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ANTIMICROBIAL RESEARCH

HENRY F. CHAMBERS, M.D., Professor of Medicine

The focus of Dr. Chambers' work is experimental therapeutics and mechanisms of bacterial resistance to antibiotics. Studies are concerned primarily with identification of drug targets and biochemical and genetic characteristics of resistance in Staphylococcus aureus and Mycobacterium tuberculosis. Research projects range from molecular investigations of beta-lactamase, penicillin-binding proteins and their regulatory elements; animal models of infection; and clinical drug development, particularly promising agents for treatment of staphylococcal and mycobacterial infections.

SELECTED PUBLICATIONS:

  1. Chambers HF. Evaluation of ceftobiprole in a rabbit model of aortic valve endocarditis due to methicillin-resistant and vancomycin-intermediate Staphylococcus aureus. Antimicrob Agents Chemother, 49(3):884-888, 2005.
  2. Chambers HF. Community-associated MRSA--resistance and virulence converge. N Engl J Med, 352(14):1485-1487, 2005.
  3. Siboo IR, Chambers HF, Sullam PM. Role of SraP, a Serine-Rich Surface Protein of Staphylococcus aureus, in binding to human platelets. Infect Immun, 73(4):2273-2280, 2005.

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