Volume 29 of Issue 11 | Journal of cardiac failure
Authors: Cauwenberghs N, Haddad F, Daubert MA, Chatterjee R, Salerno M, Mega JL, Heidenreich P, Hernandez A, Amsallem M, Kobayashi Y, Mahaffey KW, Shah SH, Bloomfield GS, Kuznetsova T, Douglas PS, PROJECT BASELINE HEALTH STUDY INVESTIGATORS
BACKGROUND
Clinical and echocardiographic features may carry diverse information about the development of heart failure (HF). Therefore, we determined heterogeneity in clinical and echocardiographic phenotypes and its association with exercise capacity.
METHODS
In 2036 community-dwelling individuals, we defined echocardiographic profiles of left and right heart remodeling and dysfunction. We subdivided the cohort based on presence (+) or absence (-) of HF risk factors (RFs) and echocardiographic abnormalities (RF-/Echo-, RF-/Echo+, RF+/Echo-, RF+/Echo+). Multivariable-adjusted associations between subgroups and physical performance metrics from 6-minute walk and treadmill exercise testing were assessed.
RESULTS
The prevalence was 35.3% for RF-/Echo-, 4.7% for RF-/Echo+, 39.3% for RF+/Echo-, and 20.6% for RF+/Echo+. We observed large diversity in echocardiographic profiles in the Echo+ group. Participants with RF-/Echo+ (18.6% of Echo+) had predominantly echocardiographic abnormalities other than left ventricular (LV) diastolic dysfunction, hypertrophy and reduced ejection fraction, whereas their physical performance was similar to RF-/Echo-. In contrast, participants with RF+/Echo+ presented primarily with LV hypertrophy or dysfunction, features that related to lower 6-minute walking distance and lower exercise capacity.
CONCLUSIONS
Subclinical echocardiographic abnormalities suggest HF pathogenesis, but the presence of HF risk factors and type of echo abnormality should be considered so as to distinguish adverse from benign adaptation and to stratify HF risk.
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bioRxiv : the preprint server for biology
Authors: Tanaka M, Lum L, Hu K, Ledezma-Soto C, Superville D, Ng K, Adams Z, Kersten K, Fong L, Krummel M, Reeves M
Journal of the American College of Surgeons
Authors: Ma M, Peters XD, Zhang LM, Hornor M, Christensen K, Coleman J, Finlayson E, Flood KL, Katlic M, Lagoo-Deenadayalan S, Robinson TN, Rosenthal RA, Tang VL, Ko CY, Russell MM
European journal of heart failure
Authors: Tsutsui H, Albert NM, Coats AJS, Anker SD, Bayes-Genis A, Butler J, Chioncel O, Defilippi CR, Drazner MH, Felker GM, Filippatos G, Fiuzat M, Ide T, Januzzi JL, Kinugawa K, Kuwahara K, Matsue Y, Mentz RJ, Metra M, Pandey A, Rosano G, Saito Y, Sakata Y, Sato N, Seferovic PM, Teerlink J, Yamamoto K, Yoshimura M
Clinical science (London, England : 1979)
Authors: Kumar R, Lee MH, Kassa B, Fonseca Balladares DC, Mickael C, Sanders L, Andruska A, Kumar M, Spiekerkoetter E, Bandeira A, Stenmark KR, Tuder RM, Graham BB
AIDS research and human retroviruses
Authors: Sanders-Beer BE, Archin NM, Brumme ZL, Busch M, Deleage C, O'Doherty U, Hughes SH, Jerome K, Jones RB, Karn J, Kearney MF, Keele B, Kulpa D, Laird G, Li JZ, Lichterfeld M, Nussenzweig MC, Persaud D, Yukl S, Siliciano RF, Mellors JW
Neurology
Authors: Freddie Kibengo, Anita Kabarambi, Paddy Kafeero, Patrick Muhumuza, Maria Nakimbugwe, Anthony Ssemaganda, Colman Tayebwa, Payam Nahid, Fiona Cresswell, Felicia Chow
Neurology
Authors: Ethan Brown, Samuel Goldman, Marta San Luciano, Monica Korell, Caroline Tanner
JHEP reports : innovation in hepatology
Authors: Wu X, Lokken RP, Mehta N
ESC heart failure
Authors: Screever EM, Yousif LIE, Moslehi JJ, Salem JE, Voors AA, Silljé HHW, de Boer RA, Meijers WC
