PHARMACOGENOMICS
ESTEBAN GONZÁLEZ BURCHARD, M.D., Assistant Professor, Biopharmaceutical Sciences and Clinical Pharmacology, Division of Pulmonary and Critical Care, Departments of Medicine and Biopharmaceutical Sciences
Dr. Esteban Burchard’s research focuses on identifying ethnic-specific genetic risk factors for asthma, asthma severity and drug responsiveness. He is studying biological and genetic risk factors for asthma among Latino Americans (Genetics of Asthma in Latino Americans, GALA study) and in African Americans (Genetic & Environmental Risk Factors in Ethnically Diverse Asthmatic and Therapeutic Groups, GREAT study). His team uses a family based approach (transmission/disequilibrium test or TDT) to identify genetic variants among asthma candidate genes. Identified variants are analyzed to determine whether these alleles are associated with asthma and asthma severity among these populations. Dr. Burchard is also developing methods to apply population based genetic studies to ethnically admixed populations. In addition, Dr. Burchard’s team is performing whole genome association and admixture mapping studies to identifying genes related to asthma and drug responsiveness in Latino and African Americans.
SELECTED PUBLICATIONS:
- Salari, K, Choudhry S, Lind, D, Tang, H, Clark SL, Ung, N, Matallana, H, Avila, PC, Nazario, S, Casal J, Torres, A, Toscano, M, Castro, R, Rodriguez-Cintron, W, Shriver, MD, Kwok, Sheppard, D, Pui-Yan, Risch, N, Ziv, E and Burchard, EG. Individual Ancestry is Associated with Asthma Severity from the Genetics of Asthma in Latino Americans (GALA) Study.
Genetic Epidemiology Nov 2004.
- Choudhry, S, Ung, N, Avila, PC, Ziv, E, Nazario, S, Casal, J, Torres, A, Gorman, JD, Salari, K, Rodriguez-Santana, JR, Toscano, M, Senter-Sylvia, J, Alioto, ME, Salazar, M, Gomez I, Fagan, JK, Salas, J, Clark, S, Lilly, C, Matallana, H, Selman, M, Chapela, R, Sheppard, D, Weiss, ST, Ford, JG, Boushey, HA, Drazen, JM, Rodriguez-Cintron, W, Silverman, EK and Burchard, EG from the Genetics of Asthma in Latino Americans (GALA) Study. Pharmacogenetic Differences in Response to Bronchodilators Between Puerto Rican and Mexican Asthmatics. AJRCCM e-pub Nov 14, 2004.
- Burchard, EG, Avila, PC, Nazario, S, Casal, J, Torres, A, Rodriguez-Santana, JR, Toscano, M, Senter-Sylvia, J, Alioto, ME, Salazar, M, Gomez, I, Fagan, JK, Salas, J, Lilly, C, Matallana, H, Ziv, E, Castro, R, Selman, M, Chapela, R, Sheppard, D, Weiss, ST, Ford, JG, Boushey, HA, Rodriguez-Cintron, W, Drazen, JM and Silverman, EK, from the Genetics of Asthma in Latino Americans (GALA) Study. Lower Bronchodilator Responsiveness in Puerto Rican than in Mexican Asthmatic Subjects. AJRCCM e-pub Nov 14, 2003.
