UCSF Department of Medicine Grand Rounds

Medical Grand Rounds generally takes place once a week at Parnassus, ZSFG, and the VA.

An archive of previous medical grand rounds is available here.

Here is a list of upcoming medical grand rounds:

See All | Parnassus/Mt Zion | ZSFG

Thu Dec 14

Approaches to Hypermidichlorianemia and Undiagnosed Diseases

Parnassus: HSW-300 noon - 1:00 pm

Matthew Wheeler, MD

Clinical Assistant Professor, Stanford University

Medical Director of the Center for Undiagnosed Diseases


*Give examples of the use of exome and genome sequencing in the diagnostic work up

*Recognize patients with undiagnosed diseases and approaches to evaluation

*Describe an approach to defining diagnostic certainty

Dr. Matthew Wheeler is Clinical Assistant Professor and Medical Director of the Center for Undiagnosed Diseases at Stanford University in Stanford, California. An expert in cardiovascular genetics, he has clinical interest in advanced heart failure and inherited cardiomyopathies. His background includes research in myocardial and skeletal muscle biology as well as molecular genetics and genomics. He has extensive translational science experience, participating in ongoing clinical trials for hypertrophic cardiomyopathy, dilated cardiomyopathy, cardiac amyloidosis, and mechanical circulatory support. In genetics and genomics, he has led analysis of whole genome and whole exome sequencing focusing on identifying clinically actionable rare and novel variants, first from whole genome sequencing of a single patient and now in cohorts of inherited cardiomyopathy and undiagnosed disease patients. He is the Adult Medical Director of Stanford’s NIH-funded Center for Undiagnosed Diseases and a core member of the Undiagnosed Diseases Network. He teaches physician and genetic counselor trainees on genomic medicine and approach to undiagnosed diseases. In addition to his work in genetics and genomics of disease, he is a member of the Bioinformatics Core of the Molecular Transducers of Physical Activity Consortium, whose goal is to create a multiomic map of the response to physical activity, and co-PI on the Exercise at the Limit – Inherited Traits of Endurance, a project whose goal is to identify the genetic contributors to human performance.


Parnassus Statement


The University of California San Francisco, School of Medicine (UCSF) is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

UCSF designates this live activity for a maximum of 35 AMA PRA Category Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

The above credit is inclusive of all Fiscal Year 2017 Department of Medicine Grand Rounds sessions. Up to 1 credit may be claimed against any individual session.

You must sign in to qualify for CME credit.

Course Number MGR 18002

*Faculty Relationship Disclosure

All speakers listed above have declared that neither they, nor any immediate member of their family, have a financial arrangement or other relationship with the manufacturers of any commercial products except *.

* All conflicts of interest have been resolved in accordance with the ACCME's Standards for Commercial Support.

Medical Grand Rounds Commercial Support Disclosure

No commercial support received for Medical Grand Rounds.