Publications

Department of Medicine faculty members published more than 3,000 peer-reviewed articles in 2022.

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Volume 14 of Issue 2 | EMBO reports

Caspase signalling in the absence of apoptosis drives Jnk-dependent invasion.

2013

Authors: Rudrapatna VA, Bangi E, Cagan RL

Tumours evolve several mechanisms to evade apoptosis, yet many resected carcinomas show significantly elevated caspase activity. Moreover, caspase activity is positively correlated with tumour aggression and adverse patient outcome. These observations indicate that caspases might have a functional role in promoting tumour invasion and metastasis. Using a Drosophila model of invasion, we show that precise effector caspase activity drives cell invasion without initiating apoptosis. Affected cells express the matrix metalloprotinase Mmp1 and invade by activating Jnk. Our results link Jnk and effector caspase signalling during the invasive process and suggest that tumours under apoptotic stresses from treatment, immune surveillance or intrinsic signals might be induced further along the metastatic cascade.

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CA: a cancer journal for clinicians

American Cancer Society lung cancer screening guidelines.

2013

Authors: Wender R, Fontham ET, Barrera E, Colditz GA, Church TR, Ettinger DS, Etzioni R, Flowers CR, Gazelle GS, Kelsey DK, LaMonte SJ, Michaelson JS, Oeffinger KC, Shih YC, Sullivan DC, Travis W, Walter L, Wolf AM, Brawley OW, Smith RA

Clinical lymphoma, myeloma & leukemia

Complete remission achieved with single agent CNTO 328, an anti-IL-6 monoclonal antibody, in relapsed and refractory myeloma.

2013

Authors: Chari A, Pri-Chen H, Jagannath S

American journal of respiratory and critical care medicine

Clinical risk factors for primary graft dysfunction after lung transplantation.

2013

Authors: Diamond JM, Lee JC, Kawut SM, Shah RJ, Localio AR, Bellamy SL, Lederer DJ, Cantu E, Kohl BA, Lama VN, Bhorade SM, Crespo M, Demissie E, Sonett J, Wille K, Orens J, Shah AS, Weinacker A, Arcasoy S, Shah PD, Wilkes DS, Ware LB, Palmer SM, Christie JD

Annals of epidemiology