Alan Verkman, MD, PhD

Professor In Residence

Research Interests :

Aquaporin water channels – Biophysics of cell membrane water permeability. Generation of transgenic mouse models to discover novel roles of aquaporins in tumor angiogenesis, cell migration, brain swelling, neuroexcitation, fat and tumor metabolism, skin hydration, saliva secretion, kidney tubule fluid transport, and others.

Cystic fibrosis – Drug discovery and elucidation of lung pathogenesis mechanisms. Developed screening methods to identify CFTR modulators, including the initial conceptualization and discovery of CFTR inhibitors, and potentiators and correctors of mutant CFTRs that cause cystic fibrosis.

Drug discovery and modeling of epithelial transport – High-throughput screening to identify small molecule modulators of epithelial chloride transporters, including CFTR, CaCCs, urea, and SLC26 proteins (DRA, pendrin, PAT1). Testing in animal models of secretory diarrheas, constipation, kidney stones, hypertension, edema, polycystic kidney disease, and dry eye disease.

Neuroinflammation / neuromyelitis optica spectrum disorders – Discovery of AQP4 pathogenesis mechanisms in NMOSD, including bystander complement and antibody-dependent cytotoxicity. Novel NMOSD therapeutics, including aquaporumab anti-AQP4 antibodies. Development of passive-transfer animal models of NMOSD.

Fluid and solute transport in cellular and extracellular compartments – Experimental measurements by photobleaching and single molecule methods using genetically targeted fluorescent proteins. Mathematical modeling of molecular crowding, diffusion and advection in cellular and extracellular spaces with recent application to the glymphatic hypothesis.

Assay and instrument development – Optical assays for drug screening including cell anion and volume sensors. Initial application of genetically encoded proteins to measure pH and Cl in cells. Microscopy developments including microfiberoptic & TIRFM photobleaching, astigmatic optics, single-particle tracking, tissue super-resolution imaging, and in vivo transport measurements.

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Google Scholars (h-index >175, citations > 100,000):
https://scholar.google.com/citations user=8HhBMvQAAAAJ&hl=en

Patent portfolio (link to published US patents):
https://patents.justia.com/inventor/alan-s-verkman

Global Health: Development of CFTR inhibitors for treatment of secretory diarrheas, including cholera, in developing countries. See news:
https://innovation.ucsf.edu/news/fda-grants-orphan-drug-designation-vandas-cholera-treatment
https://innovation.ucsf.edu/news/vanda-and-ucsf-announce-license-agreement-cftr-activators-and-inhibitors
https://www.ucsf.edu/news/2006/11/102223/ucsf-discovery-major-focus-46-million-grant-combat-diarrhea
https://www.nature.com/articles/news030106-16

Education
Residency, - Medicine, Brigham & Womens Hospital
M.D., - , Harvard Medical School / Harvard-M.I.T. Program in Health Sciences and Technology
M.A., Ph.D., - Physics, Harvard University
S.B., S.B., - Physics, Biology, M.I.T.
Fellowship, - Nephrology, University of California, San Francisco
Honors and Awards
  • Verkman, Hans H. Ussing Award, American Physiological Society, 2025
  • Verkman, Paul Quinton Cystic Fibrosis Legacy Research Award, CFRI, 2019
  • Verkman, Robert J. Beall CF Therapeutics Development Award, Cystic Fibrosis Foundation, 2015
  • Verkman, NIH/NIBIB R37 MERIT award, 2007-2017
  • Verkman, NIH/NIDDK R37 MERIT award, 1999-2009
  • Verkman, Elected, Association of American Physicians (AAP), 1996
  • Verkman, Young Investigator Award, American Society of Nephrology and American Heart Association, 1993
  • Verkman, Elected, American Society for Clinical Investigation (ASCI), 1989
  • Verkman, Established Investigator, American Heart Association, 1988
  • Verkman, M.D. magna cum laude, Harvard Medical School, 1981
  • Verkman, National Science Foundation fellowship in Physics, Harvard University, 1975
Publications

  1. Verma V, Lindgren ES, Levin MH, Cil O, Tradtrantip L, Yan R, Pasricha ND, Verkman AS. Model of ocular surface ion and water transport predicts efficacy of dry eye therapeutics. The Journal of general physiology 2026. PMID: 42171532


  2. Verkman AS. Epithelial plasma membrane transporters as drug targets. Physiological reviews 2026. PMID: 41778727


  3. Christ-Crain M, Bichet DG, Fenske WK, Goldman MB, Rittig S, Verbalis JG, Verkman AS. Author Correction: Diabetes insipidus. Nature reviews. Disease primers 2025. PMID: 40467570


  4. Lindgren ES, Yan R, Kuo YM, Gao Q, de Souza Goncalves L, Chen FY, Chan MF, Verkman AS, Cil O, Pasricha ND. Lysophosphatidic acid receptor 3 (LPAR3) regulates ocular surface chloride transport via calcium signaling. Experimental eye research 2025. PMID: 40112945


  5. Master RJ, Karmakar J, Haggie PM, Anthony-Tan J, Chu T, Verkman AS, Anderson MO, Cil O. High potency 3-carboxy-2-methylbenzofuran pendrin inhibitors as novel diuretics. European journal of medicinal chemistry 2024. PMID: 39642691


  6. Pasricha ND, Lindgren ES, Yan R, Kuo YM, Chan M, Verkman AS, Chu T, Yottasan P, de Souza Goncalves L, Cil O. Calcium-sensing receptor (CaSR) modulates ocular surface chloride transport and its inhibition promotes ocular surface hydration. The ocular surface 2024. PMID: 38871216


  7. Ahmadi M, de Souza Goncalves L, Verkman AS, Cil O, Anderson MO. Substituted 4-methylcoumarin inhibitors of SLC26A3 (DRA) for treatment of constipation and hyperoxaluria. RSC medicinal chemistry 2024. PMID: 38784456


  8. Lindgren ES, Yan R, Cil O, Verkman AS, Chan MF, Seitzman GD, Farooq AV, Huppert LA, Rugo HS, Pohlmann PR, Lu J, Esserman LJ, Pasricha ND. Incidence and Mitigation of Corneal Pseudomicrocysts Induced by Antibody-Drug Conjugates (ADCs). Current ophthalmology reports 2024. PMID: 38756824


  9. Tong XJ, Akdemir G, Wadhwa M, Verkman AS, Smith AJ. Large molecules from the cerebrospinal fluid enter the optic nerve but not the retina of mice. Fluids and barriers of the CNS 2024. PMID: 38178155


  10. Yuan F, Gasser GN, Lemire E, Montoro DT, Jagadeesh K, Zhang Y, Duan Y, Ievlev V, Wells KL, Rotti PG, Shahin W, Winter M, Rosen BH, Evans I, Cai Q, Yu M, Walsh SA, Acevedo MR, Pandya DN, Akurathi V, Dick DW, Wadas TJ, Joo NS, Wine JJ, Birket S, Fernandez CM, Leung HM, Tearney GJ, Verkman AS, Haggie PM, Scott K, Bartels D, Meyerholz DK, Rowe SM, Liu X, Yan Z, Haber AL, Sun X, Engelhardt JF. Transgenic ferret models define pulmonary ionocyte diversity and function. Nature 2023. PMID: 37730992


  11. Chu T, Karmakar J, Haggie PM, Tan JA, Master R, Ramaswamy K, Verkman AS, Anderson MO, Cil O. Selective isoxazolopyrimidine PAT1 (SLC26A6) inhibitors for therapy of intestinal disorders. RSC medicinal chemistry 2023. PMID: 37974969


  12. Sagan SA, Moinfar Z, Moseley CE, Dandekar R, Spencer CM, Verkman AS, Ottersen OP, Sobel RA, Sidney J, Sette A, Anderson MS, Steinman L, Wilson MR, Sabatino JJ, Zamvil SS. T cell deletional tolerance restricts AQP4 but not MOG CNS autoimmunity. Proceedings of the National Academy of Sciences of the United States of America 2023. PMID: 37463205


  13. Cil O, Anderson MO, de Souza Goncalves L, Tan JA, Haggie PM, Verkman AS. Small molecule inhibitors of intestinal epithelial anion exchanger SLC26A3 (DRA) with a luminal, extracellular site of action. European journal of medicinal chemistry 2023. PMID: 36724632


  14. Lindgren ES, Cil O, Verkman AS, Pasricha ND. Ocular Surface Ion Transport and Dry Eye Disease. Current ophthalmology reports 2022. PMID: 38213468


  15. Cil O, Chu QT, Lee S, Haggie PM, Verkman AS. Small molecule inhibitor of intestinal anion exchanger SLC26A3 for therapy of hyperoxaluria and nephrolithiasis. 2022. PMID: 35608921


  16. Boecking CA, Walentek P, Zlock LT, Sun DI, Wolters PJ, Ishikawa H, Jin BJ, Haggie PM, Marshall WF, Verkman AS, Finkbeiner WE. A simple method to generate human airway epithelial organoids with externally-oriented apical membranes. 2022. PMID: 35080188


  17. Tradtrantip L, Yeaman MR, Verkman AS. Cytoprotective IgG antibodies in sera from a subset of patients with AQP4-IgG seropositive neuromyelitis optica spectrum disorder. 2021. PMID: 34753987


  18. Verkman AS, Galietta LJV. Chloride transport modulators as drug candidates. 2021. PMID: 34644122


  19. Smith AJ, Akdemir G, Wadhwa M, Song D, Verkman AS. Application of fluorescent dextrans to the brain surface under constant pressure reveals AQP4-independent solute uptake. 2021. PMID: 34128962


  20. Cil O, Haggie PM, Tan JT, Rivera AA, Verkman AS. SLC26A6-selective inhibitor identified in a small-molecule screen blocks fluid absorption in small intestine. 2021. PMID: 34100381


  21. Cil O, Chen X, Askew Page HR, Baldwin SN, Jordan MC, Myat Thwe P, Anderson MO, Haggie PM, Greenwood IA, Roos KP, Verkman AS. A small molecule inhibitor of the chloride channel TMEM16A blocks vascular smooth muscle contraction and lowers blood pressure in spontaneously hypertensive rats. 2021. PMID: 33836171


  22. Oak AA, Chhetri PD, Rivera A, Verkman AS, Cil O. Repurposing calcium sensing receptor agonist cinacalcet for treatment of CFTR-mediated secretory diarrheas. JCI insight 2021. PMID: 33400691


  23. Asavapanumas N, Tradtrantip L, Verkman AS. Targeting the complement system in neuromyelitis optica spectrum disorder. Expert opinion on biological therapy 2021. PMID: 33513036


  24. Nalle SC, Barreira da Silva R, Zhang H, Decker M, Chalouni C, Xu M, Posthuma G, de Mazière A, Klumperman J, Baz Morelli A, Fleire SJ, Verkman AS, Trombetta ES, Albert ML, Mellman I. Aquaporin-3 regulates endosome-to-cytosol transfer via lipid peroxidation for cross presentation. PloS one 2020. PMID: 33232321


  25. Hara-Chikuma M, Tanaka M, Verkman AS, Yasui M. Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury. Nature communications 2020. PMID: 33168815


  26. Pasricha ND, Smith AJ, Levin MH, Schallhorn JM, Verkman AS. Ocular Surface Potential Difference Measured in Human Subjects to Study Ocular Surface Ion Transport. Translational vision science & technology 2020. PMID: 33117611


  27. Son JH, Phuan PW, Zhu JS, Lipman E, Cheung A, Tsui KY, Tantillo DJ, Verkman AS, Haggie PM, Kurth MJ. 1-BENZYLSPIRO[PIPERIDINE-4,1'-PYRIDO[3,4-b]indole] 'co-potentiators' for minimal function CFTR mutants. European journal of medicinal chemistry 2020. PMID: 33092904


  28. Phuan PW, Haggie PM, Tan JA, Rivera AA, Finkbeiner WE, Nielson DW, Thomas MM, Janahi IA, Verkman AS. CFTR modulator therapy for cystic fibrosis caused by the rare c.3700A>G mutation. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2020. PMID: 32674984


  29. Donowitz M, Turner JR, Verkman AS, Zachos NC. Current and potential future applications of human stem cell models in drug development. The Journal of clinical investigation 2020. PMID: 32452833


  30. Ortiz-Munoz G, Yu MA, Lefrançais E, Mallavia B, Valet C, Tian JJ, Ranucci S, Wang KM, Liu Z, Kwaan N, Dawson D, Kleinhenz ME, Khasawneh FT, Haggie PM, Verkman AS, Looney MR. Cystic fibrosis transmembrane conductance regulator dysfunction in platelets drives lung hyperinflammation. The Journal of clinical investigation 2020. PMID: 31961827


  31. Tradtrantip L, Asavapanumas N, Verkman AS. Emerging therapeutic targets for neuromyelitis optica spectrum disorders. Expert opinion on therapeutic targets 2020. PMID: 32070155


  32. Chen X, Lee S, Zhang T, Duan T, Pasricha ND, Schallhorn JM, Levin MH, Koprivica V, Verkman AS. Nanomolar Potency Aminophenyltriazine CFTR Activator Reverses Corneal Epithelial Injury in a Mouse Model of Dry Eye. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2020. PMID: 31934802


  33. Phuan PW, Tan JA, Rivera AA, Zlock L, Nielson DW, Finkbeiner WE, Haggie PM, Verkman AS. Nanomolar-potency 'co-potentiator' therapy for cystic fibrosis caused by a defined subset of minimal function CFTR mutants. Scientific Reports 2019. PMID: 31776420


  34. Duan T, Tradtrantip L, Phuan PW, Bennett JL, Verkman AS. Affinity-matured 'aquaporumab' anti-aquaporin-4 antibody for therapy of seropositive neuromyelitis optica spectrum disorders. Neuropharmacology 2019. PMID: 31654702


  35. Duan T, Verkman AS. Experimental animal models of aquaporin-4-IgG seropositive neuromyelitis optica spectrum disorders: Progress and shortcomings. Brain pathology (Zurich, Switzerland) 2019. PMID: 31587392


  36. Lee S, Cil O, Haggie P, Verkman AS. 4,8-Dimethylcoumarin inhibitors of intestinal anion exchanger slc26a3 (down-regulated in adenoma, DRA) for anti-absorptive therapy of constipation. Journal of medicinal chemistry 2019. PMID: 31389695


  37. Christ-Crain M, Bichet DG, Fenske WK, Goldman MB, Rittig S, Verbalis JG, Verkman AS. Diabetes insipidus. Nature reviews. Disease primers 2019. PMID: 31395885


  38. Smith AJ, Verkman AS. CrossTalk opposing view: Going against the flow: interstitial solute transport in brain is diffusive and aquaporin-4 independent. The Journal of physiology 2019. PMID: 31389038


  39. Smith AJ, Verkman AS. Rebuttal from Alex J. Smith and Alan S. Verkman. The Journal of physiology 2019. PMID: 31389015


  40. Armirotti A, Tomati V, Matthes E, Veit G, Cholon DM, Phuan PW, Braccia C, Guidone D, Gentzsch M, Lukacs GL, Verkman AS, Galietta LJV, Hanrahan JW, Pedemonte N. Bioactive Thymosin Alpha-1 Does Not Influence F508del-CFTR Maturation and Activity. Scientific Reports 2019. PMID: 31311979


  41. Cil O, Anderson MO, Yen R, Kelleher B, Huynh TL, Seo Y, Nilsen SP, Turner JR, Verkman AS. Slowed gastric emptying and improved oral glucose tolerance produced by a nanomolar-potency inhibitor of calcium-activated chloride channel TMEM16A. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019. PMID: 31299174


  42. Duan T, Smith AJ, Verkman AS. Complement-independent bystander injury in AQP4-IgG seropositive neuromyelitis optica produced by antibody-dependent cellular cytotoxicity. Acta neuropathologica communications 2019. PMID: 31296268


  43. Duan T, Cil O, Tse CM, Sarker R, Lin R, Donowitz M, Verkman AS. Inhibition of CFTR-mediated intestinal chloride secretion as potential therapy for bile acid diarrhea. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019. PMID: 31268738


  44. Zhu JS, Lu JY, Tan JA, Rivera AA, Phuan PW, Shatskikh ME, Son JH, Haggie PM, Verkman AS, Kurth MJ. Synthesis and evaluation of tetrahydropyrazolopyridine inhibitors of anion exchange protein SLC26A4 (pendrin). Bioorganic & medicinal chemistry letters 2019. PMID: 31281021


  45. Smith AJ, Duan T, Verkman AS. Aquaporin-4 reduces neuropathology in a mouse model of Alzheimer's disease by remodeling peri-plaque astrocyte structure. Acta neuropathologica communications 2019. PMID: 31068220


  46. Tradtrantip L, Duan T, Yeaman MR, Verkman AS. CD55 upregulation in astrocytes by statins as potential therapy for AQP4-IgG seropositive neuromyelitis optica. Journal of neuroinflammation 2019. PMID: 30851734


  47. Duan T, Cil O, Thiagarajah JR, Verkman AS. Intestinal epithelial potassium channels and CFTR chloride channels activated in ErbB tyrosine kinase inhibitor diarrhea. JCI insight 2019. PMID: 30668547


  48. Wang W, Geng X, Lei L, Jia Y, Li Y, Zhou H, Verkman AS, Yang B. Aquaporin-3 deficiency slows cyst enlargement in experimental mouse models of autosomal dominant polycystic kidney disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019. PMID: 30768374


  49. Tse CM, Yin J, Singh V, Sarker R, Lin R, Verkman AS, Turner JR, Donowitz M. cAMP Stimulates SLC26A3 Activity in Human Colon by a CFTR-Dependent Mechanism That Does Not Require CFTR Activity. Cellular and molecular gastroenterology and hepatology 2019. PMID: 30659943


  50. Yao X, Adams MS, Jones PD, Diederich CJ, Verkman AS. Noninvasive, Targeted Creation of Neuromyelitis Optica Pathology in AQP4-IgG Seropositive Rats by Pulsed Focused Ultrasound. Journal of neuropathology and experimental neurology 2019. PMID: 30500945


  51. Duan T, Smith AJ, Verkman AS. Complement-dependent bystander injury to neurons in AQP4-IgG seropositive neuromyelitis optica. Journal of neuroinflammation 2018. PMID: 30348195


  52. Haggie PM, Cil O, Lee S, Tan JA, Rivera AA, Phuan PW, Verkman AS. SLC26A3 inhibitor identified in small molecule screen blocks colonic fluid absorption and reduces constipation. JCI insight 2018. PMID: 30046015


  53. Phuan PW, Son JH, Tan JA, Li C, Musante I, Zlock L, Nielson DW, Finkbeiner WE, Kurth MJ, Galietta LJ, Haggie PM, Verkman AS. Combination potentiator ('co-potentiator') therapy for CF caused by CFTR mutants, including N1303K, that are poorly responsive to single potentiators. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2018. PMID: 29903467


  54. Jin BJ, Lee S, Verkman AS. Hollow Micropillar Array Method for High-Capacity Drug Screening on Filter-Grown Epithelial Cells. Analytical chemistry 2018. PMID: 29779372


  55. Agbani EO, Williams CM, Li Y, van den Bosch MT, Moore SF, Mauroux A, Hodgson L, Verkman AS, Hers I, Poole AW. Aquaporin-1 regulates platelet procoagulant membrane dynamics and in vivo thrombosis. JCI insight 2018. PMID: 29769447


  56. Lee S, Cil O, Diez-Cecilia E, Anderson MO, Verkman AS. Nanomolar-Potency 1,2,4-Triazoloquinoxaline Inhibitors of the Kidney Urea Transporter UT-A1. Journal of medicinal chemistry 2018. PMID: 29589443


  57. Phuan PW, Veit G, Tan JA, Roldan A, Finkbeiner WE, Haggie PM, Lukacs GL, Verkman AS. ?F508-CFTR Modulator Screen Based on Cell Surface Targeting of a Chimeric Nucleotide Binding Domain 1 Reporter. SLAS discovery : advancing life sciences R & D 2018. PMID: 29533733


  58. Tradtrantip L, Felix CM, Spirig R, Morelli AB, Verkman AS. Recombinant IgG1 Fc hexamers block cytotoxicity and pathological changes in experimental in vitro and rat models of neuromyelitis optica. Neuropharmacology 2018. PMID: 29428821


  59. Verkman AS, Yao X, Smith AJ. The evolving mystery of why skeletal muscle is spared in seropositive neuromyelitis optica. Journal of cellular and molecular medicine 2018. PMID: 29363875


  60. Smith AJ, Verkman AS. The "glymphatic" mechanism for solute clearance in Alzheimer's disease: game changer or unproven speculation? FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018. PMID: 29101220


  61. Verkman AS, Smith AJ, Phuan PW, Tradtrantip L, Anderson MO. The aquaporin-4 water channel as a potential drug target in neurological disorders. Expert opinion on therapeutic targets 2017. PMID: 29072508


  62. Felix CM, Lee S, Levin MH, Verkman AS. Pro-Secretory Activity and Pharmacology in Rabbits of an Aminophenyl-1,3,5-Triazine CFTR Activator for Dry Eye Disorders. Investigative ophthalmology & visual science 2017. PMID: 28873176


  63. Smith AJ, Yao X, Dix JA, Jin BJ, Verkman AS. Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma. eLife 2017. PMID: 28826498


  64. Yao X, Verkman AS. Complement regulator CD59 prevents peripheral organ injury in rats made seropositive for neuromyelitis optica immunoglobulin G. Acta neuropathologica communications 2017. PMID: 28750658


  65. Tradtrantip L, Yao X, Su T, Smith AJ, Verkman AS. Bystander mechanism for complement-initiated early oligodendrocyte injury in neuromyelitis optica. Acta neuropathologica 2017. PMID: 28567523


  66. Ludwig RJ, Vanhoorelbeke K, Leypoldt F, Kaya Z, Bieber K, McLachlan SM, Komorowski L, Luo J, Cabral-Marques O, Hammers CM, Lindstrom JM, Lamprecht P, Fischer A, Riemekasten G, Tersteeg C, Sondermann P, Rapoport B, Wandinger KP, Probst C, El Beidaq A, Schmidt E, Verkman A, Manz RA, Nimmerjahn F. Mechanisms of Autoantibody-Induced Pathology. Frontiers in immunology 2017. PMID: 28620373


  67. Truong EC, Phuan PW, Reggi AL, Ferrera L, Galietta LJV, Levy SE, Moises AC, Cil O, Diez-Cecilia E, Lee S, Verkman AS, Anderson MO. Substituted 2-Acylaminocycloalkylthiophene-3-carboxylic Acid Arylamides as Inhibitors of the Calcium-Activated Chloride Channel Transmembrane Protein 16A (TMEM16A). Journal of medicinal chemistry 2017. PMID: 28493701


  68. Alberga D, Trisciuzzi D, Lattanzi G, Bennett JL, Verkman AS, Mangiatordi GF, Nicolotti O. Comparative molecular dynamics study of neuromyelitis optica-immunoglobulin G binding to aquaporin-4 extracellular domains. Biochimica et biophysica acta. Biomembranes 2017. PMID: 28477975


  69. Lei L, Wang W, Jia Y, Su L, Zhou H, Verkman AS, Yang B. Aquaporin-3 deletion in mice results in renal collecting duct abnormalities and worsens ischemia-reperfusion injury. Biochimica et biophysica acta. Molecular basis of disease 2017. PMID: 28344130


  70. Son JH, Zhu JS, Phuan PW, Cil O, Teuthorn AP, Ku CK, Lee S, Verkman AS, Kurth MJ. High-Potency Phenylquinoxalinone Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activators. Journal of medicinal chemistry 2017. PMID: 28230981


  71. Jin BJ, Verkman AS. Microfluidic platform for rapid measurement of transepithelial water transport. Lab on a chip 2017. PMID: 28184395


  72. Yao X, Verkman AS. Marked central nervous system pathology in CD59 knockout rats following passive transfer of Neuromyelitis optica immunoglobulin G. Acta neuropathologica communications 2017. PMID: 28212662


  73. Lee S, Phuan PW, Felix CM, Tan JA, Levin MH, Verkman AS. Nanomolar-Potency Aminophenyl-1,3,5-triazine Activators of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Chloride Channel for Prosecretory Therapy of Dry Eye Diseases. Journal of medicinal chemistry 2017. PMID: 28099811


  74. Thiagarajah JR, Chang J, Goettel JA, Verkman AS, Lencer WI. Aquaporin-3 mediates hydrogen peroxide-dependent responses to environmental stress in colonic epithelia. Proceedings of the National Academy of Sciences of the United States of America 2017. PMID: 28049834


  75. Tradtrantip L, Jin BJ, Yao X, Anderson MO, Verkman AS. Aquaporin-Targeted Therapeutics: State-of-the-Field. Advances in experimental medicine and biology 2017. PMID: 28258578


  76. Verkman AS, Tradtrantip L, Smith AJ, Yao X. Aquaporin Water Channels and Hydrocephalus. Pediatric neurosurgery 2016. PMID: 27978530


  77. Sagan SA, Winger RC, Cruz-Herranz A, Nelson PA, Hagberg S, Miller CN, Spencer CM, Ho PP, Bennett JL, Levy M, Levin MH, Verkman AS, Steinman L, Green AJ, Anderson MS, Sobel RA, Zamvil SS. Tolerance checkpoint bypass permits emergence of pathogenic T cells to neuromyelitis optica autoantigen aquaporin-4. Volume 113 of Issue 51. Proceedings of the National Academy of Sciences of the United States of America 2016. PMID: 27940915


  78. Haggie PM, Phuan PW, Tan JA, Xu H, Avramescu RG, Perdomo D, Zlock L, Nielson DW, Finkbeiner WE, Lukacs GL, Verkman AS. Correctors and Potentiators Rescue Function of the Truncated W1282X-Cystic Fibrosis Transmembrane Regulator (CFTR) Translation Product. The Journal of biological chemistry 2016. PMID: 27895116


  79. Jin BJ, Smith AJ, Verkman AS. Spatial model of convective solute transport in brain extracellular space does not support a "glymphatic" mechanism. The Journal of general physiology 2016. PMID: 27836940


  80. Cil O, Phuan PW, Gillespie AM, Lee S, Tradtrantip L, Yin J, Tse M, Zachos NC, Lin R, Donowitz M, Verkman AS. Benzopyrimido-pyrrolo-oxazine-dione CFTR inhibitor (R)-BPO-27 for antisecretory therapy of diarrheas caused by bacterial enterotoxins. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016. PMID: 27871064


  81. Felix CM, Levin MH, Verkman AS. Complement-independent retinal pathology produced by intravitreal injection of neuromyelitis optica immunoglobulin G. Journal of neuroinflammation 2016. PMID: 27765056


  82. Cil O, Phuan PW, Son JH, Zhu JS, Ku CK, Tabib NA, Teuthorn AP, Ferrera L, Zachos NC, Lin R, Galietta LJV, Donowitz M, Kurth MJ, Verkman AS. Phenylquinoxalinone CFTR activator as potential prosecretory therapy for constipation. Translational research : the journal of laboratory and clinical medicine 2016. PMID: 27815136


  83. Reed GD, von Morze C, Verkman AS, Koelsch BL, Chaumeil MM, Lustig M, Ronen SM, Bok RA, Sands JM, Larson PE, Wang ZJ, Larsen JH, Kurhanewicz J, Vigneron DB. Imaging Renal Urea Handling in Rats at Millimeter Resolution using Hyperpolarized Magnetic Resonance Relaxometry. Tomography (Ann Arbor, Mich.) 2016. PMID: 27570835


  84. Tradtrantip L, Verkman AS. Aquaporin gene therapy for disorders of cholestasis? Hepatology (Baltimore, Md.) 2016. PMID: 27115396


  85. Ikezoe K, Oga T, Honda T, Hara-Chikuma M, Ma X, Tsuruyama T, Uno K, Fuchikami J, Tanizawa K, Handa T, Taguchi Y, Verkman AS, Narumiya S, Mishima M, Chin K. Aquaporin-3 potentiates allergic airway inflammation in ovalbumin-induced murine asthma. Scientific Reports 2016. PMID: 27165276


  86. Cil O, Haggie PM, Phuan PW, Tan JA, Verkman AS. Small-Molecule Inhibitors of Pendrin Potentiate the Diuretic Action of Furosemide. Journal of the American Society of Nephrology : JASN 2016. PMID: 27153921


  87. Yao X, Su T, Verkman AS. Clobetasol promotes remyelination in a mouse model of neuromyelitis optica. Acta neuropathologica communications 2016. PMID: 27117475


  88. Esteva-Font C, Jin BJ, Lee S, Phuan PW, Anderson MO, Verkman AS. Experimental Evaluation of Proposed Small-Molecule Inhibitors of Water Channel Aquaporin-1. Molecular pharmacology 2016. PMID: 26993802


  89. Haggie PM, Phuan PW, Tan JA, Zlock L, Finkbeiner WE, Verkman AS. Inhibitors of pendrin anion exchange identified in a small molecule screen increase airway surface liquid volume in cystic fibrosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016. PMID: 26932931


  90. Flores AM, Casey SD, Felix CM, Phuan PW, Verkman AS, Levin MH. Small-molecule CFTR activators increase tear secretion and prevent experimental dry eye disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016. PMID: 26842854


  91. Piechowicz KA, Truong EC, Javed KM, Chaney RR, Wu JY, Phuan PW, Verkman AS, Anderson MO. Synthesis and evaluation of 5,6-disubstituted thiopyrimidine aryl aminothiazoles as inhibitors of the calcium-activated chloride channel TMEM16A/Ano1. Journal of enzyme inhibition and medicinal chemistry 2016. PMID: 26796863


  92. Hirt L, Fukuda AM, Ambadipudi K, Rashid F, Binder D, Verkman A, Ashwal S, Obenaus A, Badaut J. Improved long-term outcome after transient cerebral ischemia in aquaporin-4 knockout mice. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2016. PMID: 26767580


  93. Cil O, Phuan PW, Lee S, Tan J, Haggie PM, Levin MH, Sun L, Thiagarajah JR, Ma T, Verkman AS. CFTR activator increases intestinal fluid secretion and normalizes stool output in a mouse model of constipation. Cellular and molecular gastroenterology and hepatology 2016. PMID: 27127798


  94. Smith AJ, Verkman AS. Superresolution Imaging of Aquaporin-4 Cluster Size in Antibody-Stained Paraffin Brain Sections. Biophysical journal 2015. PMID: 26682810


  95. Verkman AS, Edelman A, Amaral M, Mall MA, Beekman JM, Meiners T, Galietta LJ, Bear CE. Finding new drugs to enhance anion secretion in cystic fibrosis: Toward suitable systems for better drug screening. Report on the pre-conference meeting to the 12th ECFS Basic Science Conference, Albufeira, 25-28 March 2015. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2015. PMID: 26474804


  96. Jo AO, Ryskamp DA, Phuong TT, Verkman AS, Yarishkin O, MacAulay N, Križaj D. TRPV4 and AQP4 Channels Synergistically Regulate Cell Volume and Calcium Homeostasis in Retinal Müller Glia. The Journal of neuroscience : the official journal of the Society for Neuroscience 2015. PMID: 26424896


  97. Jin BJ, Esteva-Font C, Verkman AS. Droplet-based microfluidic platform for measurement of rapid erythrocyte water transport. Lab on a chip 2015. PMID: 26159099


  98. Phuan PW, Veit G, Tan JA, Finkbeiner WE, Lukacs GL, Verkman AS. Potentiators of Defective ?F508-CFTR Gating that Do Not Interfere with Corrector Action. Molecular pharmacology 2015. PMID: 26245207


  99. Kim Y, Anderson MO, Park J, Lee MG, Namkung W, Verkman AS. Benzopyrimido-pyrrolo-oxazine-dione (R)-BPO-27 Inhibits CFTR Chloride Channel Gating by Competition with ATP. Molecular pharmacology 2015. PMID: 26174774


  100. Thiagarajah JR, Donowitz M, Verkman AS. Secretory diarrhoea: mechanisms and emerging therapies. Nature reviews. Gastroenterology & hepatology 2015. PMID: 26122478


  101. Hara-Chikuma M, Satooka H, Watanabe S, Honda T, Miyachi Y, Watanabe T, Verkman AS. Aquaporin-3-mediated hydrogen peroxide transport is required for NF-?B signalling in keratinocytes and development of psoriasis. Nature communications 2015. PMID: 26100668


  102. Yao X, Uchida K, Papadopoulos MC, Zador Z, Manley GT, Verkman AS. Mildly Reduced Brain Swelling and Improved Neurological Outcome in Aquaporin-4 Knockout Mice following Controlled Cortical Impact Brain Injury. Journal of neurotrauma 2015. PMID: 25790314


  103. Cil O, Esteva-Font C, Tas ST, Su T, Lee S, Anderson MO, Ertunc M, Verkman AS. Salt-sparing diuretic action of a water-soluble urea analog inhibitor of urea transporters UT-A and UT-B in rats. Kidney international 2015. PMID: 25993324


  104. Smith AJ, Jin BJ, Verkman AS. Muddying the water in brain edema? Trends in neurosciences 2015. PMID: 25980601


  105. Yao X, Smith AJ, Jin BJ, Zador Z, Manley GT, Verkman AS. Aquaporin-4 regulates the velocity and frequency of cortical spreading depression in mice. Glia 2015. PMID: 25944186


  106. Owens GP, Ritchie A, Rossi A, Schaller K, Wemlinger S, Schumann H, Shearer A, Verkman AS, Bennett JL. Mutagenesis of the aquaporin 4 extracellular domains defines restricted binding patterns of pathogenic neuromyelitis optica IgG. The Journal of biological chemistry 2015. PMID: 25792738


  107. Esteva-Font C, Phuan PW, Lee S, Su T, Anderson MO, Verkman AS. Structure-activity analysis of thiourea analogs as inhibitors of UT-A and UT-B urea transporters. Biochimica et biophysica acta 2015. PMID: 25613743


  108. Zhang H, Verkman AS. Aquaporin-1 water permeability as a novel determinant of axonal regeneration in dorsal root ganglion neurons. Experimental neurology 2015. PMID: 25585012


  109. Wang W, Li F, Sun Y, Lei L, Zhou H, Lei T, Xia Y, Verkman AS, Yang B. Aquaporin-1 retards renal cyst development in polycystic kidney disease by inhibition of Wnt signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2015. PMID: 25573755


  110. Lee S, Esteva-Font C, Phuan PW, Anderson MO, Verkman AS. Discovery, synthesis and structure-activity analysis of symmetrical 2,7-disubstituted fluorenones as urea transporter inhibitors. MedChemComm 2015. PMID: 26191399


  111. Esteva-Font C, Anderson MO, Verkman AS. Urea transporter proteins as targets for small-molecule diuretics. Nature reviews. Nephrology 2014. PMID: 25488859


  112. Yao X, Derugin N, Manley GT, Verkman AS. Reduced brain edema and infarct volume in aquaporin-4 deficient mice after transient focal cerebral ischemia. Neuroscience letters 2014. PMID: 25449874


  113. Ye L, Hu B, El-Badri F, Hudson BM, Phuan PW, Verkman AS, Tantillo DJ, Kurth MJ. ?F508-CFTR correctors: synthesis and evaluation of thiazole-tethered imidazolones, oxazoles, oxadiazoles, and thiadiazoles. Bioorganic & medicinal chemistry letters 2014. PMID: 25452003


  114. Malik R, Lewis A, Cree BA, Ratelade J, Rossi A, Verkman AS, Bollen AW, Ralph JW. Transient hyperckemia in the setting of neuromyelitis optica (NMO). Muscle & nerve 2014. PMID: 24862586


  115. Tradtrantip L, Asavapanumas N, Phuan PW, Verkman AS. Potential therapeutic benefit of C1-esterase inhibitor in neuromyelitis optica evaluated in vitro and in an experimental rat model. PloS one 2014. PMID: 25191939


  116. Papadopoulos MC, Bennett JL, Verkman AS. Treatment of neuromyelitis optica: state-of-the-art and emerging therapies. Nature reviews. Neurology 2014. PMID: 25112508


  117. Coffman KC, Nguyen HH, Phuan PW, Hudson BM, Yu GJ, Bagdasarian AL, Montgomery D, Lodewyk MW, Yang B, Yoo CL, Verkman AS, Tantillo DJ, Kurth MJ. Constrained bithiazoles: small molecule correctors of defective ?F508-CFTR protein trafficking. Journal of medicinal chemistry 2014. PMID: 25061695


  118. Veit G, Avramescu RG, Perdomo D, Phuan PW, Bagdany M, Apaja PM, Borot F, Szollosi D, Wu YS, Finkbeiner WE, Hegedus T, Verkman AS, Lukacs GL. Some gating potentiators, including VX-770, diminish ?F508-CFTR functional expression. Science translational medicine 2014. PMID: 25101887


  119. Ratelade J, Verkman AS. Inhibitor(s) of the classical complement pathway in mouse serum limit the utility of mice as experimental models of neuromyelitis optica. Molecular immunology 2014. PMID: 24980869


  120. Esteva-Font C, Cil O, Phuan PW, Su T, Lee S, Anderson MO, Verkman AS. Diuresis and reduced urinary osmolality in rats produced by small-molecule UT-A-selective urea transport inhibitors. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014. PMID: 24843071


  121. Asavapanumas N, Verkman AS. Neuromyelitis optica pathology in rats following intraperitoneal injection of NMO-IgG and intracerebral needle injury. Acta neuropathologica communications 2014. PMID: 24758159


  122. Phuan PW, Veit G, Tan J, Roldan A, Finkbeiner WE, Lukacs GL, Verkman AS. Synergy-based small-molecule screen using a human lung epithelial cell line yields ?F508-CFTR correctors that augment VX-809 maximal efficacy. Molecular pharmacology 2014. PMID: 24737137


  123. Akdemir G, Ratelade J, Asavapanumas N, Verkman AS. Neuroprotective effect of aquaporin-4 deficiency in a mouse model of severe global cerebral ischemia produced by transient 4-vessel occlusion. Neuroscience letters 2014. PMID: 24717641


  124. Jin BJ, Battula S, Zachos N, Kovbasnjuk O, Fawlke-Abel J, In J, Donowitz M, Verkman AS. Microfluidics platform for measurement of volume changes in immobilized intestinal enteroids. Biomicrofluidics 2014. PMID: 24738013


  125. Zhang H, Verkman AS. Longitudinally extensive NMO spinal cord pathology produced by passive transfer of NMO-IgG in mice lacking complement inhibitor CD59. Journal of autoimmunity 2014. PMID: 24698947


  126. Verkman AS, Anderson MO, Papadopoulos MC. Aquaporins: important but elusive drug targets. Nature reviews. Drug discovery 2014. PMID: 24625825


  127. Ratelade J, Smith AJ, Verkman AS. Human immunoglobulin G reduces the pathogenicity of aquaporin-4 autoantibodies in neuromyelitis optica. Experimental neurology 2014. PMID: 24636863


  128. Tradtrantip L, Ko EA, Verkman AS. Antidiarrheal efficacy and cellular mechanisms of a Thai herbal remedy. PLoS neglected tropical diseases 2014. PMID: 24551253


  129. Smith AJ, Jin BJ, Ratelade J, Verkman AS. Aggregation state determines the localization and function of M1- and M23-aquaporin-4 in astrocytes. The Journal of cell biology 2014. PMID: 24515349


  130. Asavapanumas N, Ratelade J, Papadopoulos MC, Bennett JL, Levin MH, Verkman AS. Experimental mouse model of optic neuritis with inflammatory demyelination produced by passive transfer of neuromyelitis optica-immunoglobulin G. Journal of neuroinflammation 2014. PMID: 24468108


  131. Verkman AS, Esteva-Font C, Cil O, Anderson MO, Li F, Li M, Lei T, Ren H, Yang B. Small-molecule inhibitors of urea transporters. Sub-cellular biochemistry 2014. PMID: 25298345


  132. Esteva-Font C, Jin BJ, Verkman AS. Aquaporin-1 gene deletion reduces breast tumor growth and lung metastasis in tumor-producing MMTV-PyVT mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013. PMID: 24334548


  133. Rama Rao KV, Verkman AS, Curtis KM, Norenberg MD. Aquaporin-4 deletion in mice reduces encephalopathy and brain edema in experimental acute liver failure. Neurobiology of disease 2013. PMID: 24321433


  134. Thiagarajah JR, Ko EA, Tradtrantip L, Donowitz M, Verkman AS. Discovery and development of antisecretory drugs for treating diarrheal diseases. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2013. PMID: 24316107


  135. Blanchard E, Zlock L, Lao A, Mika D, Namkung W, Xie M, Scheitrum C, Gruenert DC, Verkman AS, Finkbeiner WE, Conti M, Richter W. Anchored PDE4 regulates chloride conductance in wild-type and ?F508-CFTR human airway epithelia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013. PMID: 24200884


  136. Asavapanumas N, Ratelade J, Verkman AS. Unique neuromyelitis optica pathology produced in naïve rats by intracerebral administration of NMO-IgG. Acta neuropathologica 2013. PMID: 24190619


  137. Verkman AS, Phuan PW, Asavapanumas N, Tradtrantip L. Biology of AQP4 and anti-AQP4 antibody: therapeutic implications for NMO. Brain pathology (Zurich, Switzerland) 2013. PMID: 24118484


  138. Katada R, Akdemir G, Asavapanumas N, Ratelade J, Zhang H, Verkman AS. Greatly improved survival and neuroprotection in aquaporin-4-knockout mice following global cerebral ischemia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013. PMID: 24186965


  139. Singh V, Yang J, Chen TE, Zachos NC, Kovbasnjuk O, Verkman AS, Donowitz M. Translating molecular physiology of intestinal transport into pharmacologic treatment of diarrhea: stimulation of Na+ absorption. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2013. PMID: 24184676


  140. Jin BJ, Ko EA, Namkung W, Verkman AS. Microfluidics platform for single-shot dose-response analysis of chloride channel-modulating compounds. Lab on a chip 2013. PMID: 23907501


  141. Esteva-Font C, Phuan PW, Anderson MO, Verkman AS. A small molecule screen identifies selective inhibitors of urea transporter UT-A. Chemistry & biology 2013. PMID: 24055006


  142. Ko EA, Jin BJ, Namkung W, Ma T, Thiagarajah JR, Verkman AS. Chloride channel inhibition by a red wine extract and a synthetic small molecule prevents rotaviral secretory diarrhoea in neonatal mice. Gut 2013. PMID: 24052273


  143. Ratelade J, Asavapanumas N, Ritchie AM, Wemlinger S, Bennett JL, Verkman AS. Involvement of antibody-dependent cell-mediated cytotoxicity in inflammatory demyelination in a mouse model of neuromyelitis optica. Acta neuropathologica 2013. PMID: 23995423


  144. Thiagarajah JR, Verkman AS. Chloride channel-targeted therapy for secretory diarrheas. Current opinion in pharmacology 2013. PMID: 23992767


  145. Valentine CD, Zhang H, Phuan PW, Nguyen J, Verkman AS, Haggie PM. Small molecule screen yields inhibitors of Pseudomonas homoserine lactone-induced host responses. Cellular microbiology 2013. PMID: 23910799


  146. Verkman AS. Diffusion in the extracellular space in brain and tumors. Physical biology 2013. PMID: 23913007


  147. Jin BJ, Thiagarajah JR, Verkman AS. Response to "Diffusion versus convection". The Journal of general physiology 2013. PMID: 23898009


  148. Rowe SM, Verkman AS. Cystic fibrosis transmembrane regulator correctors and potentiators. Cold Spring Harbor perspectives in medicine 2013. PMID: 23818513


  149. Namkung W, Park J, Seo Y, Verkman AS. Novel amino-carbonitrile-pyrazole identified in a small molecule screen activates wild-type and ?F508 cystic fibrosis transmembrane conductance regulator in the absence of a cAMP agonist. Molecular pharmacology 2013. PMID: 23788656


  150. Jin BJ, Zhang H, Binder DK, Verkman AS. Response to "When can AQP4 assist transporter-mediated K? uptake?". The Journal of general physiology 2013. PMID: 23752331


  151. Phuan PW, Zhang H, Asavapanumas N, Leviten M, Rosenthal A, Tradtrantip L, Verkman AS. C1q-targeted monoclonal antibody prevents complement-dependent cytotoxicity and neuropathology in in vitro and mouse models of neuromyelitis optica. Acta neuropathologica 2013. PMID: 23677375


  152. Okiyoneda T, Veit G, Dekkers JF, Bagdany M, Soya N, Xu H, Roldan A, Verkman AS, Kurth M, Simon A, Hegedus T, Beekman JM, Lukacs GL. Mechanism-based corrector combination restores ?F508-CFTR folding and function. Nature chemical biology 2013. PMID: 23666117


  153. Snyder DS, Tradtrantip L, Battula S, Yao C, Phuan PW, Fettinger JC, Kurth MJ, Verkman AS. ABSOLUTE CONFIGURATION AND BIOLOGICAL PROPERTIES OF ENANTIOMERS OF CFTR INHIBITOR BPO-27. ACS medicinal chemistry letters 2013. PMID: 23814642


  154. Tradtrantip L, Asavapanumas N, Verkman AS. Therapeutic cleavage of anti-aquaporin-4 autoantibody in neuromyelitis optica by an IgG-selective proteinase. Molecular pharmacology 2013. PMID: 23571414


  155. Zhang H, Verkman AS. Eosinophil pathogenicity mechanisms and therapeutics in neuromyelitis optica. The Journal of clinical investigation 2013. PMID: 23563310


  156. Liu Y, Esteva-Font C, Yao C, Phuan PW, Verkman AS, Anderson MO. 1,1-Difluoroethyl-substituted triazolothienopyrimidines as inhibitors of a human urea transport protein (UT-B): new analogs and binding model. Bioorganic & medicinal chemistry letters 2013. PMID: 23597791


  157. Levin MH, Bennett JL, Verkman AS. Optic neuritis in neuromyelitis optica. Progress in retinal and eye research 2013. PMID: 23545439


  158. Papadopoulos MC, Verkman AS. Aquaporin water channels in the nervous system. Nature reviews. Neuroscience 2013. PMID: 23481483


  159. Jin BJ, Thiagarajah JR, Verkman AS. Convective washout reduces the antidiarrheal efficacy of enterocyte surface-targeted antisecretory drugs. The Journal of general physiology 2013. PMID: 23359285


  160. Davis AJ, Shi J, Pritchard HA, Chadha PS, Leblanc N, Vasilikostas G, Yao Z, Verkman AS, Albert AP, Greenwood IA. Potent vasorelaxant activity of the TMEM16A inhibitor T16A(inh) -A01. British journal of pharmacology 2013. PMID: 22946562


  161. Verkman AS. Aquaporins. Current biology : CB 2013. PMID: 23347934


  162. Jin BJ, Zhang H, Binder DK, Verkman AS. Aquaporin-4-dependent K(+) and water transport modeled in brain extracellular space following neuroexcitation. The Journal of general physiology 2013. PMID: 23277478


  163. Verkman AS, Synder D, Tradtrantip L, Thiagarajah JR, Anderson MO. CFTR inhibitors. Current pharmaceutical design 2013. PMID: 23331030


  164. Saadoun S, Bridges LR, Verkman AS, Papadopoulos MC. Paucity of natural killer and cytotoxic T cells in human neuromyelitis optica lesions. Neuroreport 2012. PMID: 23108041


  165. Valentine CD, Lukacs GL, Verkman AS, Haggie PM. Reduced PDZ interactions of rescued ?F508CFTR increases its cell surface mobility. The Journal of biological chemistry 2012. PMID: 23115232


  166. Tradtrantip L, Ratelade J, Zhang H, Verkman AS. Enzymatic deglycosylation converts pathogenic neuromyelitis optica anti-aquaporin-4 immunoglobulin G into therapeutic antibody. Annals of neurology 2012. PMID: 23055279


  167. Phuan PW, Anderson MO, Tradtrantip L, Zhang H, Tan J, Lam C, Bennett JL, Verkman AS. A small-molecule screen yields idiotype-specific blockers of neuromyelitis optica immunoglobulin G binding to aquaporin-4. The Journal of biological chemistry 2012. PMID: 22989877


  168. Rossi A, Ratelade J, Papadopoulos MC, Bennett JL, Verkman AS. Neuromyelitis optica IgG does not alter aquaporin-4 water permeability, plasma membrane M1/M23 isoform content, or supramolecular assembly. Glia 2012. PMID: 22987455


  169. Veit G, Bossard F, Goepp J, Verkman AS, Galietta LJ, Hanrahan JW, Lukacs GL. Proinflammatory cytokine secretion is suppressed by TMEM16A or CFTR channel activity in human cystic fibrosis bronchial epithelia. Molecular biology of the cell 2012. PMID: 22973054


  170. Hara-Chikuma M, Chikuma S, Sugiyama Y, Kabashima K, Verkman AS, Inoue S, Miyachi Y. Chemokine-dependent T cell migration requires aquaporin-3-mediated hydrogen peroxide uptake. The Journal of experimental medicine 2012. PMID: 22927550


  171. Thiagarajah JR, Verkman AS. CFTR inhibitors for treating diarrheal disease. Clinical pharmacology and therapeutics 2012. PMID: 22850599


  172. Donald MB, Rodriguez KX, Shay H, Phuan PW, Verkman AS, Kurth MJ. Click-based synthesis of triazolobithiazole ?F508-CFTR correctors for cystic fibrosis. Bioorganic & medicinal chemistry 2012. PMID: 22841006


  173. Rossi A, Moritz TJ, Ratelade J, Verkman AS. Super-resolution imaging of aquaporin-4 orthogonal arrays of particles in cell membranes. Journal of cell science 2012. PMID: 22718347


  174. Anderson MO, Zhang J, Liu Y, Yao C, Phuan PW, Verkman AS. Nanomolar potency and metabolically stable inhibitors of kidney urea transporter UT-B. Journal of medicinal chemistry 2012. PMID: 22694147


  175. Ratelade J, Verkman AS. Neuromyelitis optica: aquaporin-4 based pathogenesis mechanisms and new therapies. The international journal of biochemistry & cell biology 2012. PMID: 22713791


  176. Kumar S, Namkung W, Verkman AS, Sharma PK. Novel 5-substituted benzyloxy-2-arylbenzofuran-3-carboxylic acids as calcium activated chloride channel inhibitors. Bioorganic & medicinal chemistry 2012. PMID: 22739085


  177. Yao Z, Namkung W, Ko EA, Park J, Tradtrantip L, Verkman AS. Fractionation of a herbal antidiarrheal medicine reveals eugenol as an inhibitor of Ca2+-Activated Cl- channel TMEM16A. PloS one 2012. PMID: 22666439


  178. Papadopoulos MC, Verkman AS. Aquaporin 4 and neuromyelitis optica. The Lancet. Neurology 2012. PMID: 22608667


  179. Rossi A, Ratelade J, Papadopoulos MC, Bennett JL, Verkman AS. Consequences of NMO-IgG binding to aquaporin-4 in neuromyelitis optica. Proceedings of the National Academy of Sciences of the United States of America 2012. PMID: 22589299


  180. Ratelade J, Zhang H, Saadoun S, Bennett JL, Papadopoulos MC, Verkman AS. Neuromyelitis optica IgG and natural killer cells produce NMO lesions in mice without myelin loss. Acta neuropathologica 2012. PMID: 22526022


  181. Yao C, Anderson MO, Zhang J, Yang B, Phuan PW, Verkman AS. Triazolothienopyrimidine inhibitors of urea transporter UT-B reduce urine concentration. Journal of the American Society of Nephrology : JASN 2012. PMID: 22491419


  182. Phuan PW, Ratelade J, Rossi A, Tradtrantip L, Verkman AS. Complement-dependent cytotoxicity in neuromyelitis optica requires aquaporin-4 protein assembly in orthogonal arrays. The Journal of biological chemistry 2012. PMID: 22393049


  183. Saadoun S, Waters P, MacDonald C, Bell BA, Vincent A, Verkman AS, Papadopoulos MC. Neutrophil protease inhibition reduces neuromyelitis optica-immunoglobulin G-induced damage in mouse brain. Annals of neurology 2012. PMID: 22374891


  184. Tradtrantip L, Zhang H, Anderson MO, Saadoun S, Phuan PW, Papadopoulos MC, Bennett JL, Verkman AS. Small-molecule inhibitors of NMO-IgG binding to aquaporin-4 reduce astrocyte cytotoxicity in neuromyelitis optica. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012. PMID: 22319008


  185. Tradtrantip L, Zhang H, Saadoun S, Phuan PW, Lam C, Papadopoulos MC, Bennett JL, Verkman AS. Anti-aquaporin-4 monoclonal antibody blocker therapy for neuromyelitis optica. Annals of neurology 2012. PMID: 22271321


  186. Knapp JM, Wood AB, Phuan PW, Lodewyk MW, Tantillo DJ, Verkman AS, Kurth MJ. Structure-activity relationships of cyanoquinolines with corrector-potentiator activity in ?F508 cystic fibrosis transmembrane conductance regulator protein. Journal of medicinal chemistry 2012. PMID: 22214395


  187. Davison HR, Solano DM, Phuan PW, Verkman AS, Kurth MJ. Fluorinated ?F508-CFTR correctors and potentiators for PET imaging. Bioorganic & medicinal chemistry letters 2012. PMID: 22281185


  188. Verkman AS. Aquaporins in clinical medicine. Annual review of medicine 2012. PMID: 22248325


  189. Baumgart F, Rossi A, Verkman AS. Light inactivation of water transport and protein-protein interactions of aquaporin-Killer Red chimeras. The Journal of general physiology 2012. PMID: 22200949


  190. Verkman AS, Rossi A, Crane JM. Live-cell imaging of aquaporin-4 supramolecular assembly and diffusion. Methods in enzymology 2012. PMID: 22264543


  191. Lukacs GL, Verkman AS. CFTR: folding, misfolding and correcting the ?F508 conformational defect. Trends in molecular medicine 2011. PMID: 22138491


  192. Davison HR, Taylor S, Drake C, Phuan PW, Derichs N, Yao C, Jones EF, Sutcliffe J, Verkman AS, Kurth MJ. Functional fluorescently labeled bithiazole ?F508-CFTR corrector imaged in whole body slices in mice. Bioconjugate chemistry 2011. PMID: 22034937


  193. Ratelade J, Bennett JL, Verkman AS. Evidence against cellular internalization in vivo of NMO-IgG, aquaporin-4, and excitatory amino acid transporter 2 in neuromyelitis optica. The Journal of biological chemistry 2011. PMID: 22069320


  194. Zhang H, Bennett JL, Verkman AS. Ex vivo spinal cord slice model of neuromyelitis optica reveals novel immunopathogenic mechanisms. Annals of neurology 2011. PMID: 22069219


  195. Rossi A, Baumgart F, van Hoek AN, Verkman AS. Post-Golgi supramolecular assembly of aquaporin-4 in orthogonal arrays. Traffic (Copenhagen, Denmark) 2011. PMID: 21981006


  196. Ratelade J, Bennett JL, Verkman AS. Intravenous neuromyelitis optica autoantibody in mice targets aquaporin-4 in peripheral organs and area postrema. PloS one 2011. PMID: 22076159


  197. Valentine CD, Verkman AS, Haggie PM. Protein trafficking rates assessed by quantum dot quenching with bromocresol green. Traffic (Copenhagen, Denmark) 2011. PMID: 21951589


  198. Namkung W, Yao Z, Finkbeiner WE, Verkman AS. Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011. PMID: 21836025


  199. Snyder DS, Tradtrantip L, Yao C, Kurth MJ, Verkman AS. Potent, metabolically stable benzopyrimido-pyrrolo-oxazine-dione (BPO) CFTR inhibitors for polycystic kidney disease. Journal of medicinal chemistry 2011. PMID: 21707078


  200. Phuan PW, Yang B, Knapp JM, Wood AB, Lukacs GL, Kurth MJ, Verkman AS. Cyanoquinolines with independent corrector and potentiator activities restore ?Phe508-cystic fibrosis transmembrane conductance regulator chloride channel function in cystic fibrosis. Molecular pharmacology 2011. PMID: 21730204


  201. Verkman AS. Aquaporins at a glance. Journal of cell science 2011. PMID: 21670197


  202. Jin BJ, Rossi A, Verkman AS. Model of aquaporin-4 supramolecular assembly in orthogonal arrays based on heterotetrameric association of M1-M23 isoforms. Biophysical journal 2011. PMID: 21689527


  203. Crane JM, Rossi A, Gupta T, Bennett JL, Verkman AS. Orthogonal array formation by human aquaporin-4: examination of neuromyelitis optica-associated aquaporin-4 polymorphisms. Journal of neuroimmunology 2011. PMID: 21621278


  204. Verkman AS, Ratelade J, Rossi A, Zhang H, Tradtrantip L. Aquaporin-4: orthogonal array assembly, CNS functions, and role in neuromyelitis optica. Acta pharmacologica Sinica 2011. PMID: 21552296


  205. Skucas VA, Mathews IB, Yang J, Cheng Q, Treister A, Duffy AM, Verkman AS, Hempstead BL, Wood MA, Binder DK, Scharfman HE. Impairment of select forms of spatial memory and neurotrophin-dependent synaptic plasticity by deletion of glial aquaporin-4. The Journal of neuroscience : the official journal of the Society for Neuroscience 2011. PMID: 21525279


  206. Saadoun S, Waters P, Macdonald C, Bridges LR, Bell BA, Vincent A, Verkman AS, Papadopoulos MC. T cell deficiency does not reduce lesions in mice produced by intracerebral injection of NMO-IgG and complement. Journal of neuroimmunology 2011. PMID: 21492943


  207. Rossi A, Crane JM, Verkman AS. Aquaporin-4 Mz isoform: brain expression, supramolecular assembly and neuromyelitis optica antibody binding. Glia 2011. PMID: 21491501


  208. Derichs N, Jin BJ, Song Y, Finkbeiner WE, Verkman AS. Hyperviscous airway periciliary and mucous liquid layers in cystic fibrosis measured by confocal fluorescence photobleaching. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011. PMID: 21427214


  209. Crane JM, Lam C, Rossi A, Gupta T, Bennett JL, Verkman AS. Binding affinity and specificity of neuromyelitis optica autoantibodies to aquaporin-4 M1/M23 isoforms and orthogonal arrays. The Journal of biological chemistry 2011. PMID: 21454592


  210. Carpenter RD, Verkman AS. Function-Oriented Synthesis of a Didesmethyl Triazacryptand Analogue for Fluorescent Potassium Ion Sensing. European journal of organic chemistry 2011. PMID: 23914138


  211. Li L, Zhang H, Varrin-Doyer M, Zamvil SS, Verkman AS. Proinflammatory role of aquaporin-4 in autoimmune neuroinflammation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011. PMID: 21257712


  212. Nakahigashi K, Kabashima K, Ikoma A, Verkman AS, Miyachi Y, Hara-Chikuma M. Upregulation of aquaporin-3 is involved in keratinocyte proliferation and epidermal hyperplasia. The Journal of investigative dermatology 2010. PMID: 21191421


  213. Namkung W, Phuan PW, Verkman AS. TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells. The Journal of biological chemistry 2010. PMID: 21084298


  214. Wang D, Nykanen M, Yang N, Winlaw D, North K, Verkman AS, Owler BK. Altered cellular localization of aquaporin-1 in experimental hydrocephalus in mice and reduced ventriculomegaly in aquaporin-1 deficiency. Molecular and cellular neurosciences 2010. PMID: 21040788


  215. Thiagarajah JR, Song Y, Derichs N, Verkman AS. Airway surface liquid depth imaged by surface laser reflectance microscopy. The Journal of general physiology 2010. PMID: 20713545


  216. Zhang H, Verkman AS. Microfiberoptic measurement of extracellular space volume in brain and tumor slices based on fluorescent dye partitioning. Biophysical journal 2010. PMID: 20713014


  217. Namkung W, Thiagarajah JR, Phuan PW, Verkman AS. Inhibition of Ca2+-activated Cl- channels by gallotannins as a possible molecular basis for health benefits of red wine and green tea. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010. PMID: 20581223


  218. Namkung W, Finkbeiner WE, Verkman AS. CFTR-adenylyl cyclase I association responsible for UTP activation of CFTR in well-differentiated primary human bronchial cell cultures. Molecular biology of the cell 2010. PMID: 20554763


  219. Kimura A, Hsu M, Seldin M, Verkman AS, Scharfman HE, Binder DK. Protective role of aquaporin-4 water channels after contusion spinal cord injury. Annals of neurology 2010. PMID: 20517941


  220. Ye L, Knapp JM, Sangwung P, Fettinger JC, Verkman AS, Kurth MJ. Pyrazolylthiazole as DeltaF508-cystic fibrosis transmembrane conductance regulator correctors with improved hydrophilicity compared to bithiazoles. Journal of medicinal chemistry 2010. PMID: 20373765


  221. Yu GJ, Yang B, Verkman AS, Kurth MJ. Isoxazolopyrimidines as Novel ?F508-CFTR Correctors. Synlett : accounts and rapid communications in synthetic organic chemistry 2010. PMID: 23710112


  222. Carpenter RD, Verkman AS. Synthesis of a sensitive and selective potassium-sensing fluoroionophore. Organic letters 2010. PMID: 20148571


  223. Tait MJ, Saadoun S, Bell BA, Verkman AS, Papadopoulos MC. Increased brain edema in aqp4-null mice in an experimental model of subarachnoid hemorrhage. Neuroscience 2010. PMID: 20132873


  224. Tajima M, Crane JM, Verkman AS. Aquaporin-4 (AQP4) associations and array dynamics probed by photobleaching and single-molecule analysis of green fluorescent protein-AQP4 chimeras. The Journal of biological chemistry 2010. PMID: 20071343


  225. Saadoun S, Waters P, Bell BA, Vincent A, Verkman AS, Papadopoulos MC. Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice. Brain : a journal of neurology 2010. PMID: 20047900


  226. Crane JM, Bennett JL, Verkman AS. Live cell analysis of aquaporin-4 m1/m23 interactions and regulated orthogonal array assembly in glial cells. The Journal of biological chemistry 2009. PMID: 19843522


  227. Zhang H, Verkman AS. Aquaporin-1 tunes pain perception by interaction with Na(v)1.8 Na+ channels in dorsal root ganglion neurons. The Journal of biological chemistry 2009. PMID: 20018876


  228. Crane JM, Verkman AS. Reversible, temperature-dependent supramolecular assembly of aquaporin-4 orthogonal arrays in live cell membranes. Biophysical journal 2009. PMID: 19948131


  229. Mills AD, Yoo C, Butler JD, Yang B, Verkman AS, Kurth MJ. Design and synthesis of a hybrid potentiator-corrector agonist of the cystic fibrosis mutant protein DeltaF508-CFTR. Bioorganic & medicinal chemistry letters 2009. PMID: 19954980


  230. Tradtrantip L, Sonawane ND, Namkung W, Verkman AS. Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model. Journal of medicinal chemistry 2009. PMID: 19785436


  231. Song Y, Namkung W, Nielson DW, Lee JW, Finkbeiner WE, Verkman AS. Airway surface liquid depth measured in ex vivo fragments of pig and human trachea: dependence on Na+ and Cl- channel function. American journal of physiology. Lung cellular and molecular physiology 2009. PMID: 19820035


  232. Tradtrantip L, Namkung W, Verkman AS. Crofelemer, an antisecretory antidiarrheal proanthocyanidin oligomer extracted from Croton lechleri, targets two distinct intestinal chloride channels. Molecular pharmacology 2009. PMID: 19808995


  233. Crane JM, Tajima M, Verkman AS. Live-cell imaging of aquaporin-4 diffusion and interactions in orthogonal arrays of particles. Neuroscience 2009. PMID: 19699275


  234. Li L, Zhang H, Verkman AS. Greatly attenuated experimental autoimmune encephalomyelitis in aquaporin-4 knockout mice. BMC neuroscience 2009. PMID: 19660138


  235. Verkman AS. Aquaporins: translating bench research to human disease. The Journal of experimental biology 2009. PMID: 19448080


  236. Namkung W, Song Y, Mills AD, Padmawar P, Finkbeiner WE, Verkman AS. In situ measurement of airway surface liquid [K+] using a ratioable K+-sensitive fluorescent dye. The Journal of biological chemistry 2009. PMID: 19364771


  237. Saadoun S, Tait MJ, Reza A, Davies DC, Bell BA, Verkman AS, Papadopoulos MC. AQP4 gene deletion in mice does not alter blood-brain barrier integrity or brain morphology. Neuroscience 2009. PMID: 19345723


  238. Feng X, Papadopoulos MC, Liu J, Li L, Zhang D, Zhang H, Verkman AS, Ma T. Sporadic obstructive hydrocephalus in Aqp4 null mice. Journal of neuroscience research 2009. PMID: 18951529


  239. Haggie PM, Verkman AS. Defective organellar acidification as a cause of cystic fibrosis lung disease: reexamination of a recurring hypothesis. American journal of physiology. Lung cellular and molecular physiology 2009. PMID: 19329540


  240. Magzoub M, Zhang H, Dix JA, Verkman AS. Extracellular space volume measured by two-color pulsed dye infusion with microfiberoptic fluorescence photodetection. Biophysical journal 2009. PMID: 19289063


  241. Ruiz-Ederra J, Verkman AS. Aquaporin-1-facilitated keratocyte migration in cell culture and in vivo corneal wound healing models. Experimental eye research 2009. PMID: 19298815


  242. Crane JM, Haggie PM, Verkman AS. QUANTUM DOT SINGLE MOLECULE TRACKING REVEALS A WIDE RANGE OF DIFFUSIVE MOTIONS OF MEMBRANE TRANSPORT PROTEINS. Proceedings of SPIE--the International Society for Optical Engineering 2009. PMID: 24386532


  243. Crane JM, Verkman AS. Determinants of aquaporin-4 assembly in orthogonal arrays revealed by live-cell single-molecule fluorescence imaging. Journal of cell science 2009. PMID: 19240114


  244. Hara-Chikuma M, Takahashi K, Chikuma S, Verkman AS, Miyachi Y. The expression of differentiation markers in aquaporin-3 deficient epidermis. Archives of dermatological research 2009. PMID: 19184071


  245. Li L, Zhang H, Ma T, Verkman AS. Very high aquaporin-1 facilitated water permeability in mouse gallbladder. American journal of physiology. Gastrointestinal and liver physiology 2009. PMID: 19179619


  246. Ruiz-Ederra J, Levin MH, Verkman AS. In situ fluorescence measurement of tear film [Na+], [K+], [Cl-], and pH in mice shows marked hypertonicity in aquaporin-5 deficiency. Investigative ophthalmology & visual science 2009. PMID: 19136711


  247. Haggie PM, Verkman AS. Unimpaired lysosomal acidification in respiratory epithelial cells in cystic fibrosis. The Journal of biological chemistry 2009. PMID: 19136560


  248. Tradtrantip L, Tajima M, Li L, Verkman AS. Aquaporin water channels in transepithelial fluid transport. The journal of medical investigation : JMI 2009. PMID: 20224178


  249. Verkman AS. Knock-out models reveal new aquaporin functions. Handbook of experimental pharmacology 2009. PMID: 19096787


  250. Yang B, Zhao D, Verkman AS. Hsp90 inhibitor partially corrects nephrogenic diabetes insipidus in a conditional knock-in mouse model of aquaporin-2 mutation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008. PMID: 18854434


  251. Tradtrantip L, Yangthara B, Padmawar P, Morrison C, Verkman AS. Thiophenecarboxylate suppressor of cyclic nucleotides discovered in a small-molecule screen blocks toxin-induced intestinal fluid secretion. Molecular pharmacology 2008. PMID: 18824527


  252. Yu GJ, Yoo CL, Yang B, Lodewyk MW, Meng L, El-Idreesy TT, Fettinger JC, Tantillo DJ, Verkman AS, Kurth MJ. Potent s-cis-locked bithiazole correctors of DeltaF508 cystic fibrosis transmembrane conductance regulator cellular processing for cystic fibrosis therapy. Journal of medicinal chemistry 2008. PMID: 18788728


  253. Zhang H, Verkman AS. Evidence against involvement of aquaporin-4 in cell-cell adhesion. Journal of molecular biology 2008. PMID: 18708067


  254. Sonawane ND, Verkman AS. Thiazolidinone CFTR inhibitors with improved water solubility identified by structure-activity analysis. Bioorganic & medicinal chemistry 2008. PMID: 18691893


  255. Sonawane ND, Zhao D, Zegarra-Moran O, Galietta LJ, Verkman AS. Nanomolar CFTR inhibition by pore-occluding divalent polyethylene glycol-malonic acid hydrazides. Chemistry & biology 2008. PMID: 18635008


  256. Haggie PM, Verkman AS. Monomeric CFTR in plasma membranes in live cells revealed by single molecule fluorescence imaging. The Journal of biological chemistry 2008. PMID: 18617526


  257. Caci E, Caputo A, Hinzpeter A, Arous N, Fanen P, Sonawane N, Verkman AS, Ravazzolo R, Zegarra-Moran O, Galietta LJ. Evidence for direct CFTR inhibition by CFTR(inh)-172 based on Arg347 mutagenesis. The Biochemical journal 2008. PMID: 18366345


  258. Hara-Chikuma M, Verkman AS. Roles of aquaporin-3 in the epidermis. The Journal of investigative dermatology 2008. PMID: 18548108


  259. Yang B, Zhang H, Verkman AS. Lack of aquaporin-4 water transport inhibition by antiepileptics and arylsulfonamides. Bioorganic & medicinal chemistry 2008. PMID: 18572411


  260. Namkung W, Padmawar P, Mills AD, Verkman AS. Cell-based fluorescence screen for K+ channels and transporters using an extracellular triazacryptand-based K+ sensor. Journal of the American Chemical Society 2008. PMID: 18512924


  261. Lu DC, Zhang H, Zador Z, Verkman AS. Impaired olfaction in mice lacking aquaporin-4 water channels. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008. PMID: 18511552


  262. Verkman AS. From the farm to the lab: the pig as a new model of cystic fibrosis lung disease. American journal of physiology. Lung cellular and molecular physiology 2008. PMID: 18502814


  263. Verkman AS, Ruiz-Ederra J, Levin MH. Functions of aquaporins in the eye. Progress in retinal and eye research 2008. PMID: 18501660


  264. Crane JM, Van Hoek AN, Skach WR, Verkman AS. Aquaporin-4 dynamics in orthogonal arrays in live cells visualized by quantum dot single particle tracking. Molecular biology of the cell 2008. PMID: 18495865


  265. Verkman AS. Mammalian aquaporins: diverse physiological roles and potential clinical significance. Expert reviews in molecular medicine 2008. PMID: 18482462


  266. Jin S, Zador Z, Verkman AS. Random-walk model of diffusion in three dimensions in brain extracellular space: comparison with microfiberoptic photobleaching measurements. Biophysical journal 2008. PMID: 18469079


  267. Verkman AS. Dissecting the roles of aquaporins in renal pathophysiology using transgenic mice. Seminars in nephrology 2008. PMID: 18519083


  268. Yang B, Sonawane ND, Zhao D, Somlo S, Verkman AS. Small-molecule CFTR inhibitors slow cyst growth in polycystic kidney disease. Journal of the American Society of Nephrology : JASN 2008. PMID: 18385427


  269. Yang B, Zador Z, Verkman AS. Glial cell aquaporin-4 overexpression in transgenic mice accelerates cytotoxic brain swelling. The Journal of biological chemistry 2008. PMID: 18375385


  270. Yoo CL, Yu GJ, Yang B, Robins LI, Verkman AS, Kurth MJ. 4'-Methyl-4,5'-bithiazole-based correctors of defective delta F508-CFTR cellular processing. Bioorganic & medicinal chemistry letters 2008. PMID: 18394886


  271. Verkman AS, Hara-Chikuma M, Papadopoulos MC. Aquaporins--new players in cancer biology. Journal of molecular medicine (Berlin, Germany) 2008. PMID: 18311471


  272. Verkman AS. A cautionary note on cosmetics containing ingredients that increase aquaporin-3 expression. Experimental dermatology 2008. PMID: 18312385


  273. Sonawane ND, Zegarra-Moran O, Namkung W, Galietta LJ, Verkman AS. Alpha-aminoazaheterocyclic-methylglyoxal adducts do not inhibit cystic fibrosis transmembrane conductance regulator chloride channel activity. The Journal of pharmacology and experimental therapeutics 2008. PMID: 18272811


  274. Saadoun S, Bell BA, Verkman AS, Papadopoulos MC. Greatly improved neurological outcome after spinal cord compression injury in AQP4-deficient mice. Brain : a journal of neurology 2008. PMID: 18267965


  275. Verkman AS, Galietta LJ. Chloride channels as drug targets. Nature reviews. Drug discovery 2008. PMID: 19153558


  276. Dix JA, Verkman AS. Crowding effects on diffusion in solutions and cells. Annual review of biophysics 2008. PMID: 18573081


  277. Papadopoulos MC, Verkman AS. Potential utility of aquaporin modulators for therapy of brain disorders. Progress in brain research 2008. PMID: 18655912


  278. De La Fuente R, Namkung W, Mills A, Verkman AS. Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel. Molecular pharmacology 2007. PMID: 18083779


  279. Hara-Chikuma M, Verkman AS. Aquaporin-3 facilitates epidermal cell migration and proliferation during wound healing. Journal of molecular medicine (Berlin, Germany) 2007. PMID: 17968524


  280. Papadopoulos MC, Saadoun S, Verkman AS. Aquaporins and cell migration. Pflugers Archiv : European journal of physiology 2007. PMID: 17968585


  281. Hara-Chikuma M, Verkman AS. Prevention of skin tumorigenesis and impairment of epidermal cell proliferation by targeted aquaporin-3 gene disruption. Molecular and cellular biology 2007. PMID: 17967887


  282. Zador Z, Magzoub M, Jin S, Manley GT, Papadopoulos MC, Verkman AS. Microfiberoptic fluorescence photobleaching reveals size-dependent macromolecule diffusion in extracellular space deep in brain. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007. PMID: 17965267


  283. Ruiz-Ederra J, Verkman AS. Aquaporin-1 independent microvessel proliferation in a neonatal mouse model of oxygen-induced retinopathy. Investigative ophthalmology & visual science 2007. PMID: 17898307


  284. Crane JM, Verkman AS. Long-range nonanomalous diffusion of quantum dot-labeled aquaporin-1 water channels in the cell plasma membrane. Biophysical journal 2007. PMID: 17890385


  285. Magzoub M, Jin S, Verkman AS. Enhanced macromolecule diffusion deep in tumors after enzymatic digestion of extracellular matrix collagen and its associated proteoglycan decorin. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007. PMID: 17761521


  286. Haggie PM, Verkman AS. Cystic fibrosis transmembrane conductance regulator-independent phagosomal acidification in macrophages. The Journal of biological chemistry 2007. PMID: 17724021


  287. Zhang H, Verkman AS. Aquaporin-4 independent Kir4.1 K+ channel function in brain glial cells. Molecular and cellular neurosciences 2007. PMID: 17869537


  288. Thiagarajah JR, Zhao D, Verkman AS. Impaired enterocyte proliferation in aquaporin-3 deficiency in mouse models of colitis. Gut 2007. PMID: 17573386


  289. Ruiz-Ederra J, Zhang H, Verkman AS. Evidence against functional interaction between aquaporin-4 water channels and Kir4.1 potassium channels in retinal Müller cells. The Journal of biological chemistry 2007. PMID: 17525153


  290. Jin S, Haggie PM, Verkman AS. Single-particle tracking of membrane protein diffusion in a potential: simulation, detection, and application to confined diffusion of CFTR Cl- channels. Biophysical journal 2007. PMID: 17483157


  291. Yangthara B, Mills A, Chatsudthipong V, Tradtrantip L, Verkman AS. Small-molecule vasopressin-2 receptor antagonist identified by a g-protein coupled receptor "pathway" screen. Molecular pharmacology 2007. PMID: 17435162


  292. Jin S, Verkman AS. Single particle tracking of complex diffusion in membranes: simulation and detection of barrier, raft, and interaction phenomena. The journal of physical chemistry. B 2007. PMID: 17388520


  293. Papadopoulos MC, Verkman AS. Aquaporin-4 and brain edema. Pediatric nephrology (Berlin, Germany) 2007. PMID: 17347837


  294. Verkman AS. Role of aquaporins in lung liquid physiology. Respiratory physiology & neurobiology 2007. PMID: 17369110


  295. Sonawane ND, Zhao D, Zegarra-Moran O, Galietta LJ, Verkman AS. Lectin conjugates as potent, nonabsorbable CFTR inhibitors for reducing intestinal fluid secretion in cholera. Gastroenterology 2007. PMID: 17408659


  296. Levin MH, de la Fuente R, Verkman AS. Urearetics: a small molecule screen yields nanomolar potency inhibitors of urea transporter UT-B. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007. PMID: 17202246


  297. Auguste KI, Jin S, Uchida K, Yan D, Manley GT, Papadopoulos MC, Verkman AS. Greatly impaired migration of implanted aquaporin-4-deficient astroglial cells in mouse brain toward a site of injury. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006. PMID: 17135365


  298. Yang B, Kim JK, Verkman AS. Comparative efficacy of HgCl2 with candidate aquaporin-1 inhibitors DMSO, gold, TEA+ and acetazolamide. FEBS letters 2006. PMID: 17126329


  299. Magzoub M, Padmawar P, Dix JA, Verkman AS. Millisecond association kinetics of K+ with triazacryptand-based K+ indicators measured by fluorescence correlation spectroscopy. The journal of physical chemistry. B 2006. PMID: 17048948


  300. Levin MH, Verkman AS. Aquaporin-3-dependent cell migration and proliferation during corneal re-epithelialization. Investigative ophthalmology & visual science 2006. PMID: 17003427