| San Francisco VA Medical Center
Immunology Section 111R4
4150 Clement St.
San Francisco, CA 94121
phone:
415-750-2104
fax: 415-750-6920
Education and Training
1999 University of Pittsburgh Medical School--MD (Cum Laude)
1999-2002 University of California, San Francisco--Medical residency
2002-2005 University of California, San Francisco--Rheumatology fellowship
Research Program
My research is focused on systemic lupus erythematosus (SLE), a prototypic autoimmune disease characterized by loss of immune tolerance, autoantibody production to a range of self-antigens (autoantigens) and tissue destruction of multiple organ systems. I am studying the role of regulatory T-cells (Tregs) in the development and treatment of SLE. Regulatory T cells are an essential component of the normal immune system and serve a critical role in modulating the activation and proliferation of lymphocytes including autoreactive lymphocytes. In some murine models and human studies, defects in Treg prevalence and/or function have been associated with organ specific autoimmune diseases. This project is examining the role of Tregs in the development of systemic autoimmunity and the therapeutic potential of these cells in the treatment of lupus.
Publications
Scalapino, KJ, Conner JM, Varon S. The Role of NGF and Afferent Denervation in the Process of Sympathetic Fiber Ingrowth into the Hippocampal Formation. Experimental Neurology. 1996 141, 310-317.
Scalapino, KJ, Davis, JC Jr., The treatment of ankylosing spondylitis. Clin Exp Med. 2003 Feb;2(4):159-65.
Scalapino, KJ, Arkachaisri, T, Lucas, M, Fertig, N, Helfrich, D, Londino, AV, Steen, VD, Medsger, TA, et al. Childhood Onset Systemic Sclerosis: Clinical and Serologic Features and Survival in Comparison with Adult Onset Disease. Journal Of Rheumatology. 2006 May;33(5), 1004-13.
Scalapino, KJ, Q. Tang, J. Bluestone, M. Bonyhadi, and D. Daikh. Suppression of disease in NZB/NZW lupus prone mice by adoptive transfer of ex vivo expanded regulatory T cells. The Journal of Immunology, 2006, 177: 1451-1459.
Strachan, L, K.J. Scalapino, H. Lawrence, and R. Ghadially. Rapid adhesion to collagen isolates murine keratinocytes with limited long-term repopulating ability in vivo despite high clonogenicity in vitro. Stem Cells, 2008, 26(1): 235-243.
Boonyaratanakornkit, JB, L. Yue, L.R. Strachan, S. P. Leong, K.J. Scalapino, P.E. Leboit, Y. Lu, J.E. Smith, R. Ghadially. Melanoma initiating cells predict metastasis-free survival. Submitted Nature , February, 2008.
Scalapino, KJ, D. Daikh. Suppression of glomerulonephritis in NZB/NZW lupus prone mice by adoptive transfer of ex vivo expanded regulatory T cells. Submitted Arthritis Research and Therapy , April, 2008.
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