Sarah Staedke, M.D.
Assistant Adjunct Professor
staedke@itsa.ucsf.edu

Mailing Address:
Box 0811, SFGH Bldg 30, 4th Floor
University of California, San Francisco
San Francisco, CA. 94143 - 0811

Office Location:
San Francisco General Hospital, Box 0811

Research Interests:
The primary focus of my research is antimalarial drug efficacy in Uganda.  We have conducted a series of clinical trials comparing new combinations of antimalarial regimens for treatment of uncomplicated malaria in Kampala, and we are currently assembling a large cohort of Ugandan children to evaluate the efficacy, safety, and tolerability of three different combination antimalarial regimens over 3 years. In addition, for my PhD thesis project (London School of Hygiene & Tropical Medicine, Department of Infectious and Tropical Diseases), we plan to assemble a second cohort of children to assess the effectiveness of antimalarial drugs at the community level. In this study we will evaluate the utility of home-based management of fever, using artemether + lumefantrine (Coartem) for presumptive treatment of malaria, comparing it with the current standard of care.  The impact of home-based management of fever on malaria-associated morbidity and economic parameters will be assessed.  My additional research interests include antimalarial drug policy, assessment of drug safety and evaluation of adverse events, and cost-effectiveness of antimalarial interventions. 

Select Publications:

Staedke S, Kamya M, Dorsey G, Gasasira A, Ndeezi G, Charlebois E, Rosenthal P. Amodiaquine, sulfadoxine-pyrimethamine, and combination therapy for treatment of uncomplicated falciparum malaria in Kampala, Uganda: a randomized trial. Lancet 2001; 358: 368-74.

Kamya M, Bakyaita N, Talisuna A, Were W, Staedke SG. Increasing antimalarial drug resistance in Uganda and revision of the national drug policy. Tropical Medicine and International Health 2002; 7: 1031-41.

Staedke SG, Nottingham EW, Cox J, Kamya MR, Rosenthal PJ, Dorsey G. Short report: proximity to mosquito breeding sites as a risk factor for clinical malaria episodes in an urban cohort of Ugandan children. American Journal of Tropical Medicine and Hygiene 2003; 69: 244-6.

Staedke SG, Sendagire H, Lamola S, Kamya MR, Dorsey G, Rosenthal PJ. Relationship between age, molecular markers, and response to sulphadoxine-pyrimethamine treatment in Kampala, Uganda. Tropical Medicine and International Health 2004; 9: 624-9.

Staedke SG, Mpimbaza A, Kamya MR, Nzarubara BK, Dorsey G, Rosenthal PJ. Combination treatments for uncomplicated falciparum malaria in Kampala, Uganda: randomised clinical trial. Lancet 2004; 364: 1950-7.

Education and Training:

MD, University of Texas Southwestern Medical School, Dallas, TX, 1989-1993

Internship and Residency, Department of Medicine, University of Colorado, Denver,1993-1996

London School of Hygiene and Tropical Medicine, London, UK, Diploma of Tropical Medicine and Hygiene, 1996

Fellow, Division of Infectious Diseases, University of California, San Francisco, 1998-2001

London School of Hygiene and Tropical Medicine, London, UK, PhD (anticipated), Department of Infectious and Tropical Diseases, 2003-present