JAMA
Authors: Volberding PA
Medical teacher
Authors: Ten Cate O, Derese A, Durning SJ, O'Sullivan P
Annals of internal medicine
Authors: Gujral UP, Vittinghoff E, Mongraw-Chaffin M, Vaidya D, Kandula NR, Allison M, Carr J, Liu K, Narayan KMV, Kanaya AM
Circulation
Authors: Ameri K, Samurkashian R, Yeghiazarians Y
Cell metabolism
Authors: Morita S, Villalta SA, Feldman HC, Register AC, Rosenthal W, Hoffmann-Petersen IT, Mehdizadeh M, Ghosh R, Wang L, Colon-Negron K, Meza-Acevedo R, Backes BJ, Maly DJ, Bluestone JA, Papa FR
Health services research
Authors: Feng C, Paasche-Orlow MK, Kressin NR, Rosen JE, López L, Kim EJ, Lin MY, Hanchate AD
Journal of palliative medicine
Authors: Rosenberg LB, Greenwald J, Caponi B, Doshi A, Epstein H, Frank J, Lindenberger E, Marzano N, Mills LM, Razzak R, Risser J, Anderson WG
Volume 106 of Issue 9 | Journal of pharmaceutical sciences
Authors: Noguchi S, Nishimura T, Mukaida S, Benet LZ, Nakashima E, Tomi M
The pharmacokinetics of cetirizine, a nonsedating antihistamine, is profoundly affected by transporter-mediated membrane transport in the kidney. In this study, we aimed to investigate the transport mechanism of levocetirizine, the pharmacologically active enantiomer of cetirizine, via human organic anion transporter 4 (OAT4) expressed in the apical membrane of renal proximal tubules and the basal plasma membrane of placental syncytiotrophoblasts. In cells expressing human OAT4 under the control of tetracycline, levocetirizine uptake was increased by tetracycline treatment. On the other hand, OAT4 expression did not facilitate efflux of preloaded levocetirizine from the cells, either in the presence or absence of extracellular Cl. The OAT4-mediated levocetirizine uptake was concentration-dependent with a K of 38 μM. The uptake rate of levocetirizine via OAT4 was approximately twice that of racemic cetirizine, indicating stereoselective uptake of levocetirizine. On the other hand, OAT4-mediated [H]dehydroepiandrosterone sulfate uptake was inhibited by dextrocetirizine and levocetirizine. Overall, our findings indicate that OAT4 mediates levocetirizine uptake but is unlikely to mediate the efflux.
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Journal of the American Heart Association
Authors: Cheng J, Kyle JW, Lang D, Wiedmeyer B, Guo J, Yin K, Huang L, Vaidyanathan R, Su T, Makielski JC.
The New England journal of medicine
Authors: Stott DJ, Rodondi N, Kearney PM, Ford I, Westendorp RGJ, Mooijaart SP, Sattar N, Aubert CE, Aujesky D, Bauer DC, Baumgartner C, Blum MR, Browne JP, Byrne S, Collet TH, Dekkers OM, den Elzen WPJ, Du Puy RS, Ellis G, Feller M, Floriani C, Hendry K, Hurley C, Jukema JW, Kean S, Kelly M, Krebs D, Langhorne P, McCarthy G, McCarthy V, McConnachie A, McDade M, Messow M, O'Flynn A, O'Riordan D, Poortvliet RKE, Quinn TJ, Russell A, Sinnott C, Smit JWA, Van Dorland HA, Walsh KA, Walsh EK, Watt T, Wilson R, Gussekloo J
