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Analysis
of Complex Genetic Traits
The overall goal of my research is to develop the tools for genetic analysis
of whole genomes and apply these tools to elucidate the genetic factors
associated with common human diseases. We are actively involved in three
areas of research. First, we are part of the International Haplotype Map
Consortium to construct linkage disequilibrium (haplotype) maps of the
human genome with markers at 2-5 kilobasepair intervals. This map will
be available to all researchers to map genes involved in common human
diseases. Second, we are developing efficient genotyping and haplotyping
methods for complex trait analysis. These methods will increase the speed
and reduce the cost of large-scale association studies. Third, we are
applying the tools we are developing to identify genetic factors associated
with complex human traits such as susceptibility to psoriasis, longevity,
and response to chemotherapy in colon cancer.
Selected Publications:
Taillon-Miller, P, Bauer-Sardiña, I, Saccone, NL, Putzel, J, Laitinen,
T, Kere, J, Pilia, G, Rice, JP and Kwok, P-Y: Juxtaposed Regions of Extensive
and Minimal Linkage Disequilibrium in Human Xq25 and Xq28. Nature Genet.
2000; 25:324 -328.
The International SNP Map Working Group: A map of human genome sequence
variation containing 1.4 million SNPs. Nature. 2001; 409:928-933.
Marth, G, Yeh, R, Minton, M, Donaldson, R, Li, Q, Duan, S, Davenport,
R, Miller, RD, and Kwok, P-Y: Single nucleotide polymorphisms in the public
database: how useful are they? Nature Genetics 2001; 27:371-372.
Marth, G, Schuler, G, Yeh, RG, Davenport, R, Agarwala, R, Church, D, Wheelan,
S, Baker, J, Ward, M, Kholodov, M, Phan, L, Czabarka, E, Murvai, J, Cutler,
D, Wooding, S, Rogers, A, Chakravarti, A, Harpending, H, Kwok, P-Y, and
Sherry, ST. Sequence variations in the public human genome data reflect
a bottlenecked population history. Proc. Natl. Acad. Sci. USA 2003; 100:376-381.
Xiao, M and Kwok, P-Y. DNA Analysis By Fluorescence Quenching Detection.
Genome Research, in press.
Contact Information:
Email:kwok@itsa.ucsf.edu
Phone: 415/514-3802
Address: Box 0130, Room L 1332
The University of California, San Francisco, CA 94143, (415) 476-9000
Copyright 2003, The Regents of the University of California.
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