Publications

Department of Medicine faculty members published more than 3,600 peer-reviewed articles in 2024.

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Nature

How cells hush a viral invader.

2018

Authors: Fozouni P, Ott M

Tuberculosis

History of tuberculosis.

2018

Authors: Robert Loddenkemper, John F. Murray, Christoph Gradmann, Philip C. Hopewell, Midori Kato-Maeda

Peer Review of Teaching: Insights From a 10-Year Experience.

2018

Authors:

Evaluation of an health-IT-enabled collective intelligence platform to improve diagnosis in primary care and urgent care settings: Study Design (Preprint).

2018

Authors: Valy Fontil, Elaine Khoong, Mekhala Hoskote, Kate Radcliffe, Neda Ratanawongsa, Courtney Rees Lyles, Urmimala Sarkar

Volume 34 of Issue 23 | Bioinformatics (Oxford, England)

GateFinder: projection-based gating strategy optimization for flow and mass cytometry.

2018

Authors: Aghaeepour N, Simonds EF, Knapp DJHF, Bruggner RV, Sachs K, Culos A, Gherardini PF, Samusik N, Fragiadakis GK, Bendall SC, Gaudilliere B, Angst MS, Eaves CJ, Weiss WA, Fantl WJ, Nolan GP

View Abstract

Motivation

High-parameter single-cell technologies can reveal novel cell populations of interest, but studying or validating these populations using lower-parameter methods remains challenging.

Results

Here, we present GateFinder, an algorithm that enriches high-dimensional cell types with simple, stepwise polygon gates requiring only two markers at a time. A series of case studies of complex cell types illustrates how simplified enrichment strategies can enable more efficient assays, reveal novel biomarkers and clarify underlying biology.