Areas of investigation
We are interested in how G protein-coupled receptors (GPCRs) control electrically active tissues. In tissues such as the heart and the brain, GPCRs orchestrate the intracellular biochemical signals with the actions of ion channels at the cell surface. To best understand this process, we have devised several new methods to control G protein signals in vivo and use new techniques to monitor signaling events on a genomic level.

Significance
GPCRs are the target for some of the most widely used pharmaceuticals to treat diseases that involve virtually all tissues of the body. New GPCR signaling systems will provide insights into GPCR-induced physiological responses and will allow for new forms of controlling engineered tissues in vivo. By defining the global gene expression response to G protein signals, we are identifying new diagnostic markers of disease and key regulatory pathways for future therapeutics.

Gladstone Institute of Cardiovascular Disease