AIDS (London, England)
Authors: Henrich TJ, Hanhauser E, Hu Z, Stellbrink HJ, Noah C, Martin JN, Deeks SG, Kuritzkes DR, Pereyra F
American journal of respiratory and critical care medicine
Authors: Steiling K, Christenson SA
Volume 130 of Issue 2 | Acta neuropathologica
Authors: Nobuta H, Cilio MR, Danhaive O, Tsai HH, Tupal S, Chang SM, Murnen A, Kreitzer F, Bravo V, Czeisler C, Gokozan HN, Gygli P, Bush S, Weese-Mayer DE, Conklin B, Yee SP, Huang EJ, Gray PA, Rowitch D, Otero JJ
Human congenital central hypoventilation syndrome (CCHS), resulting from mutations in transcription factor PHOX2B, manifests with impaired responses to hypoxemia and hypercapnia especially during sleep. To identify brainstem structures developmentally affected in CCHS, we analyzed two postmortem neonatal-lethal cases with confirmed polyalanine repeat expansion (PARM) or Non-PARM (PHOX2B∆8) mutation of PHOX2B. Both human cases showed neuronal losses within the locus coeruleus (LC), which is important for central noradrenergic signaling. Using a conditionally active transgenic mouse model of the PHOX2B∆8 mutation, we found that early embryonic expression (
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Volume 14 | Malaria journal
Authors: Boyce RM, Muiru A, Reyes R, Ntaro M, Mulogo E, Matte M, Siedner MJ
BACKGROUND
The World Health Organization recommends that all suspected malaria cases receive a parasitological diagnosis prior to treatment with artemisinin-based combination therapy. A recent meta-analysis of clinical trials evaluating RDTs for the management of patients with fever found substantial reductions in anti-malarial prescriptions when health workers adhered to treatment protocols based on test results. However few studies have reported on the impact of RDTs on health systems outside research settings.
METHODS
The study comprised a retrospective interrupted time series analysis, comparing rates of malaria diagnosis, treatment, and resource utilization before and after introduction of RDTs at a peripheral health facility in rural Western Uganda. The use of malaria diagnostic tests was graphically depicted throughout the study period and fit regression models to identify correlates of three outcomes of interest: (1) length of stay (2) the proportion of patients referred to a higher-level health facility, and (3) administration of antibiotics.
RESULTS
Over the course of the study period, 14,357 individuals underwent diagnostic testing for malaria with either a RDT (9,807) or microscopy (4,550). The proportion of patients with parasite-based diagnoses more than tripled to 34% after the introduction of RDTs. RDTs largely replaced microscopy as the diagnostic method of choice. Compared to patients admitted during the pre-RDT period, patients admitted to the health centre with malaria in the post-RDT period had significantly reduced odds of being referred to another health centre (AOR=0.49, P=0.038), receiving antibiotics (AOR=0.42, P<0.001), and a significantly shorter mean length of stay (β=-0.32 days, 95%CI -0.52 to -0.13).
CONCLUSIONS
This study is one of the few to demonstrate significant improvement in clinical outcomes and process measures following the introduction of RDTs for the diagnosis of malaria at a rural health facility in Uganda. The results show a reduction in referrals and shorter mean inpatient LOS even as antibiotics were prescribed less frequently. This change greatly increased laboratory throughput and the resultant proportion of patients receiving a parasite-based diagnosis.
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The European physical journal. C, Particles and fields
Authors: Khachatryan V, Sirunyan AM, Tumasyan A, Adam W, Bergauer T, Dragicevic M, Erö J, Friedl M, Frühwirth R, Ghete VM, Hartl C, Hörmann N, Hrubec J, Jeitler M, Kiesenhofer W, Knünz V, Krammer M, Krätschmer I, Liko D, Mikulec I, Rabady D, Rahbaran B, Rohringer H, Schöfbeck R, Strauss J, Treberer-Treberspurg W, Waltenberger W, Wulz CE, Mossolov V, Shumeiko N, Suarez Gonzalez J, Alderweireldt S, Bansal S, Cornelis T, De Wolf EA, Janssen X, Knutsson A, Lauwers J, Luyckx S, Ochesanu S, Rougny R, Van De Klundert M, Van Haevermaet H, Van Mechelen P, Van Remortel N, Van Spilbeeck A, Blekman F, Blyweert S, D'Hondt J, Daci N, Heracleous N, Keaveney J, Lowette S, Maes M, Olbrechts A, Python Q, Strom D, Tavernier S, Van Doninck W, Van Mulders P, Van Onsem GP, Villella I, Caillol C, Clerbaux B, De Lentdecker G, Dobur D, Favart L, Gay APR, Grebenyuk A, Léonard A, Mohammadi A, Perniè L, Randle-Conde A, Reis T, Seva T, Thomas L, Vander Velde C, Vanlaer P, Wang J, Zenoni F, Adler V, Beernaert K, Benucci L, Cimmino A, Costantini S, Crucy S, Fagot A, Garcia G, Mccartin J, Ocampo Rios AA, Poyraz D, Ryckbosch D, Salva Diblen S, Sigamani M, Strobbe N, Thyssen F, Tytgat M, Yazgan E, Zaganidis N, Basegmez S, Beluffi C, Bruno G, Castello R, Caudron A, Ceard L, Da Silveira GG, Delaere C, du Pree T, Favart D, Forthomme L, Giammanco A, Hollar J, Jafari A, Jez P, Komm M, Lemaitre V, Nuttens C, Pagano D, Perrini L, Pin A, Piotrzkowski K, Popov A, Quertenmont L, Selvaggi M, Vidal Marono M, Vizan Garcia JM, Beliy N, Caebergs T, Daubie E, Hammad GH, Júnior WLA, Alves GA, Brito L, Correa Martins Junior M, Martins TDR, Molina J, Mora Herrera C, Pol ME, Teles PR, Carvalho W, Chinellato J, Custódio A, Da Costa EM, De Jesus Damiao D, De Oliveira Martins C, Fonseca De Souza S, Malbouisson H, Matos Figueiredo D, Mundim L, Nogima H, Prado Da Silva WL, Santaolalla J, Santoro A, Sznajder A, Tonelli Manganote EJ, Vilela Pereira A, Bernardes CA, Dogra S, Fernandez Perez Tomei TR, Gregores EM, Mercadante PG, Novaes SF, Padula SS, Aleksandrov A, Genchev V, Hadjiiska R, Iaydjiev P, Marinov A, Piperov S, Rodozov M, Stoykova S, Sultanov G, Vutova M, Dimitrov A, Glushkov I, Litov L, Pavlov B, Petkov P, Bian JG, Chen GM, Chen HS, Chen M, Cheng T, Du R, Jiang CH, Plestina R, Romeo F, Tao J, Wang Z, Asawatangtrakuldee C, Ban Y, Liu S, Mao Y, Qian SJ, Wang D, Xu Z, Zhang F, Zhang L, Zou W, Avila C, Cabrera A, Chaparro Sierra LF, Florez C, Gomez JP, Gomez Moreno B, Sanabria JC, Godinovic N, Lelas D, Polic D, Puljak I, Antunovic Z, Kovac M, Brigljevic V, Kadija K, Luetic J, Mekterovic D, Sudic L, Attikis A, Mavromanolakis G, Mousa J, Nicolaou C, Ptochos F, Razis PA, Rykaczewski H, Bodlak M, Finger M, Finger M, Assran Y, Ellithi Kame A, Mahmoud MA, Radi A, Kadastik M, Murumaa M, Raidal M, Tiko A, Eerola P, Voutilainen M, Härkönen J, Heikkilä JK, Karimäki V, Kinnunen R, Kortelainen MJ, Lampén T, Lassila-Perini K, Lehti S, Lindén T, Luukka P, Mäenpää T, Peltola T, Tuominen E, Tuominiemi J, Tuovinen E, Wendland L, Talvitie J, Tuuva T, Besancon M, Couderc F, Dejardin M, Denegri D, Fabbro B, Faure JL, Favaro C, Ferri F, Ganjour S, Givernaud A, Gras P, Hamel de Monchenault G, Jarry P, Locci E, Malcles J, Rander J, Rosowsky A, Titov M, Baffioni S, Beaudette F, Busson P, Chapon E, Charlot C, Dahms T, Dobrzynski L, Filipovic N, Florent A, Granier de Cassagnac R, Mastrolorenzo L, Miné P, Naranjo IN, Nguyen M, Ochando C, Ortona G, Paganini P, Regnard S, Salerno R, Sauvan JB, Sirois Y, Veelken C, Yilmaz Y, Zabi A, Agram JL, Andrea J, Aubin A, Bloch D, Brom JM, Chabert EC, Collard C, Conte E, Fontaine JC, Gelé D, Goerlach U, Goetzmann C, Le Bihan AC, Skovpen K, Van Hove P, Gadrat S, Beauceron S, Beaupere N, Bernet C, Boudoul G, Bouvier E, Brochet S, Carrillo Montoya CA, Chasserat J, Chierici R, Contardo D, Courbon B, Depasse P, El Mamouni H, Fan J, Fay J, Gascon S, Gouzevitch M, Ille B, Kurca T, Lethuillier M, Mirabito L, Pequegnot AL, Perries S, Ruiz Alvarez JD, Sabes D, Sgandurra L, et al
Physical review letters
Authors: Khachatryan V, Sirunyan AM, Tumasyan A, Adam W, Bergauer T, Dragicevic M, Erö J, Friedl M, Frühwirth R, Ghete VM, Hartl C, Hörmann N, Hrubec J, Jeitler M, Kiesenhofer W, Knünz V, Krammer M, Krätschmer I, Liko D, Mikulec I, Rabady D, Rahbaran B, Rohringer H, Schöfbeck R, Strauss J, Treberer-Treberspurg W, Waltenberger W, Wulz CE, Mossolov V, Shumeiko N, Suarez Gonzalez J, Alderweireldt S, Bansal S, Cornelis T, De Wolf EA, Janssen X, Knutsson A, Lauwers J, Luyckx S, Ochesanu S, Rougny R, Van De Klundert M, Van Haevermaet H, Van Mechelen P, Van Remortel N, Van Spilbeeck A, Blekman F, Blyweert S, D'Hondt J, Daci N, Heracleous N, Keaveney J, Lowette S, Maes M, Olbrechts A, Python Q, Strom D, Tavernier S, Van Doninck W, Van Mulders P, Van Onsem GP, Villella I, Caillol C, Clerbaux B, De Lentdecker G, Dobur D, Favart L, Gay AP, Grebenyuk A, Léonard A, Mohammadi A, Perniè L, Randle-Conde A, Reis T, Seva T, Thomas L, Vander Velde C, Vanlaer P, Wang J, Zenoni F, Adler V, Beernaert K, Benucci L, Cimmino A, Costantini S, Crucy S, Fagot A, Garcia G, Mccartin J, Ocampo Rios AA, Poyraz D, Ryckbosch D, Salva Diblen S, Sigamani M, Strobbe N, Thyssen F, Tytgat M, Yazgan E, Zaganidis N, Basegmez S, Beluffi C, Bruno G, Castello R, Caudron A, Ceard L, Da Silveira GG, Delaere C, du Pree T, Favart D, Forthomme L, Giammanco A, Hollar J, Jafari A, Jez P, Komm M, Lemaitre V, Nuttens C, Pagano D, Perrini L, Pin A, Piotrzkowski K, Popov A, Quertenmont L, Selvaggi M, Vidal Marono M, Vizan Garcia JM, Beliy N, Caebergs T, Daubie E, Hammad GH, Aldá Júnior WL, Alves GA, Brito L, Correa Martins Junior M, Dos Reis Martins T, Molina J, Mora Herrera C, Pol ME, Rebello Teles P, Carvalho W, Chinellato J, Custódio A, Da Costa EM, De Jesus Damiao D, De Oliveira Martins C, Fonseca De Souza S, Malbouisson H, Matos Figueiredo D, Mundim L, Nogima H, Prado Da Silva WL, Santaolalla J, Santoro A, Sznajder A, Tonelli Manganote EJ, Vilela Pereira A, Bernardes CA, Dogra S, Tomei TR, Gregores EM, Mercadante PG, Novaes SF, Padula SS, Aleksandrov A, Genchev V, Hadjiiska R, Iaydjiev P, Marinov A, Piperov S, Rodozov M, Stoykova S, Sultanov G, Vutova M, Dimitrov A, Glushkov I, Litov L, Pavlov B, Petkov P, Bian JG, Chen GM, Chen HS, Chen M, Cheng T, Du R, Jiang CH, Plestina R, Romeo F, Tao J, Wang Z, Asawatangtrakuldee C, Ban Y, Guo W, Liu S, Mao Y, Qian SJ, Wang D, Xu Z, Zhang F, Zhang L, Zou W, Avila C, Cabrera A, Chaparro Sierra LF, Florez C, Gomez JP, Gomez Moreno B, Sanabria JC, Godinovic N, Lelas D, Polic D, Puljak I, Antunovic Z, Kovac M, Brigljevic V, Kadija K, Luetic J, Mekterovic D, Sudic L, Attikis A, Mavromanolakis G, Mousa J, Nicolaou C, Ptochos F, Razis PA, Rykaczewski H, Bodlak M, Finger M, Finger M, Assran Y, Ellithi Kamel A, Mahmoud MA, Radi A, Kadastik M, Murumaa M, Raidal M, Tiko A, Eerola P, Voutilainen M, Härkönen J, Karimäki V, Kinnunen R, Kortelainen MJ, Lampén T, Lassila-Perini K, Lehti S, Lindén T, Luukka P, Mäenpää T, Peltola T, Tuominen E, Tuominiemi J, Tuovinen E, Wendland L, Talvitie J, Tuuva T, Besancon M, Couderc F, Dejardin M, Denegri D, Fabbro B, Faure JL, Favaro C, Ferri F, Ganjour S, Givernaud A, Gras P, Hamel de Monchenault G, Jarry P, Locci E, Malcles J, Rander J, Rosowsky A, Titov M, Baffioni S, Beaudette F, Busson P, Chapon E, Charlot C, Dahms T, Dobrzynski L, Filipovic N, Florent A, Granier de Cassagnac R, Mastrolorenzo L, Miné P, Naranjo IN, Nguyen M, Ochando C, Ortona G, Paganini P, Regnard S, Salerno R, Sauvan JB, Sirois Y, Veelken C, Yilmaz Y, Zabi A, Agram JL, Andrea J, Aubin A, Bloch D, Brom JM, Chabert EC, Collard C, Conte E, Fontaine JC, Gelé D, Goerlach U, Goetzmann C, Le Bihan AC, Skovpen K, Van Hove P, Gadrat S, Beauceron S, Beaupere N, Bernet C, Boudoul G, Bouvier E, Brochet S, Carrillo Montoya CA, Chasserat J, Chierici R, Contardo D, Courbon B, Depasse P, El Mamouni H, Fan J, Fay J, Gascon S, Gouzevitch M, Ille B, Kurca T, Lethuillier M, Mirabito L, Pequegnot AL, Perries S, Ruiz Alvarez JD, Sabes D, Sgandurra L, Sordini V, et al
Physical review letters
Authors: Aad G, Abbott B, Abdallah J, Abdinov O, Aben R, Abolins M, AbouZeid OS, Abramowicz H, Abreu H, Abreu R, Abulaiti Y, Acharya BS, Adamczyk L, Adams DL, Adelman J, Adomeit S, Adye T, Affolder AA, Agatonovic-Jovin T, Aguilar-Saavedra JA, Ahlen SP, Ahmadov F, Aielli G, Akerstedt H, Åkesson TP, Akimoto G, Akimov AV, Alberghi GL, Albert J, Albrand S, Alconada Verzini MJ, Aleksa M, Aleksandrov IN, Alexa C, Alexander G, Alexopoulos T, Alhroob M, Alimonti G, Alio L, Alison J, Alkire SP, Allbrooke BM, Allport PP, Aloisio A, Alonso A, Alonso F, Alpigiani C, Altheimer A, Alvarez Gonzalez B, Álvarez Piqueras D, Alviggi MG, Amadio BT, Amako K, Amaral Coutinho Y, Amelung C, Amidei D, Amor Dos Santos SP, Amorim A, Amoroso S, Amram N, Amundsen G, Anastopoulos C, Ancu LS, Andari N, Andeen T, Anders CF, Anders G, Anders JK, Anderson KJ, Andreazza A, Andrei V, Angelidakis S, Angelozzi I, Anger P, Angerami A, Anghinolfi F, Anisenkov AV, Anjos N, Annovi A, Antonelli M, Antonov A, Antos J, Anulli F, Aoki M, Aperio Bella L, Arabidze G, Arai Y, Araque JP, Arce AT, Arduh FA, Arguin JF, Argyropoulos S, Arik M, Armbruster AJ, Arnaez O, Arnal V, Arnold H, Arratia M, Arslan O, Artamonov A, Artoni G, Asai S, Asbah N, Ashkenazi A, Åsman B, Asquith L, Assamagan K, Astalos R, Atkinson M, Atlay NB, Auerbach B, Augsten K, Aurousseau M, Avolio G, Axen B, Ayoub MK, Azuelos G, Baak MA, Baas AE, Bacci C, Bachacou H, Bachas K, Backes M, Backhaus M, Badescu E, Bagiacchi P, Bagnaia P, Bai Y, Bain T, Baines JT, Baker OK, Balek P, Balestri T, Balli F, Banas E, Banerjee S, Bannoura AA, Bansil HS, Barak L, Baranov SP, Barberio EL, Barberis D, Barbero M, Barillari T, Barisonzi M, Barklow T, Barlow N, Barnes SL, Barnett BM, Barnett RM, Barnovska Z, Baroncelli A, Barone G, Barr AJ, Barreiro F, Barreiro Guimarães da Costa J, Bartoldus R, Barton AE, Bartos P, Bassalat A, Basye A, Bates RL, Batista SJ, Batley JR, Battaglia M, Bauce M, Bauer F, Bawa HS, Beacham JB, Beattie MD, Beau T, Beauchemin PH, Beccherle R, Bechtle P, Beck HP, Becker K, Becker M, Becker S, Beckingham M, Becot C, Beddall AJ, Beddall A, Bednyakov VA, Bee CP, Beemster LJ, Beermann TA, Begel M, Behr JK, Belanger-Champagne C, Bell WH, Bella G, Bellagamba L, Bellerive A, Bellomo M, Belotskiy K, Beltramello O, Benary O, Benchekroun D, Bender M, Bendtz K, Benekos N, Benhammou Y, Benhar Noccioli E, Benitez Garcia JA, Benjamin DP, Bensinger JR, Bentvelsen S, Beresford L, Beretta M, Berge D, Bergeaas Kuutmann E, Berger N, Berghaus F, Beringer J, Bernard C, Bernard NR, Bernius C, Bernlochner FU, Berry T, Berta P, Bertella C, Bertoli G, Bertolucci F, Bertsche C, Bertsche D, Besana MI, Besjes GJ, Bessidskaia Bylund O, Bessner M, Besson N, Betancourt C, Bethke S, Bevan AJ, Bhimji W, Bianchi RM, Bianchini L, Bianco M, Biebel O, Bieniek SP, Biglietti M, Bilbao De Mendizabal J, Bilokon H, Bindi M, Binet S, Bingul A, Bini C, Black CW, Black JE, Black KM, Blackburn D, Blair RE, Blanchard JB, Blanco JE, Blazek T, Bloch I, Blocker C, Blum W, Blumenschein U, Bobbink GJ, Bobrovnikov VS, Bocchetta SS, Bocci A, Bock C, Boehler M, Bogaerts JA, Bogdanchikov AG, Bohm C, Boisvert V, Bold T, Boldea V, Boldyrev AS, Bomben M, Bona M, Boonekamp M, Borisov A, Borissov G, Borroni S, Bortfeldt J, Bortolotto V, Bos K, Boscherini D, Bosman M, Boudreau J, Bouffard J, Bouhova-Thacker EV, Boumediene D, Bourdarios C, Bousson N, Boveia A, Boyd J, Boyko IR, Bozic I, Bracinik J, Brandt A, Brandt G, Brandt O, Bratzler U, Brau B, Brau JE, Braun HM, Brazzale SF, Brendlinger K, Brennan AJ, Brenner L, Brenner R, Bressler S, Bristow K, Bristow TM, Britton D, Britzger D, Brochu FM, Brock I, Brock R, Bronner J, Brooijmans G, Brooks T, Brooks WK, Brosamer J, Brost E, Brown J, Bruckman de Renstrom PA, Bruncko D, Bruneliere R, Bruni A, Bruni G, Bruschi M, Bryngemark L, Buanes T, Buat Q, Buchholz P, Buckley AG, Buda SI, Budagov IA, Buehrer F, Bugge L, Bugge MK, Bulekov O, Bullock D, Burckhart H, Burdin S, Burghgrave B, Burke S, Burmeister I, Busato E, et al
Cancer research
Authors: Lemnrau A, Brook MN, Fletcher O, Coulson P, Tomczyk K, Jones M, Ashworth A, Swerdlow A, Orr N, Garcia-Closas M
American journal of public health
Authors: Brown RT, Miao Y, Mitchell SL, Bharel M, Patel M, Ard KL, Grande LJ, Blazey-Martin D, Floru D, Steinman MA
JACC. Heart failure
Authors: Carson PE, Anand IS, Win S, Rector T, Haass M, Lopez-Sendon J, Miller A, Teerlink JR, White M, McKelvie RS, Komajda M, Zile MR, McMurray JJ, Massie B