Amir Munir, MD

HS Clinical Instructor

I am a cardiologist with a specialization in cardio-oncology and immunology. The specialty of cardio-oncology is focused on the cardiovascular care of cancer patients and survivors who have pre-existing cardiovascular disease, or who may have developed cardiovascular disease from their specific cancer therapies.

I am also a physician-scientist with a research focus on elucidating the mechanisms of cancer therapy cardiotoxicities. New, targeted cancer immunotherapies called immune checkpoint inhibitors (ICIs) can cause a rare, but fatal, condition called ICI myocarditis. I am currently defining the essential immune cell populations and pathways of ICI myocarditis in pre-clinical models and human tissue samples.

Education
2020 - Internal Medicine Residency, Brigham and Women's Hospital
M.D., 2017 - , Case Western Reserve University School of Medicine
A.B., 2012 - Chemistry, Washington University in St Louis
Honors and Awards
  • Sarnoff Scholar Career Development Award, 2024-2026
  • Chan-Zuckerberg Biohub Physician-Scientist Fellowship, 2022-2024
  • Myron F. Kanter and Lawrence J. Kanter Endowment Award, 2017
  • Stanley Sarnoff Fellowship in Cardiovascular Research, 2015-2016
Publications

  1. Munir AZ, Gutierrez A, Krawiec CJ, Manandhar P, Shyani AC, Ma P, Gougis P, Baylis RA, Hou L, Remold-O'Donnell E, Balko JM, Salem JE, Lavine KJ, Lichtman AH, Qin J, Moslehi JJ. CXCR6+ T Cells Drive Immune Checkpoint Inhibitor Myocarditis. Circulation 2026. PMID: 41498147


  2. Munir AZ, Gutierrez A, Qin J, Lichtman AH, Moslehi JJ. Immune-checkpoint inhibitor-mediated myocarditis: CTLA4, PD1 and LAG3 in the heart. Nature reviews. Cancer 2024. PMID: 38982146


  3. Chan H, Savoie MB, Munir A, Moslehi J, Anwar M, Laffan A, Rowen T, Salmon R, Varma M, Van Loon K. Multi-Disciplinary Management in Rectal Cancer Survivorship: A Clinical Practice Review. Journal of gastrointestinal cancer 2023. PMID: 36622517


  4. Makarewich CA, Munir AZ, Bezprozvannaya S, Gibson AM, Young Kim S, Martin-Sandoval MS, Mathews TP, Szweda LI, Bassel-Duby R, Olson EN. The cardiac-enriched microprotein mitolamban regulates mitochondrial respiratory complex assembly and function in mice. Volume 119 of Issue 6. Proceedings of the National Academy of Sciences of the United States of America 2022. PMID: 35101990


  5. Eberly LA, Richterman A, Beckett AG, Wispelwey B, Marsh RH, Cleveland Manchanda EC, Chang CY, Glynn RJ, Brooks KC, Boxer R, Kakoza R, Goldsmith J, Loscalzo J, Morse M, Lewis EF, Abel S, Adams A, Anaya J, Andrews EH, Atkinson B, Avutu V, Bachorik A, Badri O, Bailey M, Baird K, Bakshi S, Balaban D, Barshop K, Baumrin E, Bayomy O, Beamesderfer J, Becker N, Berg DD, Berman AN, Blum SM, Boardman AP, Boden K, Bonacci RA, Brown S, Campbell K, Case S, Cetrone E, Charrow A, Chiang D, Clark D, Cohen AJ, Cooper A, Cordova T, Cuneo CN, de Feria AA, Deffenbacher K, DeFilippis EM, DeGregorio G, Deutsch AJ, Diephuis B, Divakaran S, Dorschner P, Downing N, Drescher C, D'Silva KM, Dunbar P, Duong D, Earp S, Eckhardt C, Elman SA, England R, Everett K, Fedotova N, Feingold-Link T, Ferreira M, Fisher H, Foo P, Foote M, Franco I, Gilliland T, Greb J, Greco K, Grewal S, Grin B, Growdon ME, Guercio B, Hahn CK, Hasselfeld B, Haydu EJ, Hermes Z, Hildick-Smith G, Holcomb Z, Holroyd K, Horton L, Huang G, Jablonski S, Jacobs D, Jain N, Japa S, Joseph R, Kalashnikova M, Kalwani N, Kang D, Karan A, Katz JT, Kellner D, Kidia K, Kim JH, Knowles SM, Kolbe L, Kore I, Koullias Y, Kuye I, Lang J, Lawlor M, Lechner MG, Lee K, Lee S, Lee Z, Limaye N, Lin-Beckford S, Lipsyc M, Little J, Loewenthal J, Logaraj R, Lopez DM, Loriaux D, Lu Y, Ma K, Marukian N, Matias W, Mayers JR, McConnell I, McLaughlin M, Meade C, Meador C, Mehta A, Messenger E, Michaelidis C, Mirsky J, Mitten E, Mueller A, Mullur J, Munir A, Murphy E, Nagami E, Natarajan A, Nsahlai M, Nze C, Okwara N, Olds P, Paez R, Pardo M, Patel S, Petersen A, Phelan L, Pimenta E, Pipilas D, Plovanich M, Pong D, Powers BW, Rao A, Ramirez Batlle H, Ramsis M, Reichardt A, Reiger S, Rengarajan M, Rico S, Rome BN, Rosales R, Rotenstein L, Roy A, Royston S, Rozansky H, Rudder M, Ryan CE, Salgado S, Sanchez P, Schulte J, Sekar A, Semenkovich N, Shannon E, Shaw N, Shorten AB, Shrauner W, Sinnenberg L, Smithy JW, Snyder G, Sreekrishnan A, Stabenau H, Stavrou E, Stergachis A, Stern R, Stone A, Tabrizi S, Tanyos S, Thomas C, Thun H, Torres-Lockhart K, Tran A, Treasure C, Tsai FD, Tsaur S, Tschirhart E, Tuwatananurak J, Venkateswaran RV, Vishnevetsky A, Wahl L, Wall A, Wallace F, Walsh E, Wang P, Ward HB, Warner LN, Weeks LD, Weiskopf K, Wengrod J, Williams JN, Winkler M, Wong JL, Worster D, Wright A, Wunsch C, Wynter JS, Yarbrough C, Yau WY, Yazdi D, Yeh J, Yialamas MA, Yozamp N, Zambrotta M, Zon R. Identification of Racial Inequities in Access to Specialized Inpatient Heart Failure Care at an Academic Medical Center. Circulation. Heart failure 2019. PMID: 31658831


  6. Makarewich CA, Munir AZ, Schiattarella GG, Bezprozvannaya S, Raguimova ON, Cho EE, Vidal AH, Robia SL, Bassel-Duby R, Olson EN. The DWORF micropeptide enhances contractility and prevents heart failure in a mouse model of dilated cardiomyopathy. Volume 7. eLife 2018. PMID: 30299255


  7. Makarewich CA, Baskin KK, Munir AZ, Bezprozvannaya S, Sharma G, Khemtong C, Shah AM, McAnally JR, Malloy CR, Szweda LI, Bassel-Duby R, Olson EN. MOXI Is a Mitochondrial Micropeptide That Enhances Fatty Acid β-Oxidation. Volume 23 of Issue 13. Cell reports 2018. PMID: 29949755


  8. Origanti S, Cai SR, Munir AZ, White LS, Piwnica-Worms H. Synthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cells. Volume 32 of Issue 5. Oncogene 2012. PMID: 22430210