Volume 131 of Issue 6 | Circulation
Authors: Grana R, Benowitz N, Glantz S
Volume 42 of Issue 2 | Immunity
Authors: DuPage M, Chopra G, Quiros J, Rosenthal WL, Morar MM, Holohan D, Zhang R, Turka L, Marson A, Bluestone JA
Regulatory T cells (Treg cells) are required for immune homeostasis. Chromatin remodeling is essential for establishing diverse cellular identities, but how the epigenetic program in Treg cells is maintained throughout the dynamic activation process remains unclear. Here we have shown that CD28 co-stimulation, an extracellular cue intrinsically required for Treg cell maintenance, induced the chromatin-modifying enzyme, Ezh2. Treg-specific ablation of Ezh2 resulted in spontaneous autoimmunity with reduced Foxp3(+) cells in non-lymphoid tissues and impaired resolution of experimental autoimmune encephalomyelitis. Utilizing a model designed to selectively deplete wild-type Treg cells in adult mice co-populated with Ezh2-deficient Treg cells, Ezh2-deficient cells were destabilized and failed to prevent autoimmunity. After activation, the transcriptome of Ezh2-deficient Treg cells was disrupted, with altered expression of Treg cell lineage genes in a pattern similar to Foxp3-deficient Treg cells. These studies reveal a critical role for Ezh2 in the maintenance of Treg cell identity during cellular activation.
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International journal of cardiology
Authors: Güder G, Gelbrich G, Edelmann F, Wachter R, Pieske B, Pankuweit S, Maisch B, Prettin C, Brenner S, Morbach C, Berliner D, Deubner N, Ertl G, Angermann CE, Störk S
Cardiology research
Authors: Howie-Esquivel J, Carroll M, Brinker E, Kao H, Pantilat S, Rago K, De Marco T
Diabetes care
Authors: Araneta MR, Kanaya AM, Hsu WC, Chang HK, Grandinetti A, Boyko EJ, Hayashi T, Kahn SE, Leonetti DL, McNeely MJ, Onishi Y, Sato KK, Fujimoto WY
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Authors: Cruz ML, Gleason N, Wang M, Wrenn K, Gonzales R
Nature genetics
Authors: Lin L, Sabnis AJ, Chan E, Olivas V, Cade L, Pazarentzos E, Asthana S, Neel D, Yan JJ, Lu X, Pham L, Wang MM, Karachaliou N, Cao MG, Manzano JL, Ramirez JL, Torres JM, Buttitta F, Rudin CM, Collisson EA, Algazi A, Robinson E, Osman I, Muñoz-Couselo E, Cortes J, Frederick DT, Cooper ZA, McMahon M, Marchetti A, Rosell R, Flaherty KT, Wargo JA, Bivona TG
Journal of diabetes and its complications
Authors: Fisher L, Polonsky WH, Hessler DM, Masharani U, Blumer I, Peters AL, Strycker LA, Bowyer V
Journal of comparative pathology
Authors: Laing ST, Griffey SM, Moreno ME, Stoddart CA
Volume 81 of Issue 4 | Gastrointestinal endoscopy
Authors:
