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University
of California, San Francisco
513 Parnassus Avenue, Room S-1032, Box 0795
San Francisco, CA. 94143-0795
email: Mehrdad.Matloubian@ucsf.edu
Dr. Matloubian received his Ph.D. (Virology, 1996) and M.D. (1996) degrees from University of California, Los Angeles. He completed his training in internal medicine and rheumatology at UCSF. In 2004, he joined the faculty of the Division of Rheumatology at the University of California, San Francisco.
Research
Interests
The cells of the immune system are regulated through complex interactions with many proteins with different functions. One group of such regulatory proteins is the chemokine family, which consists of about 40 small proteins with chemoattractant property, i.e. the ability to attract the very motile white blood cells of the immune system. The chemokines are important for the development and organization of the immune system and play a crucial role in guiding the white blood cells to sites of infection and inflammation. They play an important role in inflammatory diseases such as asthma as well as autoimmune diseases such as rheumatoid arthritis. Dr. Matloubian's interest is in better understanding of the role of chemokines in autoimmune diseases and how they contribute to maintenance and progression of disease.
Recent
Publications
Matloubian, M. , A. David, S. Engel, J. E. Ryan, and J. G. Cyster. A transmembrane CXC chemokine is ligand for HIV-coreceptor Bonzo. 2000 Nature Immunology1:298-304.
Luther S. A., A. Bidgol, D. C. Hargreaves, A. Schmidt, Y. Xu, J J. Paniyadi, M. Matloubian,J. G. Cyster. Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis. 2002 J. Immunol. 169:424-433.
Matloubian, M. , C. G. Lo, G. Cinamon, M. J. Lesneski, Y. Xu, V. Brinkmann, M. L. Allende, R. L. Proia, and J. G. Cyster. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. 2004 Nature 427:355-360.
Cinamon, G., M. Matloubian, M. J. Lesneski, Y. Xu, C. Low, T. Lu, R. L. Proia, and J. G. Cyster. Sphingosine-1-phosphate receptor-1 promotes B cell localization in the splenic marginal zone. 2004 Nature Immunology 5:713-720.
Schwab, S. R., J. Pereira, M. Matloubian, Y. Xu, Y. Huang,, and J. G. Cyster. Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. 2005 Science 309:1735-1739.
Shiow, R. L., D. B. Rosen, N. Brdickova, Y. Xu, J. An, L. L. Lanier, J. G. Cyster, and M. Matloubian. CD69 acts downstream of interferon-a/b to inhibit S1P 1 and lymphocyte egress from lymphoid organs. 2006 Nature 440:540-544.
Mueller, S. N., K. A. Hosiawa-Meagher, B. T. Konieczny, B.M. Sullivan, M. F. Bachman, R. M. Locksley, R. Ahmed, and M. Matloubian. Regulation of homeostatic chemokine expression and cell trafficking during immune responses. 2007 Science 317:670.
Mueller, S.N., M. Matloubian, D. M. Clemens, A. H. Sharpe, G. J. Freeman, S. Gangappa, C. P. Larsen, and R. Ahmed. Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection. 2007 PNAS 104:15430.
Pham, T.H., T. Okada, M. Matloubian, C.G. Lo, and J.G. Cyster. S1P1 receptor signaling overrides retention mediated by Gai coupled receptors to promote T cell egress. 2008 Immunity 28:122.
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