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UCSF Division of Nephrology
521 Parnassus Avenue
Clinical Sciences, Room C443
San Francisco, CA 94143-0532
Administrative: (415)476-2172
Clinical: (415)476-2173
Fax: (415)476-3381
The Division of Nephrology at the University of California-San Francisco has a long and distinguished history. Over the past four decades, the UCSF has been a major source of leaders and investigators in nephrology at academic centers throughout the United States. Prior faculty members have included Drs. Robert Alpern, Allen Arieff, Barry Brenner, Martin Cogan, Laurence Earley, Isidore Edelman, Floyd Rector, Jr., Robert Schrier, and David Warnock.
Our mission today continues to be expanding the frontiers of basic and clinical investigation in nephrology, training the next generation of academic nephrology leaders and providing the highest level of patient care.
Current faculty members are based at UCSF Medical Center, San Francisco General Hospital and the VA Medical Center. They include winners of the American Society of Nephrology Young Investigators Award (Stephen Gluck, Alan Verkman) and the Belding Schribner Award (Curtis Morris, Anthony Sebastian); multiple members of the American Society for Clinical Investigation or Association of American Physicians (Glenn Chertow, Steve Gluck, Harlan Ives, David Lovett, Curtis Morris, Anthony Sebastian, Alan Verkman), and the current President of the American Society of Transplantation (Flavio Vincenti).
Available mentors include numerous physician-scientists in the Nephrology Division who hold R01-level grants in basic science (Stephen Gluck, Michael Humphreys, David Lovett, David Pearce, Alan Verkman) or clinical research (Chi-yuan Hsu, Kirsten Johansen, Curtis Morris). Active basic research programs focus on the molecular and cell biology of vacuolar H-ATPase, regulation of sodium balance, regulation of epithelial ion transport, mechanisms of water transport in renal epithelia and pathology of renal matrix metabolism. Patient-oriented and clinical research projects include the impact of intensity of dialytic therapy on patient outcomes, epidemiology of chronic kidney disease, acute renal failure and end-stage renal disease and mechanisms of salt-sensitive hypertension. Numerous UCSF faculty members in the Departments of Anatomy, Biochemistry and Biophysics, Epidemiology and Biostatistics as well as the Division of General Internal Medicine are also active members of our fellowship training program.
Our training program includes tracks for both clinician-educators as well as physician-scientists. In the past 10 years, among the 50 physician-scientist trainees who graduated, 32 (64%) now hold United States or Canadian university faculty positions. Fifteen graduates have gone on to become principal investigators of K08/K23, their equivalent (e.g. VA Career Development) or higher (e.g. R01, P01) awards.
We also take great pride in the excellence of our clinical programs. UCSF Medical Center has performed more kidney transplants than any other institution in the world (over 8,000 since 1964). Members of the Division are active participants in several NIH-sponsored clinical trials of dialysis therapy, both for acute renal failure and for end-stage renal diseases, thus bringing cutting edge theapuetic interventions to the bedside.
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