Current HIV/AIDS reports
Authors: Spinelli MA, Jones BLH, Gandhi M
American journal of public health
Authors: Heinzerling A, Nguyen A, Frederick M, Chan E, Gibb K, Rodriguez A, Wong J, Epson E, Watt J, Materna B, Jain S
Health affairs (Project Hope)
Authors: Kwan A, Garcia-Grossman I, Sears D, Bertozzi SM, Williams BA
Echocardiography (Mount Kisco, N.Y.)
Authors: Jani V, Kapoor K, Meyer J, Lu J, Goerlich E, Metkus TS, Madrazo JA, Michos E, Wu K, Bavaro N, Kutty S, Hays AG, Mukherjee M
International journal of environmental research and public health
Authors: Maya S, McCorvie R, Jacobson K, Shete PB, Bardach N, Kahn JG
PloS one
Authors: Kim KM, Evans DS, Jacobson J, Jiang X, Browner W, Cummings SR
Critical care medicine
Authors: Gupta N, Settle L, Brown BR, Armaignac DL, Baram M, Perkins NE, Kaufman M, Melamed RR, Christie AB, Danesh VC, Denson JL, Cheruku SR, Boman K, Bansal V, Kumar VK, Walkey AJ, Domecq JP, Kashyap R, Aston CE, Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study
American journal of preventive medicine
Authors: Chen YH, Matthay EC, Chen R, DeVost MA, Duchowny KA, Riley AR, Bibbins-Domingo K, Glymour MM
Environmental advances
Authors: English PB, Von Behren J, Balmes JR, Boscardin J, Carpenter C, Goldberg DE, Horiuchi S, Richardson M, Solomon G, Valle J, Reynolds P
Volume 54 of Issue 8 | Nature genetics
Authors: Biering SB, Sarnik SA, Wang E, Zengel JR, Leist SR, Schäfer A, Sathyan V, Hawkins P, Okuda K, Tau C, Jangid AR, Duffy CV, Wei J, Gilmore RC, Alfajaro MM, Strine MS, Nguyenla X, Van Dis E, Catamura C, Yamashiro LH, Belk JA, Begeman A, Stark JC, Shon DJ, Fox DM, Ezzatpour S, Huang E, Olegario N, Rustagi A, Volmer AS, Livraghi-Butrico A, Wehri E, Behringer RR, Cheon DJ, Schaletzky J, Aguilar HC, Puschnik AS, Button B, Pinsky BA, Blish CA, Baric RS, O'Neal WK, Bertozzi CR, Wilen CB, Boucher RC, Carette JE, Stanley SA, Harris E, Konermann S, Hsu PD
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a range of symptoms in infected individuals, from mild respiratory illness to acute respiratory distress syndrome. A systematic understanding of host factors influencing viral infection is critical to elucidate SARS-CoV-2-host interactions and the progression of Coronavirus disease 2019 (COVID-19). Here, we conducted genome-wide CRISPR knockout and activation screens in human lung epithelial cells with endogenous expression of the SARS-CoV-2 entry factors ACE2 and TMPRSS2. We uncovered proviral and antiviral factors across highly interconnected host pathways, including clathrin transport, inflammatory signaling, cell-cycle regulation, and transcriptional and epigenetic regulation. We further identified mucins, a family of high molecular weight glycoproteins, as a prominent viral restriction network that inhibits SARS-CoV-2 infection in vitro and in murine models. These mucins also inhibit infection of diverse respiratory viruses. This functional landscape of SARS-CoV-2 host factors provides a physiologically relevant starting point for new host-directed therapeutics and highlights airway mucins as a host defense mechanism.
View on PubMed
