David H. Lovett, MD

College:	Indiana University
Medical School:	Indiana University, School of Medicine
Internal Medicine Residency:	Yale-New Haven Hospital
Nephrology Fellowship:	Yale-New Haven Hospital
Fellow:	Alexander von Humboldt Stiftung, FRG

Interests

Research: Molecular pathogenesis of renal fibrosis and progression, haplotype analyses of proinflammatory genes

Scholarly and Creative Activities (selected)

Chen S, Jaume A, Steinmann K, Mertens P, Lovett DH: The metastasis inhibition factor, nm-23, suppresses transcription of the gelatinase A gene by interference with transactivator YB-1. Biochemical J 2002; 366:807

Olaso E, Labrador P, Wang LH, Ikeda K, Eng F, Klein R, Lovett DH, Lin HC, Friedman SL: DDR2 receptor regulates fibroblast proliferation and migration through extracellular matrix by transcriptional activation of MMP-2. J Biol Chem 2002; 277:3606

Reisdorff J, En-Nia A, Stefanidis I, Floege J, Lovett DH, Mertens PR: Transcription factor Ets-1 regulates gelatinase A gene expression in mesangial cells. J Amer Soc Nephrol 2002; 13:1568

Mertens P, Steinmann K, Jaume A-M, Lovett DH: Combinatorial interactions of p53, AP2 and YB-1 with a single enhancer element regulate gelatinase A expression in neoplastic cells. J Biol Chem 2002; 277:24875

Ikeda K, Wang LH, Torres R, Zhao H, Olaso E, Eng Francis J, Labrador P, Klein R, Lovett D, Yancopoulos GD, Friedman SL, Lin HC: Discoidin domain receptor 2 (DDR2) interacts with Src and Shc following its activation by type I collagen. J Biol Chem 2002; 277:19206

Bergman MR, Cheng S, Honbo N, Piacentini L, Karliner JS, Lovett DH: A functional AP-1 site regulates cardiac cell-specific MMP-2 transcription through interactions with JunB/Fra1 and JunB/FosB heterodimers. Biochemical J 2003; 369:485

Pollock AS, Turck J, Lovett DH: The pro-domain of Interleukin-1 . interacts with elements of the RNA processing apparatus and induces apoptosis in malignant cells. FASEB Journal 2003; 17:203

Cheng S and Lovett, DH: Gelatinase A is necessary and sufficient for myofibroblastic transdifferentiation of renal tubular epithelial cells. Amer J Pathol 2003; 162:1937

Harendza S, Lovett DH, Panzer U, Kuehnl P and Stahl RAK: Linked common polymorphisms in the gelatinase A promoter are associated with diminished transcriptional response to estrogen and genetic fitness. J Biol Chem 2003; 278:20490

Alfonso-Jaume MA, Mahimkar R, and Lovett DH: NFATc1 coordinately regulates MT1-MMP transcription in cooperation with zinc finger transcription factors, Sp1/Sp3 and Egr1 in glomerular mesangial cells. Biochem J 2004; 380: 735

Visaya O, Mahimkar R, Pollock AS, Lovett DH: The disintegrin domain of the renal epithelial cell metalloprotease-disintegrin MDC9 mediates cellular attachment and is a ligand for multiple ?1 integrins. Biochem J 2005; 385:461

En-Nia A, Yilmax E, Klinge U, Lovett DH, Stefanidis I, Mertens PR: Transcription factor YB-1 mediates DNA-polymerase alpha gene expression. J Biol Chem 2005; 280:7702

Parsa A, Lovett DH, Peden, EA, Zhu L, Seldin MF, Criswell LA: Renin-angiotensin system gene polymorphisms predict the progression to renal insufficiency among Asians with lupus nephritis. Genes Immun 2005; 6:217

Wetmore J, Hung A, Sen S, Lovett DH and Johansen K: Defined haplotypes in the Interleukin-1 gene cluster predict risk of ESRD. Kidney International 2005; 68:278

Dahi S, Lee JG, Lovett DH, Sarkar R. Differential transcriptional activation of matrix metalloproteinase-2 and membrane type I matrix metalloproteinase by experimental deep venous thrombosis and thrombin. J Vasc Surgery 2005; 42:539

Lee JG, Dahi S, Mahimkar R, Tullock NL, Alfonso-Jaume MA, Lovett DH, Sarkar R. Intronic regulation of matrix metalloproteinase-2 revealed by in vivo transcriptional analysis in ischemia. Proceed Nat Acad USA 2005; 102: 16345

Wang G-Y, Bergman MR, Nguyen AP, Turcato S, Karliner JS, Lovett DH and Baker AJ: Cardiac transgenic matrix metalloproteinase-2 expression directly induces impaired contractility. Cardiovasc Research 2006; 69:688

Mukherjee, R, Mingoia JT, Bruce JA, Alfonso-Juame, MA, Fini, E, Lovett, DH and Spinale, FG: Selective spatiotemporal induction of matrix metalloproteinases -2 and -9 transcription following myocardial infarction in mice. Am J Physiol Heart Circ Physiol 2006; 291:H2216

Alfonso-Jaume MA, Bergman M, Karliner J and Lovett DH: Ischemia-reperfusion injury mediates MMP-2 gene expression via induction of FosB/JunB heterodimers. Am J Physiol Heart Circ Physiol 2006; 291:H1838

Wetmore J, Sen S, Johansen K and Lovett DH: The angiotensin converting enzyme promoter polymorphism A-239T predictis survival in patients with end stage renal disease. Human Genetics 2006; 120:201

Cheng S, Pollock, AS, Mahimkar R, Olsen JL and Lovett,DH: Matrix metalloproteinase 2 and basement membrane integrity: a unifying mechanism for progressive renal injury. FASEB J 2006; 20:1898

Jansen PL, Kever M, Rosch R, Jansen M, Alfonso-Jaume A, Doley S, Klinge U, Lovett DH, Mertens PR: Response to alloplastic material involves zonal regulation of matrix metalloproteinase-2 gene expression in macrophages and fibroblasts. FASEB J 2007; 21:1047

Bergman M, Teerlink, Li L, Zhu B, Karliner J and Lovett DH: Cardiac matrix metalloproteinase-2 transgene expression independently induces marked ventricular remodeling and systolic dysfunction. Am J Physiol Heart Circ Physiol 2007; 292:H1847

Jansen PL, Rosch R, Jansen M, Binnebosel M, Junge K, Alfonso-Jaume A, Klinge U, Lovett DH, Mertens PR. Regulation of MMP-2 gene transcription in dermal wounds. J Invest Dermatology 2007; 127:1762

Zhou H-Z, Ma, X, Gray MO, Zhu B, Nguyen AP, Simonis U, Cecchini G, Lovett DH, and Karliner J: Transgenic MMP-2 expression induces latent cardiac mitochondrial dysfunction. Biochem Biophys Res Comm 2007; 358:189

Recent Presentations
Visiting Professor, New College, Oxford University, 2002
Invited Speaker, Fibrogen Corporation, 2002
Invited Speaker, Millenium Pharmaceuticals, 2002
Invited Speaker, State of the Art Lecture, American Society of Nephrology Annual Meeting, 11/02
Invited Speaker, Millenium Pharmaceutical, 2003
Invited Speaker, Fibrogen Corporation, 2003
Invited Speaker, University of Southern California, 2003
Invited Speaker, University of California, Los Angeles, 2003
Invited Speaker, University of Washington, 2003
Invited Speaker, Exilixis Corporation, 2004

For more publications: PubMed for Lovett, David