UCSF Department of Medicine Grand Rounds

Medical Grand Rounds generally takes place once a week at Parnassus, SFGH, and the VA.

An archive of previous medical grand rounds is available here.

Here is a list of upcoming medical grand rounds:

See All | Parnassus/Mt Zion | SFGH

DateDescription
Thu Sep 29

Engineering Human T Cell Circuitry

Parnassus: HSW-300 noon - 1:00 pm

Alexander Marson, MD, PhD

Assistant Professor, UCSF

http://tiny.ucsf.edu/mQfRW1



*Genetic variants associated with human autoimmune diseases and other complex diseases

*Recent advances in CRISPR/Cas9 as a tool for genome engineering

*Applications of Cas9 Genome Engineering for experimental editing of human immune cells, and potential for applications in cell-based therapies



Alex Marson completed medical school at Harvard, PhD training at the Whitehead Institute/MIT with Richard Young and Rudolf Jaenisch, Internal Medicine residency at the Brigham and Women’s and clinical training in Infectious Diseases at UCSF. He was a UCSF Sandler Faculty Fellow from 2013-2016. He is now an assistant professor in the UCSF Department of Microbiology and Immunology, with joint appointments in the Department of Medicine and the Diabetes Center.



Dr. Marson’s group integrates systems-scale investigations of human T cell circuitry with functional perturbation studies, including genome editing in primary T cells. His work has employed genomic techniques to study the transcriptional circuits that enable immune cells to establish highly specialized identities. He and his collaborators have systematically identified enhancers and non-coding transcripts in human immune cell subsets and developed new methodology to learn how fine-mapped genetic variants disrupt these regulatory elements to give rise to human autoimmune diseases. The Marson lab, along with collaborators at the Innovative Genomics Initiative (IGI), has developed new tools for genome engineering in primary human T cells using CRISPR/Cas9 ribonucleoproteins (RNPs). The ability to edit specific genomic sequences in human immune cells holds potential for identifying novel drug targets and for enhancing the next generation of cell-based therapies.

Tue Oct 04

TBD

SFGH: Carr Auditorium noon - 1:00 pm

Rochelle Dicker

Tue Oct 04

TBD

SFGH: Carr Auditorium noon - 1:00 pm

Rochelle Dicker

Thu Oct 06

Common Geriatrics Issues in General Practice

Parnassus: HSW-300 noon - 1:00 pm

Anna Chodos, MD

Assistant Professor of Medicine, Division of Geriatrics and Division of General Internal Medicine, ZSFG

http://tiny.ucsf.edu/mQfRW1



*Demonstrate 2 ways to assess a cognitive complaint.

*Describe 1 nonpharmacologic approach for addressing behavioral symptoms of dementia

*Identify 1 resource for de-prescribing medications in older adults



Dr. Anna Chodos is an Assistant Professor of Medicine in the Division of General Internal Medicine at Zuckerberg San Francisco General and the Division of Geriatrics. Her clinical work is in both general primary care and in outpatient specialty care in geriatrics, and she is the Co-Principal Investigator of the Geriatrics Workforce Enhancement Program at UCSF, which trains health care and social service providers in geriatrics.

Tue Oct 11

TBD

SFGH: Carr Auditorium noon - 1:00 pm

Neeta Thakur

Thu Oct 13

Challenges and Controversies with Diagnostic Testing for C. difficile Infection

Parnassus: HSW-300 noon - 1:00 pm

Christopher Polage, MD, MAS

Associate Professor of Medical Pathology and Infectious Diseases,

UC Davis School of Medicine

http://tiny.ucsf.edu/mQfRW1



*Learn about outcome studies showing that molecular tests lead to over-diagnosis and unnecessary treatment of C. difficile infection

*Discuss the patient and institution-level consequences of C. difficile over-diagnosis and over treatment

*Understand how toxin tests can be used to predict the likelihood of C. difficile infection, complications, and need for treatment in patients with positive molecular tests and diarrheal symptoms

*List 3 alternative causes for diarrhea in patients with C. difficile colonization and negative toxin tests



Christopher Polage is an Associate Professor of Pathology and Infectious Diseases at the University of California Davis (UC Davis), School of Medicine and Medical Director of the Clinical Microbiology Laboratory for the UC Davis Health System. He conducts outcomes and healthcare services research related to infectious disease diagnostics and healthcare-associated infections. He is on the Editorial Board for the Journal of Clinical Microbiology and received a Distinguished Clinical Research Achievement Award from the Clinical Research Forum in 2016 for his studies of clinical outcomes in hospitalized patients with discrepant test results for Clostridium difficile infection.

Tue Oct 18

Medical Education Topic

SFGH: Carr Auditorium noon - 1:00 pm

Justin Sewell

Thu Oct 20

Annual Rudi Schmid Lecture: Stressed Out: A Novel Approach to Cancer Immunotherapy

Parnassus: HSW-300 noon - 1:00 pm

Laurie Glimcher, MD*

President and CEO, Dana-Farber Cancer Institute

Principal Investigator and Director, Dana-Farber/Harvard Cancer Center

Proposed Richard and Susan Smith Professor of Medicine, Harvard Medical School

http://tiny.ucsf.edu/mQfRW1



*Overview of cancer immunotherapy

*Overview of the ER Stress Response

*Summary of the function of the IRE1/XBP1 arm of the ER Stress Response in both the tumor and in controlling immune responses in the tumor microenvironment



Laurie H. Glimcher, MD, is President and CEO of Dana-Farber Cancer Institute, Principal Investigator and Director of Dana-Farber/Harvard Cancer Center and the proposed Richard and Susan Smith Professor of Medicine at Harvard Medical School. Previously, she was the Stephen and Suzanne Weiss Dean and Professor of Medicine of Weill Cornell Medical College in New York City, and Provost for Medical Affairs of Cornell University. Prior to her work at Cornell, Dr. Glimcher was the Irene Heinz Given Professor of Immunology at the Harvard School of Public Health, where she was director of the Division of Biological Sciences, and Professor of Medicine at Harvard Medical School, where she headed one of the top immunology programs in the world.



As an immunologist, her primary research interests are elucidating the molecular pathways that regulate the immune system, critical for both the development of protective immunity and for the pathophysiologic immune responses underlying autoimmune, infectious and malignant diseases. She is a Fellow of the American Academy of Arts and Sciences, a Member of the National Academy of Medicine and a Member of the National Academy of Sciences. She sits on the Corporate Board of Directors of the Bristol-Myers Squibb Pharmaceutical Corporation and the Waters Corporation.

Tue Oct 25

TBD

SFGH: Carr Auditorium noon - 1:00 pm

Dhruv Kazi

Thu Oct 27

Personalized Genomics and Sequencing in Medical Care

Parnassus: HSW-300 noon - 1:00 pm

Joseph Shieh MD, PhD

Associate Professor, Division of Medical Genetics, Department of Pediatrics

Residency Program Director, UCSF Medical Genetics and Genomics Training Program

Co-Director Personalized Genomics Clinic

Director, NF/Ras Genetics Clinic



Anne Slavotinek, MD, PhD

Professor of Clinical Pediatrics, UCSF

http://tiny.ucsf.edu/mQfRW1



*To understand the different clinical indications for panel testing and whole exome sequencing

*To understand consent and interpretative process for variants of unknown significance and secondary variants



Dr. Shieh is a Board-Certified Medical Geneticist who trained at Penn for his MD/PhD and then at the University of Washington and at Stanford/UCSF. He worked as a geneticist at Stanford prior to joining the faculty at UCSF. His research lab in the Institute for Human Genetics applies genomic sequencing and bioinformatics for gene discovery and functional annotation. His lab focuses on the development of new tools to analyze the genome. His research has delineated novel genetic conditions using sequencing and he clinically manages these patients. He served on the Genomic Medicine Taskforce for UCSF. He has expertise in variant analysis pipelines, bioinformatics, cell and model systems and population variation. He is a member of a U grant consortium on exome sequencing that is sequencing from blood spots. He received a UC Precision Medicine grant this year.



Dr. Slavotinek is a Clinical Geneticist who has achieved Board certification or an equivalent professional qualification in the United States, United Kingdom and Australia. She has had a long-standing interest in multiple congenital anomaly syndromes and birth defects. The predominant part of her clinical practice concerns the diagnosis of children with Mendelian syndromes and unknown conditions. In dysmorphology, she has achieved national recognition and has served as an invited expert at the American Society of Human Genetics annual meeting and at the American College of Medical Genetics and Genomics annual meeting. She is a member of several Editorial Boards for journals that focus on multiple congenital anomaly syndromes, such as the Orphanet Journal of Rare Diseases, the American Journal of Medical Genetics, Clinical Dysmorphology and Molecular Genetics and Genomic Medicine. Dr. Slavotinek is an author on more than 140 peer-reviewed publications in addition to book chapters and reviews, many of them concerning the clinical aspects and gene discovery for Mendelian conditions. She also directs the Personalized Genomics clinic at UCSF and has counseled more than 100 families regarding exome sequencing consents, results and re-analysis. She is very interested in precision medicine and has numerous patients who have had negative exome sequencing results who would benefit from full genome sequencing. She is fully invested in helping to ascertain and counsel suitable patients and families for this research.

Tue Nov 01

TBD

SFGH: Carr Auditorium noon - 1:00 pm

Joe Derisi

Thu Nov 03

TBA

Parnassus: HSW-300 noon - 1:00 pm

 

Parnassus Statement

Accreditation

The University of California San Francisco, School of Medicine (UCSF) is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

This live activity is designated for a maximum of 1 AMA PRA Category 1 credit. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

You must sign in to qualify for CME credit.

Course Number MGR15002

*Faculty Relationship Disclosure

All speakers listed above have declared that neither they, nor any immediate member of their family, have a financial arrangement or other relationship with the manufacturers of any commercial products except *.

* All conflicts of interest have been resolved in accordance with the ACCME's Standards for Commercial Support.

Medical Grand Rounds Commercial Support Disclosure

No commercial support received for Medical Grand Rounds.

SFGH Statement

The speaker(s) declare that neither they nor any immediate family have financial or other arrangements with the manufacturers of any pharmaceutical products or medical devices discussed in this CME activity. The speaker(s) indicate that they do not intend to discuss investigational or off label use of pharmaceutical products or medical devices.

UCSF is accredited b the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians and allied health care professionals. -- CME credit is one hour.

No commercial support was received for this CME activity.