Publications

Department of Medicine faculty members published more than 3,600 peer-reviewed articles in 2024.

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Antimicrobial agents and chemotherapy

Pharmacokinetics, Tolerability, and Bacteriological Response of Rifampin Administered at 600, 900, and 1,200 Milligrams Daily in Patients with Pulmonary Tuberculosis.

2017

Authors: Aarnoutse RE, Kibiki GS, Reither K, Semvua HH, Haraka F, Mtabho CM, Mpagama SG, van den Boogaard J, Sumari-de Boer IM, Magis-Escurra C, Wattenberg M, Logger JGM, Te Brake LHM, Hoelscher M, Gillespie SH, Colbers A, Phillips PPJ, Plemper van Balen G, Boeree MJ

Immunotherapy

Melanoma treatment with intratumoral electroporation of tavokinogene telseplasmid (pIL-12, tavokinogene telseplasmid).

2017

Authors: Canton DA, Shirley S, Wright J, Connolly R, Burkart C, Mukhopadhyay A, Twitty C, Qattan KE, Campbell JS, Le MH, Pierce RH, Gargosky S, Daud A, Algazi A

Journal of alternative and complementary medicine (New York, N.Y.)

The Effect of Yoga on Arm Volume, Strength, and Range of Motion in Women at Risk for Breast Cancer-Related Lymphedema.

2017

Authors: Mazor M, Lee JQ, Peled A, Zerzan S, Irwin C, Chesney MA, Serrurier K, Sbitany H, Dhruva A, Sacks D, Smoot B

Neurocase

Reorganized neural activation in motor cortex following subdural fluid collection: an fMRI and DTI study.

2017

Authors: Gould L, Kelly ME, Mickleborough MJS, Ekstrand C, Brymer K, Ellchuk T, Borowsky R

BMJ quality & safety

Precommitting to choose wisely about low-value services: a stepped wedge cluster randomised trial.

2017

Authors: Kullgren JT, Krupka E, Schachter A, Linden A, Miller J, Acharya Y, Alford J, Duffy R, Adler-Milstein J

BMJ (Clinical research ed.)

Examining the role of healthcare professionals in the use of solitary confinement.

2017

Authors: Ahalt C, Rothman A, Williams BA

Antimicrobial agents and chemotherapy

Prevalence of Slow-Growth Vancomycin Nonsusceptibility in Methicillin-Resistant Staphylococcus aureus.

2017

Authors: Katayama Y, Azechi T, Miyazaki M, Takata T, Sekine M, Matsui H, Hanaki H, Yahara K, Sasano H, Asakura K, Takaku T, Ochiai T, Komatsu N, Chambers HF

Antimicrobial agents and chemotherapy

PBP4 Mediates ß-Lactam Resistance by Altered Function.

2017

Authors: Chatterjee SS, Chen L, Gilbert A, da Costa TM, Nair V, Datta SK, Kreiswirth BN, Chambers HF

Volume 61 of Issue 11 | Antimicrobial agents and chemotherapy

Mycobacterium tuberculosis Subculture Results in Loss of Potentially Clinically Relevant Heteroresistance.

2017

Authors: Metcalfe JZ, Streicher E, Theron G, Colman RE, Penaloza R, Allender C, Lemmer D, Warren RM, Engelthaler DM

View Abstract

Multidrug-resistant tuberculosis (TB) presents a major public health dilemma. Heteroresistance, the coexistence of drug-resistant and drug-susceptible strains or of multiple drug-resistant strains with discrete haplotypes, may affect accurate diagnosis and the institution of effective treatment. Subculture, or passage of cells onto fresh growth medium, is utilized to preserve cell lines and is universally employed in TB diagnostics. The impact of such passages, typically performed in the absence of drug, on drug-resistant subpopulations is hypothesized to vary according to the competitive costs of genotypic resistance-associated variants. We applied ultradeep next-generation sequencing to 61 phenotypically rifampin-monoresistant ( = 17) and preextensively ( = 41) and extensively ( = 3) drug-resistant isolates with presumptive heteroresistance at two time points in serial subculture. We found significant dynamic loss of minor-variant resistant subpopulations across all analyzed resistance-determining regions, including eight isolates (13%) whose antibiogram data would have transitioned from resistant to susceptible for at least one drug through subculture. Surprisingly, some resistance-associated variants appeared to be selected for in subculture.

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Volume 66 of Issue 2 | Journal of the American Geriatrics Society

Community-Based Palliative Care and Advance Care Planning Documentation: Evidence from a Multispecialty Group.

2017

Authors: Tai-Seale M, Yang Y, Dillon E, Tapper S, Lai S, Yu P, Allore H, Ritchie C

View Abstract

BACKGROUND/OBJECTIVES

With the growing public demand for access to critical health data across care settings, it is essential that advance care planning (ACP) information be included in the electronic health record (EHR) so that multiple clinicians can access it and understand individuals' preferences for end-of-life care. Community-based palliative care programs often incorporate ACP services. This study examined whether a community-based palliative care program is associated with digitally extractable ACP documentation in the EHR.

DESIGN

Observational study using propensity score-weighted generalized estimation equations to examine patterns of digitally extractable ACP documentation.

SETTING

Palo Alto Medical Foundation (PAMF), a multispecialty ambulatory healthcare system in northern California.

PARTICIPANTS

Individuals aged 65 and older with serious illnesses between January 1, 2013, and December 31, 2014 (N = 3,444).

INTERVENTION

Community-based palliative care program in PAMF.

MEASUREMENTS

Digitally extractable ACP in EHR.

RESULTS

We found that only 14% (n = 483) of individuals with serious illnesses had digitally extractable ACP in electronic health records. Of the 6% of individuals receiving palliative care, 65% had ACP, versus 11% of those not receiving palliative care. Study results showed a strong positive association between palliative care and ACP.

CONCLUSION

Only a small percentage of individuals with serious illnesses had ACP documentation in the EHR. Individuals with serious illnesses infrequently used palliative care delivered by board-certified palliative care specialists. Palliative care service use was associated with higher rates of ACP after controlling for organizational and individual characteristics using a propensity score weighting method. Scalable interventions targeted at non-palliative care clinicians for universal access to ACP are needed.

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