Volume 5 of Issue 51 | Science immunology
Authors: Kinet MJ, Rosenblum MD
A novel role for SWI/SNF complexes in tuning Foxp3 expression and activity in T.
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Cancer nursing
Authors: Moy S, Kober KM, Viele C, Paul SM, Hammer M, Melisko M, Wright F, Conley YP, Levine JD, Miaskowski C
Neurology
Authors: Kornblith E, Peltz CB, Xia F, Plassman B, Novakovic-Apopain T, Yaffe K
BMC public health
Authors: Dow DE, Mmbaga BT, Gallis JA, Turner EL, Gandhi M, Cunningham CK, O'Donnell KE
Annual review of medicine
Authors: Quandt Z, Young A, Perdigoto AL, Herold KC, Anderson MS
Nature communications
Authors: Rashkin SR, Graff RE, Kachuri L, Thai KK, Alexeeff SE, Blatchins MA, Cavazos TB, Corley DA, Emami NC, Hoffman JD, Jorgenson E, Kushi LH, Meyers TJ, Van Den Eeden SK, Ziv E, Habel LA, Hoffmann TJ, Sakoda LC, Witte JS
BMJ (Clinical research ed.)
Authors: Lamontagne F, Agoritsas T, Macdonald H, Leo YS, Diaz J, Agarwal A, Appiah JA, Arabi Y, Blumberg L, Calfee CS, Cao B, Cecconi M, Cooke G, Dunning J, Geduld H, Gee P, Manai H, Hui DS, Kanda S, Kawano-Dourado L, Kim YJ, Kissoon N, Kwizera A, Laake JH, Machado FR, Qadir N, Sarin R, Shen Y, Zeng L, Brignardello-Petersen R, Lytvyn L, Siemieniuk R, Zeraatkar D, Bartoszko J, Ge L, Maguire B, Rochwerg B, Guyatt G, Vandvik PO
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Authors: Huang Y, Zhao N, Wang YH, Truillet C, Wei J, Parker MFL, Blecha JE, Drake CR, VanBrocklin HF, Ruiz DG, Jacobson MP, Aggarwal R, Behr SC, Flavell RR, Wilson DM, Seo Y, Evans MJ
Journal of biomedical informatics
Authors: Kumar RP, Pelanis E, Bugge R, Brun H, Palomar R, Aghayan DL, Fretland ÅA, Edwin B, Elle OJ
Volume 28 of Issue 4 | Cell host & microbe
Authors: Nielsen SCA, Yang F, Jackson KJL, Hoh RA, Röltgen K, Jean GH, Stevens BA, Lee JY, Rustagi A, Rogers AJ, Powell AE, Hunter M, Najeeb J, Otrelo-Cardoso AR, Yost KE, Daniel B, Nadeau KC, Chang HY, Satpathy AT, Jardetzky TS, Kim PS, Wang TT, Pinsky BA, Blish CA, Boyd SD
B cells are critical for the production of antibodies and protective immunity to viruses. Here we show that patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who develop coronavirus disease 2019 (COVID-19) display early recruitment of B cells expressing a limited subset of IGHV genes, progressing to a highly polyclonal response of B cells with broader IGHV gene usage and extensive class switching to IgG and IgA subclasses with limited somatic hypermutation in the initial weeks of infection. We identify convergence of antibody sequences across SARS-CoV-2-infected patients, highlighting stereotyped naive responses to this virus. Notably, sequence-based detection in COVID-19 patients of convergent B cell clonotypes previously reported in SARS-CoV infection predicts the presence of SARS-CoV/SARS-CoV-2 cross-reactive antibody titers specific for the receptor-binding domain. These findings offer molecular insights into shared features of human B cell responses to SARS-CoV-2 and SARS-CoV.
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