Nitin Sonawane, PhD

Phone: 415.476.8530
Fax: 415.665.3847
E-mail: nitin.sonawane@ucsf.edu

College:	University of Poona, India (M.S.)
Other Graduate Training:	University of Mumbai, India (Ph.D.)

Interests

Research: CFTR based drug discovery of secretory diarrhea, polycystic kidney disease, and cystic fibrosis; non-absorbable/absorbable anti-diarrhea drugs; CFTR inhibitors & modulators; lead based drug optimization & SAR studies; pharmacology-pharmacokinetics & drug metabolism; biology of chloride transport; fluorescent chloride indicators; organic synthesis

Scholarly and Creative Activities (selected)

N.D. Sonawane, Dan Zhao, O. Zegarra-Moran, L.J.V. Galietta, and A.S. Verkman. Lectin conjugates as potent, non-absorbable CFTR inhibitors for reducing intestinal fluid secretion in cholera. Gastroenterology 132:1234-1244, (2007)

N.D. Sonawane, J. Hu, C. Muanprasat, A.S. Verkman. Luminally-active, non-absorbable CFTR inhibitors as potential therapy to reduce intestinal fluid loss in cholera. FASEB J. 20:130-132, (2006).

N.D. Sonawane, F.C. Szoka Jr, A.S. Verkman. Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes. J. Biol. Chem. 278:44826-44831 (2003).

N.D. Sonawane and A.S. Verkman. Determinants of [Cl-] in recycling and late endosomes and Golgi complex measured using fluorescent ligands. J. Cell. Biol. 160:1129-1138 (2003).

N.D. Sonawane, J.R. Thiagarajah, A.S. Verkman. Chloride concentration in endosomes measured using a ratioable fluorescent Cl- indicator: Evidence for Cl-accumulation during acidification. J. Biol. Chem. 277:5506-5513 (2002).

For more publications: PubMed for Sonawane, Nitin