UCSF DIABETES, ENDOCRINOLOGY & METABOLISM TRAINING PROGRAM FACULTY RESEARCH SUMMARIES
HULLEY, STEPHEN, M.D., M.P.H. Department of Medicine, Epidemiology, and Biostatistics |
|
I work on a number of clinical research and epidemiologic studies.
• Coronary Artery Risk Development in Young Adults (CARDIA), 1985-2008: I have served as Chairman of the Steering Committee of this NHLBI-funded study since its inception. This is a cohort study that follows young adults into middle age to discover the antecedent coronary heart disease (CHD) risk factors, such as hypertension and obesity, and to explore genetic-environmental interactions in the development of coronary artery calcium assessed by computed tomography. The 5115 participants, with roughly equal numbers of African-Americans and Caucasians, of men and women, and of lower and higher educated people, have been followed for 19 years in clinical centers in Oakland, Birmingham, Minneapolis, and Chicago.
• Heart and Estrogen/Progestin Replacement Study (HERS), 1992-2005: I am the Principal Investigator of the Coordinating Center for this study with 20 collaborating Clinical Centers. This randomized clinical trial examines the effects of estrogen plus progestin therapy on the recurrence of CHD events in postmenopausal women with coronary disease, as well as on other disease outcomes such as thromboembolism, cognitive function and quality of life. In addition to continuing to report findings from the main trial (which ended in 2002), we have two ongoing ancillary projects: (1) to study thrombosis gene polymorphisms, and (2) to examine the relationship between estrogen receptor polymorphisms and the effect of hormone therapy on HDL and other outcomes.
• Medicine or Surgery (Ms), 1996-2005: I am the Principal Investigator of this 4-center randomized clinical trial and Principal Investigator of its coordinating center. The study included two randomized trials, one comparing the impact on quality of life of hysterectomy vs medical management for abnormal uterine bleeding in pre-menopausal women, and the other comparing supracervical vs total abdominal hysterectomy.
Pharmacogenetics and Risk of Cardiovascular disease (PARC), 2001-5: I am the Principal Investigator of the Coordinating Center of this NIH-funded study headed by Dr. Ron Kraus. The goal of this study is to identify common gene variants that contribute to inter-individual differences in LDL-cholesterol response to statins and in 24-hour blood pressure response to ACE inhibitors.