UCSF DIABETES, ENDOCRINOLOGY & METABOLISM TRAINING PROGRAM FACULTY RESEARCH SUMMARIES
STAINIER, DIDIER, Ph.D. Department of Biochemistry and Biophysics
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Questions of interest include cell differentiation, tissue morphogenesis and organ function. We address these questions in the zebrafish, a model system particularly amenable to embryological and genetic studies. We first identify genes critical for these processes, usually by forward genetics, and then proceed to investigate cell biological and biochemical mechanisms. Ultimately, we would like to understand developmental processes at the single cell level, both in terms of cell differentiation, cell behavior (e.g. cell migration) and intrinsic cellular properties (e.g. cell polarization).
Selected References
Reim, G., Mizoguchi, T., Stainier, D.Y., Kikuchi, Y. and Brand, M. (2004). POU domain protein (Pou2/Oct4) is essential for endoderm formation in cooperation with the HMG domain protein Casanova. Dev. Cell 6:91-101
Trinh, L.A. and Stainier, D.Y.R. (2004). Fibronectin regulates epithelial organization during myocardial migration in zebrafish. Dev. Cell 6: 371-382.
Parker, L.H., Schmidt, M., Jin, S.-W., Gray, A.M., Beis, D., Pham, T., Frantz, G., Palmieri, S., Hillan, K., Stainier, D.Y.R., de Sauvage, F.J., Ye, W. (2004). A novel endothelial cell derived secreted factor VEMF regulates vascular tube formation. Nature 428: 754-758.
Bartman, T., Walsh, E.C., Wen, K.-K., McKane, M., Ren, J., Alexander, J., Rubenstein, P.A. and Stainier, D.Y.R. (2004). Early Myocardial Function Affects Endocardial Cushion Development in Zebrafish. PLoS Biology 2: 673-681.
Trinh, L.A., Yelon, D. and Stainier, D.Y.R. (2005). Hand2 regulates epithelial formation during myocardial differentiation. Current Biology 15: 441-446.