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Whitchurch, C., Beatson, S., Comolli, Jakobsen, T., J., Sargent,
J., Bertrand, J., Klausen, M., Waite, L., Kang, P. J., Tolker-Nielsen,
T., Mattick, J., and Engel, J. FimL, a novel Pseudomonas aeruginosa
gene product involved in Type IV fimbrial function and twitching
motility, submitted.
Whitchurch, C., Young, M., Kennedy, H. Beatson, S., Leech, A.,
Semmler, A., Duelfel, H., Jaeger, K.-E., Comolli, J., Nguyen, L.,
Engel, Engel, J., Hobbs, M., Martin, P., Alm, R., Darzins, A., and
Mattick, J., Characterisation of a complex signal transduction system
which controls twitching motility and the production of multiple
virulence factors of Pseudomonas aeruginosa,
Molecular
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Kazmierczak, B., Jou, T.-S., Mostov, K., and Engel, J., Epithelial
cell polarity alters Rho-GTPase responses to Pseudomonas aeruginosa,
Molecular
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Garrity-Ryan, L, Shafikhani, S., Balachandran, P., Nguyen, L, Oza,
J., Jakobsen, T., Sargent, J., Fang, X., Matthay, M.. and Engel,
J. The ADP ribosyltranserase domain of Pseudomonas aeruginosa
ExoT contributes to its biological activities,
Infection
and Immunity (2004) 72:546-558.
McMorran B., Town,L., Costello, E., Palmer, J., Engel, J., Hume,
D., and Wainright, B.The type III-secreted effector ExoU is an important
modulator of gene expression in lung epithelial cells in response
to Pseudomonas aeruginosa infection,
Infection
and Immunity (2003) 71:6035-6044.
Jacob, T, Lee, R., Engel, J., and Machen, T. Modulation of Cytosolic
Ca2+ Concentration in Airway Epithelial Cells by Pseudomonas
aeruginosa.
Infection
and Immunity (2002)
70: 6399-6408.
Hauser, A. R., E. Cobb, M. Bodi, D. Mariscal, J. Valles, J. N. Engel,
and J. Rello. Type III Protein Secretion is Associated With Poor
Clinical Outcomes in Patients With Ventilator-Associated Pneumonia
Caused by Pseudomonas aeruginosa.
Critical
Care Medicine (2002)
30: 521-528.
Kazmierczak, B. and Engel, J., Pseudomonas aeruginosa ExoT
Acts in vivo as a GTPase-Activating Protein for RhoA, Rac1,
and Cdc42. Infection
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74: 2198-2205.
Kazmierczak, B., Mostov, K., and Engel, J. Interaction of Bacterial
Pathogens with Polarized Epithelium.
Annual
Review of Microbiology (2001)
55: 407-435.
Kazmierczak, B., Jou, T.-S., Mostov, K., and Engel, J. Rho-Family
GTPases Modulate Pseudomonas aeruginosa Internalization by
Epithelial Cells. Cellular
Microbiology (2001)
3: 85-98.
Geiser, T., Kazmierczak, B., Garrity-Ryan, L, Matthay, M., and Engel,
J., Pseudomonas aeruginosa ExoT Inhibits in vitro
Lung Epithelial Wound Repair. Cellular
Microbiology (2001)
3: 223-236.
Garrity-Ryan, L, Kazmierczak, B., Kowal, R., Comolli, J., Hauser,
A. and Engel, J. The Arginine Finger Domain of ExoT Contributes
to Actin Cytoskeleton Disruption and Iinhibition of Internalization
of Pseudomonas aeruginosa into Epithelial Cells and Macrophages.
Infection
and Immunity (2000)
68: 7100-7113.
van Ooij, C., Kalman, L., van Ijzendoorn, S., Nishijima, M., Hanada,
K., Mostov, K., and Engel, J. Host-cell Derived Sphingolipids are
Required for the Iintracellular Growth of Chlamydia trachomatis.
Cellular
Microbiology (2000)
2: 627-638.
Stephens, R. S., Fawaz, F. S., Kennedy, K. A., Koshiyama, K., Nichols,
B., van Ooij, C., and Engel, J.N. Eukaryotic Cell Uptake of Heparin-Coated
Microspheres: A Model of Host Cell Invasion by Chlamydia.
Infection
and Immunity (2000)
68: 1080-1085.
Hauser, A., and Engel, J. Pseudomonas aeruginosa Induces
Type III Secretion-Mediated Apoptosis. Infection
and Immunity (1999)
67: 5530-5537.
Comolli, J., Hauser, A., Waite, L., Whitchurch, C., Mattick, J.,
and Engel, J. Pseudomonas aeruginosa Gene Products PilT and
PilU Are Required for Cytotoxicity In Vitro and Virulence
in a Mouse Model of Acute Pneumonia. Infection
and Immunity (1999)
67: 3625-3630.
Comolli, J., Waite, L., Mostov, K., and Engel, J. Pili Binding to
Asialo-GM1 on Epithelial Cells can Mediate Cytotoxicity or Bacterial
Internalization by Pseudomonas aeruginosa. Infection
and Immunity (1999)
67: 3207-3214.
Hauser, A., Fleizsig, S., Kang, P. J., Mostov, K., and Engel, J.,
Defects in Type III Secretion Correlate with Internalization of
Pseudomonas aeruginosa by Epithelial Cells. Infection
and Immunity (1998)
66: 1413-1420.
Hauser, A., Kang, P., and Engel, J. PepA, a novel secreted protein
of Pseudomonas aeruginosa, is necessary for cytotoxicity
and virulence. Molecular
Microbiology (1998)
2: 807-818.
Kang, P. J., Hauser, A., Apodaca, G., Wiener-Kronish, J., Mostov,
K., Fleizig, S., and Engel, J., Identification of Pseudomonas
aeruginosa Genes Required for Epithelial Cell Injury. Molecular
Microbiology (1997). 24:1249-1262.
Apodaca, G., Bomsel, M., Lindstedt, R., Engel, J. Frank, D., Mostov,
K. E., and Wiener-Kronish, J. Characterization of Pseudomonas
aeruginosa-Induced MDCK Cell Injury: Glycosylation-Defective
Host Cells Are Resistant to Bacterial Killing. Infection
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63: 1541-1551.
Chapters:
Engel, J. Molecular Pathogenesis of acute Pseudomonas aeruginosa
infections. In "Severe Infections Caused by Pseudomonas
aeruginosa," A. Hauser and J. Rello, editors, Kluwer/Plenum
Press, New York City, 2002.
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