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 Joanne Engel, M.D., Ph.D
Division Chief
Professor of Medicine and Microbiology and Immunology
Director, Microbial Pathogenesis and Host Defense Program
jengel@medicine.ucsf.edu
Mailing Address:
University of California, San Francisco
Division of Infectious Diseases
521 Parnassus Avenue, Room C-443
San Francisco, CA 94143-0654
Office Location:
Health Sciences East Building - HSE405
Research Interests:
Microbial pathogenesis of Pseudomonas aeruginosa and Chlamydia trachomatis infections
Select Publications:
Elwell, C. and Engel, J. Chlamydia trachomatis infection of Drosophila melanogaster S2 cells mimics early steps in mammalian infection, in press, Cellular Microbiology, 7:725, 2005.
Gassama-Digene, A., W. Yu, M. ter Beest, F. Martin- Ernandez, A. Kierbel, J. Engel, and K. Mostov. Phosphatidylinositol 3, 4, 5-triphosphaate is necessary and sufficient for formation of the basolateral plasma membrane, Nature Cell Biology, 9:963-970, 2006.
Shafikhani, S. and J. Engel. Pseudomonas aeruginosa type III secreted toxin ExoT inhibits host cell division by targeting cytokinesis at multiple steps, Proc Nat Acad Sci 103: 15605-15610, 2006.
Kierbel, A., Gassama-digene, A., Rocha, C., Radoshevich, L., Olson, J., Mostov, K., and Engel, J., Psuddomonas aeruginosa exploits a PIP3-dependent mechanism to transform apical into basolateral membrane, Journal of Cell Biology, 177:21-27, 2007
Balachandran, P., Dragone, L., Garrity-Ryan, L, Weiss, A., and Engel, J. Pseudomonas aeruginosa Exotoxin T-mediated virulence is limited by the ubiquitin ligase cbl-b, Journal of Clinical Investigation 117:419-427, 2007.
Education and Training:
PhD, Stanford University, 1982
MD, Stanford University, 1983
Residency, University of Pennsylvania, 1983-1986
Infectious Disease Fellowship and postdoctoral training, University of California at San Francisco, 1986-1990
Relevant Links:
http://www.ucsf.edu/immuno/faculty/Engel_main.htm
http://www.ucsf.edu/bms/faculty/engel.html
http://tetrad.ucsf.edu/faculty.php?ID=59
http://medicine.ucsf.edu/id/engellab/index.htm
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