Philip Rosenthal, M.D.
Professor
rosnthl@itsa.ucsf.edu

Mailing Address:
San Francisco General Hospital
1001 Potrero Avenue, Building 30, Rm. 421
San Francisco, CA 94110

Office Location:
San Francisco General Hospital, Bldg. 30, Rm. 421

Research Interests:
Malaria, including biochemistry of malaria parasites, antimalarial drug discovery, and clinical and translational studies of antimalarial drug efficacy and resistance in Africa

Select Publications:

Pandey, K. C., Sijwali, P. S., Singh, A., Na, B.-K., Rosenthal, P. J.: Independent intramolecular mediators of folding, activity, and inhibition for the Plasmodium falciparum cysteine protease falcipain-2. J. Biol. Chem., 279:3484-3491, 2004.

Sijwali, P. S., Rosenthal, P. J.: Gene disruption confirms a critical role for the cysteine protease falcipain-2 in hemoglobin hydrolysis by Plasmodium falciparum. Proc. Natl. Acad. Sci. USA, 101:4384-4389, 2004.

Sijwali, P. S., Kato, K., Seydel, K. B., Gut, J., Lehman, J., Klemba, M., Goldberg, D. E., Miller, L. H., Rosenthal, P. J.: Plasmodium falciparum cysteine protease falcipain-1 is not essential in erythrocytic stage malaria parasites. Proc. Natl. Acad. Sci. U S A, 101:8721-8726, 2004.

Singh, A. K., Rosenthal, P. J.: Selection of cysteine protease inhibitor resistant malaria parasites is accompanied by amplification of falcipain genes and alteration in inhibitor transport. J. Biol. Chem., 279:35236-42, 2004.

Staedke, S. G., Mpimbaza, A., Kamya, M.R., Nzarubara, B. K., Dorsey, G., Rosenthal, P. J.: Combination therapies for uncomplicated falciparum malaria in Kampala, Uganda: a randomized clinical trial. Lancet, 364:1950-1957, 2004.

Education and Training:

M.D., New York University, 1978-82

Medicine Residency, University of Michigan, 1982-85

Infectious Diseases Fellowship, University of California, San Francisco, 1985-88

Relevant Links:

BMS program: http://www.ucsf.edu/bms/