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JANICE B. SCHWARTZ, M.D., FACC, Clinical Professor of Medicine, Geriatric Clinical Pharmacology
Dr. Schwartz is an established leader in geriatric clinical pharmacology, cardiology, and women’s health. Current projects focus on clinical research into the underlying mechanisms for altered drug responses with aging and differences between the sexes in drug metabolism and responses. Projects range from population approaches to evaluate age, sex, race, genetic and clinical factors determining CYP-mediated drug clearance and pharmacodynamic responses (CYP’s 3A, 2D6, 2C19) to mechanistic studies of hormonal influences on metabolism and cardiovascular responses. Additional projects focus on the frail elderly with collaborative projects to investigate dementia treatment and genetics determinants of response. The Gray laboratory at San Francisco General Hospital focuses on novel pharmacological strategies to induce resistance to myocardial ischemia-reperfusion injury. Her group was one of the first to identify protein kinase C (PKC) activation as a signaling event required for cardioprotection and is currently exploring cellular interactions between PKC isozymes and mitochondria using cultured cardiac myocytes, ex vivo (Langendorff-perfused) mouse hearts, and in vivo myocardial infarction models. One particular area of interest is the investigation of signaling mechanisms that contribute to sustained cardioprotection during moderate alcohol consumption.
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