Publications

Department of Medicine faculty members published more than 3,000 peer-reviewed articles in 2022.

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Diseases of the colon and rectum

Expert Commentary on the Colon Cancer and the Pregnant Patient.

2023

Authors: Van Loon K

Multiple sclerosis and related disorders

Risk of dementia in older veterans with multiple sclerosis.

2023

Authors: Fleming NH, Bahorik A, Xia F, Yaffe K

Journal of general internal medicine

Mortality Among Older Medical Patients at Flagship Hospitals and Their Affiliates.

2023

Authors: Jain S, Rosenbaum PR, Reiter JG, Ramadan OI, Hill AS, Hashemi S, Brown RT, Kelz RR, Fleisher LA, Silber JH

Intensive care medicine

Unraveling the enigma of genetics and phenotypes in ARDS.

2023

Authors: Artigas A, Barbas CSV, Matthay MA

Immunity

TCR signaling promotes formation of an STS1-Cbl-b complex with pH-sensitive phosphatase activity that suppresses T cell function in acidic environments.

2023

Authors: Tsai YL, Arias-Badia M, Kadlecek TA, Lwin YM, Srinath A, Shah NH, Wang ZE, Barber D, Kuriyan J, Fong L, Weiss A

The journal of allergy and clinical immunology. In practice

Association of sputum eosinophilia with easily measured type-2 inflammatory biomarkers in untreated mild persistent asthma.

2023

Authors: Covar R, Lazarus SC, Krishnan JA, Blake KV, Sorkness CA, Dyer AM, Lang JE, Lugogo NL, Mauger DT, Wechsler ME, Wenzel SE, Cardet JC, Castro M, Israel E, Phipatanakul W, King TS, National Heart, Lung, and Blood Institute AsthmaNet

Ergonomics

Understanding contributing factors to exoskeleton use-intention in construction: A decision tree approach using results from an online survey.

2023

Authors: Kim S, Ojelade A, Moore A, Gutierrez N, Harris-Adamson C, Barr A, Srinivasan D, Rempel DM, Nussbaum MA

Journal of the American Heart Association

APOL1 Risk Variants Associate With the Prevalence of Stroke in African American Current and Past Smokers.

2023

Authors: Rakic JM, Pullinger CR, Van Blarigan EL, Movsesyan I, Stock EO, Malloy MJ, Kane JP

JMIR medical informatics

Extending cBioPortal for Therapy Recommendation Documentation in Molecular Tumor Boards: Development and Usability Study.

2023

Authors: Renner C, Reimer N, Christoph J, Busch H, Metzger P, Boerries M, Ustjanzew A, Boehm D, Unberath P

Volume 56 of Issue 2 | Nature genetics

Genetic architecture of cardiac dynamic flow volumes.

2023

Authors: Gomes B, Singh A, O'Sullivan JW, Schnurr TM, Goddard PC, Loong S, Amar D, Hughes JW, Kostur M, Haddad F, Salerno M, Foo R, Montgomery SB, Parikh VN, Meder B, Ashley EA

View Abstract

Cardiac blood flow is a critical determinant of human health. However, the definition of its genetic architecture is limited by the technical challenge of capturing dynamic flow volumes from cardiac imaging at scale. We present DeepFlow, a deep-learning system to extract cardiac flow and volumes from phase-contrast cardiac magnetic resonance imaging. A mixed-linear model applied to 37,653 individuals from the UK Biobank reveals genome-wide significant associations across cardiac dynamic flow volumes spanning from aortic forward velocity to aortic regurgitation fraction. Mendelian randomization reveals a causal role for aortic root size in aortic valve regurgitation. Among the most significant contributing variants, localizing genes (near ELN, PRDM6 and ADAMTS7) are implicated in connective tissue and blood pressure pathways. Here we show that DeepFlow cardiac flow phenotyping at scale, combined with genotyping data, reinforces the contribution of connective tissue genes, blood pressure and root size to aortic valve function.

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