Publications

In the United States, HIV prevention services are increasingly being offered in the context of healthcare settings. This includes prioritizing prevention services for people living with HIV (PLWH), otherwise known as "prevention with positives." We conducted sixty in-depth interviews to explore patients' perceptions of clinic-based HIV prevention interventions targeting people living with HIV. The majority of patients were receptive to the prevention interventions. Patients described experiencing feeling fulfilled by communicating about issues related to HIV prevention when the conversations were specific to their situation and with an interventionist who was objective, yet empathic and non-judgmental. Provider-delivered interventions opened up new areas of prevention discussions with patients. Specialist-delivered interventions, specifically group-level interventions, provided opportunities to integrate participants into social networks that in turn provided social support and a reduction in social isolation. HIV prevention counseling benefited patients regardless of risk status.

Scientific innovation and research advances have enabled significant progress toward what President Obama and Secretary Clinton have described as an AIDS-free generation. Over the past decade, the United States, through the President's Emergency Plan for AIDS Relief, has played a key role in laying the foundation for this goal. However, the global AIDS response is a shared responsibility that must be met by the global community. This article explores key questions to guide global partners' efforts in maximizing the impact of bilateral, multilateral, and partner country investments. To inform decision-making, make smart investments and support country ownership of programs, areas of analysis should include the following: the use of economic and financial data to understand expenditures; allocation of resources based on scientific evidence of impact; opportunities for collaboration with governments, the Global Fund and others to align programs; and streamlining of business processes to maximize impact. President's Emergency Plan for AIDS Relief has applied this analysis in planning expansion of antiretroviral treatment programs, allowing investments to be tailored to country circumstances-a key to making smart investments and increasing the number of lives saved with the resources given.

PURPOSE OF REVIEW

A negative correlation between HDL cholesterol levels and risk of coronary artery disease has long been recognized. Emerging knowledge of the molecular speciation and functional properties of HDL provides an opportunity to study the atheroprotective effects of specific metabolic processes. The discovery of the quantum particle among the molecular species of HDL (prebeta-1 HDL) and its role in cholesterol efflux from the artery wall, offer a means of assessing the efficiency of efflux. This review presents observations on the structure and metabolism of this particle and its emerging role as a predictor of risk for atherosclerotic vascular disease.

RECENT FINDINGS

Prebeta-1 HDL is now recognized as the primary acceptor of cholesterol effluxed by the dominant ATP-binding cassette A1 (ABCA1) transporter in arterial macrophages, a critical step in reverse cholesterol transport. Several studies have revealed an association between high levels of this particle and risk of globally defined coronary artery disease and carotid intima-media thickness. Recently, these findings have been confirmed and extended to include myocardial infarction. High levels of prebeta-1 HDL may serve as an index of functional impairment of cholesterol efflux or esterification, either of which would be expected to impede reverse cholesterol transport.

SUMMARY

Recent studies underscore the critical role of prebeta-1 HDL in reverse cholesterol transport and its use as a marker of risk for structural coronary disease, myocardial infarction, and cerebral vascular disease.

The two primary barrier functions of skin (permeability and microbial barriers) are provided by lipids and proteins delivered to the extracellular spaces of the stratum corneum by the secretion of lamellar bodies. Owing to their importance in this process, the mechanisms of and the factors regulating lamellar body formation must be better understood. Tarutani et al. (2012) provide data furthering the concept of the importance of the Golgi network in lamellar body formation and the necessity of acidification of the Golgi for normal function.

This study describes health and safety concerns and self-care strategies of San Francisco taxi drivers. Focus groups and a written cross-sectional survey were done in a convenience sample of taxi drivers working in San Francisco. Sessions were audiotaped, transcribed in English, and independently coded to identify major health and safety themes, using thematic content analysis. Strategies to manage health and safety issues are the focus of this analysis. Five focus groups were held in 2009 with 36 participants. Major health and safety themes included stress, body pain, danger, vulnerable employment status, and concerns related to unhealthy working conditions. Self-care strategies included diffusion/decompression to manage stress, maintaining a positive attitude, maintaining power and control, and practicing proactive self-care. Creative self-care strategies were described by taxi drivers to keep healthy and safe at work. These data will inform future self-care interventions to reduce health and safety risks of taxi driving.