Personal Information Name: Heather Nye, MD, PhD   General Information 7/2004-present Assistant Professor in Medicine and Pediatrics, UCSF 8/2003-7/2004 Clinical Instructor in Medicine, UCSF Department of Medicine, Hospitalist Group Clinical Instructor, UCSF Department of Pediatrics   Education 1991 Duke University, Durham, NC, B.A., Chemistry 1995 Yale University, New Haven, CT, Ph.D., Pharmacology 1998 Yale University, New Haven, CT, M.D.   Licensure and Certification 1996 United States Medical Licensing Exam Step I 1997 United States Medical Licensing Exam Step II 2000 United States Medical Licensing Exam Step III 1999-2000 Neonatal Advanced Life Support 1999-2004 Pediatric Advanced Life Support 1999-2004 Advanced Cardiac Life Support 1999-2005 Massachusetts Medical License 2003-2005 California Medical Licence 2003-2013 Internal Medicine Board Certification 2003-2010 Pediatrics Board Certification   Employment/ Clinical Training 1999-2003 Resident - Harvard Combined Internal Medicine/Pediatrics Residency Program Brigham & Women's Hospital, Children's Hospital Boston, and Massachusetts General Hospital Boston, MA   Awards      College 1987-1988 CRC Chemistry Freshman of the Year 1991 Alpha Tau & Phi Eta Sigma Honor Societies Magna Cum Laude 1991 Howard Hughes Fellowship Award 1991 Graduation with Distinction in Chemistry      Medical School 1998 Norman Herzig/Albert Schweitzer Fellowship (Zimbabwe) 1991-1998 M.D./Ph.D. Fellowship Award      Residency 2001 Residency Schliesman Memorial Travel Fellowship 2001 (Children's Hospital)   Professional Acitivities Member, Society for Neuroscience (1991-97) Member, Massachusetts Medical Society (1999-2003) Society for Hospitalist Medicine (2004) American Academy of Pediatrics (2004) American College of Physicians (2004)   Research Experience 1991-1995 "Identification and Characterization of Novel Fos-Like Proteins Induced in Rat Striatum and Nucleus Accumbens following Chronic Cocaine and Morphine Administration" (Ph.D. Thesis) Eric J. Nestler, M.D., Ph.D., Thesis Advisor, Yale University 1992 "Effects of efferent lesions on tyrosine hydroxylase expression in the ventral tegmental area of rat brain" (Research Rotation) Ariel Y. Deutch, Ph.D., Advisor. Yale University 1992-1993 "Binding properties of HA-966 enantiomers on GABA B and GHB sites" (Research Rotation) Robert H. Roth, Ph.D., Advisor, Yale University 1990-1991 "Acute effect of cocaine and other agents on norepinephrine release in the developing rat heart" (Senior Honors Thesis) Theodore Slotkin, Ph.D., Advisor, Duke University   Medical Activities, Teaching, and Leadership 1994 Admissions Committee, Yale Department of Pharmacology 1994-1996 HOPE Project Team Leader, Yale Homeless Outreach Program for Enrichment. Medical clinic for New Haven homeless population staffed by Yale School of Medicine. Organized staffing, worked in clinic, and designed teaching sessions 1998-1999 Albert Schweitzer Institute for the Humanities Volunteer, collected and coalated medications (drug samples) for supplying clinics abroad 1998-2000 2000-2003 Morning Conference, Brigham Primary Care "Depression and Primary Care" Morning Conference, Brigham Primary Care "Obesity: An American Epidemic" Emergency Department Conference, Children's Hospital Boston "Ovarian Torsion: Diagnosis and Treatment" Noon Conference, Endocrinology Dept, Children's Hospital Boston "Beckwith Wiedemann Syndrome; A Case Presentation" Pre-Clinic Conference Talks, Uphams Corner, Dorchester, MA "Anemia and Children" (selections) "The Pap Smear and Cervical Cancer" "Hepatitis C, Screening and Treatment In Primary Care" "Hematuria in Children" Noon Conference, Nephrology Dept, MGH Pediatrics "Renal Failure and IGF" 2002-2003 PACT Project Volunteer Prevention and Access to Care and Treatment for HIV positive individuals in poor and underserved neighborhoods of Boston. Once-daily directly observed therapy program, home visits, prevention and risk reduction training and teaching of clients and staff Hospitalist Home Visitation Program, Brigham & Women's Hospital Home visits to ensure optimal transition from inpatient setting to home, focusing on reducing medication errors, reducing rates of readmission. Medical student teaching and mentoring, design of curriculum for community services available to underserved and elderly Admissions Committee, Harvard Med/Peds Program 2003-2004 Daily Attending Rounds on Medicine and Pediatric Wards, UCSF Morning Conference, UCSF Fresno "Abnormal LFTs. Primary Biliary Cirrhosis" Noon Conference, UCSF Fresno "In-Flight Medical Emergencies.Is there a Doctor on the Flight?" Grand Rounds, UCSF Fresno "Low Carbohydrate Diets: The Real Skinny" Committee Member, Inpatient Insulin Use, UCSF Subcutaneous Insulin Form Development, Resident Guidelines and Training Committee Member, Sitter Task Force, UCSF Interview panel: Patient Care Coordinator, UCSF Medical Student Precepting, H & P, UCSF Medical Student Intersession Seminar Leader, Ethics 4/04, 6/04 Computer Order Entry, Physician Panel for Order Set Development, UCSF Intersession Ethics Teaching, 4/04, 6/04 New Faculty Search Committee, Department of Pediatrics Delirium Protocol Committee Heart Failure Team Member Management of the Hospitalized Patient CME meeting, San Francisco 10/04 Speaker, Take-Home Points & Summary Discussion   Community Service 1988-1991 Durham Presbyterian Homeless Shelter weekly volunteer, Durham, NC 1989-1990 Tutor/Assistant Teacher, Duke School for Children, Durham, NC 1988-1989 Umstead Psychiatric Institute weekly volunteer, Durham, NC 1993-1998 Girl Scout Troop Leader, New Haven, CT 2003 Devotion Elementary/Middle School Science Fair Judge, Brookline, MA 2002-2003 New Chardon Shelter for Women and Children Clinic, Boston, MA   Clinical Responsibilities Ward Attending 5 months medicine, 2 months pediatrics Visiting Professor, Fresno UCSF, 3 wks Resident/Medical Student Preceptor Pediatric Urgent Care, 2 sessions/week   Other Activities 1991-1995 Intramural softball, soccer 1996 Yale Medical School Music Director of 2nd Year Show 1998 Yale Medical School Yearbook Editor in Chief   Non-Medical Interests Music -- singing, piano, guitar, composition, CD recordings, solo and multiple band performances, weddings, hiking, biking, local folk music, foreign travel   International Medical Experience 3/1998-4/1998 Harare, Zimbabwe - Parirenyatwa Hospital Two months in an urban hospital working in general medicine and cardiology clinics and wards, attending medical school lectures, participating in rural .bush. clinics, as part of Herzig/Schweitzer Fellowship award. Preceptor: Dr. Ian Ternouth 4/2000 Lima, Peru - Socios de Salud One week with health care promoters (promotores) on home visits in the poorest communities of Lima as part of the multi-drug-resistant TB clinic set up by Partners In Health of Cambridge, MA 5/2001 Maun, Botswana - Delta Medical Center One month in small clinic located in rural setting. Time also spent in city hospital.with relatively few resources.in pediatrics and adult wards. Preceptor: Dr. Richard Thompson (cardiologist) 11/2001-12/2001 Barcelona, Spain - Vall de Hebron Hospital Six weeks in large tertiary care center. Participated in multiple aspects of cardiology service, including stress testing, ward medicine, nuclear imaging, and echocardiography. Preceptor: Dr. Jordi Soler Soler   Publications Atkins JB, Chlan-Fourney J, Nye HE, Hiroi N, Carlezon W, Nestler EJ. (1999) Region-Specific Induction of .FosB by Repeated Administration of Typical Versus Atypical Antipsychotic Drugs. Synapse. 33:118-128. Morrow BA, Lee EJK, Taylor JA, Elsworth JD, Nye HE, Roth RH. (1997) S-(-)HA-966, a .-hydroxybutryate-like agent, prevents enhanced mesocorticolimbic dopamine metabolism and behavioral correlates of restraint stress, conditioned fear and cocaine sensitization. JPET 283(2):712-721 Nye HE, Nestler EJ. (1996) Induction of chronic Fos-related antigens in rat brain by chronic morphine administration. Mol. Pharm. 49:636-645. Nye HE, Hope BT, Kelz MB, Iadarola M, Nestler EJ. (1995) Pharmacological studies of the regulation of chronic Fos-related antigen induction by cocaine in the striatum and nucleus accumbens. JPET. 275(3):1671-1680. Chen J, Nye HE, Kelz MB, Hiroi N, Nakabeppu Y, Hope BT, Nestler EJ. (1995) Regulation of .FosB and FosB-like proteins by electroconvulsive seizure and cocaine treatments. Mol. Pharm. 48:880-889. Hope BT, Nye HE, Kelz MB, Self DW, Iadarola MJ, Nakabeppu Y, Duman RS, Nestler EJ. (1994) Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments. Neuron 13:1235-1244. Nye HE, Seidler FJ, Slotkin T. (1991) Developmental shift from local to central control of norepinephrine release in the cardiac-sympathetic axis: Effects of cocaine and related drugs. JPET. 259(3):976-981   Abstracts/Poster Presentations Nye HE, Atkins JB, Carlezon WA, Nestler EJ. (1997) The regulation of Chronic Fras (Fos-related antigens) by antipsychotic drugs in the rat forbrain. Society for Neuroscience Abstract. 747.26 Nye HE, Nestler EJ. (1995) Pharmacological characterization of cocaine-induced chronic Fras (Fos-related antigens). Society for Neuroscience Abstract. Hope BT, Nye HE, Chen JC, Hiroi N, Nestler EJ. (1995) Purification and identification of chronically-induced Fras (Fos-related antigens). Society for Neuroscience Abstract. Morrow BA, Lee EJK, Elsworth JD, Nye HE, Roth RH. (1995) S-(-)HA-966, a .-hydroxybutryate-like agonist, blocks behavioral and mesoaccumbal in addition to mesocortical dopaminergic stress activation. Soceity for Neuroscience Abstract. Nye HE, Iadarola MJ, Nestler EJ. (1994) Chronic Morphine elicits novel Fos-Related-Proteins and persistent AP-1 binding in rat striatum. Society for Neuroscience Abstract 20:56 Hope BT, Nye HE, Kelz MB, Self D, Iadarola M, Nakabeppu Y, Duman R, Nestler EJ. (1994) Induction of long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other treatments. Society for Neuroscience Abstract 20:56. Hope BT, Nye HE, Kelz M, Genova L, Self D, Iadarola M, Duman RS, Nestler EJ. (1994) Chronic cocaine induces a long-lasting AP-1 complex containing novel Fos-related proteins, including .FosB. Society for Neuroscience Abstract 20:56. Nye HE, Deutch AY. (1992) Effects of prefrontal cortical lesions on tyrosine hydroxylase gene expression in midbrain dopamine neurons. Society for Neuroscience Abstract. 18:1378. Hope BT, Nye HE, Nestler EJ. (1992) AP-1 and CRE-binding activities are regulated in the rat locus coeruleus and nucleus accumbens following chronic morphine or cocaine. Society for Neuroscience Abstract 18:1432. Nye HE, Seidler FJ, Slotkin TA. (1991) The effects of acute cocaine challenge on norepinephrine turnover in the developing cardiac-sympathetic axis. FASEB Abstract. Bio | Hospital Medicine Faculty