Brian Graham, MD

Professor In Residence

I am the Division Chief of Pulmonary and Critical Care Medicine at Zuckerberg San Francisco General Hospital, and a Professor in Residence at UCSF. My primary clinical and research interest is in pulmonary hypertension. I particularly study schistosomiasis associated pulmonary hypertension, a common cause worldwide.

Education
2021 - Diversity, Equity and Inclusion Training, University of California
06/2010 - Pulmonary-Critical Care Fellowship, University of Colorado
06/2007 - Internal Medicine Residency, University of Colorado
MD, 06/2004 - Medicine, Harvard
MEng, 06/2000 - Electrical Engineering, MIT
SB, 06/2000 - Electrical Engineering, MIT
Honors and Awards
  • John F. Murray, MD Distinguished Professorship in Pulmonary Medicine, UCSF, 2020
  • Jo Rae Wright Award for Scientific Excellence, Parker B Francis Foundation, 2016
Websites
Publications

  1. Mickael C, Jordan M, Posey JN, Tuder RM, Nozik E, Thurman JM, Stenmark KR, Graham BB, Delaney C. Activation of Platelets and the Complement System in Mice with Schistosoma-Induced Pulmonary Hypertension. American journal of physiology. Lung cellular and molecular physiology 2024. PMID: 39254088


  2. Prabhakar A, Wadhwa M, Kumar R, Ghatpande P, Gandjeva A, Tuder RM, Graham BB, Lagna G, Hata A. Mechanisms underlying age-associated exacerbation of pulmonary veno-occlusive disease. JCI insight 2024. PMID: 39269983


  3. Mickael C, Sanders LA, Lee MH, Kumar R, Fonseca-Balladares D, Gandjeva A, Cautivo-Reyes K, Kassa B, Kumar S, Irwin D, Swindle D, Phang T, Stearman RS, Molofsky AB, McKee AS, Stenmark KR, Graham BB, Tuder RM. Classical dendritic cells contribute to hypoxia-induced pulmonary hypertension. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024. PMID: 39212294


  4. Fonseca Balladares DC, Kassa B, Mickael C, Kumar R, Nolan K, Menezes TCF, Lee MH, Lau-Xiao AM, Molofsky AB, Wells E, Graham BB. Intrapulmonary T Cells Are Sufficient for Schistosoma-Induced Pulmonary Hypertension. International journal of molecular sciences 2024. PMID: 39273153


  5. Menezes TCF, Fonseca Balladares DC, Nolan K, Graham BB. Two hits strike out causing persistent pulmonary hypertension in mice. American journal of physiology. Lung cellular and molecular physiology 2024. PMID: 39010822


  6. Prabhakar A, Kumar R, Wadhwa M, Ghatpande P, Zhang J, Zhao Z, Lizama CO, Kharbikar BN, Gräf S, Treacy CM, Morrell NW, Graham BB, Lagna G, Hata A. Reversal of pulmonary veno-occlusive disease phenotypes by inhibition of the integrated stress response. Nature cardiovascular research 2024. PMID: 39196173


  7. Kumar R, Kumar S, Mickael C, Fonseca Balladares D, Nolan K, Lee MH, Sanders L, Nilsson J, Molofsky AB, Tuder RM, Stenmark KR, Graham BB. Interstitial macrophage phenotypes in Schistosoma-induced pulmonary hypertension. Frontiers in immunology 2024. PMID: 38779688


  8. Kumar S, Mickael C, Kumar R, Prasad RR, Campbell NV, Zhang H, Li M, McKeon BA, Allen TE, Graham BB, Yu YA, Stenmark KR. Single cell transcriptomic analyses reveal diverse and dynamic changes of distinct populations of lung interstitial macrophages in hypoxia-induced pulmonary hypertension. Frontiers in immunology 2024. PMID: 38690277


  9. Ali M, Choudhary R, Singh K, Kumari S, Kumar R, Graham BB, Pasha MAQ, Rabyang S, Thinlas T, Mishra A. Hypobaric hypoxia modulated structural characteristics of circulating cell free DNA in high altitude pulmonary edema. American journal of physiology. Lung cellular and molecular physiology 2024. PMID: 38349115


  10. Kassa B, Fonseca-Balladares DC, Kumar R, Lee MH, Mickael C, Sanders L, Nolan K, Graham BB. Experimental Schistosoma haematobium pulmonary hypertension. Pulmonary circulation 2024. PMID: 38312832


  11. Sharma S, Koshy R, Kumar R, Mohammad G, Thinlas T, Graham BB, Pasha Q. Hypobaric hypoxia drives selection of altitude-associated adaptative alleles in the Himalayan population. The Science of the total environment 2023. PMID: 38159773


  12. Kumar R, Chanana N, Sharma K, Palmo T, Lee MH, Mishra A, Nolan K, Fonseca Balladares DC, Mickael C, Gupta MD, Thinlas T, Pasha Q, Graham BB. Dexamethasone prophylaxis protects from acute high-altitude illness by modifying the peripheral blood mononuclear cell inflammatory transcriptome. Bioscience reports 2023. PMID: 37975243


  13. Prabhakar A, Kumar R, Wadhwa M, Ghatpande P, Zhang J, Zhao Z, Lizama CO, Kharbikar BN, Gräf S, Treacy CM, Morrell NW, Graham BB, Lagna G, Hata A. Reversal of pulmonary veno-occlusive disease phenotypes by inhibition of the integrated stress response. bioRxiv : the preprint server for biology 2023. PMID: 38076809


  14. Graham BB, Hilton JF, Lee MH, Kumar R, Balladares DF, Rahaghi FN, Estépar RSJ, Mickael C, Lima RLB, Loureiro CMC, Lucena J, Oliveira RKF, Corrêa RA. Is pulmonary arterial hypertension associated with schistosomiasis distinct from pulmonary arterial hypertension associated with portal hypertension? JHLT open 2023. PMID: 38050478


  15. Lee JY, Stevens RP, Pastukh VV, Pastukh VM, Kozhukhar N, Alexeyev MF, Reisz JA, Nerguizian D, D'Alessandro A, Koloteva A, Gwin MS, Roberts JT, Borchert GM, Wagener BM, Pittet JF, Graham BB, Stenmark KR, Stevens T. PFKFB3 Inhibits Fructose Metabolism in Pulmonary Microvascular Endothelial Cells. American journal of respiratory cell and molecular biology 2023. PMID: 37201952


  16. Kumar R, Lee MH, Kassa B, Fonseca Balladares DC, Mickael C, Sanders L, Andruska A, Kumar M, Spiekerkoetter E, Bandeira A, Stenmark KR, Tuder RM, Graham BB. Repetitive schistosoma exposure causes perivascular lung fibrosis and persistent pulmonary hypertension. Clinical science (London, England : 1979) 2023. PMID: 37014925


  17. Brown RD, Hunter KS, Li M, Frid MG, Harral JW, Krafsur GM, Holt TN, Williams J, Zhang H, Riddle SR, Edwards MG, Kumar S, Hu CJ, Graham BB, Walker LA, Garry FB, Buttrick PM, Lahm T, Kheyfets VO, Hansen KC, Stenmark KR. Functional and Molecular Determinants of Right Ventricular Response to Severe Pulmonary Hypertension in a Large Animal Model. American journal of physiology. Heart and circulatory physiology 2023. PMID: 36961489


  18. Kumar R, Aktay-Cetin ?, Craddock V, Morales-Cano D, Kosanovic D, Cogolludo A, Perez-Vizcaino F, Avdeev S, Kumar A, Ram AK, Agarwal S, Chakraborty A, Savai R, de Jesus Perez V, Graham BB, Butrous G, Dhillon NK. Potential long-term effects of SARS-CoV-2 infection on the pulmonary vasculature: Multilayered cross-talks in the setting of coinfections and comorbidities. PLoS pathogens 2023. PMID: 36634048


  19. Mickael C, Lee MH, Graham BB. The COVID-19 pandemic and pulmonary arterial hypertension in Italy: adaptation, outcomes and valuable lessons learned. The European respiratory journal 2022. PMID: 36202406


  20. Lee MH, Menezes TCF, Reisz JA, Ferreira EVM, Graham BB, Oliveira RKF. Exercise metabolomics in pulmonary arterial hypertension: Where pulmonary vascular metabolism meets exercise physiology. Frontiers in physiology 2022. PMID: 36171971


  21. Medrano-Garcia S, Morales-Cano D, Barreira B, Vera-Zambrano A, Kumar R, Kosanovic D, Schermuly RT, Graham BB, Perez-Vizcaino F, Mathie A, Savai R, Pullamseti S, Butrous G, Fernández-Malavé E, Cogolludo A. HIV and Schistosoma Co-Exposure Leads to Exacerbated Pulmonary Endothelial Remodeling and Dysfunction Associated with Altered Cytokine Landscape. Volume 11 of Issue 15. Cells 2022. PMID: 35954255


  22. Gu S, Mickael C, Kumar R, Lee MH, Sanders L, Kassa B, Harral J, Williams J, Hansen KC, Stenmark KR, Tuder RM, Graham BB. The role of macrophages in right ventricular remodeling in experimental pulmonary hypertension. Pulmonary circulation 2022. PMID: 35874852


  23. Lee MH, Sanders L, Kumar R, Hernandez-Saavedra D, Yun X, Ford JA, Perez MJ, Mickael C, Gandjeva A, Koyanagi DE, Harral JW, Irwin DC, Kassa B, Eckel RH, Shimoda LA, Graham BB, Tuder RM. Contribution of Fatty Acid Oxidation to the Pathogenesis of Pulmonary Hypertension. American journal of physiology. Lung cellular and molecular physiology 2022. PMID: 35763400


  24. Campbell NV, Mickael C, Kumar S, Zhang H, Campbell IL, Gillen AE, Trentin CO, Diener K, Gao B, Kheyfets VO, Gu S, Kumar R, Phang T, Brown RD, Graham BB, Stenmark KR. Single Cell RNA Sequencing and Binary Hierarchical Clustering Defines Lung Interstitial Macrophage Heterogeneity in Response to Hypoxia. 2022. PMID: 35608266


  25. Chanana N, Palmo T, Sharma K, Kumar R, Shah B, Mahajan S, Palleda GM, Gupta MD, Kukreti R, Faruq M, Thinlas T, Graham BB, Pasha Q. Sexual Dimorphism of Dexamethasone as a Prophylactic Treatment in Pathologies Associated With Acute Hypobaric Hypoxia Exposure. Frontiers in pharmacology 2022. PMID: 35668947


  26. Bertero T, Lu Y, Annis S, Hale A, Bhat B, Saggar R, Saggar R, Wallace WD, Ross DJ, Vargas SO, Graham BB, Kumar R, Black SM, Fratz S, Fineman JR, West JD, Haley KJ, Waxman AB, Chau BN, Cottrill KA, Chan SY. Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension. 2022. PMID: 35575096


  27. Mickael C, Kheyfets VO, Langouët-Astrié C, Lee MH, Sanders LA, Trentin CO, Sweatt AJ, Zamanian RT, Bull TM, Stenmark K, Graham BB, Tuder RM. Peripheral Blood Inflammation Profile of Patients with Pulmonary Arterial Hypertension Using the High-Throughput Olink Proteomics Platform. 2022. PMID: 35486078


  28. Sinkala E, Ahmed HY, Sibomana JP, Lee MH, Kassa B, Kumar R, Mazimba S, Binegdie AB, Mpisa S, Wamundila K, Graham BB, Hilton JF. Rationale and design of a screening study to detect schistosomiasis-associated pulmonary hypertension in Ethiopia and Zambia. 2022. PMID: 35514775


  29. Kassa B, Lee MH, Kumar R, Mickael C, Sanders L, Tuder RM, Mentink-Kane M, Graham BB. Experimental Schistosoma japonicum-induced pulmonary hypertension. 2022. PMID: 35417453


  30. Lee MH, Graham BB, Bull TM. Double Trouble: Airflow and Pulmonary Vascular Obstruction. 2021. PMID: 34644521


  31. Lee MH, Mickael C, Graham BB. Two Birds with One Stone: Helping the Pulmonary Arteries and the Right Ventricle by Targeting BMPR2 Signaling. American journal of respiratory cell and molecular biology 2021. PMID: 34029508


  32. Kassa B, Kumar R, Mickael C, Sanders L, Vohwinkel C, Lee MH, Gu S, Poth JM, Stenmark KR, Zhao YY, Tuder RM, Graham BB. Endothelial cell PHD2-HIF1α-PFKFB3 contributes to right ventricle vascular adaptation in pulmonary hypertension. American journal of physiology. Lung cellular and molecular physiology 2021. PMID: 34346780


  33. Rahaghi FN, Hilton JF, Corrêa RA, Loureiro C, Ota-Arakaki JS, Verrastro CGY, Lee MH, Mickael C, Nardelli P, Systrom DA, Waxman AB, Washko GR, San José Estépar R, Graham BB, Oliveira RKF. Arterial vascular volume changes with haemodynamics in schistosomiasis-associated pulmonary arterial hypertension. The European respiratory journal 2021. PMID: 33446601


  34. Florentin J, Zhao J, Tai YY, Vasamsetti SB, O'Neil SP, Kumar R, Arunkumar A, Watson A, Sembrat J, Bullock GC, Sanders L, Kassa B, Rojas M, Graham BB, Chan SY, Dutta P. Interleukin-6 mediates neutrophil mobilization from bone marrow in pulmonary hypertension. Cellular & molecular immunology 2021. PMID: 33420357


  35. Sibomana JP, Campeche A, Carvalho-Filho RJ, Correa RA, Duani H, Pacheco Guimaraes V, Hilton JF, Kassa B, Kumar R, Lee MH, Loureiro CMC, Mazimba S, Mickael C, Oliveira RKF, Ota-Arakaki JS, Rezende CF, Silva LCS, Sinkala E, Ahmed HY, Graham BB. Schistosomiasis Pulmonary Arterial Hypertension. Frontiers in immunology 2020. PMID: 33362796


  36. Kumar R, Lee MH, Mickael C, Kassa B, Pasha Q, Tuder R, Graham B. Pathophysiology and potential future therapeutic targets using preclinical models of COVID-19. ERJ open research 2020. PMID: 33313306


  37. Kumar R, Mickael C, Kassa B, Sanders L, Hernandez-Saavedra D, Koyanagi DE, Kumar S, Pugliese SC, Thomas S, McClendon J, Maloney JP, Janssen WJ, Stenmark KR, Tuder RM, Graham BB. Interstitial Macrophage-Derived Thrombospondin-1 Contributes to Hypoxia-Induced Pulmonary Hypertension. Cardiovascular research 2019. PMID: 31710666


  38. George MP, Gladwin MT, Graham BB. Exploring New Therapeutic Pathways in Pulmonary Hypertension: Metabolism, Proliferation, and Personalized Medicine. American journal of respiratory cell and molecular biology 2020. PMID: 32453969


  39. Chanana N, Palmo T, Sharma K, Kumar R, Graham BB, Pasha Q. Sex-derived attributes contributing to SARS-CoV-2 mortality. American journal of physiology. Endocrinology and metabolism 2020. PMID: 32726128


  40. Hernandez-Saavedra D, Sanders L, Freeman S, Reisz JA, Lee MH, Mickael C, Kumar R, Kassa B, Gu S, D' Alessandro A, Stenmark KR, Tuder RM, Graham BB. Publisher Correction: Stable isotope metabolomics of pulmonary artery smooth muscle and endothelial cells in pulmonary hypertension and with TGF-beta treatment. Volume 10 of Issue 1. Scientific Reports 2020. PMID: 32132567


  41. Hernandez-Saavedra D, Sanders L, Freeman S, Reisz JA, Lee MH, Mickael C, Kumar R, Kassa B, Gu S, Alessandro A, Stenmark KR, Tuder RM, Graham BB. Stable isotope metabolomics of pulmonary artery smooth muscle and endothelial cells in pulmonary hypertension and with TGF-beta treatment. Volume 10 of Issue 1. Scientific Reports 2020. PMID: 31942023


  42. Hu CJ, Poth JM, Zhang H, Flockton A, Laux A, Kumar S, McKeon B, Mouradian G, Li M, Riddle S, Pugliese SC, Brown RD, Wallace EM, Graham BB, Frid MG, Stenmark KR. Suppression of HIF2 signalling attenuates the initiation of hypoxia-induced pulmonary hypertension. Volume 54 of Issue 6. The European respiratory journal 2019. PMID: 31515405


  43. Kumar R, Mickael C, Kassa B, Sanders L, Koyanagi D, Hernandez-Saavedra D, Freeman S, Morales-Cano D, Cogolludo A, McKee AS, Fontenot AP, Butrous G, Tuder RM, Graham BB. Th2 CD4+ T Cells Are Necessary and Sufficient for Schistosoma-Pulmonary Hypertension. Volume 8 of Issue 15. Journal of the American Heart Association 2019. PMID: 31339057


  44. Botoni FA, Marinho CC, Carvalho VT, Mickael CS, Graham BB. A retrospective study of schistosomiasis-associated pulmonary hypertension from an endemic area in Brazil. Volume 24. International journal of cardiology. Heart & vasculature 2019. PMID: 31334331


  45. Mickael C, Kumar R, Hernandez-Saavedra D, Kassa B, Sanders L, Koyanagi D, Gu S, Lee MH, Tuder RM, Graham BB. IL-6Ra in Smooth Muscle Cells Protects against Schistosoma- and Hypoxia-induced Pulmonary Hypertension. Volume 61 of Issue 1. American journal of respiratory cell and molecular biology 2019. PMID: 31259624


  46. Stearman RS, Bui QM, Speyer G, Handen A, Cornelius AR, Graham BB, Kim S, Mickler EA, Tuder RM, Chan SY, Geraci MW. Systems Analysis of the Human Pulmonary Arterial Hypertension Lung Transcriptome. Volume 60 of Issue 6. American journal of respiratory cell and molecular biology 2019. PMID: 30562042


  47. Yu Q, Tai YY, Tang Y, Zhao J, Negi V, Culley MK, Pilli J, Sun W, Brugger K, Mayr J, Saggar R, Saggar R, Wallace WD, Ross DJ, Waxman AB, Wendell SG, Mullett SJ, Sembrat J, Rojas M, Khan OF, Dahlman JE, Sugahara M, Kagiyama N, Satoh T, Zhang M, Feng N, Gorcsan J, Vargas SO, Haley KJ, Kumar R, Graham BB, Langer R, Anderson DG, Wang B, Shiva S, Bertero T, Chan SY. BOLA (BolA Family Member 3) Deficiency Controls Endothelial Metabolism and Glycine Homeostasis in Pulmonary Hypertension. Volume 139 of Issue 19. Circulation 2019. PMID: 30759996


  48. Mickael C, Lee MH, Gu S, Graham BB. Comparing pulmonary hypertension severity between rat strains suggests right ventricle NK cells are protective. Volume 115 of Issue 4. Cardiovascular research 2019. PMID: 30517607


  49. Mickael CS, Graham BB. The Role of Type 2 Inflammation in Schistosoma-Induced Pulmonary Hypertension. Volume 10. Frontiers in immunology 2019. PMID: 30733718


  50. Graham BB, Yu PB. Finding the Target: In Silico and Genetic Screening for Mechanistically Novel Drugs in Pulmonary Arterial Hypertension. Volume 199 of Issue 1. American journal of respiratory and critical care medicine 2019. PMID: 30130137


  51. Gu S, Kumar R, Lee MH, Mickael C, Graham BB. Common genetic variants in pulmonary arterial hypertension. Volume 7 of Issue 3. The Lancet. Respiratory medicine 2018. PMID: 30527955


  52. Kassa B, Mickael C, Kumar R, Sanders L, Koyanagi D, Hernandez-Saavedra D, Tuder RM, Graham BB. Paclitaxel blocks Th2-mediated TGF-ß activation in Schistosoma mansoni-induced pulmonary hypertension. Volume 9 of Issue 1. Pulmonary circulation 2018. PMID: 30511588


  53. Graham BB, Kumar R, Mickael C, Kassa B, Koyanagi D, Sanders L, Zhang L, Perez M, Hernandez-Saavedra D, Valencia C, Dixon K, Harral J, Loomis Z, Irwin D, Nemkov T, D'Alessandro A, Stenmark KR, Tuder RM. Vascular Adaptation of the Right Ventricle in Experimental Pulmonary Hypertension. Volume 59 of Issue 4. American journal of respiratory cell and molecular biology 2018. PMID: 29851508


  54. Stenmark KR, Graham BB. Urocortin 2: will a drug targeting both the vasculature and the right ventricle be the future of pulmonary hypertension therapy? Volume 114 of Issue 8. Cardiovascular research 2018. PMID: 29800416


  55. Samokhin AO, Stephens T, Wertheim BM, Wang RS, Vargas SO, Yung LM, Cao M, Brown M, Arons E, Dieffenbach PB, Fewell JG, Matar M, Bowman FP, Haley KJ, Alba GA, Marino SM, Kumar R, Rosas IO, Waxman AB, Oldham WM, Khanna D, Graham BB, Seo S, Gladyshev VN, Yu PB, Fredenburgh LE, Loscalzo J, Leopold JA, Maron BA. NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension. Volume 10 of Issue 445. Science translational medicine 2018. PMID: 29899023


  56. Tamosiuniene R, Manouvakhova O, Mesange P, Saito T, Qian J, Sanyal M, Lin YC, Nguyen LP, Luria A, Tu AB, Sante JM, Rabinovitch M, Fitzgerald DJ, Graham BB, Habtezion A, Voelkel NF, Aurelian L, Nicolls MR. Dominant Role for Regulatory T Cells in Protecting Females Against Pulmonary Hypertension. Volume 122 of Issue 12. Circulation research 2018. PMID: 29545367


  57. Stenmark KR, Frid MG, Graham BB, Tuder RM. Dynamic and diverse changes in the functional properties of vascular smooth muscle cells in pulmonary hypertension. Volume 114 of Issue 4. Cardiovascular research 2018. PMID: 29385432


  58. Graham BB, Koyanagi D, Kandasamy B, Tuder RM. Right Ventricle Vasculature in Human Pulmonary Hypertension Assessed by Stereology. Volume 196 of Issue 8. American journal of respiratory and critical care medicine 2017. PMID: 28278380


  59. Kumar R, Mickael C, Kassa B, Gebreab L, Robinson JC, Koyanagi DE, Sanders L, Barthel L, Meadows C, Fox D, Irwin D, Li M, McKeon BA, Riddle S, Dale Brown R, Morgan LE, Evans CM, Hernandez-Saavedra D, Bandeira A, Maloney JP, Bull TM, Janssen WJ, Stenmark KR, Tuder RM, Graham BB. TGF-ß activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension. Volume 8. Nature communications 2017. PMID: 28555642


  60. Pugliese SC, Kumar S, Janssen WJ, Graham BB, Frid MG, Riddle SR, El Kasmi KC, Stenmark KR. A Time- and Compartment-Specific Activation of Lung Macrophages in Hypoxic Pulmonary Hypertension. Volume 198 of Issue 12. Journal of immunology (Baltimore, Md. : 1950) 2017. PMID: 28500078


  61. Ali Z, Kosanovic D, Kolosionek E, Schermuly RT, Graham BB, Mathie A, Butrous G. Enhanced inflammatory cell profiles in schistosomiasis-induced pulmonary vascular remodeling. Volume 7 of Issue 1. Pulmonary circulation 2017. PMID: 28680583


  62. Graham BB, Robinson JC, Tuder RM. Fatty Acid Metabolism, Bone Morphogenetic Protein Receptor Type 2, and the Right Ventricle. Volume 194 of Issue 6. American journal of respiratory and critical care medicine 2016. PMID: 27628075


  63. Xu W, Ghosh S, Comhair SA, Asosingh K, Janocha AJ, Mavrakis DA, Bennett CD, Gruca LL, Graham BB, Queisser KA, Kao CC, Wedes SH, Petrich JM, Tuder RM, Kalhan SC, Erzurum SC. Increased mitochondrial arginine metabolism supports bioenergetics in asthma. Volume 126 of Issue 7. The Journal of clinical investigation 2016. PMID: 27214549


  64. Bertero T, Cottrill KA, Lu Y, Haeger CM, Dieffenbach P, Annis S, Hale A, Bhat B, Kaimal V, Zhang YY, Graham BB, Kumar R, Saggar R, Saggar R, Wallace WD, Ross DJ, Black SM, Fratz S, Fineman JR, Vargas SO, Haley KJ, Waxman AB, Chau BN, Fredenburgh LE, Chan SY. Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit. Volume 13 of Issue 5. Cell reports 2015. PMID: 26565914


  65. Kumar R, Mickael C, Chabon J, Gebreab L, Rutebemberwa A, Garcia AR, Koyanagi DE, Sanders L, Gandjeva A, Kearns MT, Barthel L, Janssen WJ, Mauad T, Bandeira A, Schmidt E, Tuder RM, Graham BB. The Causal Role of IL-4 and IL-13 in Schistosoma mansoni Pulmonary Hypertension. Volume 192 of Issue 8. American journal of respiratory and critical care medicine 2015. PMID: 26192556


  66. Graham BB, Kumar R, Mickael C, Sanders L, Gebreab L, Huber KM, Perez M, Smith-Jones P, Serkova NJ, Tuder RM. Severe pulmonary hypertension is associated with altered right ventricle metabolic substrate uptake. Volume 309 of Issue 5. American journal of physiology. Lung cellular and molecular physiology 2015. PMID: 26115672


  67. White K, Lu Y, Annis S, Hale AE, Chau BN, Dahlman JE, Hemann C, Opotowsky AR, Vargas SO, Rosas I, Perrella MA, Osorio JC, Haley KJ, Graham BB, Kumar R, Saggar R, Saggar R, Wallace WD, Ross DJ, Khan OF, Bader A, Gochuico BR, Matar M, Polach K, Johannessen NM, Prosser HM, Anderson DG, Langer R, Zweier JL, Bindoff LA, Systrom D, Waxman AB, Jin RC, Chan SY. Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension. Volume 7 of Issue 6. EMBO molecular medicine 2015. PMID: 25825391


  68. Robinson JC, Graham BB, Rouault TC, Tuder RM. The crossroads of iron with hypoxia and cellular metabolism. Implications in the pathobiology of pulmonary hypertension. Volume 51 of Issue 6. American journal of respiratory cell and molecular biology 2014. PMID: 24988529


  69. Graham BB, Kumar R. Schistosomiasis and the pulmonary vasculature (2013 Grover Conference series). Volume 4 of Issue 3. Pulmonary circulation 2014. PMID: 25621148


  70. Nadon AM, Perez MJ, Hernandez-Saavedra D, Smith LP, Yang Y, Sanders LA, Gandjeva A, Chabon J, Koyanagi DE, Graham BB, Tuder RM, Schmidt EP. Rtp801 suppression of epithelial mTORC1 augments endotoxin-induced lung inflammation. Volume 184 of Issue 9. The American journal of pathology 2014. PMID: 25016184


  71. Bertero T, Lu Y, Annis S, Hale A, Bhat B, Saggar R, Saggar R, Wallace WD, Ross DJ, Vargas SO, Graham BB, Kumar R, Black SM, Fratz S, Fineman JR, West JD, Haley KJ, Waxman AB, Chau BN, Cottrill KA, Chan SY. Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension. Volume 124 of Issue 8. The Journal of clinical investigation 2014. PMID: 24960162


  72. El Kasmi KC, Pugliese SC, Riddle SR, Poth JM, Anderson AL, Frid MG, Li M, Pullamsetti SS, Savai R, Nagel MA, Fini MA, Graham BB, Tuder RM, Friedman JE, Eltzschig HK, Sokol RJ, Stenmark KR. Adventitial fibroblasts induce a distinct proinflammatory/profibrotic macrophage phenotype in pulmonary hypertension. Volume 193 of Issue 2. Journal of immunology (Baltimore, Md. : 1950) 2014. PMID: 24928992


  73. Chabon JJ, Gebreab L, Kumar R, Debella E, Tanaka T, Koyanagi D, Rodriguez Garcia A, Sanders L, Perez M, Tuder RM, Graham BB. Role of vascular endothelial growth factor signaling in Schistosoma-induced experimental pulmonary hypertension. Volume 4 of Issue 2. Pulmonary circulation 2014. PMID: 25006448


  74. Stearman RS, Cornelius AR, Lu X, Conklin DS, Del Rosario MJ, Lowe AM, Elos MT, Fettig LM, Wong RE, Hara N, Cogan JD, Phillips JA, Taylor MR, Graham BB, Tuder RM, Loyd JE, Geraci MW. Functional prostacyclin synthase promoter polymorphisms. Impact in pulmonary arterial hypertension. Volume 189 of Issue 9. American journal of respiratory and critical care medicine 2014. PMID: 24605778


  75. Tuder RM, Robinson JC, Graham BB. Fat and cardiotoxicity in hereditary pulmonary hypertension. Volume 189 of Issue 3. American journal of respiratory and critical care medicine 2014. PMID: 24484329


  76. Graham BB, Chabon J, Kumar R, Kolosionek E, Gebreab L, Debella E, Edwards M, Diener K, Shade T, Bifeng G, Bandeira A, Butrous G, Jones K, Geraci M, Tuder RM. Protective role of IL-6 in vascular remodeling in Schistosoma pulmonary hypertension. Volume 49 of Issue 6. American journal of respiratory cell and molecular biology 2013. PMID: 23815102


  77. Macht M, Robinson JC, Graham BB. Updated approach for the assessment of ventilator-associated pneumonia. Volume 41 of Issue 11. Critical care medicine 2013. PMID: 24162675


  78. Tuder RM, Stacher E, Robinson J, Kumar R, Graham BB. Pathology of pulmonary hypertension. Volume 34 of Issue 4. Clinics in chest medicine 2013. PMID: 24267295


  79. Hunt JM, Bethea B, Liu X, Gandjeva A, Mammen PP, Stacher E, Gandjeva MR, Parish E, Perez M, Smith L, Graham BB, Kuebler WM, Tuder RM. Pulmonary veins in the normal lung and pulmonary hypertension due to left heart disease. Volume 305 of Issue 10. American journal of physiology. Lung cellular and molecular physiology 2013. PMID: 24039255


  80. Graham BB, Chabon J, Gebreab L, Poole J, Debella E, Davis L, Tanaka T, Sanders L, Dropcho N, Bandeira A, Vandivier RW, Champion HC, Butrous G, Wang XJ, Wynn TA, Tuder RM. Transforming growth factor-ß signaling promotes pulmonary hypertension caused by Schistosoma mansoni. Volume 128 of Issue 12. Circulation 2013. PMID: 23958565


  81. Dorosz JL, Fonseca BM, Kay JD, Graham BB, Salcedo EE, Quaife RA. A sinus venosus atrial septal defect is diagnosed by echocardiography with an unusual bubble study. Volume 30 of Issue 6. Echocardiography (Mount Kisco, N.Y.) 2013. PMID: 23551148


  82. Kolosionek E, King J, Rollinson D, Schermuly RT, Grimminger F, Graham BB, Morrell N, Butrous G. Schistosomiasis causes remodeling of pulmonary vessels in the lung in a heterogeneous localized manner: Detailed study. Volume 3 of Issue 2. Pulmonary circulation 2013. PMID: 24015336


  83. Ghosh MC, Zhang DL, Jeong SY, Kovtunovych G, Ollivierre-Wilson H, Noguchi A, Tu T, Senecal T, Robinson G, Crooks DR, Tong WH, Ramaswamy K, Singh A, Graham BB, Tuder RM, Yu ZX, Eckhaus M, Lee J, Springer DA, Rouault TA. Deletion of iron regulatory protein 1 causes polycythemia and pulmonary hypertension in mice through translational derepression of HIF2a. Volume 17 of Issue 2. Cell metabolism 2013. PMID: 23395173


  84. Lundgrin EL, Park MM, Sharp J, Tang WH, Thomas JD, Asosingh K, Comhair SA, DiFilippo FP, Neumann DR, Davis L, Graham BB, Tuder RM, Dostanic I, Erzurum SC. Fasting 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography to detect metabolic changes in pulmonary arterial hypertension hearts over 1 year. Volume 10 of Issue 1. Annals of the American Thoracic Society 2013. PMID: 23509326


  85. Stacher E, Graham BB, Hunt JM, Gandjeva A, Groshong SD, McLaughlin VV, Jessup M, Grizzle WE, Aldred MA, Cool CD, Tuder RM. Modern age pathology of pulmonary arterial hypertension. Volume 186 of Issue 3. American journal of respiratory and critical care medicine 2012. PMID: 22679007


  86. Tuder RM, Davis LA, Graham BB. Targeting energetic metabolism: a new frontier in the pathogenesis and treatment of pulmonary hypertension. Volume 185 of Issue 3. American journal of respiratory and critical care medicine 2011. PMID: 22077069


  87. Graham BB, Chabon J, Bandeira A, Espinheira L, Butrous G, Tuder RM. Significant intrapulmonary Schistosoma egg antigens are not present in schistosomiasis-associated pulmonary hypertension. Volume 1 of Issue 4. Pulmonary circulation 2011. PMID: 22530100


  88. Graham BB, Mentink-Kane MM, El-Haddad H, Purnell S, Zhang L, Zaiman A, Redente EF, Riches DW, Hassoun PM, Bandeira A, Champion HC, Butrous G, Wynn TA, Tuder RM. Schistosomiasis-induced experimental pulmonary hypertension: role of interleukin-13 signaling. Volume 177 of Issue 3. The American journal of pathology 2010. PMID: 20671265


  89. Cole BB, Smith RW, Jenkins KM, Graham BB, Reynolds PR, Reynolds SD. Tracheal Basal cells: a facultative progenitor cell pool. Volume 177 of Issue 1. The American journal of pathology 2010. PMID: 20522644


  90. Graham BB, Bandeira AP, Morrell NW, Butrous G, Tuder RM. Schistosomiasis-associated pulmonary hypertension: pulmonary vascular disease: the global perspective. Volume 137 of Issue 6 Suppl. Chest 2010. PMID: 20522577


  91. Graham BB, Keniston A, Gajic O, Trillo Alvarez CA, Medvedev S, Douglas IS. Diabetes mellitus does not adversely affect outcomes from a critical illness. Volume 38 of Issue 1. Critical care medicine 2010. PMID: 19789450


  92. Graham BB, Tuder RM. [Pathogenesis of pulmonary hypertension]. Volume 89 of Issue 30. Zhonghua yi xue za zhi 2009. PMID: 20058607


  93. Borges VM, Vandivier RW, McPhillips KA, Kench JA, Morimoto K, Groshong SD, Richens TR, Graham BB, Muldrow AM, Van Heule L, Henson PM, Janssen WJ. TNFalpha inhibits apoptotic cell clearance in the lung, exacerbating acute inflammation. Volume 297 of Issue 4. American journal of physiology. Lung cellular and molecular physiology 2009. PMID: 19648283


  94. Graham BB, Kaul DR, Saint S, Janssen WJ. Clinical problem-solving. Kiss of death. Volume 360 of Issue 24. The New England journal of medicine 2009. PMID: 19516037


  95. Graham BB, Burnham EL, Janssen JS, Janssen WJ. Dyspnea, chest pain, and altered mental status in a 33-year-old carpenter. Volume 134 of Issue 5. Chest 2008. PMID: 18988783


  96. Tuder RM, Yun JH, Graham BB. Cigarette smoke triggers code red: p21CIP1/WAF1/SDI1 switches on danger responses in the lung. Volume 39 of Issue 1. American journal of respiratory cell and molecular biology 2008. PMID: 18441278


  97. Graham BB, Mathisen DJ, Mark EJ, Takvorian RW. Primary pulmonary lymphoma. Volume 80 of Issue 4. The Annals of thoracic surgery 2005. PMID: 16181848


  98. Graham BB, Varvares MA. End-to-side venous anastomosis with the internal jugular vein stump: a preliminary report. Volume 26 of Issue 6. Head & neck 2004. PMID: 15162355


  99. Wright CD, Graham BB, Grillo HC, Wain JC, Mathisen DJ. Pediatric tracheal surgery. Volume 74 of Issue 2. The Annals of thoracic surgery 2002. PMID: 12173805