J Allergy Clin Immunol
Authors: Drake KA, Torgerson DG, Gignoux CR, Galanter JM, Roth LA, Huntsman S, Eng C, Oh SS, Yee SW, Lin L, Bustamante CD, Moreno-Estrada A, Sandoval K, Davis A, Borrell LN, Farber HJ, Kumar R, Avila PC, Brigino-Buenaventura E, Chapela R, Ford JG, Lenoir MA, Lurmann F, Meade K, Serebrisky D, Thyne S, Rodríguez-Cintrón W, Sen S, Rodríguez-Santana JR, Hernandez RD, Giacomini KM, Burchard EG
Volume 10 of Issue 6 | Alzheimer's & dementia : the journal of the Alzheimer's Association
Authors: Barnes DE, Cenzer IS, Yaffe K, Ritchie CS, Lee SJ
BACKGROUND
Our objective in this study was to develop a point-based tool to predict conversion from amnestic mild cognitive impairment (MCI) to probable Alzheimer's disease (AD).
METHODS
Subjects were participants in the first part of the Alzheimer's Disease Neuroimaging Initiative. Cox proportional hazards models were used to identify factors associated with development of AD, and a point score was created from predictors in the final model.
RESULTS
The final point score could range from 0 to 9 (mean 4.8) and included: the Functional Assessment Questionnaire (2‒3 points); magnetic resonance imaging (MRI) middle temporal cortical thinning (1 point); MRI hippocampal subcortical volume (1 point); Alzheimer's Disease Cognitive Scale-cognitive subscale (2‒3 points); and the Clock Test (1 point). Prognostic accuracy was good (Harrell's c = 0.78; 95% CI 0.75, 0.81); 3-year conversion rates were 6% (0‒3 points), 53% (4‒6 points), and 91% (7‒9 points).
CONCLUSIONS
A point-based risk score combining functional dependence, cerebral MRI measures, and neuropsychological test scores provided good accuracy for prediction of conversion from amnestic MCI to AD.
View on PubMed
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
Authors: Vardi M, Novack V, Pencina MJ, Doros G, Burke DA, Elmariah S, Cutlip DE, Mauri L, Yeh RW
Safety and health at work
Authors: You D, Smith AH, Rempel D
The Journal of clinical endocrinology and metabolism
Authors: Schwartz JB, Lai J, Lizaola B, Kane L, Markova S, Weyland P, Terrault NA, Stotland N, Bikle D
BMC cardiovascular disorders
Authors: Jones CD, Holmes GM, DeWalt DA, Erman B, Wu JR, Cene CW, Baker DW, Schillinger D, Ruo B, Bibbins-Domingo K, Macabasco-O'Connell A, Hawk V, Broucksou K, Pignone M
Journal of epidemiology and community health
Authors: Pandit AU, Bailey SC, Curtis LM, Seligman HK, Davis TC, Parker RM, Schillinger D, DeWalt D, Fleming D, Mohr DC, Wolf MS
Bioorganic & medicinal chemistry letters
Authors: Weldon DJ, Shah F, Chittiboyina AG, Sheri A, Chada RR, Gut J, Rosenthal PJ, Shivakumar D, Sherman W, Desai P, Jung JC, Avery MA
Immunofluorescence and Immunohistochemistry.
Authors: Blaisdell A, Erlebacher A.
Flow Cytometric Analysis of Myometrial and Decidual Cell Suspensions.
Authors: Blaisdell A, Erlebacher A.
