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Michelle's
Title
Our research focuses on the role of
Selected Publications:
Malone, R.E., Bullard, S., Hermiston, M.L., Rieger, R., Cool, M., and
Galbraith, A. Isolation of mutants defective in early steps of meiotic
recombination in the yeast Saccharomyces cerevisiae. Genetics, 128:79-88
(1991).
Roth, K.A., Hermiston, M.L., and Gordon, J.I. Use of transgenic mice to
infer the biological properties of small intestinal stem cells and to
examine the lineage relationships of their descendants. Proc. Natl. Acad.
Sci. USA, 88:9407-9411 (1991).
Hermiston, M.L., Latham, C.B., Gordon, J.I., and Roth, K.A. Simultaneous
localization of six antigens in sections of transgenic mouse intestine
using a combination of light and fluorescence microscopy. J. Histochem.
Cytochem., 40:1283-1290 (1992).
Hermiston, M.L., Green, R.P., and Gordon, J.I. Chimeric-transgenic mice
represent a powerful tool for studying how the proliferation and differentiation
programs of intestinal epithelial cell lineages are regulated. Proc. Natl.
Acad. Sci. USA, 90:8866-8870 (1993).
Hermiston, M.L., and Gordon, J.I. In vivo analysis of cadherin function
in the mouse intestinal epithelium: essential roles in adhesion, maintenance
of differentiation, and regulation of programmed cell death. J. Cell Biol.,
129:489-506 (1995).
Hermiston, M.L., and Gordon, J.I. Functional organization of the crypt-villus
axis and evolution of its stem cell hierarchy during intestinal development.
Amer. J. Physiol., 268 (Gastrointest. Liver Physiol. 31):G813-G822 (1995).
Hermiston, M.L., and Gordon, J.I. Inflammatory bowel disease and adenomas
in mice expressing a dominant negative N-cadherin. Science, 270:1203-1207
(1995).
Hermiston, M.L., Wong, M.H., and Gordon, J.I. Forced expression of E-cadherin
in the mouse intestinal epithelium slows cell migration and provides evidence
for non-autonomous regulation of cell fate in a self-renewing system.
Genes and Development, 10:985-996 (1996) (Cover photo).
Wong, M.H., Hermiston, M.L., Snider, D., and Gordon, J.I. Forced expression
of the tumor suppresser adeneomatosis polyposis coli protein induces disordered
cell migration in the intestinal epithelium. Proc. Natl. Acad. Sci. USA,
93:9588-9593 (1996)
Fazeli, A., Dickinson, S.L., Hermiston, M.L., Tighe, R., Steen, R.G.,
Small, C.G., Stoeckli, E.T., Keino-Masu, K., Masu, M., Rayburn, H., Simons,
J., Bronson, R.T., Gordon, J.I., Tessier-Lavigne, M., and Weinberg, R.A.
Phenotype of mice lacking Deleted in colorectal cancer (DCC) gene. Nature,
386:796-804 (1997)
Contact Information:
Email: hermist@itsa.ucsf.edu
Phone: 415/476-3831
Address: Box 0106
The University of California, San Francisco, CA 94143, (415) 476-9000
Copyright 2003, The Regents of the University of California.
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