David Pearce, MD

Phone: 415.476.7015
Fax: 415.502.8644
E-mail: pearced@medicine.ucsf.edu

College:	University of California, Berkeley
Medical School:	University of Chicago, Pritzker School of Medicine
Internal Medicine Residency:	Harbor-UCLA Medical Center
Nephrology Fellowship:	University of California, San Francisco

Interests

Clinical: Acute Renal Failure, Acid-base and electrolyte disorders; hypertension and abnormalities in volume homeostasis.

Research:
1) Signaling mechanisms involved in the regulation of epithelial ion transport in health and disease.

2) Mechanism of aldosterone signaling.

3) Interconnections between diabetes and hypertension.

Scholarly and Creative Activities (selected)

Selected original publications:

Chen, S-Y, Bhargava, A, Mastroberardino, L, Meijer, OC, Wang, J, Buse, P, Firestone, GL, Verrey, F, and Pearce, D, Epithelial sodium channel regulated by aldosterone-induced protein sgk. Proc Natl Acad Sci U S A, 1999. 96 (5): 2514-9.

Wang, J, Barbry, P, Maiyar, AC, Rozansky, DJ, Bhargava, A, Leong, M, Firestone, GL, and Pearce, D, SGK integrates insulin and mineralocorticoid regulation of epithelial sodium transport. Am. J. Physiol., 2001. 280 (2): F303-F313.

V. Bhalla, D. Daidié, H. Li, A. C. Pao, L. P. LaGrange, J. Wang, A. Vandewalle, J. D. Stockand, O. Staub, and D. Pearce. SGK1 regulates ubiquitin ligase Nedd4-2 by inducing interaction with 14-3-3. Mol Endocrinol, 19: 3073-84, 2005.

R. Soundararajan, T. T. Zhang, J. Wang, A. Vandewalle and D. Pearce. A Novel Role for Glucocorticoid-Induced Leucine Zipper Protein (GILZ) in ENAC-Mediated Sodium Transport. J Biol Chem, 280: 39970-81, 2005.

A. C. Pao, J. A. McCormick, H. Li, J. Siu, C. Govaerts, V. Bhalla, R. Soundararajan, and D. Pearce. The N-terminus of Serum and Glucocorticoid Regulated Kinase 1 is Essential for Isoform-Specific Physiologic Functions but not for Kinase Activity. Am J Physiol- Renal Phys, 292: F1741-50, 2007.

Selected review articles:

A. Bhargava and D. Pearce. Mechanisms of mineralocorticoid action: determinants of receptor specificity and actions of regulated gene products. Trends in Endocrinology and Metabolism, 15: 147-53, 2004.

J. A. McCormick, V. Bhalla, A. C. Pao, and D. Pearce. SGK1: a rapid aldosterone-induced regulator of renal sodium reabsorption. Physiology, 20:134-9, 2005.

V. Bhalla, R. Soundararajan, A. C. Pao, H. Li, and D. Pearce. Disinhibitory Pathways for Control of Sodium Transport: Regulation of ENaC by SGK1 and GILZ. Am J Physiol: Renal Phys, 291:F714-21, 2006.

D. Pearce and T.R. Kleyman. Salt, sodium channels, and SGK1. J. Clin. Invest, 117: 592, 2007.

For more publications (since 2002): PubMed for Pearce, David