Journal of virology
Authors: Sufiawati I, Herrera R, Mayer W, Cai X, Borkakoti J, Lin V, Rosbe K, Tugizov SM
Volume 93 of Issue 10 | Journal of medical virology
Authors: Camargo JF, Lin RY, Komanduri KV
PROBLEM
The utility of the polymerase chain reaction (PCR) cycle threshold (C ) values in the management of patients with coronavirus disease 2019 (COVID-19) remains controversial.
METHODS
We assessed the correlation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) C values in nasopharyngeal swab samples with the oxygen requirements at the time of sample collection. Specimens were tested with the Simplexa PCR platform, which targets the SARS-CoV-2 ORF1ab and S genes.
RESULTS
We identified 23 COVID-19 patients with 49 C values available. While C values from ORF1ab and S genes were highly correlated for a given specimen, there was no correlation between C values for any of these target genes and the oxygen requirements of the patient at the time of sample collection. We found no differences in the initial nor the nadir C values between survivors and non-survivors or mild/moderate versus severe/critical illness at the maximum point of illness.
CONCLUSION
SARS-CoV-2 C values have limited value in the management of COVID-19.
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Volume 96 of Issue 10 | American journal of hematology
Authors: Lee EJ, Seshadri M, Bussel JB
Respiratory medicine case reports
Authors: Bawaadam H, Ivanick N, AlShelli I, Krishna G
Authors: Horwitz RI, Lobitz G, Mawn M, Conroy AH, Cullen MR, Sim I, Singer BH
Authors: Dodagatta-Marri E, Ma HY, Liang B, Li J, Meyer DS, Chen SY, Sun KH, Ren X, Zivak B, Rosenblum MD, Headley MB, Pinzas L, Reed NI, Del Cid JS, Hann BC, Yang S, Giddabasappa A, Noorbehesht K, Yang B, Dal Porto J, Tsukui T, Niessen K, Atakilit A, Akhurst RJ, Sheppard D
Journal of the American Geriatrics Society
Authors: Deardorff WJ, Binford SS, Cole I, James T, Rathfon M, Rennke S, Wallhagen M
Academic medicine : journal of the Association of American Medical Colleges
Authors: Hoops K, Fahimi J, Khoeur L, Studenmund C, Barber C, Barnhorst A, Betz ME, Crifasi CK, Davis JA, Dewispelaere W, Fisher L, Howard PK, Ketterer A, Marcolini E, Nestadt PS, Rozel J, Simonetti JA, Spitzer S, Victoroff M, Williams BH, Howley L, Ranney ML
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Authors: Gonciulea AR, Wang Y, Bikle DD, Sellmeyer DE
mBio
Authors: Li YY, Cai RJ, Yang JY, Hendrickson TL, Xiang Y, Javid B