Publications
Department of Medicine faculty members published more than 3,000 peer-reviewed articles in 2022.
2008
2008
2008
BACKGROUND
This study was conducted to assess the potential impact of an unintended pregnancy on women's quality of life.
STUDY DESIGN
We asked 192 nonpregnant women to report how they would feel if they learned that they were pregnant using a visual analog scale (VAS), a time trade-off (TTO) metric, a standard gamble (SG) metric and a willingness-to-pay (WTP) metric.
RESULTS
Women's anticipated responses to an unintended pregnancy varied widely. Using a VAS, 8% reported pregnancy would make them feel like they were dying. To avoid pregnancy, 28% of women were willing to trade time from the end of their life (TTO), 16% of women were willing to accept an immediate risk of death (SG) and 60% of women were willing to pay some amount of money (WTP). On average, women, using the VAS, TTO and SG metrics, reported that an unintended pregnancy would create a health utility state (where 0 represents death and 1 represents perfect health) of 0.487, 0.992 and 0.997, respectively.
CONCLUSION
The anticipated effects of pregnancy on women's quality of life should be integrated into cost-effectiveness analyses of family planning services.
View on PubMed2008
2008
2008
2008
BACKGROUND
We studied the pharmacology of l-methamphetamine, the less abused isomer, when used as a nasal decongestant.
METHODS
12 subjects self-administered l-methamphetamine from a nonprescription inhaler at the recommended dose (16 inhalations over 6 hours) then at 2 and 4 (32 and 64 inhalations) times this dose. In a separate session intravenous phenylephrine (200 microg) and l-methamphetamine (5 mg) were given to define alpha agonist pharmacology and bioavailability. Physiological, cardiovascular, pharmacokinetic, and subjective effects were measured.
RESULTS
Plasma l-methamphetamine levels were often below the level of quantification so bioavailability was estimated by comparing urinary excretion of the intravenous and inhaled doses, yielding delivered dose estimates of 74.0 +/- 56.1, 124.7 +/- 106.6, and 268.1 +/- 220.5 microg for ascending exposures (mean 4.2 +/- 3.3 microg/inhalation). Physiological changes were minimal and not dose-dependent. Small decreases in stroke volume and cardiac output suggesting mild cardiodepression were seen.
CONCLUSION
Inhaled l-methamphetamine delivered from a non-prescription product produced minimal effects but may be a cardiodepressant.
View on PubMed2008