|
*** Research
activities of the Division can also be viewed on the bio-sketches
of individual faculty members.
M. Kari Connolly, MD
Lindsey A. Criswell, MD, MPH
Maria Dall'Era , MD
Edward Yelin, PhD
***************************************************
Research -- Clinical
Research by M. Kari Connolly, M.D.
The UCSF Scleroderma Database and Tissue Bank.
This study is open to all patients with scleroderma. A one-page information sheet is completed and signed. This form can be downloaded at http://www.dermatology.ucsf.edu/autoimmune/ and then returned by fax or mail to the address below. The information is entered into a computer database. Based on the information, together with what studies are active, patients may be contacted for study participation which could include: blood draws, skin biopsies and/or other studies.
- Sponsor: Scleroderma Research Foundation
- Investigator: M. Kari Connolly, M.D. (Dermatologist/Rheumatologist)
- Call and leave info on machine: 415-502-5358
The Scleroderma Lung Study.
This is a two-year study that looks at the affect of daily oral cytoxan for one year versus placebo on lung disease in scleroderma patients. This study is open to patients with scleroderma (systemic sclerosis) for less than 7 years with symptomatic lung involvement (short of breath going up one flight of steps).
- Sponsor: The NIH
- Investigator: M. Kari Connolly, M.D.
- Research coordinator: 415-502-6229
Anti-TGFb in scleroderma patients.
This study is in the planning stages. This study will be a phase II trial of anti-TGF-b in scleroderma patients (4 IV infusions 6-weeks apart over 6 months.). The goal of this experimental therapy is to soften skin and improve fibrosis.
- Sponsor: Genzyme, Inc.
- Investigator: M. Kari Connolly, M.D.
Immune tolerance therapy in pemphigus patients.
This a phase I trial of synthetic desmoglein 3 (the immuno dominant antigen for pemphigus) in stable, active pemphigus vulgaris patients.
- Sponsor: Peptimmune, Inc.
- Investigator: M. Kari Connolly, M.D.
- Research coordinator: 415-502-6229
Research by Lindsey Ann Criswell, M.D., M.P.H.
Lupus Genetics Research Project
Any patient with a diagnosis of systemic lupus (SLE) is welcome to participate in this study. This ongoing study is investigating the genes that may predispose an individual to develop lupus. Participation can be completed by mail and involves completing a questionnaire, consent form, as well as providing a small saliva sample.
- Sponsor: National Institute of Health (NIH)
- Investigator: Lindsey Criswell, M.D., M.P.H.
- Contact: toll free 888-223-3067 x1
Rheumatoid Arthritis Genetics Research Project
Any patient with a diagnosis of rheumatoid arthritis (RA) is welcome to participate in this study. This ongoing study is investigating the genes that may predispose an individual to develop rheumatoid arthritis. Participation can be completed by mail and involves completing a questionnaire, consent form, as well as providing a small saliva sample.
- Sponsor: National Institute of Health (NIH)
- Investigator: Lindsey Criswell, M.D., M.P.H.
- Contact: toll-free 888-223-3067 x4
Mother-Child Immunogenetic Study
This study involves a collaboration with the UC Berkeley School of Public Health to investigate the role that pregnancy plays in rheumatoid arthritis (RA) and lupus (SLE). Criteria for participation include: (1) a diagnosis of RA or SLE, (2) at least one pregnancy resulting in a live birth, (3) at least one child must be willing to participate and over the age of 7, and (4) participation of the biological father is encouraged but not required. Participation can be completed by mail and involves completing a questionnaire, consent form, as well as providing a small saliva sample.
- Sponsor: National Institute of Health (NIH)
- Investigators: Lindsey Criswell, M.D., M.P.H. & Lisa Barcellos, Ph.D.(UC Berkeley)
- Contact: toll-free 888-223-3067 x3
Research by Maria Dall'Era, M.D.
The Natural History, Pathogenesis, and Disease Analysis of Systemic Lupus Erythematosus
The purpose of this study is to learn more about the disease systemic lupus erythematosus (SLE). The goals of this research are 1) to evaluate patients with lupus to better understand how the disease begins and how it affects patients, 2) to follow patients during the course of the disease to understand how disease changes over time and, 3) to conduct research to develop better treatments for lupus. There is no cost for participation.
- Sponsor: Rosalind Russell Center for Arthritis Research
- Investigator: Maria Dall'Era, M.D. & David Wofsy, M.D.
- Contact: Stephanie Morgan (415) 502-1698
Relationships among Disease Status, Immune Markers, Cognitive Functioning, and Psychiatric Symptoms in Systemic Lupus Erythematosus (SLE)
The purpose of this study is to examine neuropsychiatric symptoms in SLE. The goals of this investigation are to (1) evaluate cognitive and psychiatric symptoms in SLE, (2) to examine the relationship among SLE disease status, immune functioning, cognitive functioning and psychiatric symptoms, and (3) to follow patients in order to understand how these neuropsychiatric symptoms change over time. Patients with and without a previous history of neuropsychiatric symptoms are invited to participate. There is no cost for participation, and treatment is not provided.
- Investigators: Maria Dall'Era, M.D.& Laura J. Julian, Ph.D.
- Contact: Stephanie Morgan (415) 502-1886 & Laura Julian (415) 221-4810 x 3134
|
