DAVIDE VEROTTA, Ph.D., Professor of Biopharmaceutical Sciences and
Pharmaceutical Chemistry
Dr. Verotta's main research interests are in
pharmacokinetics/pharmacodynamics and mathematical/statistical
modeling. The main areas of interest are: experimental design, Bayesian
modeling with particular regard to inverse problems mechanistic and
empirical mathematical modeling to analyze, simulate and control PK/PD
data and systems; population PK/PD modeling with particular regard to
empirical methods for population data analysis.
Dr. Verotta is involved in collaborative research with scientists and
different investigators in PK/PD and clinical therapy (notably HIV
therapy) modeling.
SELECTED PUBLICATIONS:
- Verotta, D., Models and Estimation Methods for Clinical HIV-1 Data. Journal of Computational and Applied Mathematics, 184:275-300,
2005.
- Kang, D., J.B. Schwartz, and D. Verotta, A sample size computation
method for nonlinear mixed effects models with applications to
pharmacokinetics models.
Statistics in Medicine, 23:2551-2566, 2004.
- Csajka, C., C.A. Haller, N.L. Benowitz, and D. Verotta, Mechanistic
Pharmacokinetic Modeling of Ephedrine, Norephedrine and Caffeine in
Healthy Subjects. Br J Pharmacol, 59:335-345,
2005.
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Med Tox
CHRISTINE A. HALLER, M.D. Assistant Professor of Medicine, Clinical
Pharmacology
Dr. Haller is interested in the pharmacology and toxicology of herbal
products, and is currently conducting clinical research studies on the
pharmacokinetics (PK) and pharmacodynamics (PD) of thermogenic dietary
supplements that contain ephedra, caffeine, and related stimulant
botanicals. She has recently completed a study that showed that a
single dose of a weight loss herbal supplement can produce significant
increases in blood pressure and resting heart rate in healthy young
adults. Her current research is investigating potential PK and PD
interactions of pure ephedrine and caffeine compared to each drug
alone. Dr. Haller is also involved in the initiation of a new clinical
research program to investigate the pharmacology of gamma
hydroxybutyrate (GHB) in humans. A number of studies involving GHB are
planned including investigating GHB’s effects on cognitive performance,
and potential interactions of GHB and ethanol, in an effort to model
the recreational use of GHB as a club drug. SELECTED PUBLICATIONS
1. Haller CA, Benowitz NL. Adverse cardiovascular and central nervous
system events associated with dietary supplements containing ephedra
alkaloids. N Engl J Med 2000;343:1833-8.
2. Haller C, Dyer JE, Ko R, Olson K. Making a Diagnosis of
Herbal-Related Toxic Hepatitis. West J of Med. 2002;176:39-44.
3. Haller CA, Jacob P, Benowitz NL. Pharmacology of ephedrine and
caffeine after single dose dietary supplement use. Clin Pharmacol Ther
2002;71:421-432.
