Publications

Department of Medicine faculty members published more than 3,600 peer-reviewed articles in 2024.

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Circulation. Cardiovascular imaging

Characterization of right ventricular remodeling in pulmonary hypertension associated with patient outcomes by 3-dimensional wall motion tracking echocardiography.

2015

Authors: Ryo K, Goda A, Onishi T, Delgado-Montero A, Tayal B, Champion HC, Simon MA, Mathier MA, Gladwin MT, Gorcsan J

Volume 7 of Issue 6 | EMBO molecular medicine

Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension.

2015

Authors: White K, Lu Y, Annis S, Hale AE, Chau BN, Dahlman JE, Hemann C, Opotowsky AR, Vargas SO, Rosas I, Perrella MA, Osorio JC, Haley KJ, Graham BB, Kumar R, Saggar R, Saggar R, Wallace WD, Ross DJ, Khan OF, Bader A, Gochuico BR, Matar M, Polach K, Johannessen NM, Prosser HM, Anderson DG, Langer R, Zweier JL, Bindoff LA, Systrom D, Waxman AB, Jin RC, Chan SY

View Abstract

Iron-sulfur (Fe-S) clusters are essential for mitochondrial metabolism, but their regulation in pulmonary hypertension (PH) remains enigmatic. We demonstrate that alterations of the miR-210-ISCU1/2 axis cause Fe-S deficiencies in vivo and promote PH. In pulmonary vascular cells and particularly endothelium, hypoxic induction of miR-210 and repression of the miR-210 targets ISCU1/2 down-regulated Fe-S levels. In mouse and human vascular and endothelial tissue affected by PH, miR-210 was elevated accompanied by decreased ISCU1/2 and Fe-S integrity. In mice, miR-210 repressed ISCU1/2 and promoted PH. Mice deficient in miR-210, via genetic/pharmacologic means or via an endothelial-specific manner, displayed increased ISCU1/2 and were resistant to Fe-S-dependent pathophenotypes and PH. Similar to hypoxia or miR-210 overexpression, ISCU1/2 knockdown also promoted PH. Finally, cardiopulmonary exercise testing of a woman with homozygous ISCU mutations revealed exercise-induced pulmonary vascular dysfunction. Thus, driven by acquired (hypoxia) or genetic causes, the miR-210-ISCU1/2 regulatory axis is a pathogenic lynchpin causing Fe-S deficiency and PH. These findings carry broad translational implications for defining the metabolic origins of PH and potentially other metabolic diseases sharing similar underpinnings.

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Journal of vascular surgery

RR15. Renal Progression in the Advanced Chronic Kidney Disease Populations: Creation of the ESRD Prediction Scorecard.

2015

Authors: Marcos K. Lau, Joy L. Meier, Warren Gasper, David H. Lovett, Pauline M. Velez, Christopher D. Owens

Annals of the rheumatic diseases

SAT0415 Performance of Anti-Nuclear Antibodies (ANA) for Classifying Systemic Lupus Erythematosus (SLE): A Systematic Literature Review and Meta-Regression of Diagnostic Data.

2015

Authors: N. Leuchten, R. Brinks, A. Hoyer, M. Schoels, M. Aringer, S. Johnson, G. Schmajuk, D. Daikh, T. Dörner, G. Bertsias

AACE Clinical Case Reports

Hereditary Spherocytosis and Other Factors That Alter HBA1C Levels.

2015

Authors: Robert J. Rushakoff, Heidemarie Windham MacMaster, Arti D. Shah

Journal of global health

Barriers and facilitators to the quality use of essential medicines for maternal health in low-resource countries: An Ishikawa framework.

2015

Authors: Tran DN, Bero LA

Texas Heart Institute journal

Thrombus-in-transit entrapped in a patent foramen ovale and related to underlying antiphospholipid syndrome.

2015

Authors: Hirai T, Henry C, Phan BA

Journal of the National Comprehensive Cancer Network : JNCCN

Rectal Cancer, Version 2.2015.

2015

Authors: Benson AB, Venook AP, Bekaii-Saab T, Chan E, Chen YJ, Cooper HS, Engstrom PF, Enzinger PC, Fenton MJ, Fuchs CS, Grem JL, Grothey A, Hochster HS, Hunt S, Kamel A, Kirilcuk N, Leong LA, Lin E, Messersmith WA, Mulcahy MF, Murphy JD, Nurkin S, Rohren E, Ryan DP, Saltz L, Sharma S, Shibata D, Skibber JM, Sofocleous CT, Stoffel EM, Stotsky-Himelfarb E, Willett CG, Gregory KM, Freedman-Cass D

JACC. Cardiovascular imaging

RV Dyssynchrony by Speckle Tracking Strain in Pulmonary Arterial Hypertension: Will This Outcome Variable Take Root?

2015

Authors: Schiller NB, Singh S

Journal of urban health : bulletin of the New York Academy of Medicine

Hypertension in a Brazilian urban slum population.

2015

Authors: Unger A, Felzemburgh RD, Snyder RE, Ribeiro GS, Mohr S, Costa VB, Melendez AX, Reis RB, Santana FS, Riley LW, Reis MG, Ko AI