Publications

Department of Medicine faculty members published more than 3,000 peer-reviewed articles in 2022.

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Sexually transmitted diseases

COVID-19, HIV, and Syphilis Contact Tracing: What have we learned and where are we headed?

2022

Authors: Sachdev D, Chew Ng RA, Hernandez K, Nguyen TQ, Cohen SE

Respiratory research

Safety and efficacy of RT234 vardenafil inhalation powder on exercise parameters in pulmonary arterial hypertension: phase II, dose-escalation study design.

2022

Authors: Benza RL, Franco V, Aras MA, Spikes L, Grinnan D, Satler C

Volume 378 of Issue 6625 | Science (New York, N.Y.)

Synthetic cytokine circuits that drive T cells into immune-excluded tumors.

2022

Authors: Allen GM, Frankel NW, Reddy NR, Bhargava HK, Yoshida MA, Stark SR, Purl M, Lee J, Yee JL, Yu W, Li AW, Garcia KC, El-Samad H, Roybal KT, Spitzer MH, Lim WA

View Abstract

Chimeric antigen receptor (CAR) T cells are ineffective against solid tumors with immunosuppressive microenvironments. To overcome suppression, we engineered circuits in which tumor-specific synNotch receptors locally induce production of the cytokine IL-2. These circuits potently enhance CAR T cell infiltration and clearance of immune-excluded tumors, without systemic toxicity. The most effective IL-2 induction circuit acts in an autocrine and T cell receptor (TCR)- or CAR-independent manner, bypassing suppression mechanisms including consumption of IL-2 or inhibition of TCR signaling. These engineered cells establish a foothold in the target tumors, with synthetic Notch-induced IL-2 production enabling initiation of CAR-mediated T cell expansion and cell killing. Thus, it is possible to reconstitute synthetic T cell circuits that activate the outputs ultimately required for an antitumor response, but in a manner that evades key points of tumor suppression.

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Journal of palliative medicine

Top Ten Tips Palliative Care Clinicians Should Know About Leveraging the Electronic Health Record for Data Collection and Quality Improvement.

2022

Authors: Huber MT, Ling DY, Rozen AS, Terauchi SY, Sharma P, Fleischer-Black J, Schoenherr LA, Hutchinson RN, Lindvall C, Jones CA, Guerry RT, Berlin A

Journal of addiction medicine

A Mixed-methods Evaluation of an Addiction/Cardiology Pilot Clinic With Contingency Management for Patients With Stimulant-associated Cardiomyopathy.

2022

Authors: Leyde S, Abbs E, Suen LW, Martin M, Mitchell A, Davis J, Azari S

Heart rhythm O2

American Indians and atrial fibrillation.

2022

Authors: Sanchez JM, Marcus GM

European heart journal

Randomized trials fit for the 21st century. A joint opinion from the European Society of Cardiology, American Heart Association, American College of Cardiology, and the World Heart Federation.

2022

Authors: Bowman L, Weidinger F, Albert MA, Fry ETA, Pinto FJ, Clinical Trial Expert Group and ESC Patient Forum

Circulation

Randomized Trials Fit for the 21st Century: A Joint Opinion From the European Society of Cardiology, American Heart Association, American College of Cardiology, and the World Heart Federation.

2022

Authors: Bowman L, Weidinger F, Albert MA, Fry ETA, Pinto FJ, Clinical Trial Expert Group; and for the ESC Patient Forum

Global heart

Randomized Trials Fit for the 21st Century. A Joint Opinion from the European Society of Cardiology, American Heart Association, American College of Cardiology, and the World Heart Federation.

2022

Authors: Bowman L, Weidinger F, Albert MA, Fry ETA, Pinto FJ, Clinical Trial Expert Group and ESC Patient Forum

American journal of medical quality : the official journal of the American College of Medical Quality

Utilizing Inpatient Admissions to Increase HIV Screening During the COVID-19 Pandemic and Beyond.

2022

Authors: Garcia-Grossman I, Hauser K, Adamo M, Flynn S, Burbank S, Crawford C, Davis J, Lydon E, Reed G, Kochanska M, Guzman K