemics in sub-Saharan Africa: a modelling study. 2022. PMID: 35489378


  11. Ayieko J, Petersen ML, Kabami J, Mwangwa F, Opel F, Nyabuti M, Charlebois ED, Peng J, Koss CA, Balzer LB, Chamie G, Bukusi EA, Kamya MR, Havlir DV. Uptake and outcomes of a novel community-based HIV post-exposure prophylaxis (PEP) programme in rural Kenya and Uganda. Journal of the International AIDS Society 2021. PMID: 34152067


  12. Okochi H, Louie A, Phung N, Zhang K, Tallerico RM, Kuncze K, Spinelli MA, Koss CA, Benet LZ, Gandhi M. Tenofovir and emtricitabine concentrations in hair are comparable between individuals on tenofovir disoproxil fumarate versus tenofovir alafenamide-based ART. Drug testing and analysis 2021. PMID: 33742745


  13. Koss CA, Havlir DV, Ayieko J, Kwarisiima D, Kabami J, Chamie G, Atukunda M, Mwinike Y, Mwangwa F, Owaraganise A, Peng J, Olilo W, Snyman K, Awuonda B, Clark TD, Black D, Nugent J, Brown LB, Marquez C, Okochi H, Zhang K, Camlin CS, Jain V, Gandhi M, Cohen CR, Bukusi EA, Charlebois ED, Petersen ML, Kamya MR, Balzer LB. HIV incidence after pre-exposure prophylaxis initiation among women and men at elevated HIV risk: A population-based study in rural Kenya and Uganda. PLoS medicine 2021. PMID: 33561143


  14. Mwangwa F, Getahun M, Itiakorit H, Jain V, Ayieko J, Owino L, Akatukwasa C, Maeri I, Koss CA, Chamie G, Clark TD, Kabami J, Atukunda M, Kwarisiima D, Sang N, Bukusi EA, Kamya MR, Petersen ML, Cohen CR, Charlebois ED, Havlir DV, Camlin CS. Provider and Patient Perspectives of Rapid ART Initiation and Streamlined HIV Care: Qualitative Insights From Eastern African Communities. 2021. PMID: 34841945


  15. Balzer LB, Havlir DV, Kamya MR, Chamie G, Charlebois ED, Clark TD, Koss CA, Kwarisiima D, Ayieko J, Sang N, Kabami J, Atukunda M, Jain V, Camlin CS, Cohen CR, Bukusi EA, van der Laan M, Petersen ML. Machine learning to identify persons at high-risk of HIV acquisition in rural Kenya and Uganda. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2019. PMID: 31697383


  16. Kabami J, Balzer LB, Saddiki H, Ayieko J, Kwarisiima D, Atukunda M, Charlebois ED, Clark TD, Koss CA, Ruel T, Bukusi EA, Cohen CR, Musoke P, Petersen ML, Havlir DV, Kamya MR, Chamie G. Population-level viral suppression among pregnant and postpartum women in a universal test and treat trial. AIDS (London, England) 2020. PMID: 32472768


  17. Camlin CS, Koss CA, Getahun M, Owino L, Itiakorit H, Akatukwasa C, Maeri I, Bakanoma R, Onyango A, Atwine F, Ayieko J, Kabami J, Mwangwa F, Atukunda M, Owaraganise A, Kwarisiima D, Sang N, Bukusi EA, Kamya MR, Petersen ML, Cohen CR, Charlebois ED, Havlir DV. Understanding Demand for PrEP and Early Experiences of PrEP Use Among Young Adults in Rural Kenya and Uganda: A Qualitative Study. AIDS and behavior 2020. PMID: 31955361


  18. Budak JZ, Brickman CE, Abdoler EA, Wallender EK, Mulliken JS, Kerkhoff AD, Lampiris H, Babik JM, Koss CA, Schwartz BS. Response to: Is Burnout Infectious? Understanding Drivers of Burnout and Job Satisfaction Among Academic Infectious Diseases Physicians. Open forum infectious diseases 2020. PMID: 32284950


  19. Koss CA, Charlebois ED, Ayieko J, Kwarisiima D, Kabami J, Balzer LB, Atukunda M, Mwangwa F, Peng J, Mwinike Y, Owaraganise A, Chamie G, Jain V, Sang N, Olilo W, Brown LB, Marquez C, Zhang K, Ruel TD, Camlin CS, Rooney JF, Black D, Clark TD, Gandhi M, Cohen CR, Bukusi EA, Petersen ML, Kamya MR, Havlir DV. Uptake, engagement, and adherence to pre-exposure prophylaxis offered after population HIV testing in rural Kenya and Uganda: 72-week interim analysis of observational data from the SEARCH study. The lancet. HIV 2020. PMID: 32087152


  20. Lesosky M, Raboud JM, Glass T, Brummel SS, Ciarnello AL, Currier JS, Essajee S, Havlir DV, Koss CA, Ogwu A, Shapiro RL, Abrams EJ, Myer L. Comparison of guidelines for HIV viral load monitoring among pregnant and breastfeeding women in sub-Saharan Africa: a simulation study. AIDS (London, England) 2019. PMID: 31634186


  21. Olilo WA, Petersen ML, Koss CA, Wafula E, Kwarisiima D, Kadede K, Clark TD, Cohen CR, Bukusi EA, Kamya MR, Charlebois ED, Havlir DV, Ayieko J. Pre-Exposure Prophylaxis (Prep) Uptake among Older Individuals in Rural Western Kenya. Journal of acquired immune deficiency syndromes (1999) 2019. PMID: 31490343


  22. Jehan Budak, Cristina Brickman, Emily Abdoler, Erika Wallender, Jennifer S Mulliken, Andrew D Kerkhoff, Harry Lampiris, Jennifer M Babik, Catherine Koss, Brian Schwartz, Brian Schwartz. 2534. Development of an Infectious Diseases Fellowship Well-Being Program. Open forum infectious diseases 2019. PMID:


  23. Riley ED, Vittinghoff E, Koss CA, Christopoulos KA, Clemenzi-Allen A, Dilworth SE, Carrico AW. Housing First: Unsuppressed Viral Load Among Women Living with HIV in San Francisco. AIDS and behavior 2019. PMID: 31324996


  24. Havlir DV, Balzer LB, Charlebois ED, Clark TD, Kwarisiima D, Ayieko J, Kabami J, Sang N, Liegler T, Chamie G, Camlin CS, Jain V, Kadede K, Atukunda M, Ruel T, Shade SB, Ssemmondo E, Byonanebye DM, Mwangwa F, Owaraganise A, Olilo W, Black D, Snyman K, Burger R, Getahun M, Achando J, Awuonda B, Nakato H, Kironde J, Okiror S, Thirumurthy H, Koss C, Brown L, Marquez C, Schwab J, Lavoy G, Plenty A, Mugoma Wafula E, Omanya P, Chen YH, Rooney JF, Bacon M, van der Laan M, Cohen CR, Bukusi E, Kamya MR, Petersen M. HIV Testing and Treatment with the Use of a Community Health Approach in Rural Africa. The New England journal of medicine 2019. PMID: 31314966


  25. Guimaraes AO, Cao Y, Hong K, Mayba O, Peck M, Gutierrez J, Ruffin F, Carrasco-Triguero M, Dinoso JB, Clemenzi-Allen A, Koss CA, Maskarinec S, Chambers HF, Fowler VG, Baruch A, Rosenberger CM. A prognostic model of persistent bacteremia and mortality in complicated S. aureus bloodstream infection. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2018. PMID: 30165412


  26. Mayer CM, Owaraganise A, Kabami J, Kwarisiima D, Koss CA, Charlebois ED, Kamya MR, Petersen ML, Havlir DV, Jewell BL. Distance to clinic is a barrier to PrEP uptake and visit attendance in a community in rural Uganda. Journal of the International AIDS Society 2019. PMID: 31037845


  27. Gutierrez J, Guimaraes AO, Lewin-Koh N, Berhanu A, Xu M, Cao Y, Kim J, Yan D, Chang JK, Dinoso JB, Koss CA, Clemenzi-Allen A, Chambers HF, Peck MC, Baruch A, Rosenberger CM. Sustained Circulating Bacterial Deoxyribonucleic Acid Is Associated With Complicated Staphylococcus aureus Bacteremia. Open forum infectious diseases 2019. PMID: 31024970


  28. Koss CA, Ayieko J, Mwangwa F, Owaraganise A, Kwarisiima D, Balzer LB, Plenty A, Sang N, Kabami J, Ruel TD, Black D, Camlin CS, Cohen CR, Bukusi EA, Clark TD, Charlebois ED, Petersen ML, Kamya MR, Havlir DV. Early Adopters of Human Immunodeficiency Virus Preexposure Prophylaxis in a Population-based Combination Prevention Study in Rural Kenya and Uganda. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2018. PMID: 29741594


  29. Koss CA, Liu AY, Castillo-Mancilla J, Bacchetti P, McHugh C, Kuncze K, Morrow M, Louie A, Seifert S, Okochi H, MaWhinney S, Gandhi M, Anderson PL. Similar tenofovir hair concentrations in men and women after directly observed dosing of tenofovir disoproxil fumarate/emtricitabine: implications for preexposure prophylaxis adherence monitoring. AIDS (London, England) 2018. PMID: 30212404


  30. Gandhi M, Bacchetti P, Rodrigues WC, Spinelli M, Koss CA, Drain PK, Baeten JM, Mugo NR, Ngure K, Benet LZ, Okochi H, Wang G, Vincent M. Development and Validation of an Immunoassay for Tenofovir in Urine as a Real-Time Metric of Antiretroviral Adherence. EClinicalMedicine 2018. PMID: 30906930


  31. Johnny Gutierrez, Alessander Guimaraes, Melicent C. Peck, Aklile Barhanu, Min Xu, Yi Cao, Janice Kim, Donghong Yan, Joanna K. Chang, Jason Dinoso, Catherine Koss, Angelo Clemenzi-Allen, Henry F. Chambers, Carrie Rosenberger, Amos Baruch. Circulating bacterial DNA is associated with disease severity in patients with S. aureus bacteremia. The Journal of Immunology 2018. PMID:


  32. McDonald CR, Conroy AL, Gamble JL, Papp E, Hawkes M, Olwoch P, Natureeba P, Kamya M, Silverman M, Cohan D, Koss CA, Dorsey G, Kain KC, Serghides L. Estradiol Levels Are Altered in Human Immunodeficiency Virus-Infected Pregnant Women Randomized to Efavirenz-Versus Lopinavir/Ritonavir-Based Antiretroviral Therapy. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2018. PMID: 29136115


  33. Koss CA, Hosek SG, Bacchetti P, Anderson PL, Liu AY, Horng H, Benet LZ, Kuncze K, Louie A, Saberi P, Wilson CM, Gandhi M. Comparison of Measures of Adherence to HIV Preexposure Prophylaxis among Adolescent and Young Men Who Have Sex with Men in the United States. Volume 66 of Issue 2. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2017. PMID: 29020194


  34. Roh ME, Shiboski S, Natureeba P, Kakuru A, Muhindo M, Ochieng T, Plenty A, Koss CA, Clark TD, Awori P, Nakalambe M, Cohan D, Jagannathan P, Gosling R, Havlir DV, Kamya MR, Dorsey G. Protective effect of indoor residual spraying of insecticide on preterm birth among pregnant women with HIV in Uganda: A secondary data analysis. Volume 216 of Issue 12. The Journal of infectious diseases 2017. PMID: 29029337


  35. Pintye J, Bacchetti P, Teeraananchai S, Kerr S, Prasitsuebsai W, Singtoroj T, Kuncze K, Louie A, Koss CA, Jin C, Phung N, Horng H, Sohn AH, Gandhi M. Brief Report: Lopinavir Hair Concentrations Are the Strongest Predictor of Viremia in HIV-Infected Asian Children and Adolescents on Second-Line Antiretroviral Therapy. Journal of acquired immune deficiency syndromes (1999) 2017. PMID: 28825944


  36. Saberi P, Neilands TB, Ming K, Johnson MO, Kuncze K, Koss CA, Gandhi M. Strong Correlation Between Concentrations of Antiretrovirals in Home-Collected and Study-Collected Hair Samples: Implications for Adherence Monitoring. Journal of acquired immune deficiency syndromes (1999) 2017. PMID: 28657913


  37. Gandhi M, Murnane PM, Bacchetti P, Elion R, Kolber MA, Cohen SE, Horng H, Louie A, Kuncze K, Koss CA, Anderson PL, Buchbinder S, Liu A. Hair levels of preexposure prophylaxis drugs measure adherence and are associated with renal decline among men/transwomen. AIDS (London, England) 2017. PMID: 28832411


  38. Natureeba P, Kakuru A, Muhindo M, Ochieng T, Ategeka J, Koss CA, Plenty A, Charlebois ED, Clark TD, Nzarubara B, Nakalembe M, Cohan D, Rizzuto G, Muehlenbachs A, Ruel T, Jagannathan P, Havlir DV, Kamya MR, Dorsey G. Intermittent Preventive Treatment With Dihydroartemisinin-Piperaquine for the Prevention of Malaria Among HIV-Infected Pregnant Women. The Journal of infectious diseases 2017. PMID: 28329368


  39. Kajubi R, Huang L, Jagannathan P, Chamankhah N, Were M, Ruel T, Koss CA, Kakuru A, Mwebaza N, Kamya M, Havlir D, Dorsey G, Rosenthal PJ, Aweeka FT. Antiretroviral Therapy With Efavirenz Accentuates Pregnancy-Associated Reduction of Dihydroartemisinin-Piperaquine Exposure During Malaria Chemoprevention. Clinical pharmacology and therapeutics 2017. PMID: 28187497


  40. Koss CA, Bacchetti P, Hillier SL, Livant E, Horng H, Mgodi N, Mirembe BG, Gomez Feliciano K, Horn S, Liu AY, Glidden DV, Grant RM, Benet LZ, Louie A, van der Straten A, Chirenje ZM, Marrazzo JM, Gandhi M. Differences in Cumulative Exposure and Adherence to Tenofovir in the VOICE, iPrEx OLE, and PrEP Demo Studies as Determined via Hair Concentrations. AIDS research and human retroviruses 2017. PMID: 28253024


  41. Koss CA, Natureeba P, Kwarisiima D, Ogena M, Clark TD, Olwoch P, Cohan D, Okiring J, Charlebois ED, Kamya MR, Havlir DV. Viral Suppression and Retention in Care up to 5 Years After Initiation of Lifelong ART During Pregnancy (Option B+) in Rural Uganda. Journal of acquired immune deficiency syndromes (1999) 2017. PMID: 27828878


  42. Gerona R, Wen A, Koss C, Bacchetti P, Gandhi M, Metcalfe J. A multi-analyte panel for non-invasive pharmacokinetic monitoring of second-line anti-tuberculosis drugs. Volume 20 of Issue 7. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2016. PMID: 27287660


  43. Gerona R, Wen A, Chin AT, Koss CA, Bacchetti P, Metcalfe J, Gandhi M. Quantifying Isoniazid Levels in Small Hair Samples: A Novel Method for Assessing Adherence during the Treatment of Latent and Active Tuberculosis. Volume 11 of Issue 5. PloS one 2016. PMID: 27191185


  44. Koss CA, Natureeba P, Nyafwono D, Plenty A, Mwesigwa J, Nzarubara B, Clark TD, Ruel TD, Achan J, Charlebois ED, Cohan D, Kamya MR, Havlir DV, Young SL. Brief Report: Food Insufficiency Is Associated With Lack of Sustained Viral Suppression Among HIV-Infected Pregnant and Breastfeeding Ugandan Women. Journal of acquired immune deficiency syndromes (1999) 2016. PMID: 26397935


  45. Koss CA, Jarlsberg LG, den Boon S, Cattamanchi A, Davis JL, Worodria W, Ayakaka I, Sanyu I, Huang L. A Clinical Predictor Score for 30-Day Mortality among HIV-Infected Adults Hospitalized with Pneumonia in Uganda. Volume 10 of Issue 5. PloS one 2015. PMID: 25962069


  46. Koss CA, Natureeba P, Mwesigwa J, Cohan D, Nzarubara B, Bacchetti P, Horng H, Clark TD, Plenty A, Ruel TD, Achan J, Charlebois ED, Kamya MR, Havlir DV, Gandhi M. Hair concentrations of antiretrovirals predict viral suppression in HIV-infected pregnant and breastfeeding Ugandan women. AIDS (London, England) 2015. PMID: 25985404


  47. Cohan D, Natureeba P, Koss CA, Plenty A, Luwedde F, Mwesigwa J, Ades V, Charlebois ED, Gandhi M, Clark TD, Nzarubara B, Achan J, Ruel T, Kamya MR, Havlir DV. Efficacy and safety of lopinavir/ritonavir versus efavirenz-based antiretroviral therapy in HIV-infected pregnant Ugandan women. AIDS (London, England) 2015. PMID: 25426808


  48. Koss CA, Natureeba P, Plenty A, Luwedde F, Mwesigwa J, Ades V, Charlebois ED, Clark TD, Achan J, Ruel T, Nzarubara B, Kamya MR, Havlir DV, Cohan D. Risk factors for preterm birth among HIV-infected pregnant Ugandan women randomized to lopinavir/ritonavir- or efavirenz-based antiretroviral therapy. Journal of acquired immune deficiency syndromes (1999) 2014. PMID: 25072616


  49. Koss CA, Baras DC, Lane SD, Aubry R, Marcus M, Markowitz LE, Koumans EH. Investigation of metronidazole use during pregnancy and adverse birth outcomes. Antimicrobial agents and chemotherapy 2012. PMID: 22751543


  50. Koss CA, Dunne EF, Warner L. A systematic review of epidemiologic studies assessing condom use and risk of syphilis. Sexually transmitted diseases 2009. PMID: 19455075


  51. Huskamp HA, Donohue JM, Koss C, Berndt ER, Frank RG. Generic entry, reformulations and promotion of SSRIs in the US. PharmacoEconomics 2008. PMID: 18563951