Carolyn Hendrickson, MD, MPH

Associate Professor

Dr. Hendrickson is a pulmonary and critical care medicine subspecialist with an expertise and research focus in acute lung injury and acute respiratory distress syndrome (ARDS), the most common life-threatening manifestation of COVID-19 disease in the earliest years of the pandemic. She is the medical director of the Medical Intensive Care Unit at Zuckerberg San Francisco General Hospital. In recent years there have been several retrospective studies published showing an association between race and differences in pulse oximeter performance. Dr. Hendrickson and the EquiOx Team are leading an FDA-sponsored study to measure pulse oximeter bias across a range of skin pigmentation among hospitalized patients. This research program aims to better understand how pulse oximeter performance might be improved to ensure these critical devices perform equally well for all patients regardless of skin pigmentation.

During the first two years of the COVID-19 pandemic, ZSFG, a safety-net hospital for our county cared for approximately half of all ICU patients with COVID-19 disease in San Francisco and Dr. Hendrickson served as the physician lead to establish and run the COVID ICU. Dr. Hendrickson served as a site investigator to offer participation in clinical research studies and access to potential therapeutic agents for patients hospitalized at ZSFG.

COVID-19 Related Research Efforts:
As an ARDS translational researcher and the Medical Director of the Intensive Care Unit at Zuckerberg San Francisco General Hospital (ZSFG), Dr. Hendrickson pivoted her research endeavors to study COVID-19 disease with a specific interest in pneumonia and ARDS. She is the site principal investigator for two important COVID-19- related studies:
1. STAT Trial - a randomized clinical trial sponsored by the Department of Defense testing mesenchymal stromal cells for ARDS that primarily enrolls critically ill patients with ARDS
from COVID-19
2. COMET Study- a longitudinal cohort study of hospitalized patients with COVID-19 disease with biospecimen collection sponsored by the National Institute of Health (https://www.comet-study.org). She is also the Clinical Operations Lead and a member of the Executive Committee for the COMET study.

Additionally, Dr. Hendrickson has leadership and site director roles in three other COVID-19-related randomized controlled clinical trials studying anticoagulation strategies, anti-inflammatory medications, and novel cell-based therapy for patients hospitalized with SARS-CoV-2 infection.

Education
06/2021 - Diversity, Equity, and Inclusion Champion Training, University of California
Certificate, 2014 - Clinical Research, University of California, San Francisco
MPH, 2008 - Epidemiology, University of California, Berkeley
M.D., 2007 - Medicine, University of California, San Francisco
MA, 2003 - Molecular, Cellular, Developmental Biology, University of California, Santa Barbara
BA, 2001 - English Literature, University of California, Santa Barbara
BS, 2001 - Molecular, Cellular, Developmental Biology, University of California, Santa Barbara
Publications

  1. Zalucky AA, Evrard B, Delucchi K, Zhuo H, Wu N, Liu KD, Hendrickson CM, Matthay MA, Kangelaris KN, Calfee CS. Agreement Between Sepsis-2 and Sepsis-3 Definitions Among Patients Admitted to the Intensive Care Unit. Annals of the American Thoracic Society 2024. PMID: 39471317


  2. Spottiswoode N, Tsitsiklis A, Chu VT, Phan HV, DeVoe C, Love C, Ghale R, Bloomstein J, Zha BS, Maguire CP, Glascock A, Sarma A, Mourani PM, Kalantar KL, Detweiler A, Neff N, Haller SC, COMET Consortium, DeRisi JL, Erle DJ, Hendrickson CM, Kangelaris KN, Krummel MF, Matthay MA, Woodruff PG, Calfee CS, Langelier CR. Microbial dynamics and pulmonary immune responses in COVID-19 secondary bacterial pneumonia. Nature communications 2024. PMID: 39472555


  3. Fong N, Lipnick MS, Behnke E, Chou Y, Elmankabadi S, Ortiz L, Almond CS, Auchus I, Burnett GW, Bisegerwa R, Conrad DR, Hendrickson CM, Hooli S, Kopotic R, Leeb G, Martin D, McCollum ED, Monk EP, Moore KL, Shmuylovich L, Scott JB, Wong AI, Zhou T, Pirracchio R, Bickler PE, Feiner J, Law T. Open Access Data Repository and Common Data Model for Pulse Oximeter Performance Data. medRxiv : the preprint server for health sciences 2024. PMID: 39252896


  4. Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Bernard O, Simoneau CR, Hysenaj L, Hu KH, Maishan M, Conrad C, Gbenedio OM, Samad B, Consortium TUC, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR. Immediate myeloid depot for SARS-CoV-2 in the human lung. Science advances 2024. PMID: 39083602


  5. Neyton LPA, Patel RK, Sarma A, UCSF COMET Consortium, Willmore A, Haller SC, Kangelaris KN, Eckalbar WL, Erle DJ, Krummel MF, Hendrickson CM, Woodruff PG, Langelier CR, Calfee CS, Fragiadakis GK. Distinct pulmonary and systemic effects of dexamethasone in severe COVID-19. Nature communications 2024. PMID: 38942804


  6. Evrard B, Sinha P, Delucchi K, Hendrickson CM, Kangelaris KN, Liu KD, Willmore A, Wu N, Neyton L, Schmiege E, Gomez A, Kerchberger VE, Zalucky A, Matthay MA, Ware LB, Calfee CS. Causes and attributable fraction of death from ARDS in inflammatory phenotypes of sepsis. Critical care (London, England) 2024. PMID: 38745253


  7. Avery M. Bogart, Christine R. Lopez, Sarah N. Obeidalla, Chunxue Wang, Andrew Willmore, Alejandra Jauregui, Kirsten N. Kangelaris, Carolyn Hendrickson, Antonio Gomez, Kathleen D. Liu, Michael A. Matthay, Ciara M. Shaver, Julie A. Bastarache, Carolyn S. Calfee, V. Eric Kerchberger, Lorraine B. Ware. Elevated Hemoglobin A1c and the Risk of Developing Acute Respiratory Distress Syndrome in Two Cohort Studies. CHEST Critical Care 2024. PMID:


  8. Valda Toro PL, Willmore A, Wu NE, Delucchi KL, Jauregui A, Sinha P, Liu KD, Hendrickson CM, Sarma A, Neyton LPA, Leligdowicz A, Langelier CR, Zhuo H, Jones C, Kangelaris KN, Gomez AD, Matthay MA, Calfee CS. Rapidly improving ARDS differs clinically and biologically from persistent ARDS. Critical care (London, England) 2024. PMID: 38649920


  9. Neyton LPA, Sinha P, Sarma A, Mick E, Kalantar K, Chen S, Wu N, Delucchi K, Zhuo H, Bos LDJ, Jauregui A, Gomez A, Hendrickson CM, Kangelaris KN, Leligdowicz A, Liu KD, Matthay MA, Langelier CR, Calfee CS. Host and Microbe Blood Metagenomics Reveals Key Pathways Characterizing Critical Illness Phenotypes. American journal of respiratory and critical care medicine 2024. PMID: 38190719


  10. Gudelunas MK, Lipnick M, Hendrickson C, Vanderburg S, Okunlola B, Auchus I, Feiner JR, Bickler PE. Low Perfusion and Missed Diagnosis of Hypoxemia by Pulse Oximetry in Darkly Pigmented Skin: A Prospective Study. Anesthesia and analgesia 2023. PMID: 38109495


  11. Hackney JA, Shivram H, Vander Heiden J, Overall C, Orozco L, Gao X, Kim E, West N, Qamra A, Chang D, Chakrabarti A, Choy DF, Combes AJ, Courau T, Fragiadakis GK, Rao AA, Ray A, Tsui J, Hu K, Kuhn NF, Krummel MF, Erle DJ, Kangelaris K, Sarma A, Lyon Z, Calfee CS, Woodruff PG, Ghale R, Mick E, Byrne A, Zha BS, Langelier C, Hendrickson CM, van der Wijst MGP, Hartoularos GC, Grant T, Bueno R, Lee DS, Greenland JR, Sun Y, Perez R, Ogorodnikov A, Ward A, Ye CJ, UCSF COMET Consortium, Ramalingam T, McBride JM, Cai F, Teterina A, Bao M, Tsai L, Rosas IO, Regev A, Kapadia SB, Bauer RN, Rosenberger CM. A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling. iScience 2023. PMID: 37810211


  12. Sinha P, Kerchberger VE, Willmore A, Chambers J, Zhuo H, Abbott J, Jones C, Wickersham N, Wu N, Neyton L, Langelier CR, Mick E, He J, Jauregui A, Churpek MM, Gomez AD, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Delucchi KL, Liu KD, Russell JA, Matthay MA, Walley KR, Ware LB, Calfee CS. Identifying molecular phenotypes in sepsis: an analysis of two prospective observational cohorts and secondary analysis of two randomised controlled trials. The Lancet. Respiratory medicine 2023. PMID: 37633303


  13. Fragiadakis G, Neyton L, Patel R, Sarma A, Consortium UC, Willmore A, Haller SC, Kangelaris K, Eckalbar W, Erle D, Krummel M, Hendrickson C, Woodruff P, Langelier C, Calfee C. Distinct pulmonary and systemic effects of dexamethasone in severe COVID-19. Research square 2023. PMID: 37577607


  14. Rosenberger CM, Wick KD, Zhuo H, Wu N, Chen Y, Kapadia SB, Guimaraes A, Chang D, Choy DF, Chen H, Peck M, Sullivan KM, Ke S, Jauregui A, Leligdowicz A, Sinha P, Gomez AD, Kangelaris KN, Delucchi K, Liu KD, Calfee CS, Matthay MA, Hendrickson CM. Early plasma angiopoietin-2 is prognostic for ARDS and mortality among critically ill patients with sepsis. Critical care (London, England) 2023. PMID: 37312169


  15. Burns GD, Phillips JS, Kallet RH, Glidden DV, Hendrickson CM, Metcalfe JZ. Time to Extubation among ARDS Subjects with and without COVID-19 Pneumonia. Respiratory care 2023. PMID: 37280079


  16. Matthay ZA, Fields AT, Wick KD, Jones C, Lane HC, Herrera K, Nu?ez-Garcia B, Gennatas E, Hendrickson CM, Kornblith AE, Matthay MA, Kornblith LZ, COVID-19 Associated Coagulopathy Inflammation Thrombosis (Co-ACIT) Study Group. Association of SARS-CoV-2 nucleocapsid viral antigen and the receptor for advanced glycation end products with development of severe disease in patients presenting to the emergency department with COVID-19. Frontiers in immunology 2023. PMID: 37026003


  17. Fields AT, Andraska EA, Kaltenmeier C, Matthay ZA, Herrera K, Nu?ez-Garcia B, Jones CM, Wick KD, Liu S, Luo JH, Yu YP, Matthay MA, Hendrickson CM, Bainton RJ, Barrett TJ, Berger JS, Neal MD, Kornblith LZ. Effects of the circulating environment of COVID-19 on platelet and neutrophil behavior. Frontiers in immunology 2023. PMID: 36999030


  18. Alipanah-Lechner N, Neyton L, Mick E, Willmore A, Leligdowicz A, Contrepois K, Jauregui A, Zhuo H, Hendrickson C, Gomez A, Sinha P, Kangelaris KN, Liu KD, Matthay MA, Rogers AJ, Calfee CS. Plasma metabolic profiling implicates dysregulated lipid metabolism and glycolytic shift in hyperinflammatory ARDS. American journal of physiology. Lung cellular and molecular physiology 2023. PMID: 36648136


  19. Moore KL, Gudelunas K, Lipnick MS, Bickler PE, Hendrickson CM. Pulse Oximeter Bias and Inequities in Retrospective Studies--Now What? Respiratory care 2022. PMID: 36442988


  20. Kalantar KL, Neyton L, Abdelghany M, Mick E, Jauregui A, Caldera S, Serpa PH, Ghale R, Albright J, Sarma A, Tsitsiklis A, Leligdowicz A, Christenson SA, Liu K, Kangelaris KN, Hendrickson C, Sinha P, Gomez A, Neff N, Pisco A, Doernberg SB, Derisi JL, Matthay MA, Calfee CS, Langelier CR. Integrated host-microbe plasma metagenomics for sepsis diagnosis in a prospective cohort of critically ill adults. Nature microbiology 2022. PMID: 36266337


  21. Joffre J, Rodriguez L, Matthay ZA, Lloyd E, Fields AT, Bainton RJ, Kurien P, Sil A, Calfee CS, Woodruff PG, Erle DJ, Hendrickson C, Krummel MF, Langelier CR, Matthay MA, Kornblith LZ, Hellman J, COMET consortium and the Co-ACIT Study Group. COVID-19-Associated Lung Microvascular Endotheliopathy: A "From the Bench" Perspective. 2022. PMID: 35649173


  22. Wick KD, Leligdowicz A, Willmore A, Carrillo SA, Ghale R, Jauregui A, Chak SS, Nguyen V, Lee D, Jones C, Dewar R, Lane HC, Kangelaris KN, Hendrickson CM, Liu KD, Sinha P, Erle DJ, Langelier CR, Krummell MF, Woodruff PG, Calfee CS, Matthay MA, COMET Consortium. Plasma SARS-CoV-2 nucleocapsid antigen levels are associated with progression to severe disease in hospitalized COVID-19. Critical care (London, England) 2022. PMID: 36104754


  23. Burnett CE, Okholm TLH, Tenvooren I, Marquez DM, Tamaki S, Munoz Sandoval P, Willmore A, UCSF COMET Consortium, Hendrickson CM, Kangelaris KN, Langelier CR, Krummel MF, Woodruff PG, Calfee CS, Erle DJ, Ansel KM, Spitzer MH. Mass cytometry reveals a conserved immune trajectory of recovery in hospitalized COVID-19 patients. Immunity 2022. PMID: 35779527


  24. Matthay ZA, Fields AT, Nunez-Garcia B, Park JJ, Jones C, Leligdowicz A, Hendrickson CM, Callcut RA, Matthay MA, Kornblith LZ. Importance of Catecholamine Signaling in the Development of Platelet Exhaustion after Traumatic Injury. 2022. PMID: 35592998


  25. Looney M, Magnen M, You R, Rao A, Davis R, Rodriguez L, Simoneau C, Hysenaj L, Hu K, Love C, Woodruff P, Erle D, Hendrickson C, Calfee C, Matthay M, Roose J, Sil A, Ott M, Langelier C, Krummel M. Immediate myeloid depot for SARS-CoV-2 in the human lung. 2022. PMID: 35611333


  26. Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, UCSF COMET Consortium, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR. Immediate myeloid depot for SARS-CoV-2 in the human lung. 2022. PMID: 35592107


  27. Moazed F, Hendrickson C, Jauregui A, Gotts J, Conroy A, Delucchi K, Zhuo H, Arambulo M, Vessel K, Ke S, Deiss T, Ni A, Leligdowicz A, Abbott J, Cohen MJ, Sinha P, Gomez A, Kangelaris K, Kornblith L, Matthay M, Benowitz N, Liu K, Calfee CS. Cigarette Smoke Exposure and ARDS in Sepsis: Epidemiology, Clinical Features, and Biologic Markers. 2022. PMID: 35050845


  28. Burnett CE, Hauge Okholm TL, Tenvooren I, Marquez DM, Tamaki S, Sandoval PM, UCSF COMET Consortium, Calfee CS, Hendrickson CM, Kangelaris KN, Langelier CR, Krummel MF, Woodruff PG, Erle DJ, Ansel KM, Spitzer MH. A conserved immune trajectory of recovery in hospitalized COVID-19 patients. 2022. PMID: 35313585


  29. Maddali MV, Churpek M, Pham T, Rezoagli E, Zhuo H, Zhao W, He J, Delucchi KL, Wang C, Wickersham N, McNeil JB, Jauregui A, Ke S, Vessel K, Gomez A, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Liu KD, Matthay MA, Ware LB, Laffey JG, Bellani G, Calfee CS, Sinha P, LUNG SAFE Investigators and the ESICM Trials Group. Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis. 2022. PMID: 35026177


  30. Weiner J, Suwalski P, Holtgrewe M, Rakitko A, Thibeault C, Müller M, Patriki D, Quedenau C, Krüger U, Ilinsky V, Popov I, Balnis J, Jaitovich A, Helbig ET, Lippert LJ, Stubbemann P, Real LM, Macías J, Pineda JA, Fernandez-Fuertes M, Wang X, Karadeniz Z, Saccomanno J, Doehn JM, Hübner RH, Hinzmann B, Salvo M, Blueher A, Siemann S, Jurisic S, Beer JH, Rutishauser J, Wiggli B, Schmid H, Danninger K, Binder R, Corman VM, Mühlemann B, Arjun Arkal R, Fragiadakis GK, Mick E, Comet C, Calfee CS, Erle DJ, Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Langelier CR, Venkataramani U, García F, Zyla J, Drosten C, Alice B, Jones TC, Suttorp N, Witzenrath M, Hippenstiel S, Zemojtel T, Skurk C, Wolfgang P, Borodina T, Pa-Covid SG, Ripke S, Sander LE, Beule D, Landmesser U, Guettouche T, Kurth F, Heidecker B. Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01. EClinicalMedicine 2021. PMID: 34490415


  31. Sarma A, Christenson SA, Byrne A, Mick E, Pisco AO, DeVoe C, Deiss T, Ghale R, Zha BS, Tsitsiklis A, Jauregui A, Moazed F, Detweiler AM, Spottiswoode N, Sinha P, Neff N, Tan M, Serpa PH, Willmore A, Ansel KM, Wilson JG, Leligdowicz A, Siegel ER, Sirota M, DeRisi JL, Matthay MA, COMET Consortium , Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Erle DJ, Calfee CS, Langelier CR. Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS. Nature communications 2021. PMID: 34446707


  32. van der Wijst MGP, Vazquez SE, Hartoularos GC, Bastard P, Grant T, Bueno R, Lee DS, Greenland JR, Sun Y, Perez R, Ogorodnikov A, Ward A, Mann SA, Lynch KL, Yun C, Havlir DV, Chamie G, Marquez C, Greenhouse B, Lionakis MS, Norris PJ, Dumont LJ, Kelly K, Zhang P, Zhang Q, Gervais A, Le Voyer T, Whatley A, Si Y, Byrne A, Combes AJ, Rao AA, Song YS, Fragiadakis GK, Kangelaris K, Calfee CS, Erle DJ, Hendrickson C, Krummel MF, Woodruff PG, Langelier CR, Casanova JL, Derisi JL, Anderson MS, Ye CJ, UCSF COMET consortium. Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19. Science translational medicine 2021. PMID: 34429372


  33. REMAP-CAP Investigators , ACTIV-4a Investigators , ATTACC Investigators , Goligher EC, Bradbury CA, McVerry BJ, Lawler PR, Berger JS, Gong MN, Carrier M, Reynolds HR, Kumar A, Turgeon AF, Kornblith LZ, Kahn SR, Marshall JC, Kim KS, Houston BL, Derde LPG, Cushman M, Tritschler T, Angus DC, Godoy LC, McQuilten Z, Kirwan BA, Farkouh ME, Brooks MM, Lewis RJ, Berry LR, Lorenzi E, Gordon AC, Ahuja T, Al-Beidh F, Annane D, Arabi YM, Aryal D, Baumann Kreuziger L, Beane A, Bhimani Z, Bihari S, Billett HH, Bond L, Bonten M, Brunkhorst F, Buxton M, Buzgau A, Castellucci LA, Chekuri S, Chen JT, Cheng AC, Chkhikvadze T, Coiffard B, Contreras A, Costantini TW, de Brouwer S, Detry MA, Duggal A, Džavík V, Effron MB, Eng HF, Escobedo J, Estcourt LJ, Everett BM, Fergusson DA, Fitzgerald M, Fowler RA, Froess JD, Fu Z, Galanaud JP, Galen BT, Gandotra S, Girard TD, Goodman AL, Goossens H, Green C, Greenstein YY, Gross PL, Haniffa R, Hegde SM, Hendrickson CM, Higgins AM, Hindenburg AA, Hope AA, Horowitz JM, Horvat CM, Huang DT, Hudock K, Hunt BJ, Husain M, Hyzy RC, Jacobson JR, Jayakumar D, Keller NM, Khan A, Kim Y, Kindzelski A, King AJ, Knudson MM, Kornblith AE, Kutcher ME, Laffan MA, Lamontagne F, Le Gal G, Leeper CM, Leifer ES, Lim G, Gallego Lima F, Linstrum K, Litton E, Lopez-Sendon J, Lother SA, Marten N, Saud Marinez A, Martinez M, Mateos Garcia E, Mavromichalis S, McAuley DF, McDonald EG, McGlothlin A, McGuinness SP, Middeldorp S, Montgomery SK, Mouncey PR, Murthy S, Nair GB, Nair R, Nichol AD, Nicolau JC, Nunez-Garcia B, Park JJ, Park PK, Parke RL, Parker JC, Parnia S, Paul JD, Pompilio M, Quigley JG, Rosenson RS, Rost NS, Rowan K, Santos FO, Santos M, Santos MO, Satterwhite L, Saunders CT, Schreiber J, Schutgens REG, Seymour CW, Siegal DM, Silva DG, Singhal AB, Slutsky AS, Solvason D, Stanworth SJ, Turner AM, van Bentum-Puijk W, van de Veerdonk FL, van Diepen S, Vazquez-Grande G, Wahid L, Wareham V, Widmer RJ, Wilson JG, Yuriditsky E, Zhong Y, Berry SM, McArthur CJ, Neal MD, Hochman JS, Webb SA, Zarychanski R. Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19. The New England journal of medicine 2021. PMID: 34351722


  34. ATTACC Investigators , ACTIV-4a Investigators , REMAP-CAP Investigators , Lawler PR, Goligher EC, Berger JS, Neal MD, McVerry BJ, Nicolau JC, Gong MN, Carrier M, Rosenson RS, Reynolds HR, Turgeon AF, Escobedo J, Huang DT, Bradbury CA, Houston BL, Kornblith LZ, Kumar A, Kahn SR, Cushman M, McQuilten Z, Slutsky AS, Kim KS, Gordon AC, Kirwan BA, Brooks MM, Higgins AM, Lewis RJ, Lorenzi E, Berry SM, Berry LR, Aday AW, Al-Beidh F, Annane D, Arabi YM, Aryal D, Baumann Kreuziger L, Beane A, Bhimani Z, Bihari S, Billett HH, Bond L, Bonten M, Brunkhorst F, Buxton M, Buzgau A, Castellucci LA, Chekuri S, Chen JT, Cheng AC, Chkhikvadze T, Coiffard B, Costantini TW, de Brouwer S, Derde LPG, Detry MA, Duggal A, Džavík V, Effron MB, Estcourt LJ, Everett BM, Fergusson DA, Fitzgerald M, Fowler RA, Galanaud JP, Galen BT, Gandotra S, García-Madrona S, Girard TD, Godoy LC, Goodman AL, Goossens H, Green C, Greenstein YY, Gross PL, Hamburg NM, Haniffa R, Hanna G, Hanna N, Hegde SM, Hendrickson CM, Hite RD, Hindenburg AA, Hope AA, Horowitz JM, Horvat CM, Hudock K, Hunt BJ, Husain M, Hyzy RC, Iyer VN, Jacobson JR, Jayakumar D, Keller NM, Khan A, Kim Y, Kindzelski AL, King AJ, Knudson MM, Kornblith AE, Krishnan V, Kutcher ME, Laffan MA, Lamontagne F, Le Gal G, Leeper CM, Leifer ES, Lim G, Lima FG, Linstrum K, Litton E, Lopez-Sendon J, Lopez-Sendon Moreno JL, Lother SA, Malhotra S, Marcos M, Saud Marinez A, Marshall JC, Marten N, Matthay MA, McAuley DF, McDonald EG, McGlothlin A, McGuinness SP, Middeldorp S, Montgomery SK, Moore SC, Morillo Guerrero R, Mouncey PR, Murthy S, Nair GB, Nair R, Nichol AD, Nunez-Garcia B, Pandey A, Park PK, Parke RL, Parker JC, Parnia S, Paul JD, Pérez González YS, Pompilio M, Prekker ME, Quigley JG, Rost NS, Rowan K, Santos FO, Santos M, Olombrada Santos M, Satterwhite L, Saunders CT, Schutgens REG, Seymour CW, Siegal DM, Silva DG, Shankar-Hari M, Sheehan JP, Singhal AB, Solvason D, Stanworth SJ, Tritschler T, Turner AM, van Bentum-Puijk W, van de Veerdonk FL, van Diepen S, Vazquez-Grande G, Wahid L, Wareham V, Wells BJ, Widmer RJ, Wilson JG, Yuriditsky E, Zampieri FG, Angus DC, McArthur CJ, Webb SA, Farkouh ME, Hochman JS, Zarychanski R. Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19. The New England journal of medicine 2021. PMID: 34351721


  35. Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Chew NW, Cleary SJ, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Im KW, Serwas NK, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, UCSF COMET Consortium , Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF. Publisher Correction: Global absence and targeting of protective immune states in severe COVID-19. Nature 2021. PMID: 34341540


  36. Rogers AJ, Leligdowicz A, Contrepois K, Jauregui A, Vessel K, Deiss TJ, Belzer A, Liu T, Lippi M, Ke S, Ross E, Zhou H, Hendrickson C, Gomez A, Sinha P, Kangelaris KN, Liu KD, Calfee CS, Matthay MA. Plasma Metabolites in Early Sepsis Identify Distinct Clusters Defined by Plasma Lipids. Critical Care Explorations 2021. PMID: 34345827


  37. Bainbridge ED, Hsue PY, Esensten JH, Lynch KL, Hendrickson CM, Doernberg SB, Fung M, Chin-Hong P, Di Germanio C, Norris PJ, Simmons G, Glidden DV, Luetkemeyer AF. Characteristics of High-Titer Convalescent Plasma and Antibody Dynamics After Administration in Patients With Severe Coronavirus Disease 2019. Open forum infectious diseases 2021. PMID: 34405093


  38. Sinha P, Delucchi KL, Chen Y, Zhuo H, Abbott J, Wang C, Wickersham N, McNeil JB, Jauregui A, Ke S, Vessel K, Gomez A, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Liu KD, Matthay MA, Ware LB, Calfee CS. Latent class analysis-derived subphenotypes are generalisable to observational cohorts of acute respiratory distress syndrome: a prospective study. Thorax 2021. PMID: 34253679


  39. Tsitsiklis A, Zha B, Byrne A, DeVoe C, Levan S, Rackaityte E, Sunshine S, Mick E, Ghale R, Jauregui A, Neff N, Sarma A, Serpa P, Deiss T, Kistler A, Carrillo S, Ansel KM, Leligdowicz A, Christenson S, Jones N, Wu B, Darmanis S, Matthay M, Lynch S, DeRisi J, Consortium C, Hendrickson C, Kangelaris K, Krummel M, Woodruff P, Erle D, Rosenberg O, Calfee C, Langelier C. Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19. Research square 2021. PMID: 34013247


  40. Afshar M, Baker K, Corral J, Ross E, Lowery E, Gonzalez R, Burnham EL, Callcut RA, Kornblith LZ, Hendrickson C, Kovacs EJ, Joyce C. Internal and External Validation of an Alcohol Biomarker for Screening in Trauma. Annals of surgery 2021. PMID: 33534233


  41. Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Chew NW, Cleary SJ, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Im KW, Serwas NK, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, UCSF COMET Consortium , Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF. Global absence and targeting of protective immune states in severe COVID-19. Nature 2021. PMID: 33494096


  42. Vivek Jain, Lillian B Brown, Carina Marquez, Luis Rubio, Natasha Spottiswoode, Bethlehem Churnet, Katherine Brooks, Mengyu Zhou, Timothy Muldoon, Carolyn Hendrickson, Adithya Cattamanchi, Antonio Gomez, Brian Haas, Edwin Charlebois, Annie Luetkemeyer, Annie Luetkemeyer, Monica Gandhi, Diane Havlir, Sumant Ranji, Lisa Gail Winston. 448. Disproportionate Burden of COVID-19 on Latinx Residents among Hospitalized Patients at San Francisco’s Public Health Hospital. Open forum infectious diseases 2020. PMID:


  43. Kwong YD, Mehta K, Miaskowski C, Zhuo H, Yee K, Jauregui A, Ke S, Deiss T, Abbott J, Kangelaris KN, Sinha P, Hendrickson CM, Gomez A, Leligdowicz A, Matthay MA, Calfee CS, Liu KD. Using Best Subsets Regression to Identify Clinical Characteristics and Biomarkers Associated with Sepsis-Associated Acute Kidney Injury. American journal of physiology. Renal physiology 2020. PMID: 33044866


  44. Hendrickson CM, Kwong YD, Belzer AG, Shlipak MG, Matthay MA, Liu KD. Higher plasma cystatin C is associated with mortality after acute respiratory distress syndrome: findings from a Fluid and Catheter Treatment Trial (FACTT) substudy. Critical care (London, England) 2020. PMID: 32653023


  45. Moazed F, Hendrickson C, Conroy A, Kornblith LZ, Benowitz NL, Delucchi K, Cohen MJ, Calfee CS. Cigarette Smoking and ARDS After Blunt Trauma: The Influence of Changing Smoking Patterns and Resuscitation Practices. Chest 2020. PMID: 32574574


  46. Vanderburg S, Alipanah N, Crowder R, Yoon C, Wang R, Thakur N, Slown K, Shete PB, Rofael M, Metcalfe JZ, Merrifield C, Marquez C, Malcolm K, Lipnick M, Jain V, Gomez A, Burns G, Brown LB, Berger C, Auyeung V, Cattamanchi A, Hendrickson CM. Management and Outcomes of Critically-Ill Patients with COVID-19 Pneumonia at a Safety-net Hospital in San Francisco, a Region with Early Public Health Interventions: A Case Series. medRxiv : the preprint server for health sciences 2020. PMID: 32511538


  47. Auriemma CL, Zhuo H, Delucchi K, Deiss T, Liu T, Jauregui A, Ke S, Vessel K, Lippi M, Seeley E, Kangelaris KN, Gomez A, Hendrickson C, Liu KD, Matthay MA, Ware LB, Calfee CS. Acute respiratory distress syndrome-attributable mortality in critically ill patients with sepsis. Intensive care medicine 2020. PMID: 32206845


  48. Hendrickson CM, Matthay MA. Potential Value of Biomarker Signatures in Sepsis and Acute Respiratory Distress Syndrome in Children and Adults. Critical care medicine 2020. PMID: 32058380


  49. Liu S, Wang C, Green G, Zhuo H, Liu KD, Kangelaris KN, Gomez A, Jauregui A, Vessel K, Ke S, Hendrickson C, Matthay MA, Calfee CS, Ware LB, Wolters PJ. Peripheral Blood Leukocyte Telomere Length is Associated with Survival of Sepsis Patients. The European respiratory journal 2019. PMID: 31619475


  50. Kornblith LZ, Decker A, Conroy AS, Hendrickson CM, Fields AT, Robles AJ, Callcut RA, Cohen MJ. It's About Time: Transfusion Effects on Post-Injury Platelet Aggregation Over Time. The journal of trauma and acute care surgery 2019. PMID: 31389915


  51. James T. Ross, Carolyn M. Hendrickson, Brenda Nunez-Garcia, Erin Ross, Amanda Conroy, Michael A. Matthay, Rachael A. Callcut, Lucy Z. Kornblith. Do Plasma Biomarkers Have Value in Identifying Hypoxemic Trauma Patients Who Will Develop ARDS?. Journal of the American College of Surgeons 2019. PMID:


  52. Yen AF, Homer CM, Mohapatra A, Langnas E, Gomez A, Hendrickson CM. Embolic Hypodermic Needle Causing Traumatic Cardiac Tamponade: A Case Report. Critical Care Explorations 2019. PMID: 32166279


  53. Hendrickson CM, Calfee CS. A new frontier in ARDS trials: phenotyping before randomisation. The Lancet. Respiratory medicine 2019. PMID: 31399380


  54. Kornblith LZ, Robles AJ, Conroy AS, Redick BJ, Howard BM, Hendrickson CM, Moore S, Nelson MF, Moazed F, Callcut RA, Calfee CS, Cohen MJ. PREDICTORS OF POST-INJURY ARDS: LUNG INJURY PERSISTS IN THE ERA OF HEMOSTATIC RESUSCITATION. The journal of trauma and acute care surgery 2019. PMID: 31033882


  55. Kornblith LZ, Robles AJ, Conroy AS, Hendrickson CM, Calfee CS, Fields AT, Callcut RA, Cohen MJ. Perhaps it's not the platelet: Ristocetin uncovers the potential role of von Willebrand factor in impaired platelet aggregation following traumatic brain injury. The journal of trauma and acute care surgery 2018. PMID: 29985231


  56. Anamaria J. Robles, Lucy Z. Kornblith, Carolyn M. Hendrickson, Benjamin M. Howard, Amanda S. Conroy, Farzad Moazed, Carolyn S. Calfee, Mitchell J. Cohen, Rachael A. Callcut. Health care utilization and the cost of posttraumatic acute respiratory distress syndrome care. Journal of Trauma and Acute Care Surgery 2018. PMID:


  57. Robles AJ, Kornblith LZ, Hendrickson CM, Howard BM, Conroy AS, Moazed F, Calfee CS, Cohen MJ, Callcut RA. Health care utilization and the cost of posttraumatic acute respiratory distress syndrome care. The journal of trauma and acute care surgery 2018. PMID: 29958249


  58. Hendrickson CM, Gibb SL, Miyazawa BY, Keating SM, Ross E, Conroy AS, Calfee CS, Pati S, Cohen MJ. Elevated plasma levels of TIMP-3 are associated with a higher risk of acute respiratory distress syndrome and death following severe isolated traumatic brain injury. Trauma surgery & acute care open 2018. PMID: 30023434


  59. Hendrickson CM, Matthay MA. Endothelial biomarkers in human sepsis: pathogenesis and prognosis for ARDS. Pulmonary circulation 2018. PMID: 29575977


  60. Moazed F, Hendrickson C, Nelson M, Conroy A, Cohen MJ, Calfee CS. Platelet aggregation after blunt trauma is associated with the acute respiratory distress syndrome and altered by cigarette smoke exposure. The journal of trauma and acute care surgery 2018. PMID: 29140951


  61. Christie SA, Kornblith LZ, Howard BM, Conroy AS, Kunitake RC, Nelson MF, Hendrickson CM, Calfee CS, Callcut RA, Cohen MJ. Characterization of distinct coagulopathic phenotypes in injury: Pathway-specific drivers and implications for individualized treatment. The journal of trauma and acute care surgery 2017. PMID: 28338598


  62. Hendrickson CM, Abbott J, Zhuo H, Liu KD, Calfee CS, Matthay MA. Higher mini-BAL total protein concentration in early ARDS predicts faster resolution of lung injury measured by more ventilator-free days. American journal of physiology. Lung cellular and molecular physiology 2017. PMID: 28213470


  63. Hendrickson CM, Howard BM, Kornblith LZ, Conroy AS, Nelson MF, Zhuo H, Liu KD, Manley GT, Matthay MA, Calfee CS, Cohen MJ. The acute respiratory distress syndrome following isolated severe traumatic brain injury. The journal of trauma and acute care surgery 2016. PMID: 26881489


  64. Hendrickson CM, Dobbins S, Redick BJ, Greenberg MD, Calfee CS, Cohen MJ. Misclassification of acute respiratory distress syndrome after traumatic injury: The cost of less rigorous approaches. The journal of trauma and acute care surgery 2015. PMID: 26307875


  65. Howard BM, Kornblith LZ, Hendrickson CM, Redick BJ, Conroy AS, Nelson MF, Callcut RA, Calfee CS, Cohen MJ. Differences in degree, differences in kind: characterizing lung injury in trauma. The journal of trauma and acute care surgery 2015. PMID: 25742257


  66. Hendrickson CM, Crestani B, Matthay MA. Biology and pathology of fibroproliferation following the acute respiratory distress syndrome. Intensive care medicine 2014. PMID: 25480350


  67. Hendrickson CM, Neylan TC, Na B, Regan M, Zhang Q, Cohen BE. Lifetime trauma exposure and prospective cardiovascular events and all-cause mortality: findings from the Heart and Soul Study. Psychosomatic medicine 2013. PMID: 24149074


  68. Hendrickson CM, Matthay MA. Viral pathogens and acute lung injury: investigations inspired by the SARS epidemic and the 2009 H1N1 influenza pandemic. Seminars in respiratory and critical care medicine 2013. PMID: 23934716


  69. Fricks-Lima J, Hendrickson CM, Allgaier M, Zhuo H, Wiener-Kronish JP, Lynch SV, Yang K. Differences in biofilm formation and antimicrobial resistance of Pseudomonas aeruginosa isolated from airways of mechanically ventilated patients and cystic fibrosis patients. Volume 37 of Issue 4. International journal of antimicrobial agents 2011. PMID: 21382698